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Volumn 35, Issue 7, 2016, Pages 919-928

MALT1 is required for EGFR-induced NF-κB activation and contributes to EGFR-driven lung cancer progression

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MUCOSA ASSOCIATED LYMPHOID TISSUE 1; SCAFFOLD PROTEIN; STAT3 PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG; CASPASE; MALT1 PROTEIN, HUMAN; MALT1 PROTEIN, MOUSE; TUMOR PROTEIN;

EID: 84958669495     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2015.146     Document Type: Article
Times cited : (51)

References (43)
  • 1
    • 84856641109 scopus 로고    scopus 로고
    • NF-kappaB, the first quarter-century: Remarkable progress and outstanding questions
    • Hayden MS, Ghosh S. NF-kappaB, the first quarter-century: remarkable progress and outstanding questions. Gene Dev 2012; 26: 203-234.
    • (2012) Gene Dev , vol.26 , pp. 203-234
    • Hayden, M.S.1    Ghosh, S.2
  • 2
    • 77953859606 scopus 로고    scopus 로고
    • NF-kappaB as a critical link between inflammation and cancer
    • Karin M. NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb Perspect Biol 2009; 1: a000141.
    • (2009) Cold Spring Harb Perspect Biol , vol.1
    • Karin, M.1
  • 3
    • 46249085882 scopus 로고    scopus 로고
    • Multifunctional roles for MALT1 in T-cell activation
    • Thome M. Multifunctional roles for MALT1 in T-cell activation. Nat Rev Immunol 2008; 8: 495-500.
    • (2008) Nat Rev Immunol , vol.8 , pp. 495-500
    • Thome, M.1
  • 4
    • 0345358541 scopus 로고    scopus 로고
    • Differential requirement for Malt1 in T and B cell antigen receptor signaling
    • Ruland J, Duncan GS, Wakeham A, Mak TW. Differential requirement for Malt1 in T and B cell antigen receptor signaling. Immunity 2003; 19: 749-758.
    • (2003) Immunity , vol.19 , pp. 749-758
    • Ruland, J.1    Duncan, G.S.2    Wakeham, A.3    Mak, T.W.4
  • 5
    • 0345374583 scopus 로고    scopus 로고
    • Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase
    • Ruefli-Brasse AA, French DM, Dixit VM. Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase. Science 2003; 302: 1581-1584.
    • (2003) Science , vol.302 , pp. 1581-1584
    • Ruefli-Brasse, A.A.1    French, D.M.2    Dixit, V.M.3
  • 6
    • 18844473151 scopus 로고    scopus 로고
    • PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes
    • Sun Z, Arendt CW, Ellmeier W, Schaeffer EM, Sunshine MJ, Gandhi L et al. PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature 2000; 404: 402-407.
    • (2000) Nature , vol.404 , pp. 402-407
    • Sun, Z.1    Arendt, C.W.2    Ellmeier, W.3    Schaeffer, E.M.4    Sunshine, M.J.5    Gandhi, L.6
  • 8
    • 28844499919 scopus 로고    scopus 로고
    • Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation
    • Matsumoto R, Wang D, Blonska M, Li H, Kobayashi M, Pappu B et al. Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation. Immunity 2005; 23: 575-585.
    • (2005) Immunity , vol.23 , pp. 575-585
    • Matsumoto, R.1    Wang, D.2    Blonska, M.3    Li, H.4    Kobayashi, M.5    Pappu, B.6
  • 10
    • 78650901943 scopus 로고    scopus 로고
    • NF-kappaB signaling pathways regulated by CARMA family of scaffold proteins
    • Blonska M, Lin X. NF-kappaB signaling pathways regulated by CARMA family of scaffold proteins. Cell Res 2011; 21: 55-70.
    • (2011) Cell Res , vol.21 , pp. 55-70
    • Blonska, M.1    Lin, X.2
  • 11
    • 0033554647 scopus 로고    scopus 로고
    • A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue
    • Akagi T, Motegi M, Tamura A, Suzuki R, Hosokawa Y, Suzuki H et al. A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue. Oncogene 1999; 18: 5785-5794.
    • (1999) Oncogene , vol.18 , pp. 5785-5794
    • Akagi, T.1    Motegi, M.2    Tamura, A.3    Suzuki, R.4    Hosokawa, Y.5    Suzuki, H.6
  • 12
    • 0033151510 scopus 로고    scopus 로고
    • The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas
    • Dierlamm J, Baens M, Wlodarska I, Stefanova-Ouzounova M, Hernandez JM, Hossfeld DK et al. The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas. Blood 1999; 93: 3601-3609.
