In vitro cytochrome P450 inhibition potential of methylenedioxy-derived designer drugs studied with a two-cocktail approach

Archives of Toxicology

Volumn 90, Issue 2, 2016, Pages 305-318

  Dinger, Julia ^a   Meyer, Markus R ^a   Maurer, Hans H ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

CYP inhibition; IC50 value; LC HR MS MS; Methylenedioxy derived designer drugs

Indexed keywords

1 (2,3 METHYLENDIOXYPHENYL) 2 BUTAMINE; 1 (3,4 METHYLENDIOXYPHENYL) 2 BUTAMINE; 1 (BENZOFURAN 5 YL) N METHYLPROPAN 2 AMINE; 1 (BENZOFURAN 6 YL) N METHYLPROPAN 2 AMINE; 1 BENZOFURAN 5 YLPROPAN 2 AMINE; 1 BENZOFURAN 6 YLPROPAN 2 AMINE; 1,3 BENZODIOXOLE DERIVATIVE; 2 DIMETHYLAMINO 1 (2,3 METHYLEDIOXYPHENYL)BUTANE; 2 ETHYLAMINO 1 (2,3 METHYLEDIOXYPHENYL)BUTANE; 2 METHYLAMINO 1 (2,3 METHYLEDIOXYPHENYL)BUTANE; 2 METHYLAMINO 1 (3,4 METHYLEDIOXYPHENYL)BUTANE; 2,3 METHYLENDIOXYAMPHETAMINE; 3,4 METHYLENDIOXY ALPHA PYRROLIDINOBUTIOPHENONE; 3,4 METHYLENDIOXY ALPHA PYRROLIDIONOPROPIOPHENONE; 3,4 METHYLENDIOXY N ETHYLAMPHETAMINE; 3,4 METHYLENDIOXY N METHYLAMPHETAMINE; 3,4 METHYLENDIOXYAMPHETAMINE; 3,4 METHYLENEDIOXY N BENZYLCATHINONE; 3,4 METHYLENEDIOXYPYROVALERONE; 5,6 METHYLENEDIOXY 2 AMINOINDANE; AMPHETAMINE DERIVATIVE; BENZOFURAN DERIVATIVE; BUTYLONE; CATHINONE; CYTOCHROME P450; CYTOCHROME P450 INHIBITOR; DESIGNER DRUG; METHYLONE; PENTYLONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; 1-(2,3-METHYLENEDIOXYPHENYL)-2-AMINOPROPANE; 2-METHYL-1,1-DIPHENYL-3-(1-PIPERIDINYL)-1-PROPANOL; 3,4 METHYLENEDIOXYAMPHETAMINE; CYTOCHROME P450 2D6 INHIBITOR; PIPERIDINE DERIVATIVE;

ARTICLE; CHEMICAL ANALYSIS; CLINICAL ASSESSMENT; CLINICAL EVALUATION; DRUG DETERMINATION; DRUG SCREENING; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN TISSUE; IC50; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER PARENCHYMA; MICROSOME; PRECIPITATION; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; DRUG EFFECTS; DRUG INTERACTION; LIVER MICROSOME; METABOLISM; PROCEDURES; TOXICITY TESTING;

3,4-METHYLENEDIOXYAMPHETAMINE; CYTOCHROME P-450 CYP2D6 INHIBITORS; CYTOCHROME P-450 ENZYME INHIBITORS; DESIGNER DRUGS; DRUG INTERACTIONS; HUMANS; INHIBITORY CONCENTRATION 50; MICROSOMES, LIVER; PIPERIDINES; TOXICITY TESTS;

EID: 84958114023     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1412-6     Document Type: Article

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