Anti-osteoporotic effects of Pueraria candollei var. mirifica on bone mineral density and histomorphometry in estrogen-deficient rats

Journal of Natural Medicines

Volumn 70, Issue 2, 2016, Pages 225-233

  Suthon, Sarocha ^a   Jaroenporn, Sukanya ^a   Charoenphandhu, Narattaphol ^b   Suntornsaratoon, Panan ^b   Malaivijitnond, Suchinda ^a  

^a CHULALONGKORN UNIVERSITY   (Thailand)

^b Mahidol University   (Thailand)

Author keywords

Bone loss; Osteoblast; Osteoclast; Phytoestrogens

Indexed keywords

AGENTS ACTING ON THE PERIPHERAL NERVOUS AND NEUROMUSCULAR SYSTEMS; ESTROGEN; PUERARIA EXTRACT; PUERARIA MIRIFICA EXTRACT; PUERARIN; UNCLASSIFIED DRUG; BONE DENSITY CONSERVATION AGENT; ISOFLAVONE DERIVATIVE; PHYTOESTROGEN; PLANT EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTI OSTEOPOROTIC ACTIVITY; ARTICLE; BONE DENSITY; BONE MASS; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; ESTROGEN ACTIVITY; ESTROGEN DEFICIENCY; FEMALE; FOURTH LUMBAR VERTEBRA; METAPHYSIS; MORPHOMETRICS; MUSCULOSKELETAL SYSTEM PARAMETERS; NONHUMAN; OSTEOBLAST SURFACE; OSTEOPOROSIS; OVARIECTOMY-INDUCED OSTEOPOROSIS; PUERARIA; PUERARIA MIRIFICA; RAT; TIBIA; TRABECULAR BONE; TRABECULAR BONE AREA; TRABECULAR NUMBER; TRABECULAR SPACE; TREATMENT DURATION; ANIMAL; CHEMISTRY; DEFICIENCY; DRUG EFFECTS; HUMAN; METABOLISM; OSTEOBLAST; PATHOLOGY; PHYTOTHERAPY; SPRAGUE DAWLEY RAT;

ANIMALS; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; ESTROGENS; FEMALE; HUMANS; ISOFLAVONES; OSTEOBLASTS; OSTEOPOROSIS; PHYTOESTROGENS; PHYTOTHERAPY; PLANT EXTRACTS; PUERARIA; RATS; RATS, SPRAGUE-DAWLEY; TIBIA;

EID: 84958109871     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-016-0965-5     Document Type: Article

References (40)

