Inotropic Effects of Experimental Hyperthermia and Hypothermia on Left Ventricular Function in Pigs-Comparison with Dobutamine

Critical Care Medicine

Volumn 44, Issue 3, 2016, Pages e158-e167

  Alogna, Alessio ^a   Manninger, Martin ^a   Schwarzl, Michael ^b   Zirngast, Birgit ^a   Steendijk, Paul ^c   Verderber, Jochen ^a   Zweiker, David ^a   Maechler, Heinrich ^a   Pieske, Burkert M ^d   Post, Heiner ^d  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITY HEART CENTER HAMBURG   (Germany)

^c LEIDEN UNIVERSITY   (Netherlands)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Hyperthermia; inotropy; left ventricular systolic function; mild hypothermia; pressure volume analysis; temperature management

Indexed keywords

DOBUTAMINE;

ANIMAL EXPERIMENT; AORTA OCCLUSION; AORTA PRESSURE; ARTICLE; CENTRAL VENOUS PRESSURE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; CORE TEMPERATURE; DOSE RESPONSE; DRUG DOSE TITRATION; DRUG MEGADOSE; END TIDAL CARBON DIOXIDE TENSION; EXPERIMENTAL HYPERTHERMIA; HEART LEFT VENTRICLE CONTRACTILITY; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART LEFT VENTRICLE VOLUME; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; HEART VENTRICLE COMPLIANCE; HEMODYNAMICS; INDUCED HYPOTHERMIA; INOTROPISM; LANDRACE PIG; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SINGLE DRUG DOSE; SYSTEMIC VASCULAR RESISTANCE; VENOUS OXYGEN TENSION; ANIMAL; BLOOD GAS ANALYSIS; COMPARATIVE STUDY; DRUG EFFECTS; HEART CONTRACTION; PHYSIOLOGY; PIG; PROCEDURES; THERMOTHERAPY;

ANIMALS; BLOOD GAS ANALYSIS; CARDIAC OUTPUT; DOBUTAMINE; HEART RATE; HYPERTHERMIA, INDUCED; HYPOTHERMIA, INDUCED; MYOCARDIAL CONTRACTION; STROKE VOLUME; SUS SCROFA; VENTRICULAR FUNCTION, LEFT;

EID: 84959191536     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000001358     Document Type: Article

References (50)

