Investigating the formation and toxicity of nitrogen transformation products of diclofenac and sulfamethoxazole in wastewater treatment plants

Journal of Hazardous Materials

Volumn 309, Issue , 2016, Pages 157-164

  Osorio, Victoria ^a   Sanchís, Josep ^a   Abad, Jose Luís ^b   Ginebreda, Antoni ^a   Farré, Marinella ^a   Pérez, Sandra ^a   Barceló, Damià ^a,c  

^a INSTITUTE OF ENVIRONMENTAL ASSESSMENT AND WATER RESEARCH   (Spain)

^b CSIC   (Spain)

^c UNIVERSITY OF GIRONA   (Spain)

Author keywords

Daphnia magna; Nitrification denitrification; Pharmaceuticals; Toxicity; Vibrio fischeri

Indexed keywords

BATCH REACTORS; DRUG PRODUCTS; EFFLUENTS; MIXTURES; NITRIFICATION; NITROGEN; NITROGEN OXIDES; SEWAGE PUMPING PLANTS; WASTEWATER TREATMENT; WATER TREATMENT PLANTS;

DAPHNIA MAGNA; NITRIFICATION/DENITRIFICATION; NITRIFYING ACTIVATED SLUDGES; NITROGEN TRANSFORMATIONS; SULFAMETHOXAZOLE (SMX); TRANSFORMATION PRODUCTS; VIBRIO FISCHERI; WASTEWATER TREATMENT PLANTS;

TOXICITY;

DICLOFENAC; NITRO DERIVATIVE; NITROGEN; NITROGEN DERIVATIVE; NITROSO DERIVATIVE; SULFAMETHOXAZOLE; SURFACE WATER; WATER POLLUTANT;

ACTIVATED SLUDGE; BACTERIUM; BIOTRANSFORMATION; DENITRIFICATION; DRUG; NITROGEN COMPOUND; SURFACE WATER; TOXICITY; WASTE FACILITY; WASTEWATER; WATER TREATMENT;

ACTIVATED SLUDGE; ACUTE TOXICITY; ALIIVIBRIO FISCHERI; AQUATIC ENVIRONMENT; ARTICLE; BATCH REACTOR; DAPHNIA MAGNA; DENITRIFICATION; EFFLUENT; NITRATION; NITRIFICATION; NITROSATION; NONHUMAN; WASTE WATER TREATMENT PLANT; ANALYSIS; ANIMAL; DAPHNIA; DRUG EFFECTS; SEWAGE; TOXICITY; WATER POLLUTANT;

DAPHNIA MAGNA; VIBRIO FISCHERI;

ALIIVIBRIO FISCHERI; ANIMALS; DAPHNIA; DICLOFENAC; NITROGEN COMPOUNDS; SULFAMETHOXAZOLE; WASTE DISPOSAL, FLUID; WATER POLLUTANTS, CHEMICAL;

EID: 84958206340     PISSN: 03043894     EISSN: 18733336     Source Type: Journal    
DOI: 10.1016/j.jhazmat.2016.02.013     Document Type: Article

References (32)

