Longitudinal telomere length shortening and cognitive and physical decline in later life: The Lothian Birth Cohorts 1936 and 1921

Mechanisms of Ageing and Development

Volumn 154, Issue , 2016, Pages 43-48

  Harris, Sarah E ^a   Marioni, Riccardo E ^a,b   Martin Ruiz, Carmen ^c   Pattie, Alison ^a   Gow, Alan J ^a,d   Cox, Simon R ^a   Corley, Janie ^a   von Zglinicki, Thomas ^c   Starr, John M ^a   Deary, Ian J ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d HERIOT WATT UNIVERSITY   (United Kingdom)

Author keywords

Cognition; Cognitive ageing; Physical ageing; Telomeres

Indexed keywords

DNA;

AGE; AGED; ARTICLE; BASE PAIRING; COGNITION; COGNITIVE DEFECT; COHORT ANALYSIS; CONTROLLED STUDY; DNA EXTRACTION; DYNAMOMETRY; FEMALE; FORCED EXPIRATORY VOLUME; GRIP STRENGTH; HUMAN; HUMAN CELL; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; PHYSICAL CAPACITY; PHYSICAL DISABILITY; PREDICTION; PRIORITY JOURNAL; SCOTSMAN; TELOMERE SHORTENING; VERY ELDERLY; WALKING SPEED; WECHSLER ADULT INTELLIGENCE SCALE; AGING; CLINICAL TRIAL; LONGITUDINAL STUDY; METABOLISM; MULTICENTER STUDY; PHYSIOLOGY; SCOTLAND; TELOMERE HOMEOSTASIS;

AGED; AGED, 80 AND OVER; AGING; COGNITION; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; SCOTLAND; TELOMERE HOMEOSTASIS;

EID: 84958559284     PISSN: 00476374     EISSN: 18726216     Source Type: Journal    
DOI: 10.1016/j.mad.2016.02.004     Document Type: Article

References (47)

