A beneficial tumor microenvironment in oropharyngeal squamous cell carcinoma is characterized by a high T cell and low IL-17+ cell frequency

Cancer Immunology, Immunotherapy

Volumn 65, Issue 4, 2016, Pages 393-403

  Punt, Simone ^a   Dronkers, Emilie A C ^b   Welters, Marij J P ^a   Goedemans, Renske ^a   Koljenović, Senada ^b   Bloemena, Elisabeth ^c,d   Snijders, Peter J F ^c   Gorter, Arko ^a   van der Burg, Sjoerd H ^a   de Jong, Robert J Baatenburg ^b   Jordanova, Ekaterina S ^a,c  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Head and neck cancer; IL 17; T cell; Th17 cell; Treg; Tumor microenvironment

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 2; PROTEIN P16; VIRUS DNA; CD3 ANTIGEN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CANCER PROGNOSIS; CANCER SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE FREE SURVIVAL; DISEASE SPECIFIC SURVIVAL; FEMALE; GRANULOCYTE; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; LYMPHOCYTE COUNT; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MALE; OROPHARYNGEAL SQUAMOUS CELL CARCINOMA; OROPHARYNX CARCINOMA; PAPILLOMAVIRUS INFECTION; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; TH17 CELL; TUMOR ASSOCIATED LEUKOCYTE; TUMOR IMMUNITY; TUMOR MICROENVIRONMENT; VIRUS DETECTION; COMPLICATION; CONFOCAL MICROSCOPY; IMMUNOLOGY; KAPLAN MEIER METHOD; METABOLISM; MIDDLE AGED; OROPHARYNX TUMOR; PAPILLOMAVIRIDAE; SQUAMOUS CELL CARCINOMA; VERY ELDERLY; VIROLOGY;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD3; CARCINOMA, SQUAMOUS CELL; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GRANULOCYTES; HUMANS; INTERLEUKIN-17; KAPLAN-MEIER ESTIMATE; LYMPHOCYTE COUNT; MALE; MICROSCOPY, CONFOCAL; MIDDLE AGED; OROPHARYNGEAL NEOPLASMS; PAPILLOMAVIRIDAE; PAPILLOMAVIRUS INFECTIONS; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY; TH17 CELLS; TUMOR MICROENVIRONMENT;

EID: 84959126684     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-016-1805-x     Document Type: Article

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