Detection of anti-pentraxin-3 autoantibodies in ANCA-associated vasculitis

PLoS ONE

Volumn 11, Issue 1, 2016, Pages

  Simon, Amelie ^a,b   Subra, Jean Francois ^a,b   Guilpain, Philippe ^c   Jeannin, Pascale ^a,b   Pignon, Pascale ^b   Blanchard, Simon ^a,b   Garo, Erwan ^b   Jaillon, Sebastien ^b   Chevailler, Alain ^a,b   Renier, Gilles ^a   Puechal, Xavier ^d   Bottazzi, Barbara ^e   Mantovani, Alberto ^e   Delneste, Yves ^a,b   Augusto, Jean Francois ^a,b  

^a ANGERS UNIVERSITY HOSPITAL   (France)

^b UNIVERSITÉ D'ANGERS   (France)

^c MONTPELLIER UNIVERSITY HOSPITAL   (France)

^d Institut Cochin   (France)

^e HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; PENTRAXIN 3; PENTRAXIN 3 ANTIBODY; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; C REACTIVE PROTEIN; SERUM AMYLOID P;

ANCA ASSOCIATED VASCULITIS; ANTIBODY DETECTION; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MARKER; ENZYME LINKED IMMUNOSORBENT ASSAY; EOSINOPHILIC GRANULOMA; FEMALE; GIANT CELL ARTERITIS; HUMAN; IMMUNOFLUORESCENCE TEST; MAJOR CLINICAL STUDY; MALE; MICROSCOPIC POLYANGIITIS; OUTCOME ASSESSMENT; SYSTEMIC SCLEROSIS; WEGENER GRANULOMATOSIS; ADULT; ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS; BLOOD; CASE CONTROL STUDY; IMMUNOLOGY; INDIRECT FLUORESCENT ANTIBODY TECHNIQUE; MIDDLE AGED; PROGNOSIS;

ADULT; ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS; AUTOANTIBODIES; BIOMARKERS; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; MALE; MIDDLE AGED; PROGNOSIS; SERUM AMYLOID P-COMPONENT;

EID: 84958225170     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0147091     Document Type: Article

References (40)

