Naringin protects ultraviolet B-induced skin damage by regulating p38 MAPK signal pathway

Journal of Dermatological Science

Volumn 82, Issue 2, 2016, Pages 106-114

  Ren, Xiaolin ^a   Shi, Yuling ^b   Zhao, Di ^a   Xu, Mengyu ^a   Li, Xiaolong ^a   Dang, Yongyan ^a   Ye, Xiyun ^a  

^a EAST CHINA NORMAL UNIVERSITY   (China)

^b TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

COX 2; Naringin; P38; UVB

Indexed keywords

AURANTIIN; CYCLOOXYGENASE 2; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; FLAVANONE DERIVATIVE; IL1B PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; IL8 PROTEIN, HUMAN; INTERLEUKIN-6, MOUSE; PTGS2 PROTEIN, HUMAN; PTGS2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; COX 2 GENE; CYTOKINE PRODUCTION; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; EPIDERMIS; FEMALE; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; IL 1BETA GENE; IL 6 GENE; IL 8 GENE; IN VITRO STUDY; IN VIVO STUDY; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKIN DEFECT; SKIN PROTECTION; SKIN STIMULATION; ULTRAVIOLET B RADIATION; ADVERSE EFFECTS; ANIMAL; BAGG ALBINO MOUSE; CELL LINE; DRUG EFFECTS; INFLAMMATION; METABOLISM; NUDE MOUSE; RADIATION RESPONSE; SKIN; ULTRAVIOLET RADIATION;

ANIMALS; APOPTOSIS; CELL LINE; CYCLOOXYGENASE 2; FEMALE; FLAVANONES; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTERLEUKIN-8; KERATINOCYTES; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; MICE, NUDE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES; SKIN; ULTRAVIOLET RAYS;

EID: 84958581723     PISSN: 09231811     EISSN: 1873569X     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2015.12.008     Document Type: Article

References (27)

