Plasma inflammatory and apoptosis markers are associated with dialysis dependence and death among critically ill patients receiving renal replacement therapy

Nephrology Dialysis Transplantation

Volumn 29, Issue 10, 2014, Pages 1854-1864

  Murugan, Raghavan ^a   Wen, Xiaoyan ^a   Shah, Nilesh ^a,b   Lee, Minjae ^a,c   Kong, Lan ^a,d   Pike, Francis ^a,b   Keener, Christopher ^a,b   Unruh, Mark ^e   Finkel, Kevin ^f   Vijayan, Anitha ^g   Palevsky, Paul M ^a,h   Paganini, Emil ⁱ   Carter, Melinda ^a   Elder, Michele ^a   Kellum, John A ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d PENN STATE COLLEGE OF MEDICINE   (United States)

^e UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^g WASHINGTON UNIVERSITY   (United States)

^h VETERANS AFFAIRS MEDICAL CENTER   (United States)

ⁱ LERNER RESEARCH INSTITUTE   (United States)

Author keywords

acute kidney injury; biomarkers; mortality; renal recovery; renal replacement therapy

Indexed keywords

CREATININE; DEATH RECEPTOR 5; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE MIGRATION INHIBITION FACTOR; MARKER; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; BIOLOGICAL MARKER; CYTOKINE; DEATH RECEPTOR;

ARTICLE; ARTIFICIAL VENTILATION; BLOOD LEVEL; COHORT ANALYSIS; COMORBIDITY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CRITICALLY ILL PATIENT; DISEASE SEVERITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY (TOPIC); OBSERVATIONAL STUDY; OLIGURIA; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL (TOPIC); RENAL REPLACEMENT THERAPY; SEPSIS; ACUTE KIDNEY INJURY; BLOOD; CASE CONTROL STUDY; CLINICAL TRIAL; COMPARATIVE STUDY; CRITICAL ILLNESS; MIDDLE AGED; MULTICENTER STUDY; SURVIVAL RATE;

ACUTE KIDNEY INJURY; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CRITICAL ILLNESS; CYTOKINES; FEMALE; HUMANS; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; RECEPTORS, DEATH DOMAIN; RENAL DIALYSIS; SURVIVAL RATE;

EID: 84918804874     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfu051     Document Type: Article

References (38)

