The effects of age on health-related quality of life in cancer populations: A pooled analysis of randomized controlled trials using the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 involving 6024 cancer patients

European Journal of Cancer

Volumn 51, Issue 18, 2015, Pages 2808-2819

  Quinten, Chantal ^a   Coens, Corneel ^b   Ghislain, Irina ^b   Zikos, Efstathios ^b   Sprangers, Mirjam A G ^c   Ringash, Jolie ^d   Martinelli, Francesca ^b   Ediebah, Divine E ^e   Maringwa, John ^f   Reeve, Bryce B ^g   Greimel, Eva ^h   King, Madeleine T ⁱ   Bjordal, Kristin ^j   Flechtner, Hans Henning ^k   Schmucker Von Koch, Joseph ^l   Taphoorn, Martin J B ^m,n   Weis, Joachim ^o   Wildiers, Hans ^p   Velikova, Galina ^q   Bottomley, Andrew ^b  

^a EUROPEAN CENTRE FOR DISEASE PREVENTION AND CONTROL ECDC   (Sweden)

^b EORTC DATA CENTER   (Belgium)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF TORONTO   (Canada)

^e ABBOTT VASCULAR   (United States)

^f Quantative Solutions   (Netherlands)

^g University of North Carolina at Chapel Hill   (United States)

^h MEDICAL UNIVERSITY OF GRAZ   (Austria)

ⁱ UNIVERSITY OF SYDNEY   (Australia)

^j OSLO UNIVERSITY HOSPITAL   (Norway)

^k OTTO VON GUERICKE UNIVERSITY   (Germany)

^l UNIVERSITY OF REGENSBURG   (Germany)

^m VU UNIVERSITY MEDICAL CENTER   (Netherlands)

ⁿ MEDICAL CENTER HAAGLANDEN   (Netherlands)

^o UNIVERSITY OF FREIBURG   (Germany)

^p UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^q UNIVERSITY OF LEEDS   (United Kingdom)

more..

Author keywords

Cancer burden; General population; Health related quality of life; Increasing age; Normative data

Indexed keywords

ADULT; AGE; ARTICLE; CANCER FATIGUE; CANCER LOCALIZATION; CANCER PATIENT; COGNITION; CONSTIPATION; CONTROLLED STUDY; DIARRHEA; DISTANT METASTASIS; DYSPNEA; EMOTION; FEMALE; FINANCIAL DEFICIT; GENDER; HEALTH STATUS; HUMAN; INSOMNIA; LOSS OF APPETITE; MAJOR CLINICAL STUDY; MALE; NAUSEA AND VOMITING; NEOPLASM; PAIN; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); SOCIAL INTERACTION; ADOLESCENT; AGED; AGING; AUSTRALIA; CLINICAL TRIAL; EUROPE; GERIATRIC ASSESSMENT; META ANALYSIS; METASTASIS; MIDDLE AGED; MULTICENTER STUDY; MULTIVARIATE ANALYSIS; NEOPLASMS; NEW ZEALAND; NORTH AMERICA; PROGNOSIS; PSYCHOLOGY; QUESTIONNAIRE; RISK FACTOR; SOUTH AFRICA; STATISTICAL MODEL; TIME FACTOR; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; AUSTRALIA; EUROPE; FEMALE; GERIATRIC ASSESSMENT; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM METASTASIS; NEOPLASMS; NEW ZEALAND; NORTH AMERICA; PROGNOSIS; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK FACTORS; SOUTH AFRICA; SURVEYS AND QUESTIONNAIRES; TIME FACTORS; YOUNG ADULT;

EID: 84958773703     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2015.08.027     Document Type: Article

References (46)

