Vagus Nerve Stimulation for Epilepsy and Depression

Brain Stimulation: Methodologies and Interventions

Volumn , Issue , 2015, Pages 305-335

  Conway, Charles R ^a   Colijn, Mark A ^b   Schachter, Steven C ^c,d  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d Consortia for Improving Medicine with Innovation and Technology ^*  (United States)

Author keywords

Afferent vagal pathway; Drug resistant epilepsy (DRE); Major depressive disorder (MDD); Neuroimaging data; Neurophysiological data; Positron emission tomography (PET) imaging studies; Treatment resistant depression (TRD); Vagus nerve stimulation (VNS) therapy device

Indexed keywords

EID: 84958915606     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118568323.ch17     Document Type: Chapter

References (197)

1. Aaronson, S.T., Carpenter, L.L. et al. (2013) Vagus nerve stimulation therapy randomized to different amounts of electrical charge for treatment-resistant depression: Acute and chronic effects. Brain Stimulation, 6 (4), 631-640.
2. Agostoni, E., Chinnock, J.E. et al. (1957) Functional and histological studies of the vagus nerve and its branches to the heart, lungs and abdominal viscera in the cat. Journal of Physiology, 135 (1), 182-205.
3. Aldenkamp, A.P., Van deVeerdonk, S.H. et al. (2001) Effects of 6 months of treatment with vagus nerve stimulation on behavior in children with Lennox-Gastaut syndrome in an open clinical and nonrandomized study. Epilepsy and Behavior, 2 (4), 343-350.
4. Alexander, G.M. &McNamara, J.O. (2012) Vagus nerve stimulation elevates seizure threshold in the kindling model. Epilepsia, 53 (11), 2043-2052.
5. Ali, I.I., Pirzada, N.A. et al. (2004) Complete heart block with ventricular asystole during left vagus nerve stimulation for epilepsy. Epilepsy and Behavior, 5 (5), 768-771.
6. Amar, A.P., Apuzzo, M.L. et al. (2008) Vagus nerve stimulation therapy after failed cranial surgery for intractable epilepsy:results from the vagus nerve stimulation therapy patient outcome registry. Neurosurgery, 62 (Suppl 2), 506-513.
7. Amark, P., Stodberg, T. et al. (2007) Late onset bradyarrhythmia during vagus nerve stimulation. Epilepsia, 48 (5), 1023-1024.
8. Andriola, M.R., Rosenzweig, T. et al. (2000) Vagus nerve stimulator (VNS): induction of asystole during implantation with subsequent successful stimulation. Epilepsia, 41 (Suppl 7), 223.
9. Andriola, M.R. & Vitale, S.A. (2001) Vagus nerve stimulation in the developmentally disabled. Epilepsy and Behavior, 2 (2), 129-134.
10. Annegers, J.F., Coan, S.P. et al. (2000) Epilepsy, vagal nerve stimulation by the NCP system, all-cause mortality, and sudden, unexpected, unexplained death. Epilepsia, 41 (5), 549-553.
11. Arya, R., Greiner, H.M. et al. (2013) Vagus nerve stimulation for medically refractory absence epilepsy. Seizure, 22 (4), 267-270.
12. Asconape, J.J., Moore, D.D. et al. (1999) Bradycardia and asystole with the use of vagus nerve stimulation for the treatment of epilepsy: a rare complication of intraoperative device testing. Epilepsia, 40 (10), 1452-1454.
13. Aston-Jones, G., Shipley, M.T. et al. (1991) Afferent regulation of locus coeruleus neurons: anatomy, physiology and pharmacology. Progress in Brain Research, 88, 47-75.
14. Bajbouj, M., Merkl, A. et al. (2010) Two-year outcome of vagus nerve stimulation in treatment-resistant depression. Journal of Clinical Psychopharmacology, 30 (3), 273-281.
15. Banzett, R.B., Guz, A. et al. (1999) Cardiorespiratory variables and sensation during stimulation of the left vagus in patients with epilepsy. Epilepsy Research, 35 (1), 1-11.
16. Beckstead, R.M. (1979) An autoradiographic examination of corticocortical and subcortical projections of the mediodorsal-projection (prefrontal) cortex in the rat. Journal of Comparative Neurology, 184 (1), 43-62.
17. Beckstead, R.M., Morse, J.R. et al. (1980) The nucleus of the solitary tract in the monkey: projections to the thalamus and brain stem nuclei. Journal of Comparative Neurology, 190 (2), 259-282.
18. Ben-Menachem, E. (2001) Vagus nerve stimulation, side effects, and long-term safety. Journal of Clinical Neurophysiology, 18 (5), 415-418.
19. Ben-Menachem, E., Hamberger, A. et al. (1995) Effects of vagus nerve stimulation on amino acids and other metabolites in the CSF of patients with partial seizures. Epilepsy Research, 20 (3), 221-227.
20. Ben-Menachem, E., Hellstrom, K. et al. (1999) Evaluation of refractory epilepsy treated with vagus nerve stimulation for up to 5 years. Neurology, 52 (6), 1265-1267.
21. Ben-Menachem, E., Manon-Espaillat, R. et al. (1994) Vagus nerve stimulation for treatment of partial seizures: 1.Acontrolled study of effect on seizures. First International Vagus Nerve Stimulation Study Group. Epilepsia, 35 (3), 616-626.