1. Bernard SA, Gray TW, Buist MD, et al: Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002; 346:557-563
2. Hypothermia after Cardiac Arrest Study Group: Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002; 346:549-556
3. Chamberlain D; Founding Members of the International Liaison Committee on Resuscitation: The International Liaison Committee on Resuscitation (ILCOR)-past and present: Compiled by the Founding Members of the International Liaison Committee on Resuscitation. Resuscitation 2005; 67:157-161
4. Nielsen N, Wetterslev J, Cronberg T, et al; TTM Trial Investigators: Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med 2013; 369:2197-2206
5. Hiranandani N, Varian KD, Monasky MM, et al: Frequency-dependent contractile response of isolated cardiac trabeculae under hypo-, normo-, and hyperthermic conditions. J Appl Physiol (1985) 2006; 100:1727-1732
6. Weisser J, Martin J, Bisping E, et al: Influence of mild hypothermia on myocardial contractility and circulatory function. Basic Res Cardiol 2001; 96:198-205
7. Fukunami M, Hearse DJ: The inotropic consequences of cooling: Studies in the isolated rat heart. Heart Vessels 1989; 5:1-9
8. Mattheussen M, Mubagwa K, Van Aken H, et al: Interaction of heart rate and hypothermia on global myocardial contraction of the isolated rabbit heart. Anesth Analg 1996; 82:975-981
9. Nishimura Y, Naito Y, Nishioka T, et al: The effects of cardiac cooling under surface-induced hypothermia on the cardiac function in the in situ heart. Interact Cardiovasc Thorac Surg 2005; 4:101-105
10. Post H, Schmitto JD, Steendijk P, et al: Cardiac function during mild hypothermia in pigs: Increased inotropy at the expense of diastolic dysfunction. Acta Physiol (Oxf) 2010; 199:43-52
11. Saeki A, Goto Y, Hata K, et al: Negative inotropism of hyperthermia increases oxygen cost of contractility in canine hearts. Am J Physiol Heart Circ Physiol 2000; 279:H2855-H2864
12. Schmidt-Schweda S, Ohler A, Post H, et al: Moderate hypothermia for severe cardiogenic shock (COOL Shock Study I & II). Resuscitation 2013; 84:319-325
13. Stegman B, Aggarwal B, Senapati A, et al: Serial hemodynamic measurements in post-cardiac arrest cardiogenic shock treated with therapeutic hypothermia. Eur Heart J Acute Cardiovasc Care 2015; 4:263-269
14. Dae MW, Gao DW, Sessler DI, et al: Effect of endovascular cooling on myocardial temperature, infarct size, and cardiac output in human-sized pigs. Am J Physiol Heart Circ Physiol 2002; 282:H1584-H1591
15. Götberg M, Olivecrona GK, Engblom H, et al: Rapid short-duration hypothermia with cold saline and endovascular cooling before reperfusion reduces microvascular obstruction and myocardial infarct size. BMC Cardiovasc Disord 2008; 8:7
16. Götberg M, van der Pals J, Olivecrona GK, et al: Mild hypothermia reduces acute mortality and improves hemodynamic outcome in a cardiogenic shock pig model. Resuscitation 2010; 81:1190-1196
17. Schwarzl M, Seiler S, Wallner M, et al: Mild hypothermia attenuates circulatory and pulmonary dysfunction during experimental endotoxemia. Crit Care Med 2013; 41:e401-e410
18. Schwarzl M, Alogna A, Zirngast B, et al: Mild hypothermia induces incomplete left ventricular relaxation despite spontaneous bradycardia in pigs. Acta Physiol (Oxf) 2015; 213:653-663
19. Weiss JL, Frederiksen JW, Weisfeldt ML: Hemodynamic determinants of the time-course of fall in canine left ventricular pressure. J Clin Invest 1976; 58:751-760
20. Parker JD, Landzberg JS, Bittl JA, et al: Effects of beta-adrenergic stimulation with dobutamine on isovolumic relaxation in the normal and failing human left ventricle. Circulation 1991; 84:1040-1048
21. Karliner JS, LeWinter MM, Mahler F, et al: Pharmacologic and hemodynamic influences on the rate of isovolumic left ventricular relaxation in the normal conscious dog. J Clin Invest 1977; 60:511-521
22. Aghajani E, Muller S, Kjørstad KE, et al: The pressure-volume loop revisited: Is the search for a cardiac contractility index a futile cycle Shock 2006; 25:370-376
23. Burkhoff D, Mirsky I, Suga H: Assessment of systolic and diastolic ventricular properties via pressure-volume analysis: A guide for clinical, translational, and basic researchers. Am J Physiol Heart Circ Physiol 2005; 289:H501-H512
24. Ohte N, Cheng CP, Suzuki M, et al: Effects of atrial natriuretic peptide on left ventricular performance in conscious dogs before and after pacing-induced heart failure. J Pharmacol Exp Ther 1999; 291:589-595
