Plasma IL-6 and IL-10 concentrations predict AKI and long-term mortality in adults after cardiac surgery

Journal of the American Society of Nephrology

Volumn 26, Issue 12, 2015, Pages 3123-3132

  Zhang, William R ^a   Garg, Amit X ^b,c   Coca, Steven G ^a,d   Devereaux, Philip J ^e   Eikelboom, John ^e   Kavsak, Peter ^f   McArthur, Eric ^c   Thiessen Philbrook, Heather ^b   Shortt, Colleen ^f   Shlipak, Michael ^g   Whitlock, Richard ^e   Parikh, Chirag R ^a,d  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c INSTITUTE FOR CLINICAL EVALUATIVE SCIENCES   (Canada)

^d VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^e MCMASTER UNIVERSITY   (Canada)

^f MCMASTER UNIVERSITY   (Canada)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; INTERLEUKIN 10; INTERLEUKIN 6; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; ACUTE PHASE PROTEIN; BIOLOGICAL MARKER; LCN2 PROTEIN, HUMAN; LIPOCALIN; ONCOPROTEIN;

ACUTE KIDNEY FAILURE; AGED; ARTICLE; COHORT ANALYSIS; CORONARY ARTERY BYPASS GRAFT; CREATININE BLOOD LEVEL; CYTOKINE RESPONSE; FEMALE; HEART SURGERY; HEART VALVE SURGERY; HUMAN; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RENAL REPLACEMENT THERAPY; RISK ASSESSMENT; SURGICAL MORTALITY; BLOOD; CANADA; CLINICAL TRIAL; EPIDEMIOLOGY; FOLLOW UP; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; PROSPECTIVE STUDY; RISK FACTOR; TIME FACTOR; UNITED STATES; URINE; VERY ELDERLY;

ACUTE KIDNEY INJURY; ACUTE-PHASE PROTEINS; AGED; AGED, 80 AND OVER; BIOMARKERS; CANADA; CARDIAC SURGICAL PROCEDURES; CREATININE; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTERLEUKIN-10; INTERLEUKIN-6; LIPOCALIN-2; LIPOCALINS; MALE; MIDDLE AGED; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PROSPECTIVE STUDIES; PROTO-ONCOGENE PROTEINS; RISK FACTORS; TIME FACTORS; UNITED STATES;

EID: 84958252285     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2014080764     Document Type: Article

References (60)