22. Berry, S.M., Broglio, K. et al. (2013) A patient-level meta-analysis of studies evaluating vagus nerve stimulation therapy for treatment-resistant depression. Medical Devices (Auckland, NZ), 6, 17-35.
23. Bester, H., Bourgeais, L. et al. (1999) Differential projections to the intralaminar and gustatory thalamus from the parabrachial area: a PHA-L study in the rat. Journal of Comparative Neurology, 405 (4), 421-449.
24. Binks, A.P., Paydarfar, D. et al. (2001) High strength stimulation of the vagus nerve in awake humans: a lack of cardiorespiratory effects. Respiratory Physiology, 127 (2-3), 125-133.
25. Blumer, D., Davies, K. et al. (2001) Major psychiatric disorders subsequent to treating epilepsy by vagus nerve stimulation. Epilepsy and Behavior, 2 (5), 466-472.
26. Bohning, D.E., Lomarev, M.P. et al. (2001) Feasibility of vagus nerve stimulation-synchronized blood oxygenation level-dependent functional MRI. Investigative Radiology, 36 (8), 470-479.
27. Boon, P., Vonck, K. et al. (2001) Programmed and magnet-induced vagus nerve stimulation for refractory epilepsy. Journal of Clinical Neurophysiology, 18 (5), 402-407.
28. Buoni, S., Zannolli, R. et al. (2004) Delayed response of seizures with vagus nerve stimulation in Lennox-Gastaut syndrome. Neurology, 63 (8), 1539-1540.
29. Carmichael, S.T. & Price, J.L. (1995) Sensory and premotor connections of the orbital and medial prefrontal cortex of macaque monkeys. Journal of Comparative Neurology, 363 (4), 642-664.
30. Carpenter, L.L., Moreno, F.A. et al. (2004) Effect of vagus nerve stimulation on cerebrospinal fluid monoamine metabolites, norepinephrine, and gamma-aminobutyric acid concentrations in depressed patients. Biological Psychiatry, 56 (6), 418-426.
31. Cersosimo, R.O., Bartuluchi, M. et al. (2011) Vagus nerve stimulation: effectiveness and tolerability in patients with epileptic encephalopathies. Child's Nervous System, 27 (5), 787-792.
32. Chase, M.H. & Nakamura, Y. (1968) Cortical and subcortical EEG patterns of response to afferent abdominal vagal stimulation:Neurographic correlates. Physiology and Behavior, 3 (5), 605-610.
33. Chase, M.H., Nakamura, Y. et al. (1967) Afferent vagal stimulation: neurographic correlates of induced EEG synchronization and desynchronization. Brain Research, 5 (2), 236-249.
34. Chase, M.H., Sterman, M.B. et al. (1966) Cortical and subcortical patterns of response to afferent vagal stimulation. Experimental Neurology, 16 (1), 36-49.
35. Coenen, V.A., Schlaepfer, T.E. et al. (2011) Cross-species affective functions of the medial forebrain bundle-implications for the treatment of affective pain and depression in humans. Neuroscience and Biobehavioral Reviews, 35 (9), 1971-1981.
36. Colicchio, G., Montano, N. et al. (2012) Vagus nerve stimulation in drug-resistant epilepsies. Analysis of potential prognostic factors in a cohort of patients with long-term follow-up. Acta Neurochirurgica (Wien), 154 (12), 2237-2240.
37. Conway, C.R., Chibnall, J.T. et al. (2012) Pretreatment cerebral metabolic activity correlates with antidepressant efficacy of vagus nerve stimulation in treatment-resistant major depression: a potential marker for response? Journal of Affective Disorders, 139 (3), 283-290.
38. Conway, C.R., Chibnall, J.T. et al. (2013) Association of cerebral metabolic activity changes with vagus nerve stimulation antidepressant response in treatment-resistant depression. Brain Stimulation, 6 (5), 788-797.
39. Conway, C.R., Sheline, Y.I. et al. (2006) Cerebral blood flow changes during vagus nerve stimulation for depression. Psychiatry Research, 146 (2), 179-184.
40. Cook, I.A., Schrader, L.M., Degiorgio, C.M., Miller, P.R. et al. (2013) Trigeminal nerve stimulation in major depressive disorder: Acute outcomes in an open pilot study. Epilepsy and Behavior, 28 (2), 221-226.
41. Costain, D.W., Cowen, P.J. et al. (1982) Electroconvulsive therapy and the brain: evidence for increased dopamine-mediated responses. Lancet, 2 (8295), 400-404.
42. Cox, C.L., Huguenard, J.R. et al. (1997) Nucleus reticularis neurons mediate diverse inhibitory effects in thalamus. Proceedings of the National Academy of Sciences of the United States of America, 94 (16), 8854-8859.
43. Craig, A.D. (2005) Forebrain emotional asymmetry: a neuroanatomical basis? Trends in Cognitive Sciences, 9 (12), 566-571.
44. Cramer, J.A. (2001) Exploration of changes in health-related quality of life after 3 months of vagus nerve stimulation. Epilepsy and Behavior, 2 (5), 460-465.
45. De Ferrari, G.M., Crijns, H.J. et al. (2011) Chronic vagus nerve stimulation: a new and promising therapeutic approach for chronic heart failure. European Heart Journal, 32 (7), 847-855.
