-
1
-
-
34547638047
-
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
-
Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 2007;448:561-6.
-
(2007)
Nature
, vol.448
, pp. 561-566
-
-
Soda, M.1
Choi, Y.L.2
Enomoto, M.3
-
2
-
-
84869462031
-
Crizotinib for the treatment of ALK-rearranged non-small cell lung cancer: a success story to usher in the second decade of molecular targeted therapy in oncology
-
Ou SH, Bartlett CH, Mino-Kenudson M, et al. Crizotinib for the treatment of ALK-rearranged non-small cell lung cancer: a success story to usher in the second decade of molecular targeted therapy in oncology. Oncologist 2012;17:1351-75.
-
(2012)
Oncologist
, vol.17
, pp. 1351-1375
-
-
Ou, S.H.1
Bartlett, C.H.2
Mino-Kenudson, M.3
-
3
-
-
69349083935
-
Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population
-
Rodig SJ, Mino-Kenudson M, Dacic S, et al. Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population. Clin Cancer Res 2009;15:5216-23.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5216-5223
-
-
Rodig, S.J.1
Mino-Kenudson, M.2
Dacic, S.3
-
4
-
-
70349336416
-
Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
-
Shaw AT, Yeap BY, Mino-Kenudson M, et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol 2009;27:4247-53.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4247-4253
-
-
Shaw, A.T.1
Yeap, B.Y.2
Mino-Kenudson, M.3
-
5
-
-
37549060017
-
EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers
-
Inamura K, Takeuchi K, Togashi Y, et al. EML4-ALK fusion is linked to histological characteristics in a subset of lung cancers. J Thorac Oncol 2008;3:13-7.
-
(2008)
J Thorac Oncol
, vol.3
, pp. 13-17
-
-
Inamura, K.1
Takeuchi, K.2
Togashi, Y.3
-
6
-
-
78049425319
-
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
-
Kwak EL, Bang YJ, Camidge DR, et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med 2010;363:1693-703.
-
(2010)
N Engl J Med
, vol.363
, pp. 1693-1703
-
-
Kwak, E.L.1
Bang, Y.J.2
Camidge, D.R.3
-
7
-
-
84866934606
-
Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study
-
Camidge DR, Bang YJ, Kwak EL, et al. Activity and safety of crizotinib in patients with ALK-positive non-small-cell lung cancer: updated results from a phase 1 study. Lancet Oncol 2012;13:1011-9.
-
(2012)
Lancet Oncol
, vol.13
, pp. 1011-1019
-
-
Camidge, D.R.1
Bang, Y.J.2
Kwak, E.L.3
-
8
-
-
84879071011
-
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
-
Shaw AT, Kim DW, Nakagawa K, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med 2013;368:2385-94.
-
(2013)
N Engl J Med
, vol.368
, pp. 2385-2394
-
-
Shaw, A.T.1
Kim, D.W.2
Nakagawa, K.3
-
9
-
-
84918804764
-
First-line crizotinib versus chemotherapy in ALK-positive lung cancer
-
Solomon BJ, Mok T, Kim DW, et al. First-line crizotinib versus chemotherapy in ALK-positive lung cancer. N Engl J Med 2014;371:2167-77.
-
(2014)
N Engl J Med
, vol.371
, pp. 2167-2177
-
-
Solomon, B.J.1
Mok, T.2
Kim, D.W.3
-
10
-
-
84878347085
-
CH5424802 (RO5424802) for patients with ALK-rearranged advanced non-small-cell lung cancer (AF-001JP study): a single-arm, open-label, phase 1-2 study
-
Seto T, Kiura K, Nishio M, et al. CH5424802 (RO5424802) for patients with ALK-rearranged advanced non-small-cell lung cancer (AF-001JP study): a single-arm, open-label, phase 1-2 study. Lancet Oncol 2013;14:590-8.
-
(2013)
Lancet Oncol
, vol.14
, pp. 590-598
-
-
Seto, T.1
Kiura, K.2
Nishio, M.3
-
11
-
-
84896957081
-
Ceritinib in ALK-rearranged non-small-cell lung cancer
-
Shaw AT, Kim DW, Mehra R, et al. Ceritinib in ALK-rearranged non-small-cell lung cancer. N Engl J Med 2014;370:1189-97.