1. Rosner MH, Okusa MD: Acute kidney injury associated with cardiac surgery. Clin J Am Soc Nephrol 1: 19-32, 2006
2. Westenfelder C: Earlier diagnosis of acute kidney injury awaits effective therapy. Kidney Int 79: 1159-1161, 2011
3. Soni SS, Ronco C, Katz N, Cruz DN: Early diagnosis of acute kidney injury: The promise of novel biomarkers. Blood Purif 28: 165-174, 2009
4. Nechemia-Arbely Y, Barkan D, Pizov G, Shriki A, Rose-John S, Galun E, Axelrod JH: IL-6/IL-6R axis plays a critical role in acute kidney injury. J Am Soc Nephrol 19: 1106-1115, 2008
5. Jones SA, Fraser DJ, Fielding CA, Jones GW: Interleukin-6 in renal disease and therapy [published online ahead of print July 10, 2014]. Nephrol Dial Transplant doi: 10.1093/ndt/gfu233
6. Kavsak PA, Ko DT, Newman AM, Palomaki GE, Lustig V, MacRae AR, Jaffe AS: Risk stratification for heart failure and death in an acute coronary syndrome population using inflammatory cytokines and N-terminal probrain natriuretic peptide. Clin Chem 53: 2112-2118, 2007
7. Ortiz A,Massy ZA, FliserD, LindholmB,Wiecek A,Martínez-Castelao A, Covic A, Goldsmith D, Süleymanlar G, London GM, Zoccali C: Clinical usefulness of novel prognostic biomarkers in patients on hemodialysis. Nat Rev Nephrol 8: 141-150, 2012
8. Pecoits-Filho R, Bárány P, Lindholm B, Heimbürger O, Stenvinkel P: Interleukin-6 is an independent predictor of mortality in patients starting dialysis treatment. Nephrol Dial Transplant 17: 1684-1688, 2002
9. Stenvinkel P, LindholmB: C-reactive protein in end-stage renal disease: Are there reasons to measure it? Blood Purif 23: 72-78, 2005
10. Sinuani I, Beberashvili I, Averbukh Z, Sandbank J: Role of IL-10 in the progression of kidney disease. World J Transplant 3: 91-98, 2013
11. de Waal Malefyt R, Yssel H, Roncarolo MG, Spits H, de Vries JE: Interleukin-10. Curr Opin Immunol 4: 314-320, 1992
12. Kielar ML, John R, Bennett M, Richardson JA, Shelton JM, Chen L, Jeyarajah DR, Zhou XJ, Zhou H, Chiquett B, Nagami GT, Lu CY: Maladaptive role of IL-6 in ischemic acute renal failure. J Am Soc Nephrol 16: 3315-3325, 2005
13. Patel NS, Chatterjee PK, Di Paola R, Mazzon E, Britti D, De Sarro A, Cuzzocrea S, Thiemermann C: Endogenous interleukin-6 enhances the renal injury, dysfunction, and inflammation caused by ischemia/reperfusion. J Pharmacol Exp Ther 312: 1170-1178, 2005
14. Deng J, Kohda Y, Chiao H,Wang Y, Hu X, Hewitt SM, Miyaji T,McLeroy P, Nibhanupudy B, Li S, Star RA: Interleukin-10 inhibits ischemic and cisplatin-induced acute renal injury. Kidney Int 60: 2118-2128, 2001
15. Jin Y, Liu R, Xie J, Xiong H, He JC, Chen N: Interleukin-10 deficiency aggravates kidney inflammation and fibrosis in the unilateral ureteral obstruction mouse model. Lab Invest 93:801-811, 2013
16. Huang XR, Kitching AR, Tipping PG, Holdsworth SR: Interleukin-10 inhibits macrophage-induced glomerular injury. J Am Soc Nephrol 11: 262-269, 2000
17. Kitching AR, Katerelos M, Mudge SJ, Tipping PG, Power DA, Holdsworth SR: Interleukin-10 inhibits experimental mesangial proliferative glomerulonephritis. Clin Exp Immunol 128: 36-43, 2002
18. Choi YK, KimYJ, Park HS, Choi K, Paik SG, Lee YI, Park JG: Suppression of glomerulosclerosis by adenovirus-mediated IL-10 expression in the kidney. Gene Ther 10: 559-568, 2003
19. Kitching AR, Tipping PG, Timoshanko JR, Holdsworth SR: Endogenous interleukin-10 regulates Th1 responses that induce crescentic glomerulonephritis. Kidney Int 57: 518-525, 2000
