-
1
-
-
84868337504
-
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease
-
(updated 2015). Accessed on February 18, 2015.
-
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease (updated 2015). Global Initiative for Chronic Obstructive Lung Disease (GLOD). 2015. www.goldcopd.org. Accessed on February 18, 2015.
-
(2015)
Global Initiative for Chronic Obstructive Lung Disease (GLOD).
-
-
-
2
-
-
28044444899
-
Chronic obstructive pulmonary disease in five Latin American cities (the PLATINO study): a prevalence study
-
Menezes AM, Perez-Padilla R, Jardim JR, Muiño A, Lopez MV, Valdivia G, et al. Chronic obstructive pulmonary disease in five Latin American cities (the PLATINO study): a prevalence study. Lancet. 2005;366:1875-81.
-
(2005)
Lancet
, vol.366
, pp. 1875-1881
-
-
Menezes, A.M.1
Perez-Padilla, R.2
Jardim, J.R.3
Muiño, A.4
Lopez, M.V.5
Valdivia, G.6
-
3
-
-
84871051576
-
Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
-
Vos T, Flaxman AD, Naghavi M, Lozano R, Michaud C, Ezzati M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2163-96.
-
(2012)
Lancet
, vol.380
, pp. 2163-2196
-
-
Vos, T.1
Flaxman, A.D.2
Naghavi, M.3
Lozano, R.4
Michaud, C.5
Ezzati, M.6
-
4
-
-
33845338724
-
Projections of global mortality and burden of disease from 2002 to 2030
-
Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med. 2006;3, e442.
-
(2006)
PLoS Med
, vol.3
-
-
Mathers, C.D.1
Loncar, D.2
-
5
-
-
33746345878
-
Patient understanding, detection, and experience of COPD exacerbations: an observational, interview-based study
-
Kessler R, Ståhl E, Vogelmeier C, Haughney J, Trudeau E, Löfdahl CG, et al. Patient understanding, detection, and experience of COPD exacerbations: an observational, interview-based study. Chest. 2006;130:133-42.
-
(2006)
Chest
, vol.130
, pp. 133-142
-
-
Kessler, R.1
Ståhl, E.2
Vogelmeier, C.3
Haughney, J.4
Trudeau, E.5
Löfdahl, C.G.6
-
6
-
-
0036794862
-
Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease
-
Donaldson GC, Seemungal TA, Bhowmik A, Wedzicha JA. Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax. 2002;57:847-52.
-
(2002)
Thorax
, vol.57
, pp. 847-852
-
-
Donaldson, G.C.1
Seemungal, T.A.2
Bhowmik, A.3
Wedzicha, J.A.4
-
7
-
-
1842671720
-
Outcomes following acute exacerbation of severe chronic obstructive lung disease. The SUPPORT investigators (Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments)
-
Connors Jr AF, Dawson NV, Thomas C, Harrell Jr FE, Desbiens N, Fulkerson WJ, et al. Outcomes following acute exacerbation of severe chronic obstructive lung disease. The SUPPORT investigators (Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments). Am J Respir Crit Care Med. 1996;154:959-67.
-
(1996)
Am J Respir Crit Care Med
, vol.154
, pp. 959-967
-
-
Connors, A.F.1
Dawson, N.V.2
Thomas, C.3
Harrell, F.E.4
Desbiens, N.5
Fulkerson, W.J.6
-
8
-
-
77956689733
-
Susceptibility to exacerbation in chronic obstructive pulmonary disease
-
Hurst JR, Vestbo J, Anzueto A, Locantore N, Müllerova H, Tal-Singer R, et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med. 2010;363:1128-38.
-
(2010)
N Engl J Med
, vol.363
, pp. 1128-1138
-
-
Hurst, J.R.1
Vestbo, J.2
Anzueto, A.3
Locantore, N.4
Müllerova, H.5
Tal-Singer, R.6
-
9
-
-
0031914520
-
Phosphodiesterase isozymes: molecular targets for novel antiasthma agents
-
Torphy TJ. Phosphodiesterase isozymes: molecular targets for novel antiasthma agents. Am J Respir Crit Care Med. 1998;157:351-70.