-
(2014)
N Engl J Med
, vol.370
, pp. 1189-1197
-
-
Shaw, A.T.1
Kim, D.W.2
Mehra, R.3
-
12
-
-
78650390328
-
Development of central nervous system metastases in patients with advanced non-small cell lung cancer and somatic EGFR mutations treated with gefitinib or erlotinib
-
Heon S, Yeap BY, Britt GJ, et al. Development of central nervous system metastases in patients with advanced non-small cell lung cancer and somatic EGFR mutations treated with gefitinib or erlotinib. Clin Cancer Res 2010;16:5873-82.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 5873-5882
-
-
Heon, S.1
Yeap, B.Y.2
Britt, G.J.3
-
13
-
-
84929508050
-
Clinical Experience With Crizotinib in Patients With Advanced ALK-Rearranged Non-Small-Cell Lung Cancer and Brain Metastases
-
Costa DB, Shaw AT, Ou SH, et al. Clinical Experience With Crizotinib in Patients With Advanced ALK-Rearranged Non-Small-Cell Lung Cancer and Brain Metastases. J Clin Oncol 2015;33:1881-8.
-
(2015)
J Clin Oncol
, vol.33
, pp. 1881-1888
-
-
Costa, D.B.1
Shaw, A.T.2
Ou, S.H.3
-
14
-
-
84877136472
-
ALK gene translocations and amplifications in brain metastases of non-small cell lung cancer
-
Preusser M, Berghoff AS, Ilhan-Mutlu A, et al. ALK gene translocations and amplifications in brain metastases of non-small cell lung cancer. Lung Cancer 2013;80:278-83.
-
(2013)
Lung Cancer
, vol.80
, pp. 278-283
-
-
Preusser, M.1
Berghoff, A.S.2
Ilhan-Mutlu, A.3
-
15
-
-
79957487193
-
CSF concentration of the anaplastic lymphoma kinase inhibitor crizotinib
-
Costa DB, Kobayashi S, Pandya SS, et al. CSF concentration of the anaplastic lymphoma kinase inhibitor crizotinib. J Clin Oncol 2011;29:e443-5.
-
(2011)
J Clin Oncol
, vol.29
, pp. e443-e445
-
-
Costa, D.B.1
Kobayashi, S.2
Pandya, S.S.3
-
16
-
-
37549059613
-
Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma
-
Christensen JG, Zou HY, Arango ME, et al. Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma. Mol Cancer Ther 2007;6:3314-22.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 3314-3322
-
-
Christensen, J.G.1
Zou, H.Y.2
Arango, M.E.3
-
17
-
-
34249324494
-
An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms
-
Zou HY, Li Q, Lee JH, et al. An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res 2007;67:4408-17.
-
(2007)
Cancer Res
, vol.67
, pp. 4408-4417
-
-
Zou, H.Y.1
Li, Q.2
Lee, J.H.3
-
18
-
-
44849126091
-
Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors
-
McDermott U, Iafrate AJ, Gray NS, et al. Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors. Cancer Res 2008;68:3389-95.
-
(2008)
Cancer Res
, vol.68
, pp. 3389-3395
-
-
McDermott, U.1
Iafrate, A.J.2
Gray, N.S.3
-
19
-
-
79952773320
-
Pharmacokinetics (PK) of PF-02341066, a dual ALK/MET inhibitor after multiple oral doses to advanced cancer patients
-
Tan W, Wilner KD, Bang Y, et al. Pharmacokinetics (PK) of PF-02341066, a dual ALK/MET inhibitor after multiple oral doses to advanced cancer patients. J Clin Oncol 2010;28:abstr 2596.
-
(2010)
J Clin Oncol
, vol.28
-
-
Tan, W.1
Wilner, K.D.2
Bang, Y.3
-
20
-
-
84903466222
-
The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer
-
Friboulet L, Li N, Katayama R, et al. The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer. Cancer Discov 2014;4:662-73.
-
(2014)
Cancer Discov
, vol.4
, pp. 662-673
-
-
Friboulet, L.1
Li, N.2
Katayama, R.3
-
21
-
-
84907462932
-
Hypoxia induces resistance to ALK inhibitors in the H3122 non-small cell lung cancer cell line with an ALK rearrangement via epithelial-mesenchymal transition
-
Kogita A, Togashi Y, Hayashi H, et al. Hypoxia induces resistance to ALK inhibitors in the H3122 non-small cell lung cancer cell line with an ALK rearrangement via epithelial-mesenchymal transition. Int J Oncol 2014;45:1430-6.
-
(2014)
Int J Oncol
, vol.45
, pp. 1430-1436
-
-
Kogita, A.1
Togashi, Y.2
Hayashi, H.3
-
22
-
-
84856233310
-
Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802)
-
Kinoshita K, Asoh K, Furuichi N, et al. Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802). Bioorg Med Chem 2012;20:1271-80.