1. Barbieri M., Carrera J., Ayora C., Sanchez-Vila X., Licha T., Nödler K., Osorio V., Pérez S., Köck-Schulmeyer M., López de Alda M., Barceló D. Formation of diclofenac and sulfamethoxazole reversible transformation products in aquifer material under denitrifying conditions: batch experiments. Sci. Total Environ. 2012, 426:256-263.
2. Chiron S., Gómez E., Nefenet H. Nitration processes of acetaminophen in nitrifying activated sludge. Environ. Sci. Technol. 2010, 44:284-289.
3. Cleuvers M. Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects. Toxicol. Lett. 2003, 142(3):185-194.
4. Commission of the European Communities, Technical guidance document in support of commission directive 93/67/EEC on risk assessment for new notified substances and commission regulation (EC) No. 1488/94 on risk assessment for existing substances. Part II. Environmental Risk Assessment, Office for Official Publications of the European Communities, Luxembourg, 1996.
5. Díaz-Cruz M.S., García-Galán M.J., Barceló D. Highly sensitive simultaneous determination of sulfonamide antibiotics and one metabolite in environmental waters by liquid chromatography-quadrupole linear ion trap-mass spectrometry. J. Chromatogr. A 2008, 1193:50-59.
6. Directive 2013/39/EU of the European parliament and of the council of 12 August 2013 amending Directives 2000/60/EC and 2008/105/EC as regards priority substances in the field of water policy.
7. Escher B.I., Fenner K. Recent advances in environmental risk assessment of transformation products. Environ. Sci. Technol. 2011, 45:3835-3847.
8. Fent K., Weston A., Caminada D. Ecotoxicology of human pharmaceuticals. Aquat. Toxicol. 2006, 76:122-159.
9. J.P. García, F.J. de Abajo, Utilización de antiinflamatorios no esteroides (AINE) en España, 1992-2006. División de Farmacoepidemiología y Farmacovigilancia de la Agencia Española de Medicamentos y Productos Sanitarios, 2006.
10. Gros M., Petrovic M., Ginebreda A., Barceló D. Removal of pharmaceuticals during wastewater treatment and environmental risk assessment using hazard indexes. Environ. Int. 2010, 36(1):15-26.
11. GWRC The Global Water Research Coalition. Pharmaceuticals and personal care products in the water cycle. An international review, London, UK; 2004.
12. ISO 11348-2: Water quality: determination of the inhibitory effect of water samples on the light emission of Vibrio fischeri (luminiscent bacteria test), draft of revised version. ISO, Geneva, Switzerland (1994).
13. Jelić A., Rodríguez-Mozaz S., Barceló D., Gutiérrez O. Impact of in-sewer transformation on 43 pharmaceuticals in a pressurized sewer under anaerobic conditions. Water Res. 2015, 68:98-108.
14. Jelić A., Gros M., Petrović M., Ginebreda A., Barceló D., et al. Occurrence and elimination of pharmaceuticals during conventional wastewater treatment. Emerging and Priority Pollutants in Rivers, Hdb Env Chem 2012, vol. 24:1-24. Springer-Verlag Berlin Heidelberg, (10.1007/978-3-642-25722-3_1).
15. Kim Y., Choi K., Jung J., Park S., Kim P.G., Park J. Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea. Environ. Int. 2007, 33(3):370-375.
16. E.B. Lázaro, D.C. Montero, Uso de antibióticos en España División de Farmacoepidemiología y Farmacovigilancia (Agencia Española de Medicamentos y Productos Sanitarios), 2010.
17. Majewsky M., Wagner D., Delay M., Bräse Viviane S.Y., Horn H. Antibacterial activity of sulfamethoxazole transformation products (TPs): general relevance for sulfonamide TPs modified at the para position. Chem. Res. Toxicol. 2014, 27(10):1821-1828.
18. Martí E., Aumatell J., Gode J., Poch M., Sabater F. Nutrient retention efficiency in streams receiving inputs from wastewater treatment plants. J. Environ. Qual. 2004, 33:285-293.
19. Merbt S., Auguet J.C., Casamayor E., Martí E. Biofilm recovery in a wastewater treatment plant-influenced stream and spatial segregation of ammonia oxidizing microbial populations. Limnol. Oceanogr. 2011, 56(3):1054-1064.
20. Merseburger G., Martí E., Sabater F. Net changes in nutrient concentrations below a point source input in two streams draining catchments with contrasting land uses. Sci. Total Environ. 2005, 347:217-229.
21. Müller E., Schüssler W., Horn H., Lemmer H. Aerobic biodegradation of the sulfonamide antibiotic sulfamethoxazole by activated sludge applied as co-substrate and sole carbon and nitrogen source. Chemosphere 2013, 92(8):969-978.
22. Nödler K., Licha T., Barbieri M., Pérez S. Evidence for the microbially mediated abiotic formation of reversible and non-reversible sulfamethoxazole transformation products during denitrification. Water Res. 2012, 46:2131-2139.
23. Oliveira L.D., Antunes S.C., Gonçalves F., Rocha O., Nunes B. Evaluation of ecotoxicological effects of drugs on Daphnia magna using different enzymatic biomarkers. Ecotoxicol. Environ. Saf. 2015, 119:123-131.
24. Onesios K.M., Yu J.T., Bouwer E.J. Biodegradation and removal of pharmaceuticals and personal care products in treatment systems: a review. Biodegradation 2009, 20:441-466.
25. Osorio V., Pérez S., Ginebreda A., Barceló D. Pharmaceuticals on a sewage impacted section of a Mediterranean River (Llobregat River, NE Spain) and their relationship with hydrological conditions. Environ. Sci. Pollut. Res. 2012, 19:1013-1025.
26. Osorio V., Marcé R., Pérez S., Ginebreda A., Cortina J.L., Barceló D. Occurrence and modeling of pharmaceuticals on a sewage impacted Mediterranean river and their dynamics under different hydrological conditions. Sci. Total Environ. 2012, 440:3-13.
27. Osorio V., Imbert-Bouchard M., Zonja B., Abad J.L., Pérez S., Barceló D. Simultaneous determination of diclofenac, its human metabolites and microbial nitration/nitrosation transformation products in wastewaters by liquid chromatography/quadrupole-linear ion trap mass spectrometry. J. Chromatogr. A 2014, 1347:63-71.
28. Pérez S., Barceló D. First evidence for occurrence of hydroxylated human metabolites of diclofenac and aceclofenac in wastewater using QqLIT-MS and QqTOF-MS. Anal. Chem. 2008, 80:8135-8145.
29. Regulation (EC) No. 1907/2006 of the European Parliament and the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC.
30. Stadler L.B., Ernstoff A.S., Aga D.S., Love N.G. Micropollutant fate in wastewater treatment: redefining removal. Environ. Sci. Technol. 2012, 46(19):10485-10486.
31. Yang L.H., Ying G.G., Su H.G., Stauber J.L., Adams M.S., Binet M.T. Growth-inhibiting effects of 12 antibacterial agents and their mixtures on the freshwater microalga pseudokirchneriella subcapitata. Environ. Toxicol. Chem. 2008, 27(5):1201-1208.
32. Ferrari B., Paxeus N., Giudice R.L., Pollio A., Garric J. Ecotoxicological impact of pharmaceuticals found in treated wastewaters: study of carbamazepine, clofibric acid, and diclofenac. Ecotoxicol. Environ. Saf. 2003, 55(3):359-370.