1. Palevsky PM, Zhang JH, O'Connor TZ et al. Intensity of renal support in critically ill patients with acute kidney injury. N Engl J Med 2008; 359: 7-20
2. Bellomo R, Cass A, Cole L et al. Intensity of continuous renal-replacement therapy in critically ill patients. N Engl J Med 2009; 361: 1627-1638
3. Hamel MB, Phillips RS, Davis RB et al. Outcomes and cost-effectiveness of initiating dialysis and continuing aggressive care in seriously ill hospitalized adults. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. Ann Intern Med 1997; 127: 195-202
4. Palevsky PM, O'Connor TZ, Chertow GM et al. Intensity of renal replacement therapy in acute kidney injury: perspective from within the Acute Renal Failure Trial Network Study. Crit Care 2009; 13: 310
5. Ng KP, Chanouzas D, Fallouh B et al. Short and long-term outcome of patients with severe acute kidney injury requiring renal replacement therapy. QJM 2012; 105: 33-39
6. Hobson CE, Yavas S, Segal MS et al. Acute kidney injury is associated with increased long-term mortality after cardiothoracic surgery. Circulation. 2009; 119: 2444-2453
7. Bihorac A, Yavas S, Subbiah S et al. Long-term risk of mortality and acute kidney injury during hospitalization after major surgery. Ann Surg 2009; 249: 851-858
8. Elseviers MM, Lins RL, Van der NP et al. Renal replacement therapy is an independent risk factor for mortality in critically ill patients with acute kidney injury. Crit Care 2010; 14: R221
9. Metnitz PG, Krenn CG, Steltzer H et al. Effect of acute renal failure requiring renal replacement therapy on outcome in critically ill patients. Crit Care Med 2002; 30: 2051-2058
10. Morgera S, Kraft AK, Siebert G et al. Long-term outcomes in acute renal failure patients treated with continuous renal replacement therapies. Am J Kidney Dis 2002; 40: 275-279
11. Wald R, Quinn RR, Luo J et al. Chronic dialysis and death among survivors of acute kidney injury requiring dialysis. JAMA 2009; 302: 1179-1185
12. Simmons EM, Himmelfarb J, Sezer MT et al. Plasma cytokine levels predict mortality in patients with acute renal failure. Kidney Int 2004; 65: 1357-1365
13. Chawla LS, Seneff MG, Nelson DR et al. Elevated plasma concentrations of IL-6 and elevated APACHE II score predict acute kidney injury in patients with severe sepsis. Clin J Am Soc Nephrol. 2007; 2: 22-30
14. Zhang J, Tao LJ, Ning JP et al. [Effects of high-volume hemofiltration on serum levels of tumor necrosis factor and its receptors in patients with multiple organ dysfunction syndromes]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2004; 16: 81-84
15. Iglesias J, Marik PE, Levine JS. Elevated serum levels of the type I and type II receptors for tumor necrosis factor-alpha as predictive factors for ARF in patients with septic shock. Am J Kidney Dis 2003; 41: 62-75
16. Liu KD, Glidden DV, Eisner MD et al. Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Crit Care Med 2007; 35: 2755-2761
17. Murugan R, Karajala-Subramanyam V, Lee M et al. Acute kidney injury in non-severe pneumonia is associated with an increased immune response and lower survival. Kidney Int 2010; 77: 527-535
18. Gangemi S, Mallamace A, Minciullo PL et al. Involvement of interleukin-18 in patients on maintenance haemodialysis. Am J Nephrol 2002; 22: 417-421
19. Bacher M, Metz CN, Calandra T et al. An essential regulatory role for macrophage migration inhibitory factor in T-cell activation. Proc Natl Acad Sci USA. 1996; 93: 7849-7854
20. Tsuruya K, Ninomiya T, Tokumoto M et al. Direct involvement of the receptor-mediated apoptotic pathways in cisplatin-induced renal tubular cell death. Kidney Int 2003; 63: 72-82
21. Nishida M, Fujimoto S, Toiyama K et al. Effect of hematopoietic cytokines on renal function in cisplatin-induced ARF in mice. Biochem Biophys Res Commun 2004; 324: 341-347
22. Palevsky PM, O'Connor T, Zhang JH et al. Design of the VA/NIH Acute Renal Failure Trial Network (ATN) Study: intensive versus conventional renal support in acute renal failure. Clin Trials 2005; 2: 423-435
23. Charlson ME, Pompei P, Ales KL et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987; 40: 373-383
24. KnausWA, Draper EA,Wagner DP et al. APACHE II: a severity of disease classification system. Crit Care Med. 1985; 13: 818-829
25. Paganini EP, Halstenberg WK, Goormastic M. Risk modeling in acute renal failure requiring dialysis: the introduction of a new model. Clin Nephrol 1996; 46: 206-211
26. Vincent JL, Moreno R, Takala J et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996; 22: 707-710
27. Demirjian S, Chertow GM, Zhang JH et al. Model to predict mortality in critically ill adults with acute kidney injury. Clin J Am Soc Nephrol 2011; 6: 2114-2120
28. Bellomo R, Ronco C, Kellum JA et al. Acute renal failure-definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 2004; 8: R204-R212
29. Levey AS, Bosch JP, Lewis JB et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999; 13: 461-470
30. Hasuike Y, Nonoguchi H, Ito K et al. Interleukin-6 is a predictor of mortality in stable hemodialysis patients. Am J Nephrol 2009; 30: 389-398
31. Liu KD, Altmann C, Smits G et al. Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study. Crit Care 2009; 13: R104
32. Liangos O, Kolyada A, Tighiouart H et al. Interleukin-8 and acute kidney injury following cardiopulmonary bypass: a prospective cohort study. Nephron Clin Pract 2009; 113: c148-c154
33. Kwon O, Molitoris BA, Pescovitz M et al. Urinary actin, interleukin-6, and interleukin-8 may predict sustained ARF after ischemic injury in renal allografts. Am J Kidney Dis 2003; 41: 1074-1087
34. Leslie JA, Meldrum KK. The role of interleukin-18 in renal injury. J Surg Res 2008; 145: 170-175
35. Lin C-Y, Chang C-H, Fan P-C et al. Serum interleukin-18 at commencement of renal replacement therapy predicts short-term prognosis in critically ill patients with acute kidney injury. PLoS One 2013; 8: e66028
36. Payen D, Lukaszewicz AC, Legrand M et al. A multicentre study of acute kidney injury in severe sepsis and septic shock: association with inflammatory phenotype and HLA genotype. PLoS One 2012; 7: e35838
37. Kellum JA, Kong L, Fink MP et al. Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study. Arch Intern Med 2007; 167: 1655-1663
38. Rothman KJ. No adjustments are needed for multiple comparisons. Epidemiology. 1990; 1: 43-316