-
(1998)
Am J Respir Crit Care Med
, vol.157
, pp. 351-370
-
-
Torphy, T.J.1
-
10
-
-
84856142028
-
Roflumilast: a phosphodiesterase-4 inhibitor for the treatment of severe chronic obstructive pulmonary disease
-
Pinner NA, Hamilton LA, Hughes A. Roflumilast: a phosphodiesterase-4 inhibitor for the treatment of severe chronic obstructive pulmonary disease. Clin Ther. 2012;34:56-66.
-
(2012)
Clin Ther
, vol.34
, pp. 56-66
-
-
Pinner, N.A.1
Hamilton, L.A.2
Hughes, A.3
-
11
-
-
23744451716
-
Roflumilast--an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial
-
Rabe KF, Bateman ED, O'Donnell D, Witte S, Bredenbröker D, Bethke TD. Roflumilast--an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial. Lancet. 2005;366:563-71.
-
(2005)
Lancet
, vol.366
, pp. 563-571
-
-
Rabe, K.F.1
Bateman, E.D.2
O'Donnell, D.3
Witte, S.4
Bredenbröker, D.5
Bethke, T.D.6
-
12
-
-
84892445790
-
Efficacy and safety of roflumilast in patients with stable chronic obstructive pulmonary disease: a meta-analysis
-
Yan JH, Gu WJ, Pan L. Efficacy and safety of roflumilast in patients with stable chronic obstructive pulmonary disease: a meta-analysis. Pulm Pharmacol Ther. 2014;27:83-9.
-
(2014)
Pulm Pharmacol Ther
, vol.27
, pp. 83-89
-
-
Yan, J.H.1
Gu, W.J.2
Pan, L.3
-
13
-
-
69149098943
-
Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials
-
Fabbri LM, Calverley PM, Izquierdo-Alonso JL, Bundschuh DS, Brose M, Martinez FJ, et al. Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials. Lancet. 2009;374:695-703.
-
(2009)
Lancet
, vol.374
, pp. 695-703
-
-
Fabbri, L.M.1
Calverley, P.M.2
Izquierdo-Alonso, J.L.3
Bundschuh, D.S.4
Brose, M.5
Martinez, F.J.6
-
14
-
-
84945586371
-
A randomized, placebo-controlled trial of roflumilast. Effect on proline-glycine-proline and neutrophilic inflammation in chronic obstructive pulmonary disease
-
Wells JM, Jackson PL, Viera L, Bhatt SP, Gautney J, Handley G, et al. A randomized, placebo-controlled trial of roflumilast. Effect on proline-glycine-proline and neutrophilic inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2015;192:934-42.
-
(2015)
Am J Respir Crit Care Med
, vol.192
, pp. 934-942
-
-
Wells, J.M.1
Jackson, P.L.2
Viera, L.3
Bhatt, S.P.4
Gautney, J.5
Handley, G.6
-
16
-
-
11844307130
-
Roflumilast, a new orally active phosphodiesterase 4 inhibitor, is effective in the treatment of chronic obstructive pulmonary disease
-
Bredenbroker D, Syed J, Leichtl S, Rathgeb F, Wurst W. Roflumilast, a new orally active phosphodiesterase 4 inhibitor, is effective in the treatment of chronic obstructive pulmonary disease. Eur Respir J. 2002;20:374S.
-
(2002)
Eur Respir J
, vol.20
, pp. 374S
-
-
Bredenbroker, D.1
Syed, J.2
Leichtl, S.3
Rathgeb, F.4
Wurst, W.5
-
17
-
-
33646938884
-
The effect of roflumilast treatment and subsequent withdrawal in patients with COPD
-
Boszormenyi-Nagy G, Pieters WR, Steffen H, Timar M, Vinkler I, Teichmann P, et al. The effect of roflumilast treatment and subsequent withdrawal in patients with COPD. Am J Respir Crit Care Med. 2005;169:A544.
