Resting heart rate and all-cause and cardiovascular mortality in the general population: A meta-analysis

CMAJ

Volumn 188, Issue 3, 2016, Pages E53-E63

  Zhang, Dongfeng ^a   Shen, Xiaoli ^a   Qi, Xin ^a  

^a QINGDAO UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; CAUSE OF DEATH; DISEASE ASSOCIATION; HEART BEAT; HUMAN; POPULATION RISK; PREDICTION; RESTING HEART RATE; REVIEW; RISK ASSESSMENT; RISK FACTOR; SYMPATHETIC TONE; SYSTEMATIC REVIEW; VAGUS TONE; HEART RATE; META ANALYSIS; MORTALITY; PATHOPHYSIOLOGY; PHYSIOLOGY;

CARDIOVASCULAR DISEASES; CAUSE OF DEATH; HEART RATE; HUMANS; MORTALITY; RISK FACTORS;

EID: 84958687578     PISSN: 08203946     EISSN: 14882329     Source Type: Journal    
DOI: 10.1503/cmaj.150535     Document Type: Article

References (76)

1. Dobre D, Borer JS, Fox K, et al. Heart rate: a prognostic factor and therapeutic target in chronic heart failure. The distinct roles of drugs with heart rate-lowering properties. Eur J Heart Fail 2014;16:76-85.
2. Ohira T, Diez Roux AV, Prineas RJ, et al. Associations of psychosocial factors with heart rate and its short-term variability: multi-ethnic study of atherosclerosis. Psychosom Med 2008; 70:141-6.
3. Dinas PC, Koutedakis Y, Flouris AD. Effects of active and passive tobacco cigarette smoking on heart rate variability. Int J Cardiol 2013;163:109-15.
4. Mozaffarian D, Prineas RJ, Stein PK, et al. Dietary fish and n-3 fatty acid intake and cardiac electrocardiographic parameters in humans. J Am Coll Cardiol 2006;48:478-84.
5. Fox K, Borer JS, Camm AJ, et al. Resting heart rate in cardiovascular disease. J Am Coll Cardiol 2007;50:823-30.
6. Sajadieh A, Nielsen OW, Rasmussen V, et al. Increased heart rate and reduced heart-rate variability are associated with subclinical inflammation in middle-aged and elderly subjects with no apparent heart disease. Eur Heart J 2004;25:363-70.
7. Jensen MT, Marott JL, Allin KH, et al. Resting heart rate is associated with cardiovascular and all-cause mortality after adjusting for inflammatory markers: the Copenhagen City Heart Study. Eur J Prev Cardiol 2012;19:102-8.
8. Goff DC Jr, Lloyd-Jones DM, Bennett G, et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2014;63:2935-59.
9. European Guidelines on cardiovascular disease prevention in clinical practice (version 2012): the Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Eur J Prev Cardiol 2012;19:585-667.
10. Leistner DM, Klotsche J, Palm S, et al. Resting heart rate as a tool for risk stratification in primary care: Does it provide incremental prognostic information? Eur J Prev Cardiol 2012; 19:275-84.
11. Morcet JF, Safar M, Thomas F, et al. Associations between heart rate and other risk factors in a large French population. J Hypertens 1999;17:1671-6.
12. Cooney MT, Vartiainen E, Laatikainen T, et al. Elevated resting heart rate is an independent risk factor for cardiovascular disease in healthy men and women. Am Heart J 2010;159:612-619.e3.
13. Tverdal A, Hjellvik V, Selmer R. Heart rate and mortality from cardiovascular causes: a 12 year follow-up study of 379,843 men and women aged 40-45 years. Eur Heart J 2008;29:2772-81.
14. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA 2000;283:2008-12.
15. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials 1986;7:177-88.
16. Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ 2003;327:557-60.
17. Higgins JP, Thompson SG. Controlling the risk of spurious findings from meta-regression. Stat Med 2004;23:1663-82.
18. Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315:629-34.
19. Duval S, Tweedie R. Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 2000;56:455-63.
20. Wells GA, Shea B, O'Connell D, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa Hospital Research Institute. Available: www.ohri.ca/programs/clinical-epidemiology/oxford.asp (accessed 2015 Aug. 17).
21. Orsini N, Li R, Wolk A, et al. Meta-analysis for linear and nonlinear dose-response relations: examples, an evaluation of approximations, and software. Am J Epidemiol 2012;175:66-73.
22. Harrell FE Jr, Lee KL, Pollock BG. Regression models in clinical studies: determining relationships between predictors and response. J Natl Cancer Inst 1988;80:1198-202.
23. Orsini N, Bellocco R, Greenland S. Generalized least squares for trend estimation of summarized dose-response data. Stata J 2006;6:40-57.
24. Jackson D, White IR, Thompson SG. Extending DerSimonian and Laird's methodology to perform multivariate random effects meta-analyses. Stat Med 2010;29:1282-97.
25. Gillum RF, Makuc DM, Feldman JJ. Pulse rate, coronary heart disease, and death: the NHANES I Epidemiologic Follow-up Study. Am Heart J 1991;121:172-7.