    • (1999) Blood , vol.93 , pp. 3601-3609
    • Dierlamm, J.1    Baens, M.2    Wlodarska, I.3    Stefanova-Ouzounova, M.4    Hernandez, J.M.5    Hossfeld, D.K.6
  • 13
    • 0033572308 scopus 로고    scopus 로고
    • Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18
    • Morgan JA, Yin Y, Borowsky AD, Kuo F, Nourmand N, Koontz JI et al. Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18. Cancer Res 1999; 59: 6205-6213.
    • (1999) Cancer Res , vol.59 , pp. 6205-6213
    • Morgan, J.A.1    Yin, Y.2    Borowsky, A.D.3    Kuo, F.4    Nourmand, N.5    Koontz, J.I.6
  • 14
    • 33645306041 scopus 로고    scopus 로고
    • A loss-of-function RNA interference screen for molecular targets in cancer
    • Ngo VN, Davis RE, Lamy L, Yu X, Zhao H, Lenz G et al. A loss-of-function RNA interference screen for molecular targets in cancer. Nature 2006; 441: 106-110.
    • (2006) Nature , vol.441 , pp. 106-110
    • Ngo, V.N.1    Davis, R.E.2    Lamy, L.3    Yu, X.4    Zhao, H.5    Lenz, G.6
  • 15
    • 39449131430 scopus 로고    scopus 로고
    • T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20
    • Coornaert B, Baens M, Heyninck K, Bekaert T, Haegman M, Staal J et al. T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Nat Immunol 2008; 9: 263-271.
    • (2008) Nat Immunol , vol.9 , pp. 263-271
    • Coornaert, B.1    Baens, M.2    Heyninck, K.3    Bekaert, T.4    Haegman, M.5    Staal, J.6
  • 17
    • 79955592698 scopus 로고    scopus 로고
    • T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1
    • Staal J, Driege Y, Bekaert T, Demeyer A, Muyllaert D, Van Damme P et al. T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1. EMBO J 2011; 30: 1742-1752.
    • (2011) EMBO J , vol.30 , pp. 1742-1752
    • Staal, J.1    Driege, Y.2    Bekaert, T.3    Demeyer, A.4    Muyllaert, D.5    Van Damme, P.6
  • 18
    • 80052282195 scopus 로고    scopus 로고
    • Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines
    • Hailfinger S, Nogai H, Pelzer C, Jaworski M, Cabalzar K, Charton JE et al. Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines. Proc Natl Acad Sci USA 2011; 108: 14596-14601.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 14596-14601
    • Hailfinger, S.1    Nogai, H.2    Pelzer, C.3    Jaworski, M.4    Cabalzar, K.5    Charton, J.E.6
  • 19
    • 79251574621 scopus 로고    scopus 로고
    • Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation
    • Rosebeck S, Madden L, Jin X, Gu S, Apel IJ, Appert A et al. Cleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activation. Science 2011; 331: 468-472.
    • (2011) Science , vol.331 , pp. 468-472
    • Rosebeck, S.1    Madden, L.2    Jin, X.3    Gu, S.4    Apel, I.J.5    Appert, A.6
  • 20
    • 73949114883 scopus 로고    scopus 로고
    • Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma
    • Hailfinger S, Lenz G, Ngo V, Posvitz-Fejfar A, Rebeaud F, Guzzardi M et al. Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma. Proc Natl Acad Sci USA 2009; 106: 19946-19951.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 19946-19951
    • Hailfinger, S.1    Lenz, G.2    Ngo, V.3    Posvitz-Fejfar, A.4    Rebeaud, F.5    Guzzardi, M.6
  • 21
    • 70449713757 scopus 로고    scopus 로고
    • Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells
    • Ferch U, Kloo B, Gewies A, Pfander V, Duwel M, Peschel C et al. Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells. J Exp Med 2009; 206: 2313-2320.
    • (2009) J Exp Med , vol.206 , pp. 2313-2320
    • Ferch, U.1    Kloo, B.2    Gewies, A.3    Pfander, V.4    Duwel, M.5    Peschel, C.6
  • 22
    • 84870769441 scopus 로고    scopus 로고
    • Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL
    • Nagel D, Spranger S, Vincendeau M, Grau M, Raffegerst S, Kloo B et al. Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL. Cancer Cell 2012; 22: 825-837.
    • (2012) Cancer Cell , vol.22 , pp. 825-837
    • Nagel, D.1    Spranger, S.2    Vincendeau, M.3    Grau, M.4    Raffegerst, S.5    Kloo, B.6
  • 23
    • 84870856936 scopus 로고    scopus 로고
    • MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo
    • Fontan L, Yang C, Kabaleeswaran V, Volpon L, Osborne MJ, Beltran E et al. MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell 2012; 22: 812-824.