1. Klein-Nulend J, van Oers RF, Bakker AD, Bacabac RG (2014) Bone cell mechanosensitivity, estrogen deficiency, and osteoporosis. J Biomech 48:855-865
2. Khosla S, Oursler MJ, Monroe DG (2012) Estrogen and the skeleton. Trends Endocrinol Metab 23:576-581
3. Ettinger B, Genant HK, Cann CE (1985) Long-term estrogen replacement therapy prevents bone loss and fractures. Ann Intern Med 3:319-324
4. Kanis JA (1995) Treatment of osteoporosis in elderly women. Am J Med 98:60S-66S
5. Gallagher JC, Fowler SE, Detter JR, Sherman SS (2001) Combination treatment with estrogen and calcitriol in the prevention of age-related bone loss. J Clin Endocrinol Metab 86:3618-3628
6. Villareal DT, Binder EF, Williams DB, Schechtman KB, Yarasheski KE, Kohrt WM (2001) Bone mineral density response to estrogen replacement in frail elderly women: a randomized controlled trial. JAMA 286:815-820
7. Adami H, Persson I, Hoover R, Schaier C, Bergkvist L (1989) Risk of cancer in women receiving hormone replacement therapy. Int J Cardiol 44:833-839
8. Kennel KA, Drake MT (2009) Adverse effects of bisphosphonates: implications for osteoporosis management. Mayo Clin Proc 84:632-638
9. Babu S, Sandiford NA, Vrahas M (2015) Use of teriparatide to improve fracture healing: what is the evidence? World J Orthop 6:457-461
10. 2] in postmenopausal women with osteoporosis. Clin Pharmacokinet 52:995-1004
11. van der Maesen LJG (2002) Pueraria: botanical characteristics. In: Keung WM (ed) Pueraria: the genus pueraria. Taylor and Francis, London
12. Cherdshewasart W, Sriwatcharakul S (2007) Major isoflavonoid contents of the 1-year-cultivated phytoestrogen-rich herb, Pueraria mirifica. Biosci Biotechnol Biochem 71:2527-2533
13. Trisomboon H, Malaivijitnond S, Watanabe G, Taya K (2004) Estrogenic effects of Pueraria mirifica on the menstrual cycle and hormone-related ovarian functions in cyclic female cynomolgus monkeys. J Pharmacol Sci 94:51-59
14. Cherdshewasart W, Kitsamai Y, Malaivijitnond S (2007) Evaluation of the estrogenic activity of the wild Pueraria mirifica by vaginal cornification assay. J Reprod Dev 53:385-393
15. Urasopon N, Hamada Y, Asaoka K, Cherdshewasart W, Malaivijitnond S (2007) Pueraria mirifica, a phytoestrogen-rich herb, prevents bone loss in orchidectomized rats. Maturitas 56:322-331
16. Urasopon N, Hamada Y, Cherdshewasart W, Malaivijitnond S (2008) Preventive effects of Pueraria mirifica on bone loss in ovariectomized rats. Maturitas 59:137-148
17. Tiyasatkulkovit W, Charoenphandhu N, Wongdee K, Thongbunchoo J, Krishnamra N, Malaivijitnond S (2012) Upregulation of osteoblastic differentiation marker mRNA expression in osteoblast-like UMR106 cells by puerarin and phytoestrogens from Pueraria mirifica. Phytomedicine 19:1147-1155
18. Tiyasatkulkovit W, Malaivijitnond S, Charoenphandhu N, Havill LM, Ford AL, VandeBerg JL (2014) Pueraria mirifica extract and puerarin enhance proliferation and expression of alkaline phosphatase and type I collagen in primary baboon osteoblasts. Phytomedicine 21:1498-1503
19. Sheu SY, Tsai CC, Sun JS, Chen MH, Liu MH, Sun MG (2012) Stimulatory effect of puerarin on bone formation through co-activation of nitric oxide and bonemorphogenetic protein-2/mitogen-activated protein kinases pathways in mice. Chin Med J (Engl) 125:3646-3653
20. Wang C, Meng MX, Tang XL, Chen KM, Zhang L, Liu WN, Zhao YY (2014) The proliferation, differentiation, and mineralization effects of puerarin on osteoblasts in vitro. Chin J Nat Med 12:436-442
21. Wang Y, Yang C, Xie WL, Zhao YW, Li ZM, Sun WJ, Li LZ (2014) Puerarin concurrently stimulates osteoprotegerin and inhibits receptor activator of NF-κB ligand (RANKL) and interleukin-6 production in human osteoblastic MG-63 cells. Phytomedicine 21:1032-1036
22. Zhang MY, Qiang H, Yang HQ, Dang XQ, Wang KZ (2012) In vitro and in vivo effects of puerarin on promotion of osteoblast bone formation. Chin J Integr Med 18:276-282