46. DeGiorgio, C.M., Schachter, S.C. et al. (2000) Prospective long-term study of vagus nerve stimulation for the treatment of refractory seizures. Epilepsia, 41 (9), 1195-1200.
47. DeGiorgio, C.M., Shewmon, D.A. & Whitehurst, T. (2003) Trigeminal nerve stimulation for epilepsy. Neurology, 61 (3), 421-422.
48. DeGiorgio, C.M., Shewmon, A., Murray, D. & Whitehurst, T. (2006) Pilot study of trigeminal nerve stimulation (TNS) for epilepsy: a proof-of-concept trial. Epilepsia, 47 (7), 1213-15.
49. DeGiorgio, C.M., Murray, D., Markovic, D. & Whitehurst, T. (2009) Trigeminal nerve stimulation for epilepsy: long-term feasibility and efficacy. Neurology, 72 (10), 936-938.
50. DeGiorgio, C.M., Soss, J., Cook, I.A., Markovic, D. et al. (2013) Randomized double blind controlled trial of trigeminal nerve stimulation (eTNS) in 50 subjects with drug resistant epilepsy. Neurology, 80 (9), 786-791.
51. Detke, M.J., Rickels, M. et al. (1995) Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology (Berl), 121 (1), 66-72.
52. Di Lazzaro, V., Oliviero, A. et al. (2004) Effects of vagus nerve stimulation on cortical excitability in epileptic patients. Neurology, 62 (12), 2310-2312.
53. Dodrill, C.B. & Morris, G.L. (2001) Effects of vagal nerve stimulation on cognition and quality of life in epilepsy. Epilepsy and Behavior, 2 (1), 46-53.
54. Dorr, A.E. & Debonnel, G. (2006) Effect of vagus nerve stimulation on serotonergic and noradrenergic transmission. Journal of Pharmacology and Experimental Therapeutics, 318 (2), 890-898.
55. Drew, M.R. & Hen, R. (2007) Adult hippocampal neurogenesis as target for the treatment of depression. CNS and Neurological Disorders - Drug Targets, 6 (3), 205-218.
56. El Tahry, R., Raedt, R. et al. (2010) A novel implantable vagus nerve stimulation system (ADNS-300) for combined stimulation and recording of the vagus nerve: pilot trial at Ghent University Hospital. Epilepsy Research, 92 (2-3), 231-239.
57. Elger, G., Hoppe, C. et al. (2000) Vagus nerve stimulation is associated with mood improvements in epilepsy patients. Epilepsy Research, 42 (2-3), 203-210.
58. Elliott, R.E., Carlson, C. et al. (2009) Refractory epilepsy in tuberous sclerosis: vagus nerve stimulation with or without subsequent resective surgery. Epilepsy and Behavior, 16 (3), 454-460.
59. Elliott, R.E., Morsi, A. et al. (2011) Vagus nerve stimulation in 436 consecutive patients with treatment-resistant epilepsy:long-term outcomes and predictors of response. Epilepsy and Behavior, 20 (1), 57-63.
60. Englot, D.J., Chang, E.F. et al. (2011) Vagus nerve stimulation for epilepsy: a meta-analysis of efficacy and predictors of response. Journal of Neurosurgery, 115 (6), 1248-1255.
61. Fernandez-Guardiola, A., Martinez, A. et al. (1999) Vagus nerve prolonged stimulation in cats: effects on epileptogenesis (amygdala electrical kindling): behavioral and electrographic changes. Epilepsia, 40 (7), 822-829.
62. Foley, F.S. (1937) Quantitative studies of the vagus nerve in the cat. I. The ratio of sensory to motor fibers. Journal of Comparative Neurology, 67 (1), 49-67.
63. Fraschini, M., Puligheddu, M. et al. (2013) VNS induced desynchronization in gamma bands correlates with positive clinical outcome in temporal lobe pharmacoresistant epilepsy. Neuroscience Letters, 536, 14-18.
64. Frei, M.G. & Osorio, I. (2001) Left vagus nerve stimulation with the neurocybernetic prosthesis has complex effects on heart rate and on its variability in humans. Epilepsia, 42 (8), 1007-1016.
65. Frost, M., Gates, J. et al. (2001) Vagus nerve stimulation in children with refractory seizures associated with Lennox-Gastaut syndrome. Epilepsia, 42 (9), 1148-1152.
66. Furmaga, H., Shah, A. et al. (2011) Serotonergic and noradrenergic pathways are required for the anxiolytic-like and antidepressant-like behavioral effects of repeated vagal nerve stimulation in rats. Biological Psychiatry, 70 (10), 937-945.
67. Galli, R., Bonanni, E. et al. (2003a) Daytime vigilance and quality of life in epileptic patients treated with vagus nerve stimulation. Epilepsy and Behavior, 4 (2), 185-191.
68. Galli, R., Limbruno, U. et al. (2003b) Analysis of RR variability in drug-resistant epilepsy patients chronically treated with vagus nerve stimulation. Autonomic Neuroscience, 107 (1), 52-59.
69. Garnett, E.S., Nahmias, C. et al. (1992) Regional cerebral blood flow in man manipulated by direct vagal stimulation. Pacing and Clinical Electrophysiology, 15 (10 Pt 2), 1579-1580.
