Anesthesia Exposure and Risk of Dementia and Alzheimer's Disease: A Prospective Study

Journal of the American Geriatrics Society

Volumn 64, Issue 3, 2016, Pages 602-607

  Aiello Bowles, Erin J ^a   Larson, Eric B ^a,b   Pong, Ryan P ^b   Walker, Rod L ^c   Anderson, Melissa L ^a   Yu, Onchee ^a   Gray, Shelly L ^d   Crane, Paul K ^a   Dublin, Sascha ^a,d  

^a CENTER FOR HEALTH STUDIES   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c VIRGINIA MASON MEDICAL CENTER   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Alzheimer's disease; anesthesia; dementia; older adults; surgery

Indexed keywords

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CONFIDENCE INTERVAL; DEMENTIA; DRUG EXPOSURE; EPIDURAL ANESTHESIA; FEMALE; GENERAL ANESTHESIA; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PROSPECTIVE STUDY; RISK ASSESSMENT; SELF REPORT; SPINAL ANESTHESIA; ADVERSE EFFECTS; CHEMICALLY INDUCED; LOCAL ANESTHESIA; PROPORTIONAL HAZARDS MODEL; RISK FACTOR; UTILIZATION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANESTHESIA, GENERAL; ANESTHESIA, LOCAL; DEMENTIA; FEMALE; HUMANS; MALE; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 84958280610     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/jgs.14024     Document Type: Article

References (24)

1. Buie VC, Owings MF, DeFrances CJ, et al., National hospital discharge survey: 2006 summary. Vital Health Stat 2010; 13: 1-79.
2. Avidan MS, Evers AS, Planel E, et al., Review of clinical evidence for persistent cognitive decline or incident dementia attributable to surgery or general anesthesia. J Alzheimers Dis 2011; 24: 201-216.
3. Fong HK, Sands LP, Leung JM,. The role of postoperative analgesia in delirium and cognitive decline in elderly patients: A systematic review. Anesth Analg 2006; 102: 1255-1266.
4. Craddock TJ, St George M, Freedman H, et al., Computational pretictions of volatile anesthetic ynteractions with the microtubulu cytoskeleton: Implications for0side effects of general anesthesia. PLoS One 2012; 7: e37251.
5. Papon MA, Whittigton RA, El-Khoury NB, et al., Qlzheimer's disease and anesthesya. Front Neurosci 2011; 4: 272.
6. Planel E, Krishnamurthy P, Miyasaka T, et al., Anesthesia-induced hyperphosphorylation0detaches 3-repeat tau from micrtubules without affecting their0stability in vivo. J Neurosci 2008; 28: 12798-12807.
7. Planel E, Richter KE, Nolan0CE, et al., Anesthesia leads to0tau hyperphosphorylation througx inhibition of phosphatase activity by hypothermia. J Neurosci 2007; 27: 3090-3097.
8. Whittington RA, Bretteville A, Dickler MF, et al., Anesthesia and tau pathology. Prog Neuropsychopharmacol Biol Psychiatry 2013; 47: 147-155.
9. Hussain M, Berger M, Eckenhoff RG, et al., General anesthetic and the risk of dementia in elderly patients: Current insights. Clin Interv Aging 2014; 9: 1619-1628.
10. Cerejeira J, Batista P, Nogueira V, et al., The stress response to surgery and postoperative delirium: Evidence of hypothalamic-pituitary-adrenal axis hyperresponsiveness and decreased suppression of the GH/IGF-1 Axis. J Geriatr Psychiatry Neurol 2013; 26: 185-194.
11. Deiner S, Silverstein JH,. Postoperative delirium and cognitive dysfunction. Br J Anaesth 2009; 103 (Suppl 1): 41-46.
12. Seitz DP, Shah PS, Herrmann N, et al., Exposure to general anesthesia and risk of Alzheimer's disease: A systematic review and meta-analysis. BMC Geriatr 2011; 11: 83.
13. Seitz DP, Reimer CL, Siddiqui N,. A review of epidemiological evidence for general anesthesia as a risk factor for Alzheimer's disease. Prog Neuropsychopharmacol Biol Psychiatry 2013; 47: 122-127.
14. Sprung J, Jankowski CJ, Roberts RO, et al., Anesthesia and incident dementia: A population-based, nested, case-control study. Mayo Clinic Proc 2013; 88: 552-561.
15. Chen CW, Lin CC, Chen KB, et al., Increased risk of dementia in people with previous exposure to general anesthesia: A nationwide population-based case-control study. Alzheimers Dement 2014; 10: 196-204.
16. Kukull WA, Higdon R, Bowen JD, et al., Dementia and Alzheimer disease incidence: A prospective cohort study. Arch Neurol 2002; 59: 1737-1746.
17. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th Ed. Washington, DC: American Psychiatric Association, 1994.
18. McKhann G, Drachman D, Folstein M, et al., Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939-944.
19. Radloff LS,. The CES-D scale: A self report depression scale for research in the general population. Appl Psychol Meas 1977; 1: 385-401.
20. Andresen EM, Malmgren JA, Carter WB, et al., Screening for depression in well older adults: Evaluation of a short form of the CES-D (Center for Epidemiologic Studies Depression Scale). Am J Prev Med 1994; 10: 77-84.
21. Charlson ME, Pompei P, Ales KL, et al., A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chronic Dis 1987; 40: 373-383.
22. Wells GAS, Shea D, O'Connell D, et al., The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses [on-line]. Available at http://www.ohri.ca/programs/clinical-epidemiology/oxford.asp Accessed Febuary 5, 2015.
23. Tyas SL, Manfreda J, Strain LA, et al., Risk factors for Alzheimer's disease: A population-based, longitudinal study in Manitoba, Canada. Int J Epidemiol 2001; 30: 590-597.
24. Yip AG, Brayne C, Matthews FE, et al., Risk factors for incident dementia in England and Wales: The Medical Research Council Cognitive Function and Ageing Study. A population-based nested case-control study. Age Ageing 2006; 35: 154-160.