23. Li B, Liu H, Jia S (2014) Puerarin enhances bone mass by promoting osteoblastogenesis and slightly lowering bone marrow adiposity in ovariectomized rats. Biol Pharm Bull 37:1919-1925
24. Cherdshewasart W, Cheewasopit W, Picha P (2004) The differential anti-proliferation effect of white (Pueraria mirifica), red (Butea superba), and black (Mucuna collettii) Kwao Krua plants on the growth of MCF-7 cells. J Ethnopharmacol 93:255-260
25. Cherdshewasart W, Panriansaen R, Picha P (2007) Pretreatment with phytoestrogen-rich plant decreases breast tumor incidence and exhibits lower profile of mammary ERα and ERβ. Matuaritus 58:174-181
26. Jaroenporn S, Malaivijitnond S, Wattanasirmkit K, Trisomboon H, Watanabe G, Taya K, Cherdshewasart W (2007) Assessment of fertility and reproductive toxicity in adult female mice after long term exposure to Pueraria mirifica herb. J Reprod Dev 53:995-1005
27. Urasopon N, Hamada Y, Asaoka K, Poungmali U, Malaivijitnond S (2008) Isoflavone content of rodent diets and its estrogenic effecton vaginal cornification in Pueraria mirifica-treated rats. Sci Asia 34:371-376
28. Malaivijitnond S, Tungmunnithum D, Gittarasanee S, Kawin K, Limjunyawong N (2010) Puerarin exhibits weak estrogenic activity in female rats. Fitoterapia 81:569-576
29. Trisomboon H, Malaivijitnond S, Cherdshewasart W, Gen Watanabe, Taya K (2006) Effect of Pueraria mirifica on the sexual skin coloration of aged menopausal cynomolgus monkeys. J Reprod Dev 52:537-542
30. Seriwatanachai D, Thongchote K, Charoenphandhu N, Pandaranandaka J, Tudpor K, Teerapornpuntakit J, Suthiphongchai J, Krishnamra N (2008) Prolactin directly enhances bone turnover by raising osteoblast-expressed receptor activator of nuclear factor κB ligand/osteoprotegerin ratio. Bone 42:535-546
31. Chauhan NS, Sharma V, Thakur M, Christine Helena Frankland Sawaya A, Dixit VK (2013) Pueraria tuberosa DC extract improves androgenesis and sexual behavior via FSH LH cascade. Sci World J 2013:780659. doi: 10.1155/2013/780659
32. Kijkuokool P, Parhar IS, Malaivijitnond S (2006) Genistein enhances N-nitrosomethylurea-induced rat mammary tumorigenesis. Cancer Lett 242:53-59
33. Komori T (2015) Animal models for osteoporosis. Eur J Pharmacol 759:287-294
34. Trisomboon H, Malaivijitnond S, Watanabe G, Taya K (2005) Ovulation block by Pueraria mirifica: a study of its endocrinological effect in female monkeys. Endocrine 26:33-39
35. Malaivijitnond S, Kiatthaipipat P, Cherdshewasart W, Watanabe G, Taya K (2004) Different effects of Pueraria mirifica, a herb containing phytoestrogens, on LH and FSH secretion in gonadectomized female and male rats. J Pharmacol Sci 96:428-435
36. Udomsuk L, Chatuphonprasert W, Monthakantirat O, Churikhit Y, Jarukamjorn K (2012) Impact of Pueraria candollei var. mirifica and its potent phytoestrogen miroestrol on expression of bone-specific genes in ovariectomized mice. Fitoterapia 83:1687-1692
37. Nakamura T, Imai Y, Matsumoto T, Sato S, Takeuchi K, Igarashi K, Harada Y, Azuma Y, Krust A, Yamamoto Y, Nishina H, Takeda S, Takayanagi H, Metzger D, Kanno J, Takaoka K, Martin TJ, Chambon P, Kato S (2007) Estrogen prevents bone loss via estrogen receptor α and induction of Fas ligand in osteoclast. Cell 130:811-823
38. Li H, Chen B, Pang G, Chen J, Xie J, Huang H (2015) Anti-osteoporotic activity of puerarin 6″ -O-xyloside on ovariectomized mice and its potential mechanism. Pharm Biol 10:1-7
39. Michihara S, Tanaka T, Uzawa Y, Moriyama T, Kawamura Y (2012) Puerarin exerted anti-osteoporotic action independent of estrogen receptor-mediated pathway. J Nutr Sci Vitaminol (Tokyo) 58:202-209
40. Manonai J, Chittacharoen A, Udomsubpayakul U, Theppisai H, Theppisai U (2008) Effects and safety of Pueraria mirifica on lipid profiles and biochemical markers of bone turnover rates in healthy postmenopausal women. Menopause 15:530-535