-
1
-
-
49149118719
-
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
-
Li D, Ambrogio L, Shimamura T et al. BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene 2008; 27: 4702-11.
-
(2008)
Oncogene
, vol.27
, pp. 4702-4711
-
-
Li, D.1
Ambrogio, L.2
Shimamura, T.3
-
2
-
-
84862785051
-
Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial
-
Miller VA, Hirsh V, Cadranel J et al. Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial. Lancet Oncol 2012; 13: 528-38.
-
(2012)
Lancet Oncol
, vol.13
, pp. 528-538
-
-
Miller, V.A.1
Hirsh, V.2
Cadranel, J.3
-
3
-
-
84904898065
-
AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer
-
Cross DA, Ashton SE, Ghiorghiu S et al. AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. Cancer Discov 2014; 4: 1046-61.
-
(2014)
Cancer Discov
, vol.4
, pp. 1046-1061
-
-
Cross, D.A.1
Ashton, S.E.2
Ghiorghiu, S.3
-
4
-
-
84887977876
-
Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC
-
Walter AO, Sjin RT, Haringsma HJ et al. Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC. Cancer Discov 2013; 3: 1404-15.
-
(2013)
Cancer Discov
, vol.3
, pp. 1404-1415
-
-
Walter, A.O.1
Sjin, R.T.2
Haringsma, H.J.3
-
5
-
-
51349141191
-
Circulating mutant DNA to assess tumor dynamics
-
Diehl F, Schmidt K, Choti MA et al. Circulating mutant DNA to assess tumor dynamics. Nat Med 2008; 14: 985-90.
-
(2008)
Nat Med
, vol.14
, pp. 985-990
-
-
Diehl, F.1
Schmidt, K.2
Choti, M.A.3
-
6
-
-
81855208762
-
Quantitative detection of EGFR mutations in circulating tumor DNA derived from lung adenocarcinomas
-
Taniguchi K, Uchida J, Nishino K et al. Quantitative detection of EGFR mutations in circulating tumor DNA derived from lung adenocarcinomas. Clin Cancer Res 2011; 17: 7808-15.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 7808-7815
-
-
Taniguchi, K.1
Uchida, J.2
Nishino, K.3
-
7
-
-
84861746437
-
Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA
-
Forshew T, Murtaza M, Parkinson C et al. Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA. Sci Transl Med 2012; 4: 136ra68.
-
(2012)
Sci Transl Med
, vol.4
, pp. 136-168
-
-
Forshew, T.1
Murtaza, M.2
Parkinson, C.3
-
8
-
-
84877579861
-
Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA
-
Murtaza M, Dawson SJ, Tsui DW et al. Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA. Nature 2013; 497: 108-12.
-
(2013)
Nature
, vol.497
, pp. 108-112
-
-
Murtaza, M.1
Dawson, S.J.2
Tsui, D.W.3
-
9
-
-
84875520648
-
Analysis of circulating tumor DNA to monitor metastatic breast cancer
-
Dawson SJ, Tsui DW, Murtaza M et al. Analysis of circulating tumor DNA to monitor metastatic breast cancer. N Engl J Med 2013; 368: 1199-209.
-
(2013)
N Engl J Med
, vol.368
, pp. 1199-1209
-
-
Dawson, S.J.1
Tsui, D.W.2
Murtaza, M.3
-
10
-
-
80053014135
-
A noninvasive system for monitoring resistance to epidermal growth factor receptor tyrosine kinase inhibitors with plasma DNA
-
Nakamura T, Sueoka-Aragane N, Iwanaga K et al. A noninvasive system for monitoring resistance to epidermal growth factor receptor tyrosine kinase inhibitors with plasma DNA. J Thorac Oncol 2011; 6: 1639-48.
-
(2011)
J Thorac Oncol
, vol.6
, pp. 1639-1648
-
-
Nakamura, T.1
Sueoka-Aragane, N.2
Iwanaga, K.3
-
11
-
-
34548457234
-
The IASLC lung cancer staging project: Proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours
-
Goldstrow P, Crowley J, Chansky K et al. The IASLC lung cancer staging project: Proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM classification of malignant tumours. J Thorac Oncol 2007; 2: 706-14.
-
(2007)
J Thorac Oncol
, vol.2
, pp. 706-714
-
-
Goldstrow, P.1
Crowley, J.2
Chansky, K.3
-
12
-
-
84865697491
-
Application of a highly sensitive detection system for epidermal growth factor receptor mutations in plasma DNA
-
Nakamura T, Sueoka-Aragane N, Iwanaga K et al. Application of a highly sensitive detection system for epidermal growth factor receptor mutations in plasma DNA. J Thorac Oncol 2012; 7: 1369-81.
-
(2012)
J Thorac Oncol
, vol.7
, pp. 1369-1381
-
-
Nakamura, T.1
Sueoka-Aragane, N.2
Iwanaga, K.3
-
13
-
-
84901920866
-
T790M mutation is associated with better efficacy of treatment beyond progression with EGFR-TKI in advanced NSCLC patients
-
Li W, Ren S, Li J et al. T790M mutation is associated with better efficacy of treatment beyond progression with EGFR-TKI in advanced NSCLC patients. Lung Cancer 2014; 84: 295-300.
-
(2014)
Lung Cancer
, vol.84
, pp. 295-300
-
-
Li, W.1
Ren, S.2
Li, J.3
-
14
-
-
34547625913
-
Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation
-
Godin-Heymann N, Bryant I, Rivera MN et al. Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation. Cancer Res 2007; 67: 7319-26.