20. JungM, Sola A, Hughes J, Kluth DC, Vinuesa E, Viñas JL, Pérez-Ladaga A, Hotter G: Infusion of IL-10-expressing cells protects against renal ischemia through induction of lipocalin-2. Kidney Int 81: 969-982, 2012
21. Kaya K: Inflammatory response in cardiovascular surgery. In: Inflammatory Response in Cardiovascular Surgery, edited by Gabriel EA, Gabriel SA, London, Springer, 2013, pp 275-280
22. Gueret G, Lion F, Guriec N, Arvieux J, Dovergne A, Guennegan C, Bezon E, Baron R, Carre J-L, Arvieux C: Acute renal dysfunction after cardiac surgery with cardiopulmonary bypass is associated with plasmatic IL6 increase. Cytokine 45: 92-98, 2009
23. Musleh GS, Datta SS, Yonan NN, Grotte GJ, Prendergast BA, Hasan RI, Deyrania AK: Association of IL6 and IL10 with renal dysfunction and the use of haemofiltration during cardiopulmonary bypass. Eur J Cardiothorac Surg 35: 511-514, 2009
24. Liu KD, Altmann C, Smits G, Krawczeski CD, Edelstein CL, Devarajan P, Faubel S: Seruminterleukin-6 andinterleukin-8 are earlybiomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: A case-control study. Crit Care 13: R104, 2009
25. Mikłaszewska M, Korohoda P, Zachwieja K, Mroczek T, Drozdz D, Sztefko K, Moczulska A, Pietrzyk JA: Serum interleukin 6 levels as an early marker of acute kidney injury on children after cardiac surgery. Adv Clin Exp Med 22: 377-386, 2013
26. Parikh CR, Coca SG, Thiessen-Philbrook H, ShlipakMG, Koyner JL, Wang Z, EdelsteinCL,Devarajan P, PatelUD, ZappitelliM,KrawczeskiCD, Passik CS, SwaminathanM, Garg AX; TRIBE-AKI Consortium: Postoperative biomarkers predict acute kidney injury and poor outcomes after adult cardiac surgery. J Am Soc Nephrol 22: 1748-1757, 2011
27. Parikh CR, Thiessen-Philbrook H, Garg AX, Kadiyala D, Shlipak MG, Koyner JL, Edelstein CL, Devarajan P, Patel UD, Zappitelli M, Krawczeski CD, Passik CS, Coca SG; TRIBE-AKI Consortium: Performance of kidney injury molecule-1 and liver fatty acid-binding protein and combined biomarkers of AKI after cardiac surgery. Clin J Am Soc Nephrol 8: 1079-1088, 2013
28. Patel UD, Garg AX, Krumholz HM, Shlipak MG, Coca SG, Sint K, Thiessen-Philbrook H, Koyner JL, Swaminathan M, Passik CS, Parikh CR; Translational Research Investigating Biomarker Endpoints in Acute Kidney Injury (TRIBE-AKI) Consortium: Preoperative serum brain natriuretic peptide and risk of acute kidney injury after cardiac surgery. Circulation 125: 1347-1355, 2012
29. Koyner JL, Garg AX, ShlipakMG, Patel UD, Sint K, Hong K,Devarajan P, Edelstein CL, Zappitelli M, Thiessen-Philbrook H, Parikh CR; Translational Research Investigating Biomarker Endpoints in AKI (TRIBE AKI) Consortium: Urinary cystatin C and acute kidney injury after cardiac surgery. Am J Kidney Dis 61: 730-738, 2013
30. Coca SG, Garg AX, Thiessen-Philbrook H, Koyner JL, Patel UD, Krumholz HM, Shlipak MG, Parikh CR; TRIBE-AKI Consortium: Urinary biomarkers of AKI and mortality 3 years after cardiac surgery. J AmSoc Nephrol 25: 1063-1071, 2014
31. Lu JCT, Coca SG, Patel UD, Cantley L, Parikh CR; Translational Research Investigating Biomarkers and Endpoints for Acute Kidney Injury (TRIBE-AKI) Consortium: Searching for genes that matter in acute kidney injury: A systematic review. Clin J Am Soc Nephrol 4: 1020-1031, 2009
