Mild hypothermia induces incomplete left ventricular relaxation despite spontaneous bradycardia in pigs

Acta Physiologica

Volumn 213, Issue 3, 2015, Pages 653-663

  Schwarzl, M ^a   Alogna, A ^b   Zirngast, B ^b   Steendijk, P ^c   Verderber, J ^b   Zweiker, D ^b   Huber, S ^b   Maechler, H ^b   Pieske, B M ^d   Post, H ^d  

^a UNIVERSITY HEART CENTER HAMBURG   (Germany)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Left ventricular compliance; Left ventricular relaxation; Mild hypothermia; Pressure volume analysis

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRADYCARDIA; CARDIOVASCULAR PARAMETERS; END DIASTOLIC PRESSURE VOLUME RELATIONSHIP; HEART ATRIUM PACING; HEART HEMODYNAMICS; HEART LEFT VENTRICLE CONTRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE RELAXATION; HEART OUTPUT; HEART PRELOAD; HEART RATE; IN VIVO STUDY; INDUCED HYPOTHERMIA; LEFT VENTRICULAR ENDDIASTOLIC CAPACITANCE; LEFT VENTRICULAR ISOVOLUMIC RELAXATION CONSTANT; LUNG ARTERY PRESSURE; MEAN ARTERIAL PRESSURE; MILD HYPOTHERMIA; NONHUMAN; PRESSURE VOLUME CURVE; PRIORITY JOURNAL; RATIO BETWEEN DIASTOLIC TIME INTERVAL; SYSTEMIC VASCULAR RESISTANCE; ADVERSE EFFECTS; ANIMAL; DIASTOLE; HEART PACING; HEART STROKE VOLUME; HEART VENTRICLE PRESSURE; PATHOPHYSIOLOGY; PIG; TIME;

ANIMALS; BRADYCARDIA; CARDIAC PACING, ARTIFICIAL; DIASTOLE; HEART RATE; HYPOTHERMIA, INDUCED; STROKE VOLUME; SWINE; TIME FACTORS; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 84921597393     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/apha.12439     Document Type: Article

References (52)