26. Sandvik L, Erikssen J, Thaulow E, et al. Physical fitness as a predictor of mortality among healthy, middle-aged Norwegian men. N Engl J Med 1993;328:533-7.
27. Mensink GB, Hoffmeister H. The relationship between resting heart rate and all-cause, cardiovascular and cancer mortality. Eur Heart J 1997;18:1404-10.
28. Benetos A, Rudnichi A, Thomas F, et al. Influence of heart rate on mortality in a French population: role of age, gender, and blood pressure. Hypertension 1999;33:44-52.
29. Greenland P, Daviglus ML, Dyer AR, et al. Resting heart rate is a risk factor for cardiovascular and noncardiovascular mortality: the Chicago Heart Association Detection Project in Industry. Am J Epidemiol 1999;149:853-62.
30. Palatini P, Casiglia E, Julius S, et al. High heart rate: a risk factor for cardiovascular death in elderly men. Arch Intern Med 1999; 159:585-92.
31. Kristal-Boneh E, Silber H, Harari G, et al. The association of resting heart rate with cardiovascular, cancer and all-cause mortality. Eight year follow-up of 3527 male Israeli employees (the CORDrosoph Inf Serv Study). Eur Heart J 2000;21:116-24.
32. Reunanen A, Karjalainen J, Ristola P, et al. Heart rate and mortality. J Intern Med 2000;247:231-9.
33. Nilsson PM, Nilsson JA, Hedblad B, et al. Sleep disturbance in association with elevated pulse rate for prediction of mortality-consequences of mental strain? J Intern Med 2001; 250:521-9.
34. Seccareccia F, Pannozzo F, Dima F, et al. Heart rate as a predictor of mortality: the MATISS project. Am J Public Health 2001;91:1258-63.
35. Cheng YJ, Macera CA, Church TS, et al. Heart rate reserve as a predictor of cardiovascular and all-cause mortality in men. Med Sci Sports Exerc 2002;34:1873-8.
36. Kado DM, Lui LY, Cummings SR. Rapid resting heart rate: a simple and powerful predictor of osteoporotic fractures and mortality in older women. J Am Geriatr Soc 2002;50:455-60.
37. Chang M, Havlik RJ, Corti MC, et al. Relation of heart rate at rest and mortality in the Women's Health and Aging Study. Am J Cardiol 2003;92:1294-9.
38. Hozawa A, Ohkubo T, Kikuya M, et al. Prognostic value of home heart rate for cardiovascular mortality in the general population: the Ohasama study. Am J Hypertens 2004; 17: 1005-10.
39. Okamura T, Hayakawa T, Kadowaki T, et al. Resting heart rate and cause-specific death in a 16.5-year cohort study of the Japanese general population. Am Heart J 2004;147:1024-32.
40. Fisher AA, Davis MW, Srikusalanukul W, et al. Does heart rate predict mortality in older, low-level care residents? Am J Geriatr Cardiol 2006;15:208-16.
41. Savonen KP, Lakka TA, Laukkanen JA, et al. Heart rate response during exercise test and cardiovascular mortality in middle-aged men. Eur Heart J 2006;27:582-8.
42. Theobald H, Wandell PE. Effect of heart rate on long-term mortality among men and women. Acta Cardiol 2007;62:275-9.
43. Adabag AS, Grandits GA, Prineas RJ, et al. Relation of heart rate parameters during exercise test to sudden death and all-cause mortality in asymptomatic men. Am J Cardiol 2008; 101:1437-43.
44. Hansen TW, Thijs L, Boggia J, et al. Prognostic value of ambulatory heart rate revisited in 6928 subjects from 6 populations. Hypertension 2008;52:229-35.
45. Kizilbash MA, Daviglus ML, Dyer AR, et al. Relation of heart rate with cardiovascular disease in normal-weight individuals: the Chicago Heart Association Detection Project in Industry. Prev Cardiol 2008;11:141-7.
46. Mai JZ, Zhao LC, Liu XQ, et al. [Association between heart rate and all-cause death and coronary event in the Chinese cohort: 16 years follow up results] [Article in Chinese]. Zhonghua Xin Xue Guan Bing Za Zhi 2009;37:750-3.
47. Batty GD, Shipley MJ, Kivimaki M, et al. Walking pace, leisure time physical activity, and resting heart rate in relation to disease-specific mortality in London: 40 years follow-up of the original Whitehall study. An update of our work with professor Jerry N. Morris (1910-2009). Ann Epidemiol 2010;20:661-9.
48. Nauman J, Nilsen TI, Wisloff U, et al. Combined effect of resting heart rate and physical activity on ischaemic heart disease: mortality follow-up in a population study (the HUNT study, Norway). J Epidemiol Community Health 2010;64:175-81.
49. Jensen MT, Marott JL, Jensen GB. Elevated resting heart rate is associated with greater risk of cardiovascular and all-cause mortality in current and former smokers. Int J Cardiol 2011; 151:148-54.
50. Jouven X, Escolano S, Celermajer D, et al. Heart rate and risk of cancer death in healthy men. PLoS ONE 2011;6:e21310.