1. Jennette JC, Falk RJ. Small-vessel vasculitis. N Engl J Med. 1997; 337(21):1512-23. PMID: 9366584.
2. Basu N, Watts R, Bajema I, Baslund B, Bley T, Boers M, et al. EULAR points to consider in the development of classification and diagnostic criteria in systemic vasculitis. Ann Rheum Dis. 2010; 69 (10):1744-50. PMID: 20448283. doi: 10.1136/ard.2009.119032
3. Hu N, Westra J, Kallenberg CG. Dysregulated neutrophil-endothelial interaction in antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides: implications for pathogenesis and disease intervention. Autoimmun Rev. 2011; 10(9):536-43. PMID: 21513817. doi: 10.1016/j.autrev.2011.04.004
4. Lionaki S, Blyth ER, Hogan SL, Hu Y, Senior BA, Jennette CE, et al. Classification of antineutrophil cytoplasmic autoantibody vasculitides: The role of antineutrophil cytoplasmic autoantibody specificity for myeloperoxidase or proteinase 3 in disease recognition and prognosis. Arthritis Rheum. 2012; 64 (10):3452-62. PMID: 23023777. doi: 10.1002/art.34562
5. Kallenberg CG, Heeringa P, Stegeman CA. Mechanisms of Disease: pathogenesis and treatment of ANCA-associated vasculitides. Nat Clin Pract Rheumatol. 2006; 2(12):661-70. PMID: 17133251.
6. Stegeman CA. Anti-neutrophil cytoplasmic antibody (ANCA) levels directed against proteinase-3 and myeloperoxidase are helpful in predicting disease relapse in ANCA-associated small-vessel vasculitis. Nephrol Dial Transplant. 2002; 17(12):2077-80. PMID: 12454214.
7. Finkielman JD, Merkel PA, Schroeder D, Hoffman GS, Spiera R, Clair EWSt, et al. Antiproteinase 3 antineutrophil cytoplasmic antibodies and disease activity in Wegener granulomatosis. Ann Intern Med. 2007; 147(9):611-9. PMID: 17975183.
8. Bottazzi B, Garlanda C, Cotena A, Moalli F, Jaillon S, Deban L, et al. The long pentraxin PTX3asapro-totypic humoral pattern recognition receptor: interplay with cellular innate immunity. Immunol Rev. 2009; 227(1):9-18. PMID: 19120471. doi: 10.1111/j.1600-065X.2008.00719.x
9. Bottazzi B, Doni A, Garlanda C, Mantovani A. An integrated view of humoral innate immunity: pentrax-ins as a paradigm. Annu Rev Immunol. 2010; 28:157-83. PMID: 19968561. doi: 10.1146/annurev-immunol-030409-101305
10. Breviario F, dAniello EM, Golay J, Peri G, Bottazzi B, Bairoch A, et al. Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component. J Biol Chem. 1992; 267(31):22190-7. PMID: 1429570.
11. Alles VV, Bottazzi B, Peri G, Golay J, Introna M, Mantovani A. Inducible expression of PTX3, anew member of the pentraxin family, in human mononuclear phagocytes. Blood. 1994; 84(10):3483-93. PMID: 7949102.
12. Nauta AJ, de Haij S, Bottazzi B, Mantovani A, Borrias MC, Aten J, et al. Human renal epithelial cells produce the long pentraxin PTX3. Kidney Int. 2005; 67(2):543-53. PMID: 15673302.
13. Garlanda C, Hirsch E, Bozza S, Salustri A, De Acetis M, Nota R, et al. Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Nature. 2002; 420(6912):182-6. PMID: 12432394.
14. Jaillon S, Peri G, Delneste Y, Fremaux I, Doni A, Moalli F, et al. The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps. J Exp Med. 2007; 204 (4):793-804. PMID: 17389238.
15. Borregaard N, Cowland JB. Granules of the human neutrophilic polymorphonuclear leukocyte. Blood. 1997; 89(10):3503-21. PMID: 9160655.
16. Witko-Sarsat V, Cramer EM, Hieblot C, Guichard J, Nusbaum P, Lopez S, et al. Presence of proteinase 3 in secretory vesicles: evidence of a novel, highly mobilizable intracellular pool distinct from azurophil granules. Blood. 1999; 94(7):2487-96. PMID: 10498622.
17. Augusto JF, Onno C, Blanchard S, Dubuquoi S, Mantovani A, Chevailler A, et al. Detection of anti-PTX3 autoantibodies in systemic lupus erythematosus. Rheumatology (Oxford). 2009; 48(4):442-4. PMID: 19213851.
18. Bassi N, Ghirardello A, Blank M, Zampieri S, Sarzi-Puttini P, Mantovani A, et al. Ig G anti-pentraxin 3 antibodies in systemic lupus erythematosus. Ann Rheum Dis. 2010; 69(9):1704-10. PMID: 20439287. doi: 10.1136/ard.2009.117804
19. Watts R, Lane S, Hanslik T, Hauser T, Hellmich B, Koldingsnes W, et al. Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies. Ann Rheum Dis. 2007; 66(2):222-7. doi: 10.1136/ard.2006. 054593 PMID: 16901958; Pub Med Central PMCID: PMCPMC1798520.
20. Hellmich B, Flossmann O, Gross WL, Bacon P, Cohen-Tervaert JW, Guillevin L, et al. EULAR recommendations for conducting clinical studies and/or clinical trials in systemic vasculitis: focus on anti-neu-trophil cytoplasm antibody-associated vasculitis. Ann Rheum Dis. 2007; 66(5):605-17. PMID: 17170053.
