Coagulopathy and transfusion strategies in trauma. Overwhelmed by literature, supported by weak evidence

Blood Transfusion

Volumn 14, Issue 1, 2016, Pages 3-7

  Poole, Daniele ^a  

^a SAN MARTINO HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BLOOD TRANSFUSION; FIBRINOLYSIS; HUMAN; HYPOFIBRINOGENEMIA; INJURY; MORTALITY; PENETRATING TRAUMA; PROPENSITY SCORE; RANDOMIZED CONTROLLED TRIAL (TOPIC); BLOOD COAGULATION DISORDERS; COMPLICATION; PROCEDURES; WOUNDS AND INJURIES;

BLOOD COAGULATION DISORDERS; BLOOD TRANSFUSION; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; WOUNDS AND INJURIES;

EID: 84958698595     PISSN: 17232007     EISSN: None     Source Type: Journal    
DOI: 10.2450/2015.0244-15     Document Type: Article

References (45)

1. Altman DG. The scandal of poor medical research. BMJ 1994; 308: 283-4.
2. Altman DG. Poor-quality medical research: What can journals do? JAMA 2002; 287: 2765-7.
3. Poole D, Nattino G, Bertolini G. Overoptimism in the interpretation of statistics: The ethical role of statistical reviewers in medical journals. Intensive Care Med 2014; 40: 1927-9.
4. Peduzzi P, Concato J, Feinstein AR, Holford TR. Importance of events per independent variable in proportional hazards regression analysis. II. Accuracy and precision of regression estimates. J Clin Epidemiol 1995; 48: 1503-10.
5. Mallett S, Royston P, Waters R, et al. Reporting performance of prognostic models in cancer: A review. BMC Med 2010; 8: 21.
6. Ottenbacher KJ, Ottenbacher HR, Tooth L, Ostir GV. A review of two journals found that articles using multivariable logistic regression frequently did not report commonly recommended assumptions. J Clin Epidemiol 2004; 57: 1147-52.
7. Sun GW, Shook TL, Kay GL. Inappropriate use of bivariable analysis to screen risk factors for use in multivariable analysis. J Clin Epidemiol 1996; 49: 907-16.
8. Bagley SC, White H, Golomb BA. Logistic regression in the medical literature: Standards for use and reporting, with particular attention to one medical domain. J Clin Epidemiol 2001; 54: 979-85.
9. Rourke C, Curry N, Khan S, et al. Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes. J Thromb Haemost 2012; 10: 1342-51.
10. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: A severity of disease classification system. Crit Care Med 1985; 13: 818-29.
11. Knaus WA, Wagner DP, Draper EA, et al. The APACHE III prognostic system. Risk prediction of hospital mortality for critically ill hospitalized adults. Chest 1991; 100: 1619-36.
12. Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study. JAMA 1993; 270: 2957-63.
13. Katz MH. Multivariable analysis: A primer for readers of medical research. Ann Intern Med 2003; 138: 644-50.
14. Teixeira PG, Inaba K, Shulman I, et al. Impact of plasma transfusion in massively transfused trauma patients. J Trauma 2009; 66: 693-7.
15. Button KS, Ioannidis JP, Mokrysz C, et al. Power failure: Why small sample size undermines the reliability of neuroscience. Nat Rev Neurosci 2013; 14: 365-76.
16. Sylvestre MP, Huszti E, Hanley JA. Do OSCAR winners live longer than less successful peers? A reanalysis of the evidence. Ann Intern Med 2006; 145: 361-3; discussion 92.
17. Redelmeier DA, Singh SM. Survival in Academy Award-winning actors and actresses. Ann Intern Med 2001; 134: 955-62.
18. Borgman MA, Spinella PC, Holcomb JB, et al. The effect of FFP:RBC ratio on morbidity and mortality in trauma patients based on transfusion prediction score. Vox Sang 2011; 101: 44-54.
19. Inaba K, Branco BC, Rhee P, et al. Impact of plasma transfusion in trauma patients who do not require massive transfusion. J Am Coll Surg 2010; 210: 957-65.
20. Sambasivan CN, Kunio NR, Nair PV, et al. High ratios of plasma and platelets to packed red blood cells do not affect mortality in nonmassively transfused patients. J Trauma 2011; 71 (2 Suppl 3): S329-36.