1. Borlaug, B.A., Jaber, W.A., Ommen, S.R., Lam, C.S., Redfield, M.M. & Nishimura, R.A. 2011. Diastolic relaxation and compliance reserve during dynamic exercise in heart failure with preserved ejection fraction. Heart 97, 964-969.
2. Braunwald, E., Frye, R.L., Ross, J. & Lewis, R. 1960. Studies on Starling's law of the heart: determinants of the relationship between left ventricular end-diastolic pressure and circumference. Circ Res 8, 1254-1263.
3. Brutsaert, D.L. 2006. Cardiac dysfunction in heart failure: the cardiologist's love affair with time. Prog Cardiovasc Dis 49, 157-181.
4. Buckberg, G.D., Brazier, J.R., Nelson, R.L., Goldstein, S.M., McConnell, D.H. & Cooper, N. 1977. Studies of the effects of hypothermia on regional myocardial blood flow and metabolism during cardiopulmonary bypass. I. The adequately perfused beating, fibrillating, and arrested heart. J Thorac Cardiovasc Surg 73, 87-94.
5. Burkhoff, D., Mirsky, I. & Suga, H. 2005. Assessment of systolic and diastolic ventricular properties via pressure-volume analysis: a guide for clinical, translational, and basic researchers. Am J Physiol Heart Circ Physiol 289, H501-H512.
6. Deakin, C.D., Nolan, J.P., Soar, J., Sunde, K., Koster, R.W., Smith, G.B. & Perkins, G.D. 2010. European resuscitation council guidelines for resuscitation 2010 section 4. Adult advanced life support. Resuscitation 81, 1305-1352.
7. Endoh, M. 1994. The effects of theophylline on aequorin light transients and force in the isolated dog right ventricular myocardium. J Mol Cell Cardiol 26, 87-98.
8. Erlinge, D., Gotberg, M., Lang, I., Holzer, M., Noc, M., Clemmensen, P., Jensen, U., Metzler, B., James, S., Botker, H.E. et al. 2014. Rapid endovascular catheter core cooling combined with cold saline as an adjunct to percutaneous coronary intervention for the treatment of acute myocardial infarction: the CHILL-MI Trial: a randomized controlled Study of the use of central venous catheter core cooling combined with cold saline as an adjunct to percutaneous coronary intervention for the treatment of acute myocardial infarction. J Am Coll Cardiol 63, 1857-1865.
9. Gotberg, M., Olivecrona, G.K., Engblom, H., Ugander, M., van der Pals, J., Heiberg, E., Arheden, H. & Erlinge, D. 2008. Rapid short-duration hypothermia with cold saline and endovascular cooling before reperfusion reduces microvascular obstruction and myocardial infarct size. BMC Cardiovasc Disord 8, 7.
10. Gotberg, M., van der Pals, J., Olivecrona, G.K., Gotberg, M., Koul, S. & Erlinge, D. 2010. Mild hypothermia reduces acute mortality and improves hemodynamic outcome in a cardiogenic shock pig model. Resuscitation 81, 1190-1196.
11. Haasler, G.B., Rodigas, P.C. & Spotnitz, H.M. 1982. The absence of temperature effects on end-diastolic pressure-volume relations in the canine left ventricle determined by two-dimensional echocardiography. J Thorac Cardiovasc Surg 83, 878-890.
12. Hay, I., Rich, J., Ferber, P., Burkhoff, D. & Maurer, M.S. 2005. Role of impaired myocardial relaxation in the production of elevated left ventricular filling pressure. Am J Physiol Heart Circ Physiol 288, H1203-H1208.
13. Henderson, A.H. & Cattell, M.R. 1976. Length-induced changes in activation during contraction. A study of mechanical oscillations in strontium-mediated contractions of cat and frog heart muscle. Circ Res 38, 289-296.
14. Jacobshagen, C., Pelster, T., Pax, A., Horn, W., Schmidt-Schweda, S., Unsold, B.W., Seidler, T., Wagner, S., Hasenfuss, G. & Maier, L.S. 2010. Effects of mild hypothermia on hemodynamics in cardiac arrest survivors and isolated failing human myocardium. Clin Res Cardiol 99, 267-276.
15. Kass, D.A., Wolff, M.R., Ting, C.T., Liu, C.P., Chang, M.S., Lawrence, W. & Maughan, W.L. 1993. Diastolic compliance of hypertrophied ventricle is not acutely altered by pharmacologic agents influencing active processes. Ann Intern Med 119, 466-473.
