Sex-specific versus overall cut points for a high sensitivity troponin I assay in predicting 1-year outcomes in emergency patients presenting with chest pain

Heart

Volumn 102, Issue 2, 2016, Pages 120-126

  Cullen, Louise ^a,b,c   Greenslade, Jaimi H ^a,b,c   Carlton, Edward W ^d   Than, Martin ^e   Pickering, John W ^e   Ho, Ariel ^a   Greaves, Kim ^b,f   Berndt, Sara L ^a   Body, Richard ^g   Ryan, Kimberley ^a   Parsonage, William A ^a  

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^d SOUTHMEAD HOSPITAL   (United Kingdom)

^e CHRISTCHURCH HOSPITAL   (New Zealand)

^f UNIVERSITY OF THE SUNSHINE COAST   (Australia)

^g MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TROPONIN I; TROPONIN T;

ADULT; ARTICLE; CARDIOVASCULAR DISEASE; DISEASE ASSOCIATION; EMERGENCY CARE; FEMALE; GENDER; HUMAN; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PREDICTION; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SEX DIFFERENCE; THORAX PAIN; ACUTE CORONARY SYNDROME; AGED; AUSTRALIA; BLOOD; CHEST PAIN; CLINICAL TRIAL; COMPLICATION; EMERGENCY HEALTH SERVICE; EPIDEMIOLOGY; HOSPITALIZATION; INCIDENCE; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; PREDICTIVE VALUE; PROGNOSIS; RECEIVER OPERATING CHARACTERISTIC; STATISTICS AND NUMERICAL DATA;

ACUTE CORONARY SYNDROME; ADULT; AGED; AUSTRALIA; CHEST PAIN; EMERGENCY SERVICE, HOSPITAL; FEMALE; HOSPITALIZATION; HUMANS; INCIDENCE; MALE; MIDDLE AGED; MORTALITY; OUTCOME ASSESSMENT (HEALTH CARE); PREDICTIVE VALUE OF TESTS; PROGNOSIS; ROC CURVE; SEX FACTORS; TROPONIN T;

EID: 84958981652     PISSN: 13556037     EISSN: 1468201X     Source Type: Journal    
DOI: 10.1136/heartjnl-2015-308506     Document Type: Article

References (17)

1. Apple FS, Ler R, Murakami MM. Determination of 19 cardiac troponin I and T assay 99th percentile values from a common presumably healthy population. Clin Chem 2012;58:1574-81.
2. Aw TC, Phua SK, Tan SP. Measurement of cardiac troponin I in serum with a new high-sensitivity assay in a large multi-ethnic Asian cohort and the impact of gender. Clin Chim Acta 2013;422:26-8.
3. Thygesen K, Alpert JS, Jaffe AS, et al. Third universal definition of myocardial infarction. Circulation 2012;126:2020-35.
4. Shah AS, Griffiths M, Lee KK, et al. High sensitivity cardiac troponin and the under-diagnosis of myocardial infarction in women: prospective cohort study. BMJ 2015;350:g7873.
5. Eggers KM, Johnston N, James S, et al. Cardiac troponin I levels in patients with non-ST-elevation acute coronary syndrome-the importance of gender. Am Heart J 2014;168:317-24 e1.
6. Rosamond WD, Chambless LE, Folsom AR, et al. Trends in the incidence of myocardial infarction and in mortality due to coronary heart disease, 1987 to 1994. N Engl J Med 1998;339:861-7.
7. Vaccarino V, Parsons L, Every NR, et al. Sex-based differences in early mortality after myocardial infarction. National Registry of Myocardial Infarction 2 Participants. N Engl J Med 1999;341:217-25.
8. Akhter N, Milford-Beland S, Roe MT, et al. Gender differences among patients with acute coronary syndromes undergoing percutaneous coronary intervention in the American College of Cardiology-National Cardiovascular Data Registry (ACC-NCDR). Am Heart J 2009;157:141-8.
9. Radovanovic D, Erne P, Urban P, et al. Gender differences in management and outcomes in patients with acute coronary syndromes: results on 20,290 patients from the AMIS Plus Registry. Heart 2007;93:1369-75.
10. Kavsak PA, Shortt C, Pond G, et al. High-sensitivity cardiac troponin I for predicting death in a female emergency department population. Clin Chem 2014;60:271-3.
11. Rubini Gimenez M, Reiter M, Twerenbold R, et al. Sex-specific chest pain characteristics in the early diagnosis of acute myocardial infarction. JAMA Intern Med 2014;174:241-9.
12. Cullen L, Greenslade J, Merollini K, et al. Cost and outcomes of assessing patients with chest pain in an Australian emergency department. Med J Aust 2015;202:427-32.
13. Carlton EW, Cullen L, Than M, et al. A novel diagnostic protocol to identify patients suitable for discharge after a single high-sensitivity troponin. Heart 2015;101:1041-6.
14. Than M, Cullen L, Aldous S, et al. 2-Hour accelerated diagnostic protocol to assess patients with chest pain symptoms using contemporary troponins as the only biomarker: the ADAPT trial. J Am Coll Cardiol 2012;59:2091-8.
15. Cullen L, Than M, Brown AF, et al. Comprehensive standardized data definitions for acute coronary syndrome research in emergency departments in Australasia. Emerg Med Australas 2010;22:35-55.
16. Kavsak PA, Newman AM, Lustig V, et al. Long-term health outcomes associated with detectable troponin I concentrations. Clin Chem 2007; 53:220-7.
17. Bohula May EA, Bonaca MP, Jarolim P, et al. Prognostic performance of a high-sensitivity cardiac troponin I assay in patients with non-ST-elevation acute coronary syndrome. Clin Chem 2014;60:158-64.