1. Blazer D.G., Yaffe K., Karlawish J. Cognitive aging: a report from the Institute of Medicine. JAMA 2015.
2. den Ouden M.E., Schuurmans M.J., Arts I.E., van der Schouw Y.T. Physical performance characteristics related to disability in older persons: a systematic review. Maturitas 2011, 69:208-219.
3. Harley C.B., Futcher A.B., Greider C.W. Telomeres shorten during ageing of human fibroblasts. Nature 1990, 345:458-460.
4. Lindsey J., McGill N.I., Lindsey L.A., Green D.K., Cooke H.J. In vivo loss of telomeric repeats with age in humans. Mutat. Res. 1991, 256:45-48.
5. Valdes A.M., Andrew T., Gardner J.P., et al. Obesity, cigarette smoking, and telomere length in women. Lancet 2005, 366:662-664.
6. von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem. Sci. 2002, 27:339-344.
7. Robertson T., Batty G.D., Der G., Fenton C., Shiels P.G., Benzeval M. Is socioeconomic status associated with biological aging as measured by telomere length?. Epidemiol. Rev. 2013, 35:98-111.
8. Muezzinler A., Zaineddin A.K., Brenner H. A systematic review of leukocyte telomere length and age in adults. Ageing Res. Rev. 2013, 12:509-519.
9. Harris S.E., Deary I.J., MacIntyre A., et al. The association between telomere length, physical health, cognitive ageing, and mortality in non-demented older people. Neurosci. Lett. 2006, 406:260-264.
10. Yaffe K., Lindquist K., Kluse M., et al. Telomere length and cognitive function in community-dwelling elders: findings from the Health ABC Study. Neurobiol. Aging 2009.
11. Der G., Batty G.D., Benzeval M., et al. Is telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland?. PLoS One 2012, 7:e45166.
12. Harris S.E., Martin-Ruiz C., Von Z.T., Starr J.M., Deary I.J. Telomere length and aging biomarkers in 70-year-olds: the Lothian Birth Cohort 1936. Neurobiol. Aging 2012, 33:1486-1488.
13. Ma S.L., Lau E.S., Suen E.W., et al. Telomere length and cognitive function in southern Chinese community-dwelling male elders. Age Ageing 2013, 42:450-455.
14. Grodstein F., van O.M., Irizarry M.C., et al. Shorter telomeres may mark early risk of dementia: preliminary analysis of 62 participants from the nurses' health study. PLoS One 2008, 3:e1590.
15. Martin-Ruiz C., Dickinson H.O., Keys B., Rowan E., Kenny R.A., Von Z.T. Telomere length predicts poststroke mortality, dementia, and cognitive decline. Ann. Neurol. 2006, 60:174-180.
16. Panossian L.A., Porter V.R., Valenzuela H.F., et al. Telomere shortening in T cells correlates with Alzheimer's disease status. Neurobiol. Aging 2003, 24:77-84.
17. von Zglinicki T., Serra V., Lorenz M., et al. Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible risk factor?. Lab. Invest. 2000, 80:1739-1747.
18. Gardner M.P., Martin-Ruiz C., Cooper R., et al. Telomere length and physical performance at older ages: an individual participant meta-analysis. PLoS One 2013, 8:e69526.
19. Woo J., Yu R., Tang N., Leung J. Telomere length is associated with decline in grip strength in older persons aged 65 years and over. Age (Dordr.) 2014, 36:9711.
20. Masi S., D'Aiuto F., Martin-Ruiz C., et al. Rate of telomere shortening and cardiovascular damage: a longitudinal study in the 1946 British birth cohort. Eur. Heart J. 2014, 35:3296-3303.
21. Baylis D., Ntani G., Edwards M.H., et al. Inflammation, telomere length, and grip strength: a 10-year longitudinal study. Calcif. Tissue. Int. 2014, 95:54-63.
22. Njajou O.T., Cawthon R.M., Blackburn E.H., et al. Shorter telomeres are associated with obesity and weight gain in the elderly. Int. J. Obes. (Lond.) 2012, 36:1176-1179.
23. von Zglinicki T., Martin-Ruiz C.M. Telomeres as biomarkers for ageing and age-related diseases. Curr. Mol. Med. 2005, 5:197-203.
24. Mather K.A., Jorm A.F., Parslow R.A., Christensen H. Is telomere length a biomarker of aging? A review. J. Gerontol. A Biol. Sci. Med. Sci. 2011, 66:202-213.
25. Deary I.J., Weiss A., Batty G.D. Intelligence and personality as predictors of illness and death: How researchers in differential psychology and chronic disease epidemiology are collaborating to understand and address health inequalities. Psychol. Sci. Public Interest 2010, 11:53-79.
26. Schaefer J.D., Caspi A., Belsky D.W., et al. Early-life intelligence predicts midlife biological age. J. Gerontol. B Psychol. Sci. Soc. Sci. 2015.
27. Marioni R.E., Shah S., McRae A.F., et al. The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936. Int. J. Epidemiol. 2015.
28. Scottish Council for Research in Education The Trend of Scottish Intelligence: a Comparison of the 1947 and 1932 Surveys of the Intelligence of Eleven-Year-Old Pupils 1949, University of London Press, London.
29. Deary I.J., Gow A.J., Taylor M.D., et al. The Lothian Birth Cohort 1936: a study to examine influences on cognitive ageing from age 11 to age 70 and beyond. BMC Geriatr. 2007, 7:28.
30. Deary I.J., Gow A.J., Pattie A., Starr J.M. Cohort profile: the Lothian birth bohorts of 1921 and 1936. Int. J. Epidemiol. 2012, 41:1576-1584.
31. Wechsler D. WAIS-IIIUK administration and scoring manual 1998, Psychological Corporation, London, UK.
32. Scottish Council for Research in Education The Intelligence of Scottish Children: a National Survey of an Age-Group 1933, University of London Press, London.
33. Deary I.J., Whiteman M.C., Starr J.M., Whalley L.J., Fox H.C. The impact of childhood intelligence on later life: following up the Scottish mental surveys of 1932 and 1947. J. Pers. Soc. Psychol. 2004, 86:130-147.
34. Deary I.J., Yang J., Davies G., et al. Genetic contributions to stability and change in intelligence from childhood to old age. Nature 2012, 482:212-215.
35. Raven J.C., Court J.H., Raven J. Manual for Raven's Progressive Matrices and Vocabulary Scales 1977, London, H.K Lewis.
36. Lezak M. Neuropsychological Testing 1995, Oxford University Press, Oxford, England.
37. Wechsler D. Wechsler Memory Scale-Revised 1987, Psychological Corporation, New York.
38. Martin-Ruiz C., Saretzki G., Petrie J., et al. Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span. J. Biol. Chem. 2004, 279:17826-17833.
39. Kuznetsova, A., Brockhoff, P.B., Christensen, R.H.B., 2013. lmerTest: Tests for random and fixed effects for linear mixed effect. R Package Version 2 0-0.
40. Bates, D., Maechler, M., Bolker, B., Walker, S., 2013. lme4: Linear mixed-effects models using Eigen and S4. R Package Version 1 0-4.
41. Bendix L., Gade M.M., Staun P.W., et al. Leukocyte telomere length and physical ability among Danish twins age 70+. Mech. Ageing Dev. 2011, 132:568-572.
42. Cawthon R.M., Smith K.R., O'Brien E., Sivatchenko A., Kerber R.A. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 2003, 361:393-395.
43. Martin-Ruiz C.M., Gussekloo J., van Heemst D., von Zglinicki T., Westendorp R.G. Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study. Aging Cell 2005, 4:287-290.
44. Martin-Ruiz C., Jagger C., Kingston A., et al. Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study. Mech. Ageing Dev. 2011, 132:496-502.
45. Gardner M., Bann D., Wiley L., et al. Gender and telomere length: systematic review and meta-analysis. Exp. Gerontol. 2014, 51:15-27.
46. Lapham K., Kvale M.N., Lin J., et al. Automated assay of telomere length measurement and informatics for 100,000 subjects in the Genetic Epidemiology Research on Adult Health and Aging (GERA) cohort. Genetics 2015, 200:1061-1072.
47. Glei D.A., Goldman N., Weinstein M., Risques R.A. Shorter ends, faster end? Leukocyte telomere length and mortality among older Taiwanese. J. Gerontol. A Biol. Sci. Med. Sci. 2015, 70:1490-1498.