70. Gates, J., Huf, R. et al. (2001) Vagus nerve stimulation for patients in residential treatment facilities. Epilepsy and Behavior, 2 (6), 563-567.
71. Gebhardt, N., Bar, K.J. et al. (2013) Vagus nerve stimulation ameliorated deficits in one-way active avoidance learning and stimulated hippocampal neurogenesis in bulbectomized rats. Brain Stimulation, 6 (1), 78-83.
72. George, M.S., Rush, A.J. et al. (2005) A one-year comparison of vagus nerve stimulation with treatment as usual for treatment-resistant depression. Biological Psychiatry, 58 (5), 364-373.
73. George, R., Salinsky, M. et al. (1994) Vagus nerve stimulation for treatment of partial seizures: 3. Long-term follow-up on first 67 patients exiting a controlled study. First International Vagus Nerve Stimulation Study Group. Epilepsia, 35 (3), 637-643.
74. Handforth, A., DeGiorgio, C.M. et al. (1998) Vagus nerve stimulation therapy for partial-onset seizures: a randomized active-control trial. Neurology, 51 (1), 48-55.
75. Harden, C.L., Pulver, M.C. et al. (2000) A pilot study of mood in epilepsy patients treated with vagus nerve stimulation. Epilepsy and Behavior, 1 (2), 93-99.
76. Helmers, S.L., Al-Jayyousi, M. et al. (1998) Adjunctive treatment in Lennox-Gastaut syndrome using vagal nerve stimulation. Epilepsia, 39 (Suppl 6), 169.
77. Helmers, S.L., Wheless, J.W. et al. (2001) Vagus nerve stimulation therapy in pediatric patients with refractory epilepsy:retrospective study. Journal of Child Neurology, 16 (11), 843-848.
78. Henry, T.R. (2002) Therapeutic mechanisms of vagus nerve stimulation. Neurology, 59 (6 Suppl 4), S3-14.
79. Henry, T.R., Bakay, R.A. et al. (1998) Brain blood flow alterations induced by therapeutic vagus nerve stimulation in partial epilepsy: I. Acute effects at high and low levels of stimulation. Epilepsia, 39 (9), 983-990.
80. Henry, T.R., Votaw, J.R. et al. (1999) Acute blood flow changes and efficacy of vagus nerve stimulation in partial epilepsy. Neurology, 52 (6), 1166-1173.
81. Herbert, H., Moga, M.M. et al. (1990) Connections of the parabrachial nucleus with the nucleus of the solitary tract and the medullary reticular formation in the rat. Journal of Comparative Neurology, 293 (4), 540-580.
82. Holmes, M.D., Chang, M. et al. (2003) Sleep apnea and excessive daytime somnolence induced by vagal nerve stimulation. Neurology, 61 (8), 1126-1129.
83. Hoppe, C., Helmstaedter, C. et al. (2001) Self-reported mood changes following 6 months of vagus nerve stimulation in epilepsy patients. Epilepsy and Behavior, 2 (4), 335-342.
84. Hosain, S., Nikalov, B. et al. (2000) Vagus nerve stimulation treatment for Lennox-Gastaut syndrome. Journal of Child Neurology, 15 (8), 509-512.
85. Huf, R.L., Mamelak, A. et al. (2005) Vagus nerve stimulation therapy: 2-year prospective open-label study of 40 subjects with refractory epilepsy and low IQ who are living in long-term care facilities. Epilepsy and Behavior, 6 (3), 417-423.
86. Iriarte, J., Urrestarazu, E. et al. (2009) Late-onset periodic asystolia during vagus nerve stimulation. Epilepsia, 50 (4), 928-932.
87. Janszky, J., Hoppe, M. et al. (2005) Vagus nerve stimulation: predictors of seizure freedom. Journal of Neurology, Neurosurgery, and Psychiatry, 76 (3), 384-389.
88. Kalia, M. & Sullivan, J.M. (1982) Brainstem projections of sensory and motor components of the vagus nerve in the rat. Journal of Comparative Neurology, 211 (3), 248-265.
89. Kanner, A.M., Schachter, S.C. et al. (2012) Depression and epilepsy: epidemiologic and neurobiologic perspectives that may explain their high comorbid occurrence. Epilepsy and Behavior, 24 (2), 156-168.
90. Kim, W., Clancy, R.R. et al. (2001) Horner syndrome associated with implantation of a vagus nerve stimulator. American Journal of Ophthalmology, 131 (3), 383-384.
91. Kirchner, A., Birklein, F. et al. (2000) Left vagus nerve stimulation suppresses experimentally induced pain. Neurology, 55 (8), 1167-1171.
92. Klinkenberg, S., Aalbers, M.W. et al. (2012a) Vagus nerve stimulation in children with intractable epilepsy: a randomized controlled trial. Developmental Medicine and Child Neurology, 54 (9), 855-861.
93. Klinkenberg, S., Majoie, H.J. et al. (2012b) Vagus nerve stimulation has a positive effect on mood in patients with refractory epilepsy. Clinical Neurology and Neurosurgery, 114 (4), 336-340.