21. Wafaisade A, Maegele M, Lefering R, et al. High plasma to red blood cell ratios are associated with lower mortality rates in patients receiving multiple transfusion (4
22. Brown JB, Cohen MJ, Minei JP, et al. Debunking the survival bias myth: Characterization of mortality during the initial 24 hours for patients requiring massive transfusion. J Trauma Acute Care Surgery 2012; 73: 358-64.
23. Snyder CW, Weinberg JA, McGwin G Jr, et al. The relationship of blood product ratio to mortality: Survival benefit or survival bias? J Trauma 2009; 66: 358-64.
24. Altman DG, Bland JM. Statistics notes. Treatment allocation in controlled trials: Why randomise? BMJ 1999; 318: 1209.
25. Rosenbaum PR, Rubin DB. The central role of the propensity score in observational studies for causal effects. Biometrika 1983; 70: 41-55
26. Freemantle N, Marston L, Walters K, et al. Making inferences on treatment effects from real world data: Propensity scores, confounding by indication, and other perils for the unwary in observational research. BMJ 2013; 347: F6409.
27. Perel P, Clayton T, Altman DG, et al. Red blood cell transfusion and mortality in trauma patients: Risk-stratified analysis of an observational study. PLoS Med 2014; 11: E1001664.
28. CRASH-2 trial investigators; Shakur H, Roberts I, Bautista R, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): A randomised, placebo-controlled trial. Lancet 2010; 376: 23-32.
29. Perel P, Prieto-Merino D, Shakur H, et al. Predicting early death in patients with traumatic bleeding: Development and validation of prognostic model. BMJ 2012; 345: E5166.
30. Austin PC, Platt RW. Survivor treatment bias, treatment selection bias, and propensity scores in observational research. J Clin Epidemiol 2010; 63: 136-8.
31. Robins JM, Hernan MA, Brumback B. Marginal structural models and causal inference in epidemiology. Epidemiology 2000; 11: 550-60.
32. Holcomb JB, Zarzabal LA, Michalek JE, et al. Increased platelet:RBC ratios are associated with improved survival after massive transfusion. J Trauma 2011; 71 (2 Suppl 3): S318-28.
33. Scalea TM, Bochicchio KM, Lumpkins K, et al. Early aggressive use of fresh frozen plasma does not improve outcome in critically injured trauma patients. Ann Surgery 2008; 248: 578-84.
34. Mitra B, Mori A, Cameron PA, et al. Fresh frozen plasma (FFP) use during massive blood transfusion in trauma resuscitation. Injury 2010; 41: 35-9.
35. Rothwell PM. Factors that can affect the external validity of randomised controlled trials. PLoS Clin Trials 2006; 1: E9.
36. Altman DG, Royston P. What do we mean by validating a prognostic model? Stat Med 2000; 19: 453-73.
37. Poole D, Rossi C, Anghileri A, et al. External validation of the Simplified Acute Physiology Score (SAPS) 3 in a cohort of 28,357 patients from 147 Italian intensive care units. Intensive Care Med 2009; 35: 1916-24.
38. Borgman MA, Spinella PC, Perkins JG, et al. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma 2007; 63: 805-13.
39. Bellomo R, Warrillow SJ, Reade MC. Why we should be wary of single-center trials. Crit Care Med 2009; 37: 3114-9.
40. Hagemo JS, Stanworth S, Juffermans NP, et al. Prevalence, predictors and outcome of hypofibrinogenaemia in trauma: A multicentre observational study. Crit Care 2014; 18: R52.
41. Holcomb JB, Tilley BC, Baraniuk S, et al. Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: The PROPPR randomized clinical trial. JAMA 2015; 313: 471-82.
42. Lachin JM. Introduction to sample size determination and power analysis for clinical trials. Control Clin Trials 1981; 2: 93-113.
43. Spahn DR, Bouillon B, Cerny V, et al. Management of bleeding and coagulopathy following major trauma: An updated European guideline. Crit Care 2013; 17: R76.
44. Black N. Developing high quality clinical databases. BMJ 1997; 315: 381-2.
45. Marshall E. When does intellectual passion become conflict of interest? Science 1992; 257: 620-3.