    • (2012) Cancer Cell , vol.22 , pp. 812-824
    • Fontan, L.1    Yang, C.2    Kabaleeswaran, V.3    Volpon, L.4    Osborne, M.J.5    Beltran, E.6
  • 25
    • 84870885534 scopus 로고    scopus 로고
    • EGFR-induced and PKCepsilon monoubiquitylation-dependent NF-kappaB activation upregulates PKM2 expression and promotes tumorigenesis
    • Yang W, Xia Y, Cao Y, Zheng Y, Bu W, Zhang L et al. EGFR-induced and PKCepsilon monoubiquitylation-dependent NF-kappaB activation upregulates PKM2 expression and promotes tumorigenesis. Mol Cell 2012; 48: 771-784.
    • (2012) Mol Cell , vol.48 , pp. 771-784
    • Yang, W.1    Xia, Y.2    Cao, Y.3    Zheng, Y.4    Bu, W.5    Zhang, L.6
  • 26
    • 79952761245 scopus 로고    scopus 로고
    • CARMA3 is crucial for EGFR-Induced activation of NF-kappaB and tumor progression
    • Jiang T, Grabiner B, Zhu Y, Jiang C, Li H, You Y et al. CARMA3 is crucial for EGFR-Induced activation of NF-kappaB and tumor progression. Cancer Research 2011; 71: 2183-2192.
    • (2011) Cancer Research , vol.71 , pp. 2183-2192
    • Jiang, T.1    Grabiner, B.2    Zhu, Y.3    Jiang, C.4    Li, H.5    You, Y.6
  • 27
    • 84889003724 scopus 로고    scopus 로고
    • Epithelial growth factor receptor-activated nuclear factor kappaB signaling and its role in epithelial growth factor receptor-associated tumors
    • Pan D, Lin X. Epithelial growth factor receptor-activated nuclear factor kappaB signaling and its role in epithelial growth factor receptor-associated tumors. Cancer J 2013; 19: 461-467.
    • (2013) Cancer J , vol.19 , pp. 461-467
    • Pan, D.1    Lin, X.2
  • 28
    • 20044370089 scopus 로고    scopus 로고
    • Protein kinase C-{alpha} mediates epidermal growth factor receptor transactivation in human prostate cancer cells
    • Stewart JR, O'Brian CA. Protein kinase C-{alpha} mediates epidermal growth factor receptor transactivation in human prostate cancer cells. Mol Cancer Ther 2005; 4: 726-732.
    • (2005) Mol Cancer Ther , vol.4 , pp. 726-732
    • Stewart, J.R.1    O'Brian, C.A.2
  • 30
    • 2342629277 scopus 로고    scopus 로고
    • The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes
    • Sun L, Deng L, Ea CK, Xia ZP, Chen ZJ. The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol Cell 2004; 14: 289-301.
    • (2004) Mol Cell , vol.14 , pp. 289-301
    • Sun, L.1    Deng, L.2    Ea, C.K.3    Xia, Z.P.4    Chen, Z.J.5
  • 31
    • 36849012237 scopus 로고    scopus 로고
    • Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
    • Gao SP, Mark KG, Leslie K, Pao W, Motoi N, Gerald WL et al. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. J Clin Invest 2007; 117: 3846-3856.
    • (2007) J Clin Invest , vol.117 , pp. 3846-3856
    • Gao, S.P.1    Mark, K.G.2    Leslie, K.3    Pao, W.4    Motoi, N.5    Gerald, W.L.6
  • 32
    • 34247205985 scopus 로고    scopus 로고
    • Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways
    • Shambharkar PB, Blonska M, Pappu BP, Li H, You Y, Sakurai H et al. Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways. EMBO J 2007; 26: 1794-1805.
    • (2007) EMBO J , vol.26 , pp. 1794-1805
    • Shambharkar, P.B.1    Blonska, M.2    Pappu, B.P.3    Li, H.4    You, Y.5    Sakurai, H.6
  • 33
    • 4344612243 scopus 로고    scopus 로고
    • NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
    • Huber MA, Azoitei N, Baumann B, Grunert S, Sommer A, Pehamberger H et al. NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J Clin Invest 2004; 114: 569-581.
    • (2004) J Clin Invest , vol.114 , pp. 569-581
    • Huber, M.A.1    Azoitei, N.2    Baumann, B.3    Grunert, S.4    Sommer, A.5    Pehamberger, H.6
  • 34
    • 84869031100 scopus 로고    scopus 로고
    • The NF-kappaB signaling protein Bcl10 regulates actin dynamics by controlling AP1 and OCRL-bearing vesicles
    • Marion S, Mazzolini J, Herit F, Bourdoncle P, Kambou-Pene N, Hailfinger S et al. The NF-kappaB signaling protein Bcl10 regulates actin dynamics by controlling AP1 and OCRL-bearing vesicles. Dev Cell 2012; 23: 954-967.