94. Ko, D., Heck, C. et al. (1996) Vagus nerve stimulation activates central nervous system structures in epileptic patients during PET H2(15)O blood flow imaging. Neurosurgery, 39 (2), 426-430.; discussion 430-421
95. Kosel, M., Brockmann, H. et al. (2011) Chronic vagus nerve stimulation for treatment-resistant depression increases regional cerebral blood flow in the dorsolateral prefrontal cortex. Psychiatry Research, 191 (3), 153-159.
96. Koutroumanidis, M., Binnie, C.D. et al. (2003) VNS in patients with previous unsuccessful resective epilepsy surgery:antiepileptic and psychotropic effects. Acta Neurologica Scandinavica, 107 (2), 117-121.
97. Krahl, S.E., Clark, K.B. et al. (1998) Locus coeruleus lesions suppress the seizure-attenuating effects of vagus nerve stimulation. Epilepsia, 39 (7), 709-714.
98. Kraus, T., Kiess, O. et al. (2013) CNS BOLD fMRI effects of sham-controlled transcutaneous electrical nerve stimulation in the left outer auditory canal - A pilot study. Brain Stimulation, 6 (5), 798-804.
99. Krout, K.E. & Loewy, A.D. (2000) Parabrachial nucleus projections to midline and intralaminar thalamic nuclei of the rat. Journal of Comparative Neurology, 428 (3), 475-494.
100. Kuba, R., Brazdil, M. et al. (2003) Effect of vagal nerve stimulation on patients with bitemporal epilepsy. European Journal of Neurology, 10 (1), 91-94.
101. Labar, D. (2004) Vagus nerve stimulation for 1 year in 269 patients on unchanged antiepileptic drugs. Seizure, 13 (6), 392-398.
102. Labar, D., Murphy, J. et al. (1999) Vagus nerve stimulation for medication-resistant generalized epilepsy. E04 VNS Study Group. Neurology, 52 (7), 1510-1512.
103. Labar, D.R. (2002) Antiepileptic drug use during the first 12 months of vagus nerve stimulation therapy: a registry study. Neurology, 59 (6 Suppl 4), S38-43.
104. Lancman, G., Virk, M. et al. (2013) Vagus nerve stimulation vs. corpus callosotomy in the treatment of Lennox-Gastaut syndrome: a meta-analysis. Seizure, 22 (1), 3-8.
105. Levy, M.L., Levy, K.M. et al. (2010) Vagus nerve stimulation therapy in patients with autism spectrum disorder and intractable epilepsy: results from the vagus nerve stimulation therapy patient outcome registry. Journal of Neurosurgery Pediatrics, 5 (6), 595-602.
106. Liporace, J., Hucko, D. et al. (2001) Vagal nerve stimulation: adjustments to reduce painful side effects. Neurology, 57 (5), 885-886.
107. Lisanby, S.H., Bazil, C.W. et al. (2001) ECT in the treatment of status epilepticus. The Journal of ECT, 17 (3), 210-215.
108. Liu, W.C., Mosier, K. et al. (2003) BOLD fMRI activation induced by vagus nerve stimulation in seizure patients. Journal of Neurology, Neurosurgery, and Psychiatry, 74 (6), 811-813.
109. Lockard, J.S., Congdon, W.C. et al. (1990) Feasibility and safety of vagal stimulation in monkey model. Epilepsia, 31 (Suppl 2), S20-26.
110. Lomarev, M., Denslow, S. et al. (2002) Vagus nerve stimulation (VNS) synchronized BOLD fMRI suggests that VNS in depressed adults has frequency/dose dependent effects. Journal of Psychiatric Research, 36 (4), 219-227.
111. Lundgren, J., Amark, P. et al. (1998a) Vagus nerve stimulation in 16 children with refractory epilepsy. Epilepsia, 39 (8), 809-813.
112. Lundgren, J., Ekberg, O. et al. (1998b) Aspiration: a potential complication to vagus nerve stimulation. Epilepsia, 39 (9), 998-1000.
113. Magdaleno-Madrigal, V.M., Valdes-Cruz, A. et al. (2002) Effect of electrical stimulation of the nucleus of the solitary tract on the development of electrical amygdaloid kindling in the cat. Epilepsia, 43 (9), 964-969.
114. Majoie, H.J., Berfelo, M.W. et al. (2005) Vagus nerve stimulation in patients with catastrophic childhood epilepsy, a 2-year follow-up study. Seizure, 14 (1), 10-18.
115. Majoie, H.J., Rijkers, K. et al. (2011) Vagus nerve stimulation in refractory epilepsy: effects on pro- and anti-inflammatory cytokines in peripheral blood. Neuroimmunomodulation, 18 (1), 52-56.
116. Major, P. & Thiele, E.A. (2008) Vagus nerve stimulation for intractable epilepsy in tuberous sclerosis complex. Epilepsy and Behavior, 13 (2), 357-360.
117. Malow, B.A., Edwards, J. et al. (2000) Effects of vagus nerve stimulation on respiration during sleep: a pilot study. Neurology, 55 (10), 1450-1454.
118. Malow, B.A., Edwards, J. et al. (2001) Vagus nerve stimulation reduces daytime sleepiness in epilepsy patients. Neurology, 57 (5), 879-884.
119. Marangell, L.B., Rush, A.J. et al. (2002) Vagus nerve stimulation (VNS) for major depressive episodes: one year outcomes. Biological Psychiatry, 51 (4), 280-287.