32. Spahillari A, Parikh CR, Sint K, Koyner JL, Patel UD, Edelstein CL, Passik CS, Thiessen-Philbrook H, Swaminathan M, Shlipak MG; TRIBE-AKI Consortium: Serum cystatin C- versus creatinine-based definitions of acute kidney injury following cardiac surgery: A prospective cohort study. Am J Kidney Dis 60: 922-929, 2012
33. Koyner JL, Garg AX, Coca SG, Sint K, Thiessen-Philbrook H, Patel UD, Shlipak MG, Parikh CR; TRIBE-AKI Consortium: Biomarkers predict progression of acute kidney injury after cardiac surgery. J Am Soc Nephrol 23: 905-914, 2012
34. Shlipak MG, Coca SG, Wang Z, Devarajan P, Koyner JL, Patel UD, Thiessen-Philbrook H, Garg AX, Parikh CR; TRIBE-AKI Consortium: Presurgical serum cystatin C and risk of acute kidney injury after cardiac surgery. Am J Kidney Dis 58: 366-373, 2011
35. Mu W, Ouyang X, Agarwal A, Zhang L, Long DA, Cruz PE, Roncal CA, Glushakova OY, Chiodo VA, Atkinson MA, Hauswirth WW, Flotte TR, Rodriguez-Iturbe B, Johnson RJ: IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease. J Am Soc Nephrol 16: 3651-3660, 2005
36. Tadagavadi RK, Reeves WB: Endogenous IL-10 attenuates cisplatin nephrotoxicity: Role of dendritic cells. J Immunol 185: 4904-4911, 2010
37. KimM-G, Yang HN, KimH-W, Jo S-K, Cho WY, KimH-K: IL-10mediates rosiglitazone-induced kidney protection in cisplatin nephrotoxicity. J Korean Med Sci 25: 557-563, 2010
38. Zimmerman MA, Reznikov LL, Raeburn CD, Selzman CH: Interleukin-10 attenuates the response to vascular injury. J SurgRes 121: 206-213, 2004
39. Yoshidome H, Kato A, Edwards MJ, Lentsch AB: Interleukin-10 suppresses hepatic ischemia/reperfusion injury in mice: Implications of a central role for nuclear factor kappaB. Hepatology 30: 203-208, 1999
40. Olszak T, Neves JF, Dowds CM, Baker K, Glickman J, DavidsonNO, Lin C-S, Jobin C, Brand S, Sotlar K, Wada K, Katayama K, Nakajima A, MizuguchiH, Kawasaki K,Nagata K,MüllerW, Snapper SB, Schreiber S, Kaser A, Zeissig S, Blumberg RS: Protective mucosal immunity mediated by epithelial CD1d and IL-10. Nature 509: 497-502, 2014
41. Peranteau WH, Zhang L, Muvarak N, Badillo AT, Radu A, Zoltick PW, Liechty KW: IL-10 overexpression decreases inflammatory mediators and promotes regenerative healing in an adultmodel of scar formation. J Invest Dermatol 128: 1852-1860, 2008
42. Ling G-S, Cook HT, Botto M, Lau Y-L, Huang F-P: An essential protective role of IL-10 in the immunological mechanism underlying resistance vs. susceptibility to lupus induction by dendritic cells and dying cells. Rheumatology (Oxford) 50: 1773-1784, 2011
43. Mishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, Ruff SM, Zahedi K, Shao M, Bean J, Mori K, Barasch J, Devarajan P: Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 365: 1231-1238, 2005
44. Girndt M, Köhler H, Schiedhelm-Weick E, Schlaak JF, Meyer zum Büschenfelde K-H, Fleischer B: Production of interleukin-6, tumor necrosis factor alpha and interleukin-10 in vitro correlates with the clinical immune defect in chronic hemodialysis patients. Kidney Int 47: 559-565, 1995
45. Stenvinkel P, Ketteler M, Johnson RJ, Lindholm B, Pecoits-Filho R, Riella M, Heimbürger O, Cederholm T, Girndt M: IL-10, IL-6, and TNFalpha: Central factors in the altered cytokine network of uremia-the good, the bad, and the ugly. Kidney Int 67: 1216-1233, 2005
46. Vinuesa E, Hotter G, Jung M, Herrero-Fresneda I, Torras J, Sola A: Macrophage involvement in the kidney repair phase after ischaemia/reperfusion injury. J Pathol 214: 104-113, 2008