16. 2+-activated force. Am J Physiol 261, H1005-H1010.
17. Lam, C.S., Roger, V.L., Rodeheffer, R.J., Borlaug, B.A., Enders, F.T., & Redfield, M.M. 2009. Pulmonary hypertension in heart failure with preserved ejection fraction: a community-based study. J Am Coll Cardiol 53, 1119-1126.
18. Langer, G.A. & Brady, A.J. 1968. The effects of temperature upon contraction and ionic exchange in rabbit ventricular myocardium. Relation to control of active state. J Gen Physiol 52, 682-713.
19. Leeuwenburgh, B.P., Steendijk, P., Helbing, W.A. & Baan, J. 2002. Indexes of diastolic RV function: load dependence and changes after chronic RV pressure overload in lambs. Am J Physiol Heart Circ Physiol 282, H1350-H1358.
20. Leite-Moreira, A.F. & Correia-Pinto, J. 2001. Load as an acute determinant of end-diastolic pressure-volume relation. Am J Physiol Heart Circ Physiol 280, H51-H59.
21. Leite-Moreira, A.F., Correia-Pinto, J. & Gillebert, T.C. 1999. Afterload induced changes in myocardial relaxation: a mechanism for diastolic dysfunction. Cardiovasc Res 43, 344-353.
22. Liu, C.P., Ting, C.T., Lawrence, W., Maughan, W.L., Chang, M.S. & Kass, D.A. 1993. Diminished contractile response to increased heart rate in intact human left ventricular hypertrophy. Systolic versus diastolic determinants. Circulation 88, 1893-1906.
23. Lopez-de-Sa, E., Rey, J.R., Armada, E., Salinas, P., Viana-Tejedor, A., Espinosa-Garcia, S., Martinez-Moreno, M., Corral, E. & Lopez-Sendon, J. 2012. Hypothermia in comatose survivors from out-of-hospital cardiac arrest: pilot trial comparing 2 levels of target temperature. Circulation 126, 2826-2833.
24. Matsubara, H., Takaki, M., Yasuhara, S., Araki, J. & Suga, H. 1995. Logistic time constant of isovolumic relaxation pressure-time curve in the canine left ventricle. Better alternative to exponential time constant. Circulation 92, 2318-2326.
25. Mikane, T., Araki, J., Kohno, K., Nakayama, Y., Suzuki, S., Shimizu, J., Matsubara, H., Hirakawa, M., Takaki, M. & Suga, H. 1997. Mechanism of constant contractile efficiency under cooling inotropy of myocardium: simulation. Am J Physiol 273, H2891-H2898.
26. Mizuno, J., Matsubara, H., Mohri, S., Shimizu, J., Suzuki, S., Mikane, T., Araki, J., Hanaoka, K., Akins, R. & Morita, S. 2008. Half-logistic time constant: a more reliable lusitropic index than monoexponential time constant regardless of temperature in canine left ventricle. Can J Physiol Pharmacol 86, 78-87.
27. 2 consumption during hypothermia. Am J Physiol 206, 67-73.
28. Nielsen, N., Wetterslev, J., Cronberg, T., Erlinge, D., Gasche, Y., Hassager, C., Horn, J., Hovdenes, J., Kjaergaard, J., Kuiper, M. et al. 2013. Targeted temperature management at 33°C versus 36°C after cardiac arrest. N Engl J Med 369, 2197-2206.
29. Nikolic, S., Yellin, E.L., Tamura, K., Vetter, H., Tamura, T., Meisner, J.S. & Frater, R.W. 1988. Passive properties of canine left ventricle: diastolic stiffness and restoring forces. Circ Res 62, 1210-1222.
30. Nikolic, S., Yellin, E.L., Tamura, K., Tamura, T. & Frater, R.W. 1990. Effect of early diastolic loading on myocardial relaxation in the intact canine left ventricle. Circ Res 66, 1217-1226.
31. Nishimura, Y., Naito, Y., Nishioka, T. & Okamura, Y. 2005. The effects of cardiac cooling under surface-induced hypothermia on the cardiac function in the in situ heart. Interact Cardiovasc Thorac Surg 4, 101-105.
32. Post, H., Schmitto, J.D., Steendijk, P., Christoph, J., Holland, R., Wachter, R., Schondube, F.W. & Pieske, B. 2010. Cardiac function during mild hypothermia in pigs: increased inotropy at the expense of diastolic dysfunction. Acta Physiol (Oxf) 199, 43-52.
33. Raff, G.L. & Glantz, S.A. 1981. Volume loading slows left ventricular isovolumic relaxation rate. Evidence of load-dependent relaxation in the intact dog heart. Circ Res 48, 813-824.