120. Marrosu, F., Serra, A. et al. (2003) Correlation between GABA(A) receptor density and vagus nerve stimulation in individuals with drug-resistant partial epilepsy. Epilepsy Research, 55 (1-2), 59-70.
121. Marzec, M., Edwards, J. et al. (2003) Effects of vagus nerve stimulation on sleep-related breathing in epilepsy patients. Epilepsia, 44 (7), 930-935.
122. Mauro, M.P.S., Patronelli, F. et al. (2009) Nerves of the heart: a comprehensive review with a clinical point of view. Neuroanatomy, 8 (1), 26-31.
123. McGregor, A., Wheless, J. et al. (1995) Right-sided vagus nerve stimulation as a treatment for refractory epilepsy in humans. Epilepsia, 46 (1), 91-96.
124. McLachlan, R.S. (1993) Suppression of interictal spikes and seizures by stimulation of the vagus nerve. Epilepsia, 34 (5), 918-923.
125. Michael, J.E., Wegener, K. et al. (1993) Vagus nerve stimulation for intractable seizures: one year follow-up. Journal of Neuroscience Nursing, 25 (6), 362-366.
126. Morris, G.L. 3rd (2003) A retrospective analysis of the effects of magnet-activated stimulation in conjunction with vagus nerve stimulation therapy. Epilepsy and Behavior, 4 (6), 740-745.
127. Morris, G.L. 3rd & Mueller, W.M. (1999) Long-term treatment with vagus nerve stimulation in patients with refractory epilepsy. The Vagus Nerve Stimulation Study Group E01-E05. Neurology, 53 (8), 1731-1735.
128. Morrow, J.I., Bingham, E. et al. (2000) Vagal nerve stimulation in patients with refractory epilepsy. Effect on seizure frequency, severity and quality of life. Seizure, 9 (6), 442-445.
129. Mu, Q., Bohning, D.E. et al. (2004) Acute vagus nerve stimulation using different pulse widths produces varying brain effects. Biological Psychiatry, 55 (8), 816-825.
130. Murphy, J.V. (1999) Left vagal nerve stimulation in children with medically refractory epilepsy. The Pediatric VNS Study Group. Journal of Pediatrics, 134 (5), 563-566.
131. Murphy, J.V. & Hornig, G.W. (1998) Chronic intermittent stimulation of the left vagal nerve in nine children with Lennox-Gastaut syndrome. Epilepsia, 39 (Suppl 6), 169.
132. Murphy, J.V., Torkelson, R. et al. (2003) Vagal nerve stimulation in refractory epilepsy: the first 100 patients receiving vagal nerve stimulation at a pediatric epilepsy center. Archives of Pediatrics and Adolescent Medicine, 157 (6), 560-564.
133. Murphy, J.V., Wheless, J.W. et al. (2000) Left vagal nerve stimulation in six patients with hypothalamic hamartomas. Pediatric Neurology, 23 (2), 167-168.
134. Murr, N.I. & Azar, N.J. (2011) Severe new seizures after initiation of vagus nerve stimulation therapy. Epilepsy and Behavior, 22 (2), 398-400.
135. Nahas, Z., Marangell, L.B. et al. (2005) Two-year outcome of vagus nerve stimulation (VNS) for treatment of major depressive episodes. Journal of Clinical Psychiatry, 66 (9), 1097-1104.
136. Nahas, Z., Teneback, C. et al. (2007) Serial vagus nerve stimulation functional MRI in treatment-resistant depression. Neuropsychopharmacology, 32 (8), 1649-1660.
137. Narayanan, J.T., Watts, R. et al. (2002) Cerebral activation during vagus nerve stimulation: a functionalMR study. Epilepsia, 43 (12), 1509-1514.
138. Naritoku, D.K., Handforth, A. et al. (1998) Effects of reducing stimulation intervals on antiepileptic efficacy of vagus nerve stimulation (VNS). Epilepsia, 39 (Suppl 6), 194.
139. Naritoku, D.K., Terry, W.J. et al. (1995) Regional induction of fos immunoreactivity in the brain by anticonvulsant stimulation of the vagus nerve. Epilepsy Research, 22 (1), 53-62.
140. Navas, M., Navarrete, E.G. et al. (2010) Treatment of refractory epilepsy in adult patients with right-sided vagus nerve stimulation. Epilepsy Research, 90 (1-2), 1-7.
141. Nieuwenhuys, R., Voogd, J. et al. (1988) The Human Central Nervous System:A Synopsis and Atlas. Springer-Verlag, Berlin.
142. Ongur, D. & Price, J.L. (2000) The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans. Cerebral Cortex, 10 (3), 206-219.
143. Ortler, M., Luef, G. et al. (2001) Deep wound infection after vagus nerve stimulator implantation: treatment without removal of the device. Epilepsia, 42 (1), 133-135.
144. Pardo, J.V., Sheikh, S.A. et al. (2008) Chronic vagus nerve stimulation for treatment-resistant depression decreases resting ventromedial prefrontal glucose metabolism. Neuroimage, 42 (2), 879-889.
145. Parent, A. (1996) Carpenter's Human Neuroanatomy. Williams & Wilkins, Baltimore.
146. Parker, A.P., Polkey, C.E. et al. (1999) Vagal nerve stimulation in epileptic encephalopathies. Pediatrics, 103 (4 Pt 1), 778-782.
