The impact of medication adherence on health outcomes for chronic metabolic diseases: A retrospective cohort study

Research in Social and Administrative Pharmacy

Volumn 10, Issue 6, 2014, Pages e87-e98

  Han, Euna ^a   Suh, Dong Churl ^b   Lee, Seung Mi ^b   Jang, Sunmee ^c  

^a Yonsei University   (South Korea)

^b Chung Ang University   (South Korea)

^c Gachon University College of Medicine   (South Korea)

Author keywords

Diabetes; Health outcomes; Hyperlipidemia; Hypertension; Medication adherence; National health insurance claims data; South Korea

Indexed keywords

ADULT; AGED; COMPLICATION; DIABETES COMPLICATIONS; DIABETES MELLITUS; FEMALE; HOSPITALIZATION; HUMAN; HYPERLIPIDEMIAS; HYPERTENSION; MALE; MEDICATION COMPLIANCE; MIDDLE AGED; RETROSPECTIVE STUDY; SOUTH KOREA; STATISTICS AND NUMERICAL DATA; TREATMENT OUTCOME;

ADULT; AGED; DIABETES COMPLICATIONS; DIABETES MELLITUS; FEMALE; HOSPITALIZATION; HUMANS; HYPERLIPIDEMIAS; HYPERTENSION; MALE; MEDICATION ADHERENCE; MIDDLE AGED; REPUBLIC OF KOREA; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84923013699     PISSN: 15517411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sapharm.2014.02.001     Document Type: Article

References (43)