1. N.K. Arora, K.E. Weaver, M.L. Clayman, I. Oakley-Girvan, and A.L. Potosky Physicians' decision-making style and psychosocial outcomes among cancer survivors Patient Educ Couns 77 2009 404 412
2. M. Derogar, M. Van der schaaf, and P. Lagergren Reference values for the EORTC QLQ-C30 quality of life questionnaire in a random sample of the Swedish population Acta Oncol 51 2012 10 16
3. L.V. Van de Poll-Franse, F. Mold, C. Gundy, C.L. Creutzberg, R.A. Nout, I.M. Verdonck-de Leeuw, and et al. Normative data for the EORTC QLQ-C30 and EORTC-sexuality items in the general Dutch population Eur J Cancer 47 2011 667 675
4. R. Schwarz, and A. Hinz Reference data for the quality of life questionnaire EORTC QLQ-C30 in the general German population Eur J Cancer 37 2001 1345 1351
5. A. Waldmann, D. Schubert, and A. Katalinic Normative data of the EORTC QLQ-C30 for the German population: A population-based survey PLos One 8 2013 e74149
6. M. Hjermstad, P. Fayers, K. Bjordal, and S. Kaasa Health related quality of life in the general Norwegian population assessed by the European Organization for Research and Treatment of Cancer Core Quality-of-Life Questionnaire: The QLQ-C30 (+3) J Clin Oncol 16 1998 1188 1196
7. M. Pinkawa, K. Fischedick, B. Gagel, M.D. Piroth, B. Asdpour, J. Klotz, and et al. Impact of age and comorbidities on health-related quality of life for patients with prostate cancer: Evaluation before a curative treatment BMC Cancer 9 2009 296
8. M. Else, A.G. Smith, K. Cock, S.M. Richards, S. Crofts, R. Wade, and et al. Patients' experience of chronic lymphocytic leukemia: Baseline health-related quality of life results from the LRF CLL4 trial Br J Haematol 143 2008 690 697
9. E.J. Bantema-Joppe, G.H. de Bock, M. Woltman-van Iersel, D.M. Busz, A.V. Ranchor, J.A. Langendijk, and et al. The impact of age on changes in quality of life among breast cancer survivors treated with breast-conserving surgery and radiotherapy Br J Cancer 112 2015 636 643
10. M.J. Schroevers, A.V. Ranchor, and R. Sanderman The role of age at the onset of cancer in relation to survivors' long-term adjustment: A controlled comparison over an eight-year period Psychooncology 13 2004 740 752
11. M.J. Schroevers, A.V. Ranchor, and R. Sanderman Adjustment to cancer in the 8 years following diagnosis: A longitudinal study comparing cancer survivors with healthy individuals Soc Sci Med 63 2006 598 610
12. F.R. Appelbaum, H. Gundacker, D.R. Head, M.L. Slovak, C.L. Willman, J.E. Godwin, and et al. Age and acute myeloid leukemia Blood 107 2006 3481 3485
13. H. Wildiers, M. Highley, E. de Bruijn, and A.T. van Oosterom Pharmacology of anticancer drugs in the elderly population Clin Pharmacokinet 42 2003 1213 1242
14. S. Lichtman, H. Wildiers, E. Chatelut, C. Steer, D. Budman, V.A. Morrison, and et al. International Society of Geriatric Oncology taskforce: Evaluation of chemotherapy in older patients - an analysis of the medical literature J Clin Oncol 25 2007 1832 1843
15. A. Pallis, C. Fortpied, U. Wedding, M.C. van Nes, B. Penninck, A. Ring, and et al. EORTC elderly task force position paper: Approach to the older cancer patient Eur J Cancer 46 2010 1502 1513
16. A. Pallis, A. Ring, C. Fortpied, B. Penninckx, M.C. Van Nes, U. Wedding, and et al. EORTC workshop on clinical trial methodology in older individuals with a diagnosis of solid tumors Ann Oncol 22 2011 1922 1926
17. H. Wildiers, M. Mauer, A. Pallis, A. Hurria, S.G. Mohile, A. Luciani, and et al. End points and trial design in geriatric oncology research: A joint European organisation for research and treatment of cancer-alliance for Clinical Trials in Oncology-International Society of Geriatric Oncology position article J Clin Oncol 31 2013 3711 3718
18. G. Rosati, and D. Bilancia Role of chemotherapy and novel biological agents in the treatment of elderly patients with colorectal cancer World J Gastroenterol 14 2008 1812
19. A. Rossi, P. Maione, F. Del Gaizo, G. Colantuoni, C. Ferrara, D. Nicolella, and et al. Targeted therapies in the treatment of advanced Non-Small-Cell Lung Cancer elderly patients Cancer Ther 5 2007 227 238
20. N.K. Aaronson, S. Ahmedzai, B. Bergman, M. Bullinger, A. Cull, N.J. Duez, and et al. The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology J Natl Cancer Inst 85 1993 365 367
21. Fayers P, Aaronson N, Bjordal K, Groenvold M, Curran M, Bottomley, et al. EORTC QLQ-C30 Scoring Manual, EORTC Quality of Life Group 3rd edition EORTC, Brussels, Belgium.
22. Y. Hochberg A sharper Bonferroni procedure for multiple tests of significance Biometrika 75 1998 800 802