147. Patel, N.C. & Edwards, M.S. (2004) Vagal nerve stimulator pocket infections. Pediatric Infectious Disease Journal, 23 (7), 681-683.
148. Patwardhan, R.V., Stong, B. et al. (2000) Efficacy of vagal nerve stimulation in children with medically refractory epilepsy. Neurosurgery, 47 (6), 1353-1357; discussion 1357-1358
149. Penry, J.K. & Dean, J.C. (1990) Prevention of intractable partial seizures by intermittent vagal stimulation in humans: preliminary results. Epilepsia, 31 (Suppl 2), S40-43.
150. Prater, J.F. (2001) Recurrent depression with vagus nerve stimulation. The American Journal of Psychiatry, 158 (5), 816-817.
151. Raedt, R., Clinckers, R. et al. (2011) Increased hippocampal noradrenaline is a biomarker for efficacy of vagus nerve stimulation in a limbic seizure model. Journal of Neurochemistry, 117 (3), 461-469.
152. Ramsay, R.E., Uthman, B.M. et al. (1994) Vagus nerve stimulation for treatment of partial seizures: 2. Safety, side effects, and tolerability. First International Vagus Nerve Stimulation Study Group. Epilepsia, 35 (3), 627-636.
153. Rhoton, A.L. Jr., O'Leary, J.L. et al. (1966) The trigeminal, facial, vagal, and glossopharyngeal nerves in the monkey.Afferent connections. Archives of Neurology, 14 (5), 530-540.
154. Ring, H.A., White, S. et al. (2000) A SPECT study of the effect of vagal nerve stimulation on thalamic activity in patients with epilepsy. Seizure, 9 (6), 380-384.
155. Rizzo, P., Beelke, M. et al. (2003) Chronic vagus nerve stimulation improves alertness and reduces rapid eye movement sleep in patients affected by refractory epilepsy. Sleep, 26 (5), 607-611.
156. Rush, A.J., George, M.S. et al. (2000) Vagus nerve stimulation (VNS) for treatment-resistant depressions: a multicenter study. Biological Psychiatry, 47 (4), 276-286.
157. Rush, A.J., Marangell, L.B. et al. (2005a) Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial. Biological Psychiatry, 58 (5), 347-354.
158. Rush, A.J., Sackeim, H.A. et al. (2005b) Effects of 12 months of vagus nerve stimulation in treatment-resistant depression:a naturalistic study. Biological Psychiatry, 58 (5), 355-363.
159. Sahay, A. & Hen, R. (2008) Hippocampal neurogenesis and depression. Novartis Foundation Symposia, 289, 152-160.
160. Saleem, K.S., Kondo, H. et al. (2008) Complementary circuits connecting the orbital and medial prefrontal networks with the temporal, insular, and opercular cortex in the macaque monkey. Journal of Comparative Neurology, 506 (4), 659-693.
161. Salinsky, M.C., Uthman, B.M. et al. (1996) Vagus nerve stimulation for the treatment of medically intractable seizures. Results of a 1-year open-extension trial. Vagus Nerve Stimulation Study Group. Archives of Neurology, 53 (11), 1176-1180.
162. Saper, C.B. (1987) Diffuse Cortical Projection Systems: Anatomical Organization and Role in Cortical Function. Bethesda, American Physiological Society.
163. Saper, C.B., Kibbe, M.R. et al. (1990) Brain natriuretic peptide-like immunoreactive innervation of the cardiovascular and cerebrovascular systems in the rat. Circulation Research, 67 (6), 1345-1354.
164. Saper, C.B. & Loewy, A.D. (1980) Efferent connections of the parabrachial nucleus in the rat. Brain Research, 197 (2), 291-317.
165. Schachter, S.C. (2004) Vagus nerve stimulation: mood and cognitive effects. Epilepsy and Behavior, 5 (Suppl 1), S56-59.
166. Schallert, G., Foster, J. et al. (1998) Chronic stimulation of the left vagal nerve in children: effect on swallowing. Epilepsia, 39 (10), 1113-1114.
167. Schlaepfer, T.E., Frick, C. et al. (2008) Vagus nerve stimulation for depression: efficacy and safety in a European study. Psychological Medicine, 38 (5), 651-661.
168. Schrader, L.M., Cook, I.A., Miller, P.R., Maremont, E.R. et al. (2011) Trigeminal nerve stimulation in major depressive disorder: first proof of concept in an open pilot trial. Epilepsy and Behavior, 22 (3), 475-478.
169. Shahwan, A., Bailey, C. et al. (2009) Vagus nerve stimulation for refractory epilepsy in children: More to VNS than seizure frequency reduction. Epilepsia, 50 (5), 1220-1228.
170. Shoeb, A., Pang, T. et al. (2009) Non-invasive computerized system for automatically initiating vagus nerve stimulation following patient-specific detection of seizures or epileptiform discharges. International Journal of Neural Systems, 19 (3), 157-172.
171. Shoeb, A., Pang, T. et al. (2011) Vagus nerve stimulation triggered by machine learning-based seizure detection: initial implementation and evaluation. In: Osorio, I., Zaveri, H.P., Frei, M.G. & Arthurs, S. (eds), Epilepsy: The Intersection of Neurosciences, Biology, Mathematics, Engineering, and Physics. CRC Press, Boca Raton, pp. 385-396.