1. Afaq F., Adhami V.M., Mukhtar H. Photochemoprevention of ultraviolet B signaling and photocarcinogenesis. Mutat. Res. 2005, 571:153-173.
2. Thomas-Ahner J.M., Wulff B.C., Tober K.L., et al. Gender Differences in UVB-Induced skin carcinogenesis, inflammation, and DNA damage. Cancer Res. 2007, 67:3468-3474.
3. Haratake A., Uchida Y., Schmuth M., et al. UVB-Induced alterations in permeability barrier function: roles for epidermal hyperproliferation and thymocyte-mediated response. J. Invest. Dermatol. 1997, 108:769-775.
4. Liu S., Mizu H., Yamauchi H. Photoinflammatory responses to UV-irradiated ketoprofen mediated by the induction of ROS generation, enhancement of cyclooxygenase-2 expression, and regulation of multiple signaling pathways. Free Radic. Biol. Med. 2010, 48:772-780.
5. Bito T., Nishigori C. Impact of reactive oxygen species on keratinocyte signaling pathways. J. Dermatol. Sci. 2012, 1:3-8.
6. Chen W., Tang Q., Gonzales M.S., et al. Role of p38 MAP kinases and ERK in mediating ultraviolet-B induced cyclooxygenase-2 gene expression in human keratinocytes. Oncogene 2001, 20:3921-3926.
7. Liu Y., Wu H., Nie Y.C. Naringin attenuates acute lung injury in LPS-treated mice by inhibiting NF-κB pathway. Int. Immunopharmacol. 2011, 11:1606-1612.
8. Golechha M., Chaudhry U., Bhatia J., et al. Naringin protects against kainic acid-induced status epilepticus in rats: evidence for an antioxidant, anti-inflammatory and neuroprotective intervention. Biol. Pharm. Bull. 2011, 34:360-365.
9. Kim S.Y., Kim S.J., Lee J.Y., et al. Protective effects of dietary soy isoflavones against UV-induced skin-aging in hairless mouse model. J. Am. Coll. Nutr. 2004, 23:157-162.
10. Mira L., Fernandez M.T., Santos M., et al. Interactions of flavonoids with iron and copper ions: a mechanism for their antioxidant activity. Free Radic. Res. 2002, 36:1199-1208.
11. Camargo C.A., Gomes-Marcondes M.C., Wutzki N.C., et al. Naringin inhibits tumor growth and reduces interleukin-6 and tumor necrosis factor á levels in rats with Walker 256 carcinosarcoma. Anticancer Res. 2012, 32:129-133.
12. Kanno S., Shouji A., Asou K., et al. Effects of naringin on hydrogen peroxide-induced cytotoxicity and apoptosis in P388 cells. J. Pharmacol. Sci. 2003, 92:166-170.
13. Park J., Choi K., Jeong E., et al. Reactive oxygen species mediate chloroquine-induced expression of chemokines by human astroglial cells. Glia 2004, 47:9-20.
14. Heck D.E., Vetrano A.M., Mariano T.M., et al. UVB light stimulates production of reactive oxygen species. J. Bio. Chem. 2003, 20:22432-22436.
15. Peus D., Vasa R.A., Beyerle A., et al. UVB activates ERK1/2 and p38 signaling pathways via reactive oxygen species in cultured keratinocytes. J. Invest Dermatol. 1999, 112:751-756.
16. Rundhaug J.E., Fischer S.M. Cyclo-oxygenase-2 plays a critical role in UV-induced skin carcinogenesis. Photochem. Photobiol. 2008, 84:322-329.
17. Kim A.L., Labasi J.M., Zhu Y., et al. Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice. J. Invest. Dermatol. 2005, 124:1318-1325.
18. Afaq F., Mukhtar H. Botanical antioxidants in the prevention of photocarcinogenesis and photoaging. Exp. Dermatol. 2006, 15:678-684.
19. Xu H., Yan Y., Li L., Peng S., Qu T., Wang B. Ultraviolet B-induced apoptosis of human skin fibroblasts involves activation of caspase- 8 and-3 with increased expression of vimentin. Photodermatol. Photoimmunol. Photomed. 2010, 26:198-204.
20. Golbano J.M., Lóppez-Aparicio P., Recio M.N., Pérez-Albarsanz M.A. Finasteride induces apoptosis via Bcl-2, Bcl-xL, Bax and caspase-3 proteins in LNCaP human prostate cancer cell line. Int. J. Oncol. 2008, 32:919-924.
21. Chan W.H., Yu J.S. Inhibition of UV irradiation-induced oxidative stress and apoptotic biochemical changes in human epidermal carcinoma A431 cells by genistein. J. Cell Biochem. 2000, 78:73-84.
22. Isoherranen K., Punnonen K., Jansen C., et al. Ultraviolet irradiation induces cyclooxygenase-2 expression in keratinocytes. Br. J. Dermatol. 1999, 140:1017-1022.
23. O'Leary K.A., de Pascual-Tereasa S., Needs P.W., Bao Y.P., O'Brien N.M., Williamson G. Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. Mutat. Res. 2004, 551:245-254.
24. Athar M., An K.P., Morel K.D., Kim A.L., et al. Ultraviolet B (UVB)-induced Cox-2 expression in murine skin: an immunohistochemical study. Biochem. Biophys. Res. Commun. 2001, 280:1042-1047.
25. Schieven G.L. The biology of p38 kinase: a central role in inflammation. Curr. Top Med. Chem. 2005, 5:921-928.
26. Cho J.W., Park K., Kweon G.R., et al. Curcumin inhibits the expression of Cox-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targets. Exp. Mol. Med. 2005, 37:186-192.
27. Nicola J.P., Nazar M., Mascanfroni I.D., Pellizas C.G., Masini-Repiso A.M. NF-κB p65 subunit mediates lipopolysaccharide-induced Na(+)/(?) symporter gene expression by involving functional interaction with the paired domain transcription factor Pax8. Mol. Endocrinol. 2005, 24:1846-1862.