Low Pretreatment Impulsivity and High Medication Adherence Increase the Odds of Abstinence in a Trial of N-Acetylcysteine in Adolescents with Cannabis Use Disorder

Journal of Substance Abuse Treatment

Volumn 63, Issue , 2016, Pages 72-77

  Bentzley, Jessica P ^a   Tomko, Rachel L ^a   Gray, Kevin M ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Abstinence; Adolescent; Cannabis; Impulsivity; Marijuana; N acetylcysteine; Non adherence; Pharmacotherapy; Youth

Indexed keywords

ACETYLCYSTEINE; CANNABINOID;

ADOLESCENT; ADULT; ARTICLE; BARRATT IMPULSIVENESS SCALE; CANNABIS ADDICTION; CANNABIS USE; CONTROLLED STUDY; FEMALE; HELP SEEKING BEHAVIOR; HIGH PRETREATMENT IMPULSIVITY; HUMAN; IMPULSIVENESS; MAJOR CLINICAL STUDY; MALE; MEDICATION COMPLIANCE; PRIORITY JOURNAL; TREATMENT REFUSAL; WITHDRAWAL SYNDROME; MARIJUANA ABUSE; PSYCHOLOGY; YOUNG ADULT;

ACETYLCYSTEINE; ADOLESCENT; FEMALE; HUMANS; IMPULSIVE BEHAVIOR; MALE; MARIJUANA ABUSE; MEDICATION ADHERENCE; YOUNG ADULT;

EID: 84959166194     PISSN: 07405472     EISSN: 18736483     Source Type: Journal    
DOI: 10.1016/j.jsat.2015.12.003     Document Type: Article

References (41)