21. Bottazzi B, Vouret-Craviari V, Bastone A, De Gioia L, Matteucci C, Peri G, et al. Multimerformation and ligand recognition by the long pentraxin PTX3. Similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component. J Biol Chem. 1997; 272(52):32817-23. PMID: 9407058.
22. Zandman-Goddard G, Blank M, Langevitz P, Slutsky L, Pras M, Levy Y, et al. Anti-serum amyloid component P antibodies in patients with systemic lupus erythematosus correlate with disease activity. Ann Rheum Dis. 2005; 64(12):1698-702. PMID: 16014675.
23. Sjowall C, Eriksson P, Almer S, Skogh T. Autoantibodies to C-reactive protein is a common finding in SLE, but not in primary Sjogren's syndrome, rheumatoid arthritis or inflammatory bowel disease. J Auto-immun. 2002; 19(3):155-60. PMID: 12419286.
24. Tan Y, Yu F, Qu Z, Su T, Xing GQ, Wu LH, et al. Modified C-reactive protein might be a target autoanti-genofTINU syndrome. Clin J Am Soc Nephrol. 2011; 6(1):93-100. PMID: 20813859. doi: 10.2215/CJN.09051209
25. Fazzini F, Peri G, Doni A, Dell'Antonio G, Dal Cin E, Bozzolo E, et al. PTX3 in small-vessel vasculitides: an independent indicator of disease activity produced at sites of inflammation. Arthritis Rheum. 2001; 44(12):2841-50. PMID: 11762945.
26. Talor MV, Stone JH, Stebbing J, Barin J, Rose NR, Burek CL. Antibodies to selected minor target antigens in patients with anti-neutrophil cytoplasmic antibodies (ANCA). Clin Exp Immunol. 2007; 150 (1):42-8. doi: 10.1111/j.1365-2249.2007.03453.x PMID: 17614969; Pub Med Central PMCID: PMCPMC2219289.
27. Roth AJ, Ooi JD, Hess JJ, vanTimmeren MM, Berg EA, Poulton CE, et al. Epitope specificity determines pathogenicity and detectability in ANCA-associated vasculitis. J Clin Invest. 2013; 123(4):1773-83. PMID: 23549081. doi: 10.1172/JCI65292
28. Falk RJ, Terrell RS, Charles LA, Jennette JC. Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci USA. 1990; 87 (11):4115-9. PMID: 2161532.
29. Witko-Sarsat V, Pederzoli-Ribeil M, Hirsch E, Sozzani S, Cassatella MA. Regulating neutrophil apopto-sis: new players enterthe game. Trends Immunol. 2011; 32(3):117-24. PMID: 21317039. doi: 10.1016/j.it.2011.01.001
30. Xiao H, Heeringa P, Hu P, Liu Z, Zhao M, Aratani Y, et al. Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J Clin Invest. 2002; 110 (7):955-63. PMID: 12370273.
31. Falk RJ, Jennette JC. ANCA disease: where is this field heading? J Am Soc Nephrol. 2010; 21(5):745-52. PMID: 20395376. doi: 10.1681/ASN.2009121238
32. Gomez-Puerta JA, Bosch X. Anti-neutrophil cytoplasmic antibody pathogenesis in small-vessel vasculitis: an update. Am J Pathol. 2009; 175(5):1790-8. PMID: 19815703. doi: 10.2353/ajpath.2009.090533
33. Jaillon S, Jeannin P, Hamon Y, Fremaux I, Doni A, Bottazzi B, et al. Endogenous PTX3 translocates at the membrane of late apoptotic human neutrophils and is involved in their engulfment by macrophages. Cell Death Differ. 2009; 16(3):465-74. PMID: 19079137. doi: 10.1038/cdd.2008.173
34. Savill J, Dransfield I, Gregory C, Haslett C. A blast from the past: clearance of apoptotic cells regulates immune responses. Nat Rev Immunol. 2002; 2(12):965-75. PMID: 12461569.
35. Gilligan HM, Bredy B, Brady HR, Hebert MJ, Slayter HS, Xu Y, et al. Antineutrophil cytoplasmic autoantibodies interact with primary granule constituents on the surface of apoptotic neutrophils in the absence of neutrophil priming. J Exp Med. 1996; 184(6):2231-41. PMID: 8976178.
36. Harper L, Cockwell P, Adu D, Savage CO. Neutrophil priming and apoptosis in anti-neutrophil cytoplasmic autoantibody-associated vasculitis. Kidney Int. 2001; 59(5):1729-38. PMID: 11318943.
37. van Rossum AP, Pas HH, Fazzini F, Huitema MG, Limburg PC, Jonkman MF, et al. Abundance of the long pentraxin PTX3 at sites of leukocytoclastic lesions in patients with small-vessel vasculitis. Arthritis Rheum. 2006; 54(3):986-91. doi: 10.1002/art.21669 PMID: 16508993.
38. Kessenbrock K, Krumbholz M, Schonermarck U, Back W, Gross WL, Werb Z, et al. Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med. 2009; 15(6):623-5. PMID: 19448636. doi: 10.1038/nm.1959
39. Sangaletti S, Tripodo C, Chiodoni C, Guarnotta C, Cappetti B, Casalini P, et al. Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity. Blood. 2012; 120(15):3007-18. PMID: 22932797. doi: 10.1182/blood-2012-03-416156
40. Knight JS, Kaplan MJ. Lupus neutrophils: 'NET gain in understanding lupus pathogenesis. Curr Opin Rheumatol. 2012; 24(5):441-50. doi: 10.1097/BOR.0b013e3283546703 PMID: 22617827.