Composition of the gut microbiota modulates the severity of malaria

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 8, 2016, Pages 2235-2240

  Villarino, Nicolas F ^a,c   LeCleir, Gary R ^a   Denny, Joshua E ^a,b   Dearth, Stephen P ^a   Harding, Christopher L ^b   Sloan, Sarah S ^a   Gribble, Jennifer L ^a   Campagna, Shawn R ^a   Wilhelm, Steven W ^a   Schmidt, Nathan W ^a,b  

^a UNIVERSITY OF TENNESSEE   (United States)

^b University of Louisville School of Medicine   (United States)

^c WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

Gut microbiome; Plasmodium; Severe malaria

Indexed keywords

AMPICILLIN; GENTAMICIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 21; MEROZOITE SURFACE PROTEIN 1; METRONIDAZOLE; NEOMYCIN; VANCOMYCIN; YOGHURT; ANTIINFECTIVE AGENT; PROBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL STRUCTURES; BIFIDOBACTERIUM; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE SEVERITY; GERMFREE MOUSE; HUMORAL IMMUNITY; INTESTINE FLORA; LACTOBACILLUS; MALARIA; MICROBIAL COMMUNITY; MORTALITY; MOUSE; NONHUMAN; PARASITE LOAD; PARASITEMIA; PATHOGENESIS; PLASMODIUM; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; GERMFREE ANIMAL; HOST PARASITE INTERACTION; HUMAN; IMMUNOLOGY; ISOLATION AND PURIFICATION; MICROBIOLOGY; PARASITOLOGY; PHYSIOLOGY; PLASMODIUM YOELII;

ANIMALS; ANTI-BACTERIAL AGENTS; BIFIDOBACTERIUM; GASTROINTESTINAL MICROBIOME; GERM-FREE LIFE; HOST-PARASITE INTERACTIONS; HUMANS; LACTOBACILLUS; MALARIA; MICE; MICE, INBRED C57BL; PARASITE LOAD; PLASMODIUM YOELII; PROBIOTICS;

EID: 84959194509     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1504887113     Document Type: Article

References (43)