1. Status of Chronic Diseases in Korea 2011, Korea Ministry of Health and Korea Center for Disease Control, Available at:, Accessed 20.05.13. http://www.index.go.kr/egams/stts/jsp/potal/stts/PO_STTS_IdxMain.jsp?idx_cd=1438.
2. OECD. Accessed 20.05.13. http://www.oecd.org/els/emp/33906935.pdf.
3. Balkrishnan R. The importance of medication adherence in improving chronic-disease related outcomes: what we know and what we need to further know. Med Care 2005, 43:517-520.
4. Shin S., Song H., Oh S.K., Choi K.E., Kim H., Jang S. Effect of antihypertensive medication adherence on hospitalization for cardiovascular disease and mortality in hypertensive patients. Hypertens Res 2013, 1-6.
5. Sokol M.C., McGuigan K.A., Verbrugge R.R., Epstein R.S. Impact of medication adherence on hospitalization risk and healthcare cost. Med Care 2005, 43:521-530.
6. Lindgren P., Eriksson J., Buxton M., et al. The economic consequences of non-adherence to lipid-lowering therapy: results from the Anglo-Scandinavian-Cardiac Outcomes Trial. Int J Clin Pract 2010, 64:1228-1234. on Behalf of the ASCOT Trial Investigators.
7. Cramer J.A. A systematic review of adherence with medications for diabetes. Diabetes Care 2004, 27:1218-1224.
8. Tsuyuki R.T., Bungard T.J. Poor adherence with hypolipidemic drugs: a lost opportunity. Pharmacotherapy 2001, 21:576-582.
9. Kleinke J.D. The price of progress: prescription drugs in the health care market. Health Aff (Millwood) 2001, 20:43-60.
10. Bramiley T.J., Gerbind P.P., Nightengale B.S., Frech-Tamas F. Relationship of blood pressure control to adherence with antihypertensive monotherapy in 13 managed care organizations. J Manag Care Pharm 2006, 12:239-245.
11. DiMatteo M.R., Giordani P.J., Lepper H.S., Croghan T.W. Patient adherence and medical treatment outcomes: a meta-analysis. Med Care 2002, 40:794-811.
12. Wu P.H., Yang C.Y., Yao Z.L., Lin W.Z., Wu L.W., Chang C.C. Relationship of blood pressure control and hospitalization risk to medication adherence among patients with hypertension in Taiwan. Am J Hypertens 2010, 23:155-160.
13. Martin Leslie R., Williams Summer L., Haskard Kelly B., DiMatteo M.Robin The challenge of patient adherence. Ther Clin Risk Manag 2005, 1:189-199.
14. Jang S. Development of Hypertensive Medications for Prescription Assessment 2008, Health Insurance Review & Assessment Service.
15. Caspard H., Chan A.K., Walker A.M. Compliance with a statin treatment in a usual-care setting: retrospective database analysis over 3 years after treatment initiation in health maintenance organization enrollees with dyslipidemia. Clin Ther 2005, 27:1639-1646.
16. Chodick G., Shalev V., Gerber Y., et al. Long-term persistence with statin treatment in a not-for-profit health maintenance organization: a population-based retrospective cohort study in Israel. Clin Ther 2008, 30:2167-2179.
17. Gislason G.H., Rasmussen J.N., Abildstrom S.Z. Long-term compliance with beta-blockers, angiotensin-converting enzyme inhibitors, and statins after acutemyocardial infarction. Eur Heart J 2006, 27:1153-1158.
18. Kulkarni S.P., Alexander K.P., Lytle B., Heiss G., Peterson E.D. Long term adherence with cardiovascular drug regimens. Am Heart J 2006, 151:185-191.
19. Lachaine J., Rinfret S., Merikle E.P., Tarride J.E. Persistence and adherence to cholesterol lowering agents: evidence from Regiedel'AssuranceMaladie du Quebec data. Am Heart J 2006, 152:164.
20. Vinker S., Shani M., Baevsky T., Elhayany A. Adherence with statins over 8 years in a usual care setting. Am J Manag Care 2008, 14:388-392.
21. Yeaw J., Benner J.S., Walt J.G., Sian S., Smith D.B. Comparing adherence and persistence across 6 chronic medication classes. J Manag Care Pharm 2009, 15:728-740.
22. Evans C.D., Eurich D.T., Lamb D.A., et al. Retrospective observational assessment of statin adherence among subjects patronizing different types of community pharmacies in Canada. J Manag Care Pharm 2009, 15:476-484.
23. Haynes R.B., McDonald H.P., Garg A.X. Helping patients follow prescribed treatment: clinical applications. J Am Med Assoc 2002, 288:2880-2883.
24. Shin S., Song H., Jang S., Sung Y. Development of Hyperlipidemia Medications for Prescription Assessment 2009, Health Insurance Review & Assessment Service.
25. Hong J.S., Kang H.C. Relationship between oral antihyperglycemic medication adherence and hospitalization, mortality, and healthcare costs in adult ambulatory care patients with type 2 diabetes in South Korea. Med Care 2011, 49:378-384.
26. Osterberg L., Blaschke T. Adherence to medication. N Engl J Med 2005, 353:487-497.
27. Krousel-Wood M., Thomas S., Muntner P., Morisky D. Medication adherence: a key factor in achieving blood pressure control and good clinical outcomes in hypertensive patients. Curr Opin Cardiol 2004, 19:357-362.
28. Ho P.M., Magid D.J., Masoudi F.A., McClure D.L., Rumsfeld J.S. Adherence to cardio-protective medications and mortality amoba1ng patients with diabetes and ischemic heart disease. BMC Cardiovasc Disord 2006, 6:48.
29. Buja A., Cavinato M., Perissinotto E., Rausa G., Mastrangelo G., Toffanin R. Why do patients change their general practitioner? Suggestions on corrective actions. Ir J Med Sci 2011, 180(1):149-154.
30. Billinghurst B., Whitfield M. Why do patients change their general practitioner? A postal questionnaire study of patients in Avon. Br J Gen Pract 1993 August, 43(373):336-338.
31. Charlson M., Szatrowski T.P., Peterson J., Gold J. Validation of a combined comorbidity index. J Clin Epidemiol 1994, 47:1245-1251.
32. Kim S.K., Jang S.M. Relationship between antihypertension medication adherence, medical utilizations, and medical expenditure among patients with hypertension. Yakhak Hoeji 2013, 57(5):36-375.
33. Health at a Glance 2011: OECD Indicators 2011, OECD, OECD Publishing. http://dx.doi.org/10.1787/health_glance-2011-en.
34. Halperb M.T. Recommendations for evaluating compliance and persistence with hypertension therapy using retrospective data. Hypertension 2006, 47:1039-1048.
35. Jang S.M., Han E., Park T.J., Hwang J.H., Sohn H.S., Lee E.J. Development of Medication Management Program for Rational Drug Utilization 2013, National Health Insurance Service.
36. Jang S.M., Song H.J., Shin S.Y. Development of Assessment Indicator for Anti-hypertensive Drugs 2008, Health Insurance Review and Assessment.
37. Hong J.S., Kang H.J. Analyses of Prescription Patterns and Medication Adherence for Diabetes Patients 2009, Health Insurance Review and Assessment.
38. Shin S.Y., Song H.J., Jang S.M. Development of Assessment Indicator for Hyperlipidemia Medicines 2009, Health Insurance Review and Assessment.
39. Yang Y., Thumula V., Pace P.F., Banahan B.F., Wilkin N.E., Lobb W.B. Predictors of medication nonadherence among patients with diabetes in medicare Part D programs: a retrospective cohort study. Clin Ther 2009, 31(10).
40. Wong M.C.S., Jiang J.Y., Lam A.T., Fung H., Griffiths S., Mercer S.W. Patterns of antihypertensive prescribing, discontinuation and switching among a Hong Kong Chinese population from over one million prescriptions. J Hum Hypertens 2008, 22:714-716.
41. Senior V., Marteau T.M., Weinmanon J. Cardiovasc Drugs Ther 2004, 18:475-481. on Behalf of the Genetic Risk Assessment for FH Trial (GRAFT) Study Group.
42. Park Y.H., Kim H., Jang S.N., Koh C.K. Predictors of adherence to medication in older Korean patients with hypertension. Eur J Cardiovasc Nurs 2013, 12(1):17-24.
43. Krousel-Wood M.A., Paul Muntner P., Joyce C.J., et al. Adverse effects of complementary and alternative medicine use on antihypertensive medication adherence: findings from CoSMO. J Am Geriatr Soc 2010, 58(1):54-61.