51. Legeai C, Jouven X, Tafflet M, et al. Resting heart rate, mortality and future coronary heart disease in the elderly: the 3C Study. Eur J Cardiovasc Prev Rehabil 2011;18:488-97.
52. Nabi H, Kivimaki M, Empana JP, et al. Combined effects of depressive symptoms and resting heart rate on mortality: the Whitehall II prospective cohort study. J Clin Psychiatry 2011; 72:1199-206.
53. Nauman J, Janszky I, Vatten LJ, et al. Temporal changes in resting heart rate and deaths from ischemic heart disease. JAMA 2011;306:2579-87.
54. Inoue R, Ohkubo T, Kikuya M, et al. Predictive value for mortality of the double product at rest obtained by home blood pressure measurement: the Ohasama study. Am J Hypertens 2012;25:568-75.
55. Woodward M, Webster R, Murakami Y, et al. The association between resting heart rate, cardiovascular disease and mortality: evidence from 112,680 men and women in 12 cohorts. Eur J Prev Cardiol 2014;21:719-26.
56. Jensen MT, Suadicani P, Hein HO, et al. Elevated resting heart rate, physical fitness and all-cause mortality: a 16-year follow-up in the Copenhagen Male Study. Heart 2013;99:882-7.
57. Johansen CD, Olsen RH, Pedersen LR, et al. Resting, night-time, and 24 h heart rate as markers of cardiovascular risk in middle-aged and elderly men and women with no apparent heart disease. Eur Heart J 2013;34:1732-9.
58. Pittaras AM, Faselis C, Doumas M, et al. Heart rate at rest, exercise capacity, and mortality risk in veterans. Am J Cardiol 2013;112:1605-9.
59. Plichart M, Thomas F, Empana JP, et al. Gender-specific trends in heart rate in the general population from 1992-2007: a study of 226,288 French adults. Eur J Prev Cardiol 2013; 20:61-72.
60. Saxena A, Minton D, Lee DC, et al. Protective role of resting heart rate on all-cause and cardiovascular disease mortality. Mayo Clin Proc 2013;88:1420-6.
61. Aladin AI, Whelton SP, Al-Mallah MH, et al. Relation of resting heart rate to risk for all-cause mortality by gender after considering exercise capacity (the Henry Ford exercise testing project). Am J Cardiol 2014;114:1701-6.
62. Floyd JS, Sitlani CM, Wiggins KL, et al. Variation in resting heart rate over 4 years and the risks of myocardial infarction and death among older adults. Heart 2015;101:132-8.
63. Hisamatsu T, Miura K, Ohkubo T, et al. High long-chain n-3 fatty acid intake attenuates the effect of high resting heart rate on cardiovascular mortality risk: a 24-year follow-up of Japanese general population. J Cardiol 2014;64:218-24.
64. Ho JE, Larson MG, Ghorbani A, et al. Long-term cardiovascular risks associated with an elevated heart rate: the Framingham Heart Study. J Am Heart Assoc 2014;3:e000668.
65. Ó Hartaigh B, Gill TM, Shah I, et al. Association between resting heart rate across the life course and all-cause mortality: longitudinal findings from the Medical Research Council (MRC) National Survey of Health and Development (NSHD). J Epidemiol Community Health 2014;68:883-9.
66. Ryu M, Gombojav B, Nam CM, et al. Modifying effects of resting heart rate on the association of binge drinking with all-cause and cardiovascular mortality in older Korean men: the Kangwha Cohort Study. J Epidemiol 2014;24:274-80.
67. Wang A, Chen S, Wang C, et al. Resting heart rate and risk of cardiovascular diseases and all-cause death: the Kailuan study. PLoS ONE 2014;9:e110985.
68. Palatini P. Heart rate as a cardiovascular risk factor: Do women differ from men? Ann Med 2001;33:213-21.
69. Wannamethee G, Shaper AG, Macfarlane PW. Heart rate, physical activity, and mortality from cancer and other noncardiovascular diseases. Am J Epidemiol 1993;137:735-48.
70. Feiner JR, Finlay-Morreale HE, Toy P, et al. High oxygen partial pressure decreases anemia-induced heart rate increase equivalent to transfusion. Anesthesiology 2011;115:492-8.
71. Böhm M, Reil JC, Deedwania P, et al. Resting heart rate: risk indicator and emerging risk factor in cardiovascular disease. Am J Med 2015;128:219-28.
72. Fox K, Ford I, Steg PG, et al. Ivabradine in stable coronary artery disease without clinical heart failure. N Engl J Med 2014; 371:1091-9.
73. Fox K, Komajda M, Ford I, et al. Effect of ivabradine in patients with left-ventricular systolic dysfunction: a pooled analysis of individual patient data from the BEAUTIFUL and SHIFT trials. Eur Heart J 2013;34:2263-70.
74. Böhm M, Swedberg K, Komajda M, et al. Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomised placebo-controlled trial. Lancet 2010;376:886-94.
75. Reil JC, Bohm M. BEAUTIFUL results - The slower, the better? Lancet 2008;372:779-80.
76. Vogel CU, Wolpert C, Wehling M. How to measure heart rate? Eur J Clin Pharmacol 2004;60:461-6.