-
(2007)
Cancer Res
, vol.67
, pp. 7319-7326
-
-
Godin-Heymann, N.1
Bryant, I.2
Rivera, M.N.3
-
15
-
-
84877100240
-
Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers
-
Yu HA, Arcila ME, Rekhtman N et al. Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers. Clin Cancer Res 2013; 19: 2240-7.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 2240-2247
-
-
Yu, H.A.1
Arcila, M.E.2
Rekhtman, N.3
-
16
-
-
0035866393
-
DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells
-
Jahr S, Hentze H, Englisch S et al. DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res 2001; 61: 1659-65.
-
(2001)
Cancer Res
, vol.61
, pp. 1659-1665
-
-
Jahr, S.1
Hentze, H.2
Englisch, S.3
-
17
-
-
84904061727
-
Blood-based analyses of cancer: circulating tumor cells and circulating tumor DNA
-
Haber DA, Velculescu VE. Blood-based analyses of cancer: circulating tumor cells and circulating tumor DNA. Cancer Discov 2014; 4: 650-61.
-
(2014)
Cancer Discov
, vol.4
, pp. 650-661
-
-
Haber, D.A.1
Velculescu, V.E.2
-
18
-
-
84914689889
-
Correlation between plasma DNA and tumor status in an animal model
-
Sueoka-Aragane N, Sato A, Kobayashi N et al. Correlation between plasma DNA and tumor status in an animal model. PLoS ONE 2014; 9: e111881.
-
(2014)
PLoS ONE
, vol.9
, pp. e111881
-
-
Sueoka-Aragane, N.1
Sato, A.2
Kobayashi, N.3
-
19
-
-
84867021944
-
Prognostic value of acquired resistance-related molecules in Japanese patients with NSCLC treated with an EGFR-TKI
-
Uramoto H, Yamada T, Yano S et al. Prognostic value of acquired resistance-related molecules in Japanese patients with NSCLC treated with an EGFR-TKI. Anticancer Res 2012; 32: 3785-90.
-
(2012)
Anticancer Res
, vol.32
, pp. 3785-3790
-
-
Uramoto, H.1
Yamada, T.2
Yano, S.3
-
20
-
-
79952259564
-
Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay
-
Arcila ME, Oxnard GR, Nafa K et al. Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay. Clin Cancer Res 2011; 17: 1169-80.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 1169-1180
-
-
Arcila, M.E.1
Oxnard, G.R.2
Nafa, K.3
-
21
-
-
84889888266
-
Rebiopsy of non-small cell lung cancer patients with acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitor: comparison between T790M mutation-positive and mutation-negative populations
-
Hata A, Katakami N, Yoshioka H et al. Rebiopsy of non-small cell lung cancer patients with acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitor: comparison between T790M mutation-positive and mutation-negative populations. Cancer 2013; 119: 4325-32.
-
(2013)
Cancer
, vol.119
, pp. 4325-4332
-
-
Hata, A.1
Katakami, N.2
Yoshioka, H.3
-
22
-
-
79953118839
-
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
-
Sequist LV, Waltman BA, Dias-Santagata D et al. Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med 2011; 3: 75ra26.
-
(2011)
Sci Transl Med
, vol.3
, pp. 26-75
-
-
Sequist, L.V.1
Waltman, B.A.2
Dias-Santagata, D.3
-
23
-
-
84863393080
-
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
-
Gerlinger M, Rowan AJ, Horswell S et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 2012; 366: 883-92.
-
(2012)
N Engl J Med
, vol.366
, pp. 883-892
-
-
Gerlinger, M.1
Rowan, A.J.2
Horswell, S.3
-
24
-
-
78349265779
-
Reciprocal and complementary role of MET amplification and EGFR T790M mutation in acquired resistance to kinase inhibitors in lung cancer
-
Suda K, Murakami I, Katayama T et al. Reciprocal and complementary role of MET amplification and EGFR T790M mutation in acquired resistance to kinase inhibitors in lung cancer. Clin Cancer Res 2010; 16: 5489-98.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 5489-5498
-
-
Suda, K.1
Murakami, I.2
Katayama, T.3
-
25
-
-
84955202852
-
Detection of T790M, the acquired resistance EGFR mutation, by tumor biopsy versus noninvasive blood-based analyses
-
Epub ahead of print.
-
Sundaresan TK, Sequist LV, Heymach JV et al. Detection of T790M, the acquired resistance EGFR mutation, by tumor biopsy versus noninvasive blood-based analyses. Clin Cancer Res 2015; Epub ahead of print.
-
(2015)
Clin Cancer Res
-
-
Sundaresan, T.K.1
Sequist, L.V.2
Heymach, J.V.3
-
26
-
-
84959053186
-
Cell free DNA and ascites might reflect tumor heterogeneity in ovarian carcinomas. P-2389
-
Nagoya, October 8-10
-
Asada K, Oda K, Nishijima A et al. Cell free DNA and ascites might reflect tumor heterogeneity in ovarian carcinomas. P-2389, 74th Annual Meeting of the Japanese Cancer Association, Nagoya, October 8-10, 2015.
-
(2015)
74th Annual Meeting of the Japanese Cancer Association
-
-
Asada, K.1
Oda, K.2
Nishijima, A.3
|