Circulating memory T follicular helper subsets, Tfh2 and Tfh17, participate in the pathogenesis of Guillain-Barré syndrome

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Che, Yuanyuan ^a   Qiu, Jinpeng ^a   Jin, Tao ^a   Yin, Fei ^c   Li, Man ^a   Jiang, Yanfang ^a,b  

^a THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^b YANGZHOU UNIVERSITY   (China)

^c THE SECOND HOSPITAL OF JILIN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; ICOS PROTEIN, HUMAN; INDUCIBLE T CELL COSTIMULATOR; PDCD1 PROTEIN, HUMAN; PROGRAMMED DEATH 1 RECEPTOR;

ADULT; AGED; CASE CONTROL STUDY; CEREBROSPINAL FLUID; DISEASE COURSE; FEMALE; GENE EXPRESSION; GENETICS; GUILLAIN BARRE SYNDROME; HUMAN; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; IMMUNOPHENOTYPING; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; PATHOLOGY; PHENOTYPE; SEVERITY OF ILLNESS INDEX; TH1 CELL; TH17 CELL; TH2 CELL;

ADULT; AGED; AUTOANTIBODIES; CASE-CONTROL STUDIES; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION; GUILLAIN-BARRE SYNDROME; HUMANS; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; INDUCIBLE T-CELL CO-STIMULATOR PROTEIN; LYMPHOCYTE COUNT; MALE; MIDDLE AGED; PHENOTYPE; PROGRAMMED CELL DEATH 1 RECEPTOR; SEVERITY OF ILLNESS INDEX; TH1 CELLS; TH17 CELLS; TH2 CELLS;

EID: 84958521568     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep20963     Document Type: Article

References (40)