172. Siddiqui, F., Herial, N.A. et al. (2010) Cumulative effect of vagus nerve stimulators on intractable seizures observed over a period of 3years. Epilepsy and Behavior, 18 (3), 299-302.
173. Sirven, J.I., Sperling, M. et al. (2000) Vagus nerve stimulation therapy for epilepsy in older adults. Neurology, 54 (5), 1179-1182.
174. Smyth, M.D., Tubbs, R.S. et al. (2003) Complications of chronic vagus nerve stimulation for epilepsy in children. Journal of Neurosurgery, 99 (3), 500-503.
175. Spanaki, M.V., Allen, L.S. et al. (2004) Vagus nerve stimulation therapy: 5-year or greater outcome at a university-based epilepsy center. Seizure, 13 (8), 587-590.
176. Stefan, H., Kreiselmeyer, G. et al. (2012) Transcutaneous vagus nerve stimulation (t-VNS) in pharmacoresistant epilepsies:a proof of concept trial. Epilepsia, 53 (7), e115-118.
177. Sucholeiki, R., Alsaadi, T.M. et al. (2002) fMRI in patients implanted with a vagal nerve stimulator. Seizure, 11 (3), 157-162.
178. Takaya, M., Terry, W.J. et al. (1996) Vagus nerve stimulation induces a sustained anticonvulsant effect. Epilepsia, 37 (11), 1111-1116.
179. Tatum, W.O., Johnson, K.D. et al. (2001) Vagus nerve stimulation and drug reduction. Neurology, 56 (4), 561-563.
180. Tatum, W.O. & Vale, F.L. (2009) Vagus nerve stimulation and cardiac asystole. Epilepsia, 50 (12), 2671-2672.
181. Tatum, W.O.t., Ferreira, J.A. et al. (2004) Vagus nerve stimulation for pharmacoresistant epilepsy: clinical symptoms with end of service. Epilepsy and Behavior, 5 (1), 128-132.
182. Tatum, W.O.t. & Helmers, S.L. (2009) Vagus nerve stimulation and magnet use: optimizing benefits. Epilepsy and Behavior, 15 (3), 299-302.
183. Tecoma, E.S. & Iragui, V.J. (2006) Vagus nerve stimulation use and effect in epilepsy: what have we learned? Epilepsy and Behavior, 8 (1), 127-136.
184. The Vagus Nerve Stimulation Study Group (1995) A randomized controlled trial of chronic vagus nerve stimulation for treatment of medically intractable seizures. Neurology, 45 (2), 224-230.
185. Uthman, B.M., Reichl, A.M. et al. (2004) Effectiveness of vagus nerve stimulation in epilepsy patients: a 12-year observation. Neurology, 63 (6), 1124-1126.
186. Van Laere, K., Vonck, K. et al. (2002) Perfusion SPECT changes after acute and chronic vagus nerve stimulation in relation to prestimulus condition and long-term clinical efficacy. Journal of Nuclear Medicine, 43 (6), 733-744.
187. Vonck, K., Boon, P. et al. (2000) Acute single photon emission computed tomographic study of vagus nerve stimulation in refractory epilepsy. Epilepsia, 41 (5), 601-609.
188. Vonck, K., Dedeurwaerdere, S. et al. (2005) Generator replacement in epilepsy patients treated with vagus nerve stimulation. Seizure, 14 (2), 89-99.
189. Vonck, K., Thadani, V. et al. (2004) Vagus nerve stimulation for refractory epilepsy: a transatlantic experience. Journal of Clinical Neurophysiology, 21 (4), 283-289.
190. Woodbury, D.M. & Woodbury, J.W. (1990) Effects of vagal stimulation on experimentally induced seizures in rats. Epilepsia, 31, S7-S19.
191. Woodbury, J.W. &Woodbury, D.M. (1991) Vagal stimulation reduces the severity of maximal electroshock seizures in intact rats: use of a cuff electrode for stimulating and recording. Pacing and Clinical Electrophysiology, 14 (1), 94-107.
192. Yang, A.C., Zhang, J.G. et al. (2011) A new choice for the treatment of epilepsy: electrical auricula-vagus-stimulation. Medical Hypotheses, 77 (2), 244-245.
193. Yatham, L.N. (2004) Newer anticonvulsants in the treatment of bipolar disorder. Journal of Clinical Psychiatry, 65 (Suppl 10), 28-35.
194. Zabara, J. (1992) Inhibition of experimental seizures in canines by repetitive vagal stimulation. Epilepsia, 33 (6), 1005-1012.
195. Zagon, A. & Kemeny, A.A. (2000) Slow hyperpolarization in cortical neurons: a possible mechanism behind vagus nerve simulation therapy for refractory epilepsy? Epilepsia, 41 (11), 1382-1389.
196. Zamponi, N., Passamonti, C. et al. (2011) Clinical course of young patients with Dravet syndrome after vagal nerve stimulation. European Journal of Paediatric Neurology, 15 (1), 8-14.
197. Zobel, A., Joe, A. et al. (2005) Changes in regional cerebral blood flow by therapeutic vagus nerve stimulation in depression:an exploratory approach. Psychiatry Research, 139 (3), 165-179.