-
(2012)
Bioorg Med Chem
, vol.20
, pp. 1271-1280
-
-
Kinoshita, K.1
Asoh, K.2
Furuichi, N.3
-
23
-
-
79955964568
-
CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant
-
Sakamoto H, Tsukaguchi T, Hiroshima S, et al. CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. Cancer Cell 2011;19:679-90.
-
(2011)
Cancer Cell
, vol.19
, pp. 679-690
-
-
Sakamoto, H.1
Tsukaguchi, T.2
Hiroshima, S.3
-
24
-
-
84945166840
-
Efficacy and pharmacodynamic analysis of AP26113, a potent and selective orally active inhibitor of Anaplastic Lymphoma Kinase (ALK)
-
Rivera VM, Anjum R, Wang F, et al. Efficacy and pharmacodynamic analysis of AP26113, a potent and selective orally active inhibitor of Anaplastic Lymphoma Kinase (ALK). Cancer Res 2010;70:abstr 3623.
-
(2010)
Cancer Res
, vol.70
-
-
Rivera, V.M.1
Anjum, R.2
Wang, F.3
-
25
-
-
84940177095
-
AP26113, a potent ALK inhibitor, overcomes mutations in EML4-ALK that confer resistance to PF-02341066 (PF1066)
-
Zhang S, Wanf F, Keats J, et al. AP26113, a potent ALK inhibitor, overcomes mutations in EML4-ALK that confer resistance to PF-02341066 (PF1066). Cancer Res 2010;70:abstr LB-298.
-
(2010)
Cancer Res
, vol.70
-
-
Zhang, S.1
Wanf, F.2
Keats, J.3
-
27
-
-
84902455683
-
Discovery of (10R)-7-amino-12-fluoro-2, 10, 16-trimethyl-15-oxo-10, 15, 16, 17-tetrahydro-2H-8, 4-(metheno)pyrazolo(4, 3-h)(2, 5, 11)-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations
-
Johnson TW, Richardson PF, Bailey S, et al. Discovery of (10R)-7-amino-12-fluoro-2, 10, 16-trimethyl-15-oxo-10, 15, 16, 17-tetrahydro-2H-8, 4-(metheno)pyrazolo(4, 3-h)(2, 5, 11)-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a macrocyclic inhibitor of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 (ROS1) with preclinical brain exposure and broad-spectrum potency against ALK-resistant mutations. J Med Chem 2014;57:4720-44.
-
(2014)
J Med Chem
, vol.57
, pp. 4720-4744
-
-
Johnson, T.W.1
Richardson, P.F.2
Bailey, S.3
-
28
-
-
84925307919
-
PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations
-
Zou HY, Li Q, Engstrom LD, et al. PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations. Proc Natl Acad Sci U S A 2015;112:3493-8.
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, pp. 3493-3498
-
-
Zou, H.Y.1
Li, Q.2
Engstrom, L.D.3
-
29
-
-
84859124139
-
Crizotinib: a novel and first-in-class multitargeted tyrosine kinase inhibitor for the treatment of anaplastic lymphoma kinase rearranged non-small cell lung cancer and beyond
-
Ou SH. Crizotinib: a novel and first-in-class multitargeted tyrosine kinase inhibitor for the treatment of anaplastic lymphoma kinase rearranged non-small cell lung cancer and beyond. Drug Des Devel Ther 2011;5:471-85.
-
(2011)
Drug Des Devel Ther
, vol.5
, pp. 471-485
-
-
Ou, S.H.1
-
30
-
-
84893399587
-
Clinical benefit of continuing ALK inhibition with crizotinib beyond initial disease progression in patients with advanced ALK-positive NSCLC
-
Ou SH, Jänne PA, Bartlett CH, et al. Clinical benefit of continuing ALK inhibition with crizotinib beyond initial disease progression in patients with advanced ALK-positive NSCLC. Ann Oncol 2014;25:415-22.
-
(2014)
Ann Oncol
, vol.25
, pp. 415-422
-
-
Ou, S.H.1
Jänne, P.A.2
Bartlett, C.H.3
-
31
-
-
84870317390
-
Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-addicted non-small-cell lung cancer
-
Weickhardt AJ, Scheier B, Burke JM, et al. Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-addicted non-small-cell lung cancer. J Thorac Oncol 2012;7:1807-14.