25. Leeuwenburgh BP, Steendijk P, Helbing WA, et al: Indexes of diastolic RV function: Load dependence and changes after chronic RV pressure overload in lambs. Am J Physiol Heart Circ Physiol 2002; 282:H1350-H1358
26. Raff GL, Glantz SA: Volume loading slows left ventricular isovolumic relaxation rate. Evidence of load-dependent relaxation in the intact dog heart. Circ Res 1981; 48:813-824
27. Fincke R, Hochman JS, Lowe AM, et al; SHOCK Investigators: Cardiac power is the strongest hemodynamic correlate of mortality in cardiogenic shock: A report from the SHOCK trial registry. J Am Coll Cardiol 2004; 44:340-348
28. Go AS, Mozaffarian D, Roger VL, et al; American Heart Association Statistics Committee and Stroke Statistics Subcommittee: Heart disease and stroke statistics-2014 update: A report from the American Heart Association. Circulation 2014; 129:e28-e292
29. Templeton GH, Wildenthal K, Willerson JT, et al: Influence of temperature on the mechanical properties of cardiac muscle. Circ Res 1974; 34:624-634
30. Cooper T, Willman VL, Hanlon CR: Cardiovascular Responses to Hyperthermia. Dis Chest 1963; 44:88-89
31. Koroxenidis GT, Shepherd JT, Marshall RJ: Cardiovascular response to acute heat stress. J Appl Physiol 1961; 16:869-872
32. Prec O, Rosenman R: The circulatory responses to hyperthermia induced by radiant heat. J Clin Invest 1949; 28:301-306
33. Liedtke AJ, Hughes HC: Effects of hyperthermic stress on myocardial function during experimental coronary ischemia. Circ Res 1976; 39:647-653
34. D'Ambra MN, Magrassi P, Lowenstein E, et al: Myocardial temperature variation: Effect on regional function and coronary flow in dogs. Am J Physiol 1987; 252:H448-H455
35. Suga H, Goto Y, Igarashi Y, et al: Cardiac cooling increases Emax without affecting relation between O2 consumption and systolic pressurevolume area in dog left ventricle. Circ Res 1988; 63:61-71
36. Little WC, Cheng CP, Mumma M, et al: Comparison of measures of left ventricular contractile performance derived from pressure-volume loops in conscious dogs. Circulation 1989; 80:1378-1387
37. Katz AM: Cyclic adenosine monophosphate effects on the myocardium: A man who blows hot and cold with one breath. J Am Coll Cardiol 1983; 2:143-149
38. Kusuoka H, Ikoma Y, Futaki S, et al: Positive inotropism in hypothermia partially depends on an increase in maximal Ca(2+)-activated force. Am J Physiol 1991; 261:H1005-H1010
39. Langer GA, Brady AJ: The effects of temperature upon contraction and ionic exchange in rabbit ventricular myocardium. Relation to control of active state. J Gen Physiol 1968; 52:682-713
40. Mikane T, Araki J, Kohno K, et al: Mechanism of constant contractile efficiency under cooling inotropy of myocardium: Simulation. Am J Physiol 1997; 273:H2891-H2898
41. Gillebert TC, Lew WY: Influence of systolic pressure profile on rate of left ventricular pressure fall. Am J Physiol 1991; 261:H805-H813
42. Nelson OL, Robbins CT: Cardiovascular function in large to small hibernators: Bears to ground squirrels. J Comp Physiol B 2015; 185:265-279
43. Cotter G, Williams SG, Vered Z, et al: Role of cardiac power in heart failure. Curr Opin Cardiol 2003; 18:215-222
44. Holm J, Håkanson RE, Vánky F, et al: Mixed venous oxygen saturation is a prognostic marker after surgery for aortic stenosis. Acta Anaesthesiol Scand 2010; 54:589-595
45. Holm J, Håkanson E, Vánky F, et al: Mixed venous oxygen saturation predicts short-and long-term outcome after coronary artery bypass grafting surgery: A retrospective cohort analysis. Br J Anaesth 2011; 107:344-350
46. Müller S, How OJ, Jakobsen E, et al: Oxygen-wasting effect of inotropy: Is there a need for a new evaluation An experimental largeanimal study using dobutamine and levosimendan. Circ Heart Fail 2010; 3:277-285
47. Schwarzl M, Huber S, Maechler H, et al: Left ventricular diastolic dysfunction during acute myocardial infarction: Effect of mild hypothermia. Resuscitation 2012; 83:1503-1510
48. Schwarzl M, Steendijk P, Huber S, et al: The induction of mild hypothermia improves systolic function of the resuscitated porcine heart at no further sympathetic activation. Acta Physiol (Oxf) 2011; 203:409-418
49. Jacobshagen C, Pelster T, Pax A, et al: Effects of mild hypothermia on hemodynamics in cardiac arrest survivors and isolated failing human myocardium. Clin Res Cardiol 2010; 99:267-276
50. Zobel C, Adler C, Kranz A, et al: Mild therapeutic hypothermia in cardiogenic shock syndrome. Crit Care Med 2012; 40:1715-1723