34. Remensnyder, J.P. & Austen, W.G. 1965. Diastolic pressure-volume relationships of the left ventricle during hypothermia. J Thorac Cardiovasc Surg 49, 339-351.
35. Schmidt-Schweda, S., Ohler, A., Post, H. & Pieske, B. 2013. Moderate hypothermia for severe cardiogenic shock (COOL Shock Study I & II). Resuscitation 84, 319-325.
36. Schwarzl, M., Steendijk, P., Huber, S., Truschnig-Wilders, M., Obermayer-Pietsch, B., Maechler, H., Pieske, B. & Post, H. 2011. The induction of mild hypothermia improves systolic function of the resuscitated porcine heart at no further sympathetic activation. Acta Physiol (Oxf) 203, 409-418.
37. Schwarzl, M., Huber, S., Maechler, H., Steendijk, P., Seiler, S., Truschnig-Wilders, M., Nestelberger, T., Pieske, B.M. & Post, H. 2012. Left ventricular diastolic dysfunction during acute myocardial infarction: effect of mild hypothermia. Resuscitation 83, 1503-1510.
38. Schwarzl, M., Seiler, S., Wallner, M., von Lewinski, D., Huber, S., Maechler, H., Steendijk, P., Zelzer, S., Truschnig-Wilders, M., Obermayer-Pietsch, B., Lueger, A., Pieske, B.M. & Post, H. 2013. Mild hypothermia attenuates circulatory and pulmonary dysfunction during experimental endotoxemia. Crit Care Med 41, e401-e410.
39. Senzaki, H. & Kass, D.A. 2010. Analysis of isovolumic relaxation in failing hearts by monoexponential time constants overestimates lusitropic change and load dependence: mechanisms and advantages of alternative logistic fit. Circ Heart Fail 3, 268-276.
40. Senzaki, H., Fetics, B., Chen, C.H. & Kass, D.A. 1999. Comparison of ventricular pressure relaxation assessments in human heart failure: quantitative influence on load and drug sensitivity analysis. J Am Coll Cardiol 34, 1529-1536.
41. Smiseth, O.A. & Thompson, C.R. 2000. Atrioventricular filling dynamics, diastolic function and dysfunction. Heart Fail Rev 5, 291-299.
42. 2 consumption and systolic pressure-volume area in dog left ventricle. Circ Res 63, 61-71.
43. Suleiman, M.S. & Chapman, R.A. 1990. Effect of temperature on the rise in intracellular sodium caused by calcium depletion in ferret ventricular muscle and the mechanism of the alleviation of the calcium paradox by hypothermia. Circ Res 67, 1238-1246.
44. Sunde, K. & Soreide, E. 2011. Therapeutic hypothermia after cardiac arrest: where are we now? Curr Opin Crit Care 17, 247-253.
45. Templeton, G.H., Wildenthal, K., Willerson, J.T. & Reardon, W.C. 1974. Influence of temperature on the mechanical properties of cardiac muscle. Circ Res 34, 624-634.
46. Villar, J. & Slutsky, A.S. 1993. Effects of induced hypothermia in patients with septic adult respiratory distress syndrome. Resuscitation 26, 183-192.
47. Wachter, R., Schmidt-Schweda, S., Westermann, D., Post, H., Edelmann, F., Kasner, M., Luers, C., Steendijk, P., Hasenfuss, G., Tschope, C. & Pieske, B. 2009. Blunted frequency-dependent upregulation of cardiac output is related to impaired relaxation in diastolic heart failure. Eur Heart J 30, 3027-3036.
48. Weisfeldt, M.L., Frederiksen, J.W., Yin, F.C. & Weiss, J.L. 1978. Evidence of incomplete left ventricular relaxation in the dog: prediction from the time constant for isovolumic pressure fall. J Clin Invest 62, 1296-1302.
49. Weiss, J.L., Frederiksen, J.W. & Weisfeldt, M.L. 1976. Hemodynamic determinants of the time-course of fall in canine left ventricular pressure. J Clin Invest 58, 751-760.
50. Weisser, J., Martin, J., Bisping, E., Maier, L.S., Beyersdorf, F., Hasenfuss, G. & Pieske, B. 2001. Influence of mild hypothermia on myocardial contractility and circulatory function. Basic Res Cardiol 96, 198-205.
51. Zile, M.R., Baicu, C.F. & Gaasch, W.H. 2004. Diastolic heart failure-abnormalities in active relaxation and passive stiffness of the left ventricle. N Engl J Med 350, 1953-1959.
52. Zobel, C., Adler, C., Kranz, A., Seck, C., Pfister, R., Hellmich, M., Kochanek, M. & Reuter, H. 2012. Mild therapeutic hypothermia in cardiogenic shock syndrome. Crit Care Med 40, 1715-1723.