-
(2012)
J Thorac Oncol
, vol.7
, pp. 1807-1814
-
-
Weickhardt, A.J.1
Scheier, B.2
Burke, J.M.3
-
32
-
-
84866655837
-
Clinical characteristics of ALK+ NSCLC patients (pts) treated with crizotinib beyond disease progression (PD): Potential implications for management
-
Otterson GA, Riely GJ, Shaw AT, et al. Clinical characteristics of ALK+ NSCLC patients (pts) treated with crizotinib beyond disease progression (PD): Potential implications for management. Proc Am Soc Clin Oncol 2012;30:abstr 7600.
-
(2012)
Proc Am Soc Clin Oncol
, vol.30
-
-
Otterson, G.A.1
Riely, G.J.2
Shaw, A.T.3
-
33
-
-
84904035862
-
Second-generation ALK inhibitors: filling the non "MET" gap
-
Ramalingam SS, Khuri FR. Second-generation ALK inhibitors: filling the non "MET" gap. Cancer Discov 2014;4:634-6.
-
(2014)
Cancer Discov
, vol.4
, pp. 634-636
-
-
Ramalingam, S.S.1
Khuri, F.R.2
-
34
-
-
84923013946
-
Ceritinib (LDK378): a potent alternative to crizotinib for ALK-rearranged non-small-cell lung cancer
-
Li S, Qi X, Huang Y, et al. Ceritinib (LDK378): a potent alternative to crizotinib for ALK-rearranged non-small-cell lung cancer. Clin Lung Cancer 2015;16:86-91.
-
(2015)
Clin Lung Cancer
, vol.16
, pp. 86-91
-
-
Li, S.1
Qi, X.2
Huang, Y.3
-
35
-
-
84880877176
-
Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2, 4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials
-
Marsilje TH, Pei W, Chen B, et al. Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2, 4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials. J Med Chem 2013;56:5675-90.
-
(2013)
J Med Chem
, vol.56
, pp. 5675-5690
-
-
Marsilje, T.H.1
Pei, W.2
Chen, B.3
-
36
-
-
84906936412
-
Ceritinib in advanced anaplastic lymphoma kinase (ALK)-rearranged (ALK+) non-small cell lung cancer (NSCLC): Results of the ASCEND-1 trial
-
Kim DW, Mehra R, Tan DS, et al. Ceritinib in advanced anaplastic lymphoma kinase (ALK)-rearranged (ALK+) non-small cell lung cancer (NSCLC): Results of the ASCEND-1 trial. J Clin Oncol 2014;32:abstr 8003.
-
(2014)
J Clin Oncol
, vol.32
-
-
Kim, D.W.1
Mehra, R.2
Tan, D.S.3
-
37
-
-
84922325136
-
Evaluation of Ceritinib-treated patients with anaplastic lymphoma kinase rearranged (ALK+) non-small cell lung cancer (NSCLC) and brain metastases in the ASCEND-1 study
-
Shaw AT, Mehra R, Tan DS, et al. Evaluation of Ceritinib-treated patients with anaplastic lymphoma kinase rearranged (ALK+) non-small cell lung cancer (NSCLC) and brain metastases in the ASCEND-1 study. Ann Oncol 2014;25:abstr 1293P.
-
(2014)
Ann Oncol
, vol.25
-
-
Shaw, A.T.1
Mehra, R.2
Tan, D.S.3
-
38
-
-
84908569219
-
Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small-cell lung cancer (AF-002JG): results from the dose-finding portion of a phase 1/2 study
-
Gadgeel SM, Gandhi L, Riely GJ, et al. Safety and activity of alectinib against systemic disease and brain metastases in patients with crizotinib-resistant ALK-rearranged non-small-cell lung cancer (AF-002JG): results from the dose-finding portion of a phase 1/2 study. Lancet Oncol 2014;15:1119-28.
-
(2014)
Lancet Oncol
, vol.15
, pp. 1119-1128
-
-
Gadgeel, S.M.1
Gandhi, L.2
Riely, G.J.3
-
39
-
-
84919779490
-
Antitumor activity of the selective ALK inhibitor alectinib in models of intracranial metastases
-
Kodama T, Hasegawa M, Takanashi K, et al. Antitumor activity of the selective ALK inhibitor alectinib in models of intracranial metastases. Cancer Chemother Pharmacol 2014;74:1023-8.
-
(2014)
Cancer Chemother Pharmacol
, vol.74
, pp. 1023-1028
-
-
Kodama, T.1
Hasegawa, M.2
Takanashi, K.3
-
40
-
-
84883011191
-
Challenges relating to solid tumour brain metastases in clinical trials, part 1: patient population, response, and progression. A report from the RANO group
-
Lin NU, Lee EQ, Aoyama H, et al. Challenges relating to solid tumour brain metastases in clinical trials, part 1: patient population, response, and progression. A report from the RANO group. Lancet Oncol 2013;14:e396-406.