1. Barratt E.S. Anxiety and impulsiveness related to psychomotor efficiency. Perceptual and Motor Skills 1959, 9:191-198.
2. Bauer I.E., Soares J.C., Nielsen D.A. The role of opioidergic genes in the treatment outcome of drug addiction pharmacotherapy: a systematic review. The American Journal on Addictions/American Academy of Psychiatrists in Alcoholism and Addictions 2014, 10.1111/j.1521-0391.2014.12172.x.
3. Berg C.J., Ahluwalia J.S., Cropsey K. Predictors of adherence to behavioral counseling and medication among female prisoners enrolled in a smoking cessation trial. Journal of Correctional Health Care: the Official Journal of the National Commission on Correctional Health Care 2013, 19:236-247.
4. Bickel W.K., Koffarnus M.N., Moody L., Wilson A.G. The behavioral- and neuro-economic process of temporal discounting: a candidate behavioral marker of addiction. Neuropharmacology 2014, 76:518-527.
5. Bickel W.K., Yi R., Landes R.D., Hill P.F., Baxter C. Remember the future: working memory training decreases delay discounting among stimulant addicts. Biological Psychiatry 2011, 69:260-265.
6. Bitton A., Choudhry N.K., Matlin O.S., Swanton K., Shrank W.H. The impact of medication adherence on coronary artery disease costs and outcomes: a systematic review. The American Journal of Medicine 2013, 126:357.e7-357.e27.
7. Budney A.J., Vandrey R.G., Stanger C. Pharmacological and psychosocial interventions for cannabis use disorders. Revista Brasileira De Psiquiatria 2010, 32(Suppl. 1):S46-S55.
8. Churchwell J.C., Lopez-Larson M., Yurgelun-Todd D.A. Altered frontal cortical volume and decision making in adolescent cannabis users. Frontiers in Psychology 2010, 10.3389/fpsyg.2010.00225.
9. Dougherty D.M., Mathias C.W., Dawes M.A., Furr R.M., Charles N.E., Liguori A., Acheson A. Impulsivity, attention, memory, and decision-making among adolescent marijuana users. Psychopharmacology 2013, 226:307-319.
10. Gray K.M., Carpenter M.J., Baker N.L., DeSantis S.M., Kryway E., Hartwell K.J., Brady K.T. A double-blind randomized controlled trial of N-acetylcysteine in cannabis-dependent adolescents. American Journal of Psychiatry 2012, 169:805-812.
11. Han E., Suh D.C., Lee S.M., Jang S. The impact of medication adherence on health outcomes for chronic metabolic diseases: a retrospective cohort study. Research in Social & Administrative Pharmacy: RSAP 2014, 10:e87-e98.
12. Johnson M.W., Bickel W.K., Baker F., Moore B.A., Badger G.J., Budney A.J. Delay discounting in current and former marijuana-dependent individuals. Experimental and Clinical Psychopharmacology 2010, 18:99-107. 10.1037/a0018333.
13. Johnston L.D., O'Malley P.M., Miech R.A., Bachman J.G., Schulenberg J.E. Monitoring the Future National Results on Drug Use: 1975-2013: Overview, Key Findings on Adolescent Drug Use 2014, Institute for Social Research, The University of Michigan, Ann Arbor.
14. Kardas P., Lewek P., Matyjaszczyk M. Determinants of patient adherence: a review of systematic reviews. Frontiers in Pharmacology 2013, 10.3389/fphar.2013.00091/abstract.
15. Kiluk B.D., Nich C., Carroll K.M. Relationship of cognitive function and the acquisition of coping skills in computer assisted treatment for substance use disorders. Drug and Alcohol Dependence 2010, 114:169-176. 10.1016/j.drugalcdep.2010.09.019.
16. Kravitz R.L., Melnikow J. Medical adherence research: time for a change in direction?. Medical Care 2004, 42:197-199.
17. Krishnan-Sarin S., Reynolds B., Duhig A.M., Smith A., Liss T., McFetridge A., Potenza M.N. Behavioral impulsivity predicts treatment outcome in a smoking cessation program for adolescent smokers. Drug and Alcohol Dependence 2007, 88:79-82. 10.1016/j.drugalcdep.2006.09.006.
18. Lejuez C.W., Bornovalova M.A., Reynolds E.K., Daughters S.B., Curtin J.J. Risk factors in the relationship between gender and crack/cocaine. Experimental and Clinical Psychopharmacology 2007, 15:165-175. 10.1037/1064-1297.15.2.165.
19. Liraud F., Verdoux H. Association between temperamental characteristics and medication adherence in subjects presenting with psychotic or mood disorders. Psychiatry Research 2001, 102:91-95.
20. Loree A.M., Lundahl L.H., Ledgerwood D.M. Impulsivity as a predictor of treatment outcome in substance use disorders: review and synthesis. Drug and Alcohol Review 2014, 10.1111/dar.12132.
21. MacKillop J., Amlung M.T., Few L.R., Ray L.A., Sweet L.H., Munafò M.R. Delayed reward discounting and addictive behavior: a meta-analysis. Psychopharmacology 2011, 216:305-321. 10.1007/s00213-011-2229-0.
22. McDonald J., Schleifer L., Richards J.B., de Wit H. Effects of THC on behavioral measures of impulsivity in humans. Neuropsychopharmacology 2003, 28:1356-1365. 10.1038/sj.npp.1300176.