23. M.T. King, P. Kenny, A. Shiell, J. Hall, and J. Boyages Quality of life three months and one year after first treatment for early stage breast cancer: Influence of treatment and patient characteristics Qual Life Res 9 2000 789 800
24. D. Osoba, G. Rodrigues, J. Myles, B. Zee, and J. Pater Interpreting the significance of changes in health-related quality-of-life scores J Clin Oncol 16 1998 139 144
25. L. Sobin, M. Gospodarowicz, and C. Wittekind TNM classification of malignant tumors 7th ed. 2009 International Union Against Cancer, Wiley New York, United States of America
26. N. Heutte, H.H. Flechtner, N. Mounier, W.A. Mellink, J.H. Meerwaldt, H. Eghabali, and et al. Quality of life after successful treatment of early-stage Hodgkin's lymphoma: 10-year follow-up of the EORTC-GELA H8 randomised controlled trial Lancet Oncol 10 2009 60 70
27. M.T. Lee, S. Gibson, and K. Hilari Gender differences in health-related quality of life following total laryngectomy Int J Lang Commun Disord 45 2010 287 294
28. A.P. Silveira, J. Conçalves, T. Sequeira, C. Ribeiro, C. Lopes, E. Monteiro, and et al. Geriatric oncology: Comparing health related quality of life in head and neck cancer patients Head Neck Oncol 3 2011 3
29. C. Snöbohm, and S. Heiwe Stressors, coping and coping strategies among young adults, with cancer World J Psycho Social Oncol 3 2013 15 28
30. P.A. Ubel, A. Jankovi, D. Smith, K.M. Lnaga, and A. Fagerlin What is perfect health to an 85-year old? Evidence for scale recalibration in subjective health ratings Med Care 43 2005 1054 1057
31. J.R. Piazza, S.T. Charles, and D.M. Ameida Living with chronic health conditions: Age differences in affective well-being J Gerontol Ser B Psychol Sci Soc Sci 62 2007 313 321
32. J.L. Krok, A. Baker, and C. McMillan Age differences in the presence of pain and psychological distress in younger and older cancer patients J Hosp Palliat Nurs 15 2013 107 113
33. H. Wildiers, and C. Kenis Comprehensive geriatric assessment (CGA) in older oncology patients: Why and how? J Geriatr Oncol 3 2012 174 176
34. H. Wildiers, A. Pallis, U. Wedding, D. Lacombe, and P. Soubeyran Questionnaires and instruments for a multidimensional assessment of the older cancer patient: What clinicians need to know? Eur J Cancer 46 2010 1019 1025
35. H. Michelson, C. Bolund, B. Nilsson, and Y. Brandberg Health related quality of life measured by the EORTC QLQ-C30 - reference values from a large sample of Swedish population Acta Oncol 39 2000 477 484
36. J.F. Piccirillo, R.M. Tierney, I. Costas, L. Grove, and E.L. Spitznagel Jr. Prognostic importance of comorbidity in a hospital-based cancer registry J Am Med Assoc 291 2004 2441 2447
37. M.K. Bellizzi, and J.H. Rowland Role of comorbidity, symptoms and age in the health of older survivors following treatment for cancer Aging Health 3 2007 625 635
38. S. Wheelwright, A.S. Darlington, D. Fitzsimmons, P. Fayers, J.I. Arraras, F. Bonnetain, and et al. International validation of the EORTC QLQ-ELD14 questionnaire for assessment of health-related quality of life of elderly patients with cancer Br J Cancer 109 2013 852 858
39. D. Fitzsimmons, J. Gilbert, F. Howse, T. Young, J.I. Arraras, A. Brédart, and et al. A systematic review of the use and validation of health-related quality of life instruments in older cancer patients Eur J Cancer 45 2009 19 32
40. E.A. Phelan, L.A. Anderson, A.Z. LaCroix, and E.B. Larson Older adults' views of "successful aging" - how do they compare with researcher's definitions? J Am Geriatr Soc 52 2004 211 216
41. R.C. Chen, T.J. Royce, M. Extermann, and B.B. Reeve Impact of age and comorbidity on treatment and outcomes in elderly cancer patients Semin Radiat Oncol 22 2012 265 271
42. A. Hurria, W. Dale, M. Mooney, J.H. Rowland, K.V. Ballman, H.J. Cohen, and et al. Designing therapeutic clinical trials for older and frail adults with cancer: U13 conference recommendations J Clin Oncol 32 2014 2587 2594
43. Segen's Medical Dictionary Farlex 2012 http://medical-dictionary.thefreedictionary.com/Active+Life+Expectancy [accessed 15.07.15]
44. A. Hurria, H.J. Cohen, and M. Extermann Geriatric oncology research in the cooperative groups: A report of a SIOG special meeting J Geriatr Oncol 1 2010 40 44
45. Center for the Study of Drugs Likely to Be Used in the Elderly Guideline for the study of drugs likely to be used in the elderly 1989 US Department of Health and Human Services Washington, DC
46. Cancer and Aging Research Group. CARG. http://www.mycarg.org/. [accessed 15.07.15].