-
(2013)
Lancet Oncol
, vol.14
, pp. e396-e406
-
-
Lin, N.U.1
Lee, E.Q.2
Aoyama, H.3
-
41
-
-
84882951377
-
Challenges relating to solid tumour brain metastases in clinical trials, part 2: neurocognitive, neurological, and quality-of-life outcomes. A report from the RANO group
-
Lin NU, Wefel JS, Lee EQ, et al. Challenges relating to solid tumour brain metastases in clinical trials, part 2: neurocognitive, neurological, and quality-of-life outcomes. A report from the RANO group. Lancet Oncol 2013;14:e407-16.
-
(2013)
Lancet Oncol
, vol.14
, pp. e407-e416
-
-
Lin, N.U.1
Wefel, J.S.2
Lee, E.Q.3
-
42
-
-
84929513468
-
Radiation necrosis presenting as pseudoprogression (PsP) during alectinib treatment of previously radiated brain metastases in ALK-positive NSCLC: Implications for disease assessment and management
-
Ou SH, Klempner SJ, Azada MC, et al. Radiation necrosis presenting as pseudoprogression (PsP) during alectinib treatment of previously radiated brain metastases in ALK-positive NSCLC: Implications for disease assessment and management. Lung Cancer 2015;88:355-9.
-
(2015)
Lung Cancer
, vol.88
, pp. 355-359
-
-
Ou, S.H.1
Klempner, S.J.2
Azada, M.C.3
-
43
-
-
84911917752
-
Updated efficacy and safety of the ALK inhibitor AP26113 in patients (pts) with advanced malignancies, including ALK+ non-small cell lung cancer (NSCLC)
-
Gettinger S, Bazhenova L, Salgia R, et al. Updated efficacy and safety of the ALK inhibitor AP26113 in patients (pts) with advanced malignancies, including ALK+ non-small cell lung cancer (NSCLC). J Clin Oncol 2014;32:abstr 8047.
-
(2014)
J Clin Oncol
, vol.32
-
-
Gettinger, S.1
Bazhenova, L.2
Salgia, R.3
-
44
-
-
70350516326
-
Utility of unbound plasma drug levels and P-glycoprotein transport data in prediction of central nervous system exposure
-
He H, Lyons KA, Shen X, et al. Utility of unbound plasma drug levels and P-glycoprotein transport data in prediction of central nervous system exposure. Xenobiotica 2009;39:687-93.
-
(2009)
Xenobiotica
, vol.39
, pp. 687-693
-
-
He, H.1
Lyons, K.A.2
Shen, X.3
-
45
-
-
81555210969
-
Quantitative evaluation of the impact of active efflux by p-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate
-
Kodaira H, Kusuhara H, Fujita T, et al. Quantitative evaluation of the impact of active efflux by p-glycoprotein and breast cancer resistance protein at the blood-brain barrier on the predictability of the unbound concentrations of drugs in the brain using cerebrospinal fluid concentration as a surrogate. J Pharmacol Exp Ther 2011;339:935-44.
-
(2011)
J Pharmacol Exp Ther
, vol.339
, pp. 935-944
-
-
Kodaira, H.1
Kusuhara, H.2
Fujita, T.3
-
46
-
-
84924815430
-
Review of the current targeted therapies for non-small-cell lung cancer
-
Nguyen KS, Neal JW, Wakelee H. Review of the current targeted therapies for non-small-cell lung cancer. World J Clin Oncol 2014;5:576-87.
-
(2014)
World J Clin Oncol
, vol.5
, pp. 576-587
-
-
Nguyen, K.S.1
Neal, J.W.2
Wakelee, H.3
-
47
-
-
42649106522
-
Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas
-
Brandsma D, Stalpers L, Taal W, et al. Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas. Lancet Oncol 2008;9:453-61.
-
(2008)
Lancet Oncol
, vol.9
, pp. 453-461
-
-
Brandsma, D.1
Stalpers, L.2
Taal, W.3
-
48
-
-
84922281943
-
Alectinib salvages CNS relapses in ALK-positive lung cancer patients previously treated with crizotinib and ceritinib
-
Gainor JF, Sherman CA, Willoughby K, et al. Alectinib salvages CNS relapses in ALK-positive lung cancer patients previously treated with crizotinib and ceritinib. J Thorac Oncol 2015;10:232-6.
-
(2015)
J Thorac Oncol
, vol.10
, pp. 232-236
-
-
Gainor, J.F.1
Sherman, C.A.2
Willoughby, K.3
|