    • (2012) Dev Cell , vol.23 , pp. 954-967
    • Marion, S.1    Mazzolini, J.2    Herit, F.3    Bourdoncle, P.4    Kambou-Pene, N.5    Hailfinger, S.6
  • 35
    • 70449109147 scopus 로고    scopus 로고
    • Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma
    • Meylan E, Dooley AL, Feldser DM, Shen L, Turk E, Ouyang C et al. Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Nature 2009; 462: 104-107.
    • (2009) Nature , vol.462 , pp. 104-107
    • Meylan, E.1    Dooley, A.L.2    Feldser, D.M.3    Shen, L.4    Turk, E.5    Ouyang, C.6
  • 36
    • 70449091786 scopus 로고    scopus 로고
    • Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
    • Barbie DA, Tamayo P, Boehm JS, Kim SY, Moody SE, Dunn IF et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature 2009; 462: 108-112.
    • (2009) Nature , vol.462 , pp. 108-112
    • Barbie, D.A.1    Tamayo, P.2    Boehm, J.S.3    Kim, S.Y.4    Moody, S.E.5    Dunn, I.F.6
  • 37
    • 28544438023 scopus 로고    scopus 로고
    • Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancer
    • Haura EB, Zheng Z, Song L, Cantor A, Bepler G. Activated epidermal growth factor receptor-Stat-3 signaling promotes tumor survival in vivo in non-small cell lung cancer. Clin Cancer Res 2005; 11: 8288-8294.
    • (2005) Clin Cancer Res , vol.11 , pp. 8288-8294
    • Haura, E.B.1    Zheng, Z.2    Song, L.3    Cantor, A.4    Bepler, G.5
  • 38
    • 2942616855 scopus 로고    scopus 로고
    • Serum interleukin-6 levels correlate with malnutrition and survival in patients with advanced non-small cell lung cancer
    • Songur N, Kuru B, Kalkan F, Ozdilekcan C, Cakmak H, Hizel N. Serum interleukin-6 levels correlate with malnutrition and survival in patients with advanced non-small cell lung cancer. Tumori 2004; 90: 196-200.
    • (2004) Tumori , vol.90 , pp. 196-200
    • Songur, N.1    Kuru, B.2    Kalkan, F.3    Ozdilekcan, C.4    Cakmak, H.5    Hizel, N.6
  • 39
    • 84865422083 scopus 로고    scopus 로고
    • Interleukin-6 signaling pathway in targeted therapy for cancer
    • Guo Y, Xu F, Lu T, Duan Z, Zhang Z. Interleukin-6 signaling pathway in targeted therapy for cancer. Cancer Treat Rev 2012; 38: 904-910.
    • (2012) Cancer Treat Rev , vol.38 , pp. 904-910
    • Guo, Y.1    Xu, F.2    Lu, T.3    Duan, Z.4    Zhang, Z.5
  • 40
    • 33744814638 scopus 로고    scopus 로고
    • Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors
    • Politi K, Zakowski MF, Fan PD, Schonfeld EA, Pao W, Varmus HE. Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors. Gene Dev 2006; 20: 1496-1510.
    • (2006) Gene Dev , vol.20 , pp. 1496-1510
    • Politi, K.1    Zakowski, M.F.2    Fan, P.D.3    Schonfeld, E.A.4    Pao, W.5    Varmus, H.E.6
  • 41
    • 0035893318 scopus 로고    scopus 로고
    • Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes
    • Fisher GH, Wellen SL, Klimstra D, Lenczowski JM, Tichelaar JW, Lizak MJ et al. Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Gen Dev 2001; 15: 3249-3262.
    • (2001) Gen Dev , vol.15 , pp. 3249-3262
    • Fisher, G.H.1    Wellen, S.L.2    Klimstra, D.3    Lenczowski, J.M.4    Tichelaar, J.W.5    Lizak, M.J.6
  • 42
    • 0035893252 scopus 로고    scopus 로고
    • Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
    • Jackson EL, Willis N, Mercer K, Bronson RT, Crowley D, Montoya R et al. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Gene Dev 2001; 15: 3243-3248.
    • (2001) Gene Dev , vol.15 , pp. 3243-3248
    • Jackson, E.L.1    Willis, N.2    Mercer, K.3    Bronson, R.T.4    Crowley, D.5    Montoya, R.6


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