1. Murray CJ, et al. (2012) Global malaria mortality between 1980 and 2010: A systematic analysis. Lancet 379(9814):413-431.
2. Crompton PD, et al. (2014) Malaria immunity in man and mosquito: Insights into unsolved mysteries of a deadly infectious disease. Annu Rev Immunol 32:157-187.
3. Dondorp AM, et al. (2005) Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2. PLoS Med 2(8):e204.
4. Hanson J, et al. (2012) Relative contributions of macrovascular and microvascular dysfunction to disease severity in falciparum malaria. J Infect Dis 206(4):571-579.
5. Honda K, Littman DR (2012) The microbiome in infectious disease and inflammation. Annu Rev Immunol 30:759-795.
6. Turnbaugh PJ, et al. (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444(7122):1027-1031.
7. Wen L, et al. (2008) Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature 455(7216):1109-1113.
8. Hsiao EY, et al. (2013) Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 155(7):1451-1463.
9. Johnson CC, et al. (2005) Antibiotic exposure in early infancy and risk for childhood atopy. J Allergy Clin Immunol 115(6):1218-1224.
10. Joffe TH, Simpson NA (2009) Cesarean section and risk of asthma. The role of intrapartum antibiotics: A missing piece? J Pediatr 154(1):154.
11. Fujimura KE, et al. (2014) House dust exposure mediates gut microbiome Lactobacillus enrichment and airway immune defense against allergens and virus infection. Proc Natl Acad Sci USA 111(2):805-810.
12. Manichanh C, et al. (2006) Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach. Gut 55(2):205-211.
13. Frank DN, et al. (2007) Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci USA 104(34):13780-13785.
14. Peterson DA, Frank DN, Pace NR, Gordon JI (2008) Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases. Cell Host Microbe 3(6):417-427.
15. Nicholson JK, et al. (2012) Host-gut microbiota metabolic interactions. Science 336(6086):1262-1267.
16. Kamada N, Chen GY, Inohara N, Núñez G (2013) Control of pathogens and pathobionts by the gut microbiota. Nat Immunol 14(7):685-690.
17. Benson A, Pifer R, Behrendt CL, Hooper LV, Yarovinsky F (2009) Gut commensal bacteria direct a protective immune response against Toxoplasma gondii. Cell Host Microbe 6(2):187-196.
18. Naik S, et al. (2012) Compartmentalized control of skin immunity by resident commensals. Science 337(6098):1115-1119.
19. Abt MC, et al. (2012) Commensal bacteria calibrate the activation threshold of innate antiviral immunity. Immunity 37(1):158-170.
20. Yilmaz B, et al. (2014) Gut microbiota elicits a protective immune response against malaria transmission. Cell 159(6):1277-1289.
21. Yooseph S, et al. (2015) Stool microbiota composition is associated with the prospective risk of Plasmodium falciparum infection. BMC Genomics 16(1):631.
22. Ivanov II, et al. (2008) Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 4(4):337-349.
23. Ivanov II, et al. (2009) Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139(3):485-498.
24. David LA, et al. (2014) Diet rapidly and reproducibly alters the human gut microbiome. Nature 505(7484):559-563.
25. Turnbaugh PJ, et al. (2009) The effect of diet on the human gut microbiome: A metagenomic analysis in humanized gnotobiotic mice. Sci Transl Med 1(6):6ra14.
26. Carmody RN, et al. (2015) Diet dominates host genotype in shaping the murine gut microbiota. Cell Host Microbe 17(1):72-84.
27. Pérez-Enciso M, TenenhausM(2003) Prediction of clinical outcome with microarray data: A partial least squares discriminant analysis (PLS-DA) approach. Hum Genet 112(5-6):581-592.
28. Mooney JP, et al. (2015) Inflammation-associated alterations to the intestinal microbiota reduce colonization resistance against non-typhoidal Salmonella during concurrent malaria parasite infection. Sci Rep 5:14603.
29. Segata N, et al. (2011) Metagenomic biomarker discovery and explanation. Genome Biol 12(6):R60.
30. Cox MJ, et al. (2010) Lactobacillus casei abundance is associated with profound shifts in the infant gut microbiome. PLoS One 5(1):e8745.
31. McNulty NP, et al. (2011) The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins. Sci Transl Med 3(106):106ra106.
32. Pérez-Mazliah D, et al. (2015) Disruption of IL-21 signaling affects T cell-B cell interactions and abrogates protective humoral immunity to malaria. PLoS Pathog 11(3):e1004715.
33. Butler NS, et al. (2012) Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection. Nat Immunol 13(2):188-195.
34. Azambuja P, Garcia ES, Ratcliffe NA (2005) Gut microbiota and parasite transmission by insect vectors. Trends Parasitol 21(12):568-572.
35. Dong Y, Manfredini F, Dimopoulos G (2009) Implication of the mosquito midgut microbiota in the defense against malaria parasites. PLoS Pathog 5(5):e1000423.
36. Cirimotich CM, et al. (2011) Natural microbe-mediated refractoriness to Plasmodium infection in Anopheles gambiae. Science 332(6031):855-858.
37. Boissière A, et al. (2012) Midgut microbiota of the malaria mosquito vector Anopheles gambiae and interactionswith Plasmodiumfalciparuminfection. PLoS Pathog 8(5):e1002742.
38. Bahia AC, et al. (2014) Exploring Anopheles gut bacteria for Plasmodium blocking activity. Environ Microbiol 16(9):2980-2994.
39. Verhulst NO, et al. (2009) Cultured skin microbiota attracts malaria mosquitoes. Malar J 8:302.
40. Verhulst NO, et al. (2011) Composition of human skin microbiota affects attractiveness to malaria mosquitoes. PLoS One 6(12):e28991.
41. Kau AL, Ahern PP, Griffin NW, Goodman AL, Gordon JI (2011) Human nutrition, the gut microbiome and the immune system. Nature 474(7351):327-336.
42. Brestoff JR, Artis D (2013) Commensal bacteria at the interface of host metabolism and the immune system. Nat Immunol 14(7):676-684.
43. De Filippo C, et al. (2010) Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci USA 107(33):14691-14696.