1. Pritchard, J. & Hughes, R. A. Guillain-Barre syndrome. Lancet. 363, 2186-2188 (2004).
2. Hughes, R. A., Hadden, R. D., Gregson, N. A. & Smith, K. J. Pathogenesis of Guillain-Barre syndrome. J. Neuroimmunol. 100, 74-97 (1999).
3. Zhang, H. L., Zheng, X. Y. & Zhu, J. Th1/Th2/Th17/Treg cytokines in Guillain-Barre syndrome and experimental autoimmune neuritis. Cytokine Growth Factor Rev. 24, 443-453 (2013).
4. Li, S. et al. IL-17 and IL-22 in cerebrospinal fluid and plasma are elevated in Guillain-Barre syndrome. Mediators Inflamm. 2012, 260473 (2012).
5. Zhu, J., Mix, E. & Link, H. Cytokine production and the pathogenesis of experimental autoimmune neuritis and Guillain-Barre syndrome. J. Neuroimmunol. 84, 40-52 (1998).
6. Harness, J. & McCombe, P. A. Increased levels of activated T-cells and reduced levels of CD4/CD25+ cells in peripheral blood of Guillain-Barre syndrome patients compared to controls. J. Clin Neurosci. 15, 1031-1035 (2008).
7. Zepp, J., Wu, L. & Li, X. IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease. Trends Immunol. 32, 232-239 (2011).
8. Wang, X. et al. Mitigated Tregs and augmented Th17 cells and cytokines are associated with severity of experimental autoimmune neuritis. Scand J Immunol. 80, 180-190 (2014).
9. Yuki, N. Guillain-Barre syndrome and anti-ganglioside antibodies: a clinician-scientist's journey. Proc Jpn Acad Ser B Phys Biol Sci. 88, 299-326 (2012).
10. Fewou, S. N. et al. Anti-ganglioside antibody internalization attenuates motor nerve terminal injury in a mouse model of acute motor axonal neuropathy. J. Clin Invest. 122, 1037-1051 (2012).
11. Hafer-Macko, C. et al. Acute motor axonal neuropathy: an antibody-mediated attack on axolemma. Ann Neurol. 40, 635-644 (1996).
12. Abraham, P. M., Quan, S. H., Dukala, D. & Soliven, B. CD19 as a therapeutic target in a spontaneous autoimmune polyneuropathy. Clin Exp Immunol. 175, 181-191 (2014).
13. Nakano, Y. & Kanda, T. Pathology of the Peripheral Nervous System in Guillain-Barré Syndrome. Brain Nerve. 67, 1329-39 (2015).
14. Wu, X. et al. More severe manifestations and poorer short-term prognosis of ganglioside-associated Guillain-Barre syndrome in Northeast China. PLoS One. 9, e104074 (2014).
15. Crotty, S. Follicular helper CD4 T cells (TFH). Annu Rev Immunol. 29, 621-663 (2011).
16. Morita, R. et al. Human blood CXCR5(+) CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity. 34, 108-121 (2011).
17. Tellier, J. & Nutt, S. L. The unique features of follicular T cell subsets. Cell Mol Life Sci. 70, 4771-4784 (2013).
18. Li, X. Y. et al. Role of the frequency of blood CD4(+) CXCR5(+) CCR6(+) T cells in autoimmunity in patients with Sjogren's syndrome. Biochem Biophys Res Commun. 422, 238-244 (2012).
19. Romme Christensen, J. et al. Systemic inflammation in progressive multiple sclerosis involves follicular T-helper, Th17- and activated B-cells and correlates with progression. PLoS One. 8, e57820 (2013).
20. Luo, C. et al. Expansion of circulating counterparts of follicular helper T cells in patients with myasthenia gravis. J. Neuroimmunol. 256, 55-61 (2013).
21. Uncini, A. & Kuwabara, S. Electrodiagnostic criteria for Guillain-Barre syndrome: a critical revision and the need for an update. Clin Neurophysiol. 123, 1487-1495 (2012).
22. Hughes, R. A., Newsom-Davis, J. M., Perkin, G. D. & Pierce, J. M. Controlled trial prednisolone in acute polyneuropathy. Lancet. 2, 750-753 (1978).
23. Kleyweg, R. P., van der Meche, F. G. & Schmitz, P. I. Interobserver agreement in the assessment of muscle strength and functional abilities in Guillain-Barre syndrome. Muscle Nerve. 14, 1103-1109 (1991).
24. Bryant, V. L. et al. Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells. J. Immunol. 179, 8180-8190 (2007).
25. Le Coz, C. et al. Circulating TFH subset distribution is strongly affected in lupus patients with an active disease. PLoS One. 8, e75319 (2013).
26. Park, H. J. et al. Insights into the role of follicular helper T cells in autoimmunity. Immune Netw. 14, 21-29 (2014).
27. Topalian, S. L., Drake, C. G. & Pardoll, D. M. Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity. Curr Opin Immunol. 24, 207-212 (2012).
28. Zhang, X. et al. Follicular helper T cells: new insights into mechanisms of autoimmune diseases. Ochsner J. 13, 131-139 (2013).
29. Linterman, M. A. et al. Follicular helper T cells are required for systemic autoimmunity. J. Exp Med. 206, 561-576 (2009).
30. Papp, G., Szabo, K., Szekanecz, Z. & Zeher, M. Follicular helper T cells in autoimmune diseases. Rheumatology (Oxford). 53, 1159-1160 (2014).
31. Simpson, N. et al. Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum. 62, 234-244 (2010).
32. Hu, W. et al. Expression of CD28-related costimulatory molecule and its ligand in inflammatory neuropathies. Neurology. 68, 277-282 (2007).
33. Francisco, L. M., Sage, P. T. & Sharpe, A. H. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev. 236, 219-242 (2010).
34. Dai, S. et al. The PD-1/PD-Ls pathway and autoimmune diseases. Cell Immunol. 290, 72-79 (2014).
35. Carter, L. L. et al. PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis. J. Neuroimmunol. 182, 124-134 (2007).
36. Kleyweg, R. P., van der Meche, F. G. & Meulstee, J. Treatment of Guillain-Barre syndrome with high-dose gammaglobulin. Neurology. 38, 1639-1641 (1988).
37. Jacobs, B. C. et al. Immunoglobulins inhibit pathophysiological effects of anti-GQ1b-positive sera at motor nerve terminals through inhibition of antibody binding. Brain. 126, 2220-2234 (2003).
38. Zhang, G. et al. Anti-ganglioside antibody-mediated neuronal cytotoxicity and its protection by intravenous immunoglobulin: implications for immune neuropathies. Brain. 127, 1085-1100 (2004).
39. Hou, H. Q. et al. Changes in lymphocyte subsets in patients with Guillain-Barre syndrome treated with immunoglobulin. BMC Neurol. 14, 202 (2014).
40. Li, S. et al. Circulating Th17, Th22, and Th1 cells are elevated in the Guillain-Barre syndrome and downregulated by IVIg treatments. Mediators Inflamm. 2014, 740947 (2014).