47. Lee S, Huen S, Nishio H, Nishio S, Lee HK, Choi B-S, Ruhrberg C, Cantley LG: Distinct macrophage phenotypes contribute to kidney injury and repair. J Am Soc Nephrol 22: 317-326, 2011
48. Liu KD, Glidden DV, EisnerMD, Parsons PE, Ware LB,Wheeler A, Korpak A, Thompson BT, Chertow GM, Matthay MA; National Heart, Lung, and Blood Institute ARDS Network Clinical Trials Group: Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Crit Care Med 35: 2755-2761, 2007
49. Murugan R, Wen X, Shah N, Lee M, Kong L, Pike F, Keener C, Unruh M, FinkelK, VijayanA, Palevsky PM, Paganini E,CarterM,ElderM,KellumJA; Biological Markers for Recovery of Kidney (BioMaRK) Study Investigators: Plasma inflammatory and apoptosis markers are associated with dialysis dependence and death among critically ill patients receiving renal replacement therapy. Nephrol Dial Transplant 29: 1854-1864, 2014
50. Billings FT 4th, Pretorius M, Schildcrout JS, Mercaldo ND, Byrne JG, Ikizler TA, Brown NJ: Obesity and oxidative stress predict AKI after cardiac surgery. J Am Soc Nephrol 23: 1221-1228, 2012
51. Koch W, Kastrati A, Böttiger C, Mehilli J, von Beckerath N, Schömig A: Interleukin-10 and tumor necrosis factor gene polymorphisms and risk of coronary artery disease and myocardial infarction. Atherosclerosis 159: 137-144, 2001
52. Spoto B, Mattace-Raso F, Sijbrands E, Leonardis D, Testa A, Pisano A, Pizzini P, Cutrupi S, Parlongo RM, D'Arrigo G, Tripepi G, Mallamaci F, Zoccali C: Association of IL-6 and a functional polymorphism in the IL-6 gene with cardiovascular events in patients with CKD. Clin J Am Soc Nephrol 10: 232-240, 2015
53. Zhou X, Fragala MS, McElhaney JE, Kuchel GA: Conceptual and methodological issues relevant to cytokine and inflammatory marker measurements in clinical research. Curr Opin Clin Nutr Metab Care 13: 541-547, 2010
54. de Jager W, Bourcier K, Rijkers GT, Prakken BJ, Seyfert-Margolis V: Prerequisites for cytokine measurements in clinical trials with multiplex immunoassays. BMC Immunol 10: 52, 2009
55. Girndt M, Kaul H, Sester U, Ulrich C, SesterM, Georg T, Köhler H: Antiinflammatory interleukin-10 genotype protects dialysis patients from cardiovascular events. Kidney Int 62: 949-955, 2002
56. Stenvinkel P, Barany P, Heimbürger O, Pecoits-Filho R, Lindholm B: Mortality, malnutrition, and atherosclerosis in ESRD:What is the role of interleukin-6? Kidney Int Suppl 61: 103-108, 2002
57. Mehta RL,KellumJA, Shah SV,MolitorisBA, Ronco C,WarnockDG, LevinA; Acute Kidney Injury Network: Acute Kidney Injury Network: Report of an initiative to improve outcomes in acute kidney injury. Crit Care 11: R31, 2007
58. Kidney DiseaseImproving Global Outcomes (KDIGO) Acute Kidney Injury Work Group: KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl 2: 1-138, 2012
59. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P; Acute Dialysis Quality Initiative workgroup: Acute renal failure-definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 8: R204-R212, 2004
60. Mehta RH, Grab JD, O'Brien SM, Bridges CR, Gammie JS, Haan CK, Ferguson TB, Peterson ED; Society of Thoracic Surgeons National Cardiac Surgery Database Investigators: Bedside tool for predicting the risk of postoperative dialysis in patients undergoing cardiac surgery. Circulation 114: 2208-2216, quiz 2208, 2006