23. Meier M.H., Caspi A., Ambler A., Harrington H., Houts R., Keefe R.S., Moffitt T.E. Persistent cannabis users show neuropsychological decline from childhood to midlife. Proceedings of the National Academy of Sciences 2012, 109:E2657-E2664. 10.1073/pnas.1206820109/-/DCSupplemental.
24. Papachristou H., Nederkoorn C., Havermans R., Horst M., ansen A., Jansen A. Can't stop the craving: the effect of impulsivity on cue-elicited craving for alcohol in heavy and light social drinkers. Psychopharmacology 2011, 219:511-518. 10.1007/10.1007/.
25. Patton J.H., Stanford M.S. Factor structure of the Barratt impulsiveness scale. Journal of Clinical Psychology 1995, 51:768-774.
26. Perkel J.K., Bentzley B.S., Andrzejewski M.E., Martinetti M.P. Delay discounting for sucrose in alcohol-preferring and nonpreferring rats using a sipper tube within-sessions task. Alcoholism: Clinical and Experimental Research 2015, 39:232-238. 10.1111/acer.12632.
27. Peters E.N., Leeman R.F., Fucito L.M., Toll B.A., Corbin W.R., O'Malley S.S. Co-occurring marijuana use is associated with medication nonadherence and nonplanning impulsivity in young adult heavy drinkers. Addictive Behaviors 2012, 37:420-426. 10.1016/j.addbeh.2011.11.036.
28. Randolph K., Turull P., Margolis A., Tau G. Cannabis and cognitive systems in adolescents. Adolescent Psychiatry 2013, 3:135-147.
29. Rounds-Bryant J.L., Kristiansen P.L., Hubbard R.L. Drug abuse treatment outcome study of adolescents: a comparison of client characteristics and pretreatment behaviors in three treatment modalities. The American Journal of Drug and Alcohol Abuse 1999, 25:573-591.
30. Schmaal L., Veltman D.J., Nederveen A., van den Brink W., Goudriaan A.E. N-acetylcysteine normalizes glutamate levels in cocaine-dependent patients: a randomized crossover magnetic resonance spectroscopy study. Neuropsychopharmacology 2012, 37:2143-2152. 10.1038/npp.2012.66.
31. Stanford M.S., Mathias C.W., Dougherty D.M., Lake S.L., Anderson N.E., Patton J.H. Fifty years of the Barratt Impulsiveness Scale: an update and review. Personality and Individual Differences 2009, 47:385-395. 10.1016/j.paid.2009.04.008.
32. Stanger C., Ryan S.R., Fu H., Landes R.D., Jones B.A., Bickel W.K., Budney A.J. Delay discounting predicts adolescent substance abuse treatment outcome. Experimental and Clinical Psychopharmacology 2012, 20:205-212. 10.1037/a0026543.
33. Stevens L., Verdejo-García A., Goudriaan A.E., Roeyers H., Dom G., Vanderplasschen W. Impulsivity as a vulnerability factor for poor addiction treatment outcomes: a review of neurocognitive findings among individuals with substance use disorders. Journal of Substance Abuse Treatment 2014, 47:58-72. 10.1016/j.jsat.2014.01.008.
34. Substance Abuse and Mental Health Services Administration Results from the 2013 National Survey on Drug Use and Health: Summary of National Findings, NSDUH Series H-48, HHS Publication No. (SMA) 14-4863 2014, Substance Abuse and Mental Health Services Administration, Rockville, MD.
35. Substance Abuse and Mental Health Services Administration Center for Behavioral Health Statistics and Quality. Treatment Episode Data Set (TEDS): 2002-2012. National Admissions to Substance Abuse Treatment Services. BHSIS Series S-71, HHS Publication No. (SMA) 14-4850 2014, Substance Abuse and Mental Health Services Administration, Rockville, MD.
36. Swift R., Oslin D.W., Alexander M., Forman R. Adherence monitoring in naltrexone pharmacotherapy trials: a systematic review. Journal of Studies on Alcohol and Drugs 2011, 72:1012-1018.
37. Vadhan N.P., Hart C.L., van Gorp W.G., Gunderson E.W., Haney M., Foltin R.W. Acute effects of smoked marijuana on decision making, as assessed by a modified gambling task, in experienced marijuana users. Journal of Clinical and Experimental Neuropsychology 2007, 29:357-364. 10.1080/13803390600693615.
38. Vrijens B., Urquhart J. Methods for measuring, enhancing, and accounting for medication adherence in clinical trials. Clinical Pharmacology and Therapeutics 2014, 95:617-626. 10.1038/clpt.2014.59.
39. Waldron H.B., Turner C.W. Evidence-based psychosocial treatments for adolescent substance abuse. Journal of Clinical Child and Adolescent Psychology: the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 2008, 37:238-261. 10.1080/15374410701820133.
40. Winhusen T., Lewis D., Adinoff B., Brigham G., Kropp F., Donovan D.M., Somoza E. Impulsivity is associated with treatment non-completion in cocaine- and methamphetamine-dependent patients but differs in nature as a function of stimulant-dependence diagnosis. Journal of Substance Abuse Treatment 2013, 44:541-547. 10.1016/j.jsat.2012.12.005.
41. Wrege J., Schmidt A., Walter A., Smieskova R., Bendfeldt K., Radue E.W., Borgwardt S. Effects of cannabis on impulsivity: a systematic review of neuroimaging findings. Current Pharmaceutical Design 2014, 20:2126-2137.