-
(2005)
Am J Respir Crit Care Med
, vol.169
, pp. A544
-
-
Boszormenyi-Nagy, G.1
Pieters, W.R.2
Steffen, H.3
Timar, M.4
Vinkler, I.5
Teichmann, P.6
-
18
-
-
34447310046
-
Effect of 1-year treatment with roflumilast in severe chronic obstructive pulmonary disease
-
Calverley PM, Sanchez-Toril F, McIvor A, Teichmann P, Bredenbroeker D, Fabbri LM. Effect of 1-year treatment with roflumilast in severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2007;176:154-61.
-
(2007)
Am J Respir Crit Care Med
, vol.176
, pp. 154-161
-
-
Calverley, P.M.1
Sanchez-Toril, F.2
McIvor, A.3
Teichmann, P.4
Bredenbroeker, D.5
Fabbri, L.M.6
-
19
-
-
69149103642
-
Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials
-
Calverley PM, Rabe KF, Goehring UM, Kristiansen S, Fabbri LM, Martinez FJ. Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials. Lancet. 2009;374:685-94.
-
(2009)
Lancet
, vol.374
, pp. 685-694
-
-
Calverley, P.M.1
Rabe, K.F.2
Goehring, U.M.3
Kristiansen, S.4
Fabbri, L.M.5
Martinez, F.J.6
-
20
-
-
80155129530
-
Roflumilast in Asian patients with COPD: a randomized placebo-controlled trial
-
Lee SD, Hui DS, Mahayiddin AA, Roa Jr CC, Kwa KH, Goehring UM, et al. Roflumilast in Asian patients with COPD: a randomized placebo-controlled trial. Respirology. 2011;16:1249-57.
-
(2011)
Respirology
, vol.16
, pp. 1249-1257
-
-
Lee, S.D.1
Hui, D.S.2
Mahayiddin, A.A.3
Roa, C.C.4
Kwa, K.H.5
Goehring, U.M.6
-
21
-
-
79251588730
-
Reduction of exacerbations by the PDE4 inhibitor roflumilast--the importance of defining different subsets of patients with COPD
-
Rennard SI, Calverley PM, Goehring UM, Bredenbröker D, Martinez FJ. Reduction of exacerbations by the PDE4 inhibitor roflumilast--the importance of defining different subsets of patients with COPD. Respir Res. 2011;12:18.
-
(2011)
Respir Res
, vol.12
, pp. 18
-
-
Rennard, S.I.1
Calverley, P.M.2
Goehring, U.M.3
Bredenbröker, D.4
Martinez, F.J.5
-
22
-
-
84958053361
-
Roflumilast treatment in COPD patients taking a fixed-dose combination of long-acting beta2 agonist (LABA) and inhaled corticosteroid (ICS): Rationale and design of a prospective randomized controlled trial.
-
Accessed on February 18, 2015.
-
Ferguson GT, Rennard SI, Hanania NA, Zhu H, Siddiqui S, Sacks H, et al. Roflumilast treatment in COPD patients taking a fixed-dose combination of long-acting beta2 agonist (LABA) and inhaled corticosteroid (ICS): Rationale and design of a prospective randomized controlled trial. Am J Respir Crit Care Med. 2012;185.
-
(2012)
Am J Respir Crit Care Med.
, vol.185
-
-
Ferguson G.T.Rennard, S.I.1
Hanania, N.A.2
Zhu, H.3
Siddiqui, S.4
Sacks, H.5
-
23
-
-
84860473468
-
Physiological effects of roflumilast at rest and during exercise in COPD
-
O'Donnell DE, Bredenbröker D, Brose M, Webb KA. Physiological effects of roflumilast at rest and during exercise in COPD. Eur Respir J. 2012;39:1104-12.
-
(2012)
Eur Respir J
, vol.39
, pp. 1104-1112
-
-
O'Donnell, D.E.1
Bredenbröker, D.2
Brose, M.3
Webb, K.A.4
-
24
-
-
84892664131
-
Roflumilast for the treatment of COPD in an Asian population: a randomized, double-blind, parallel-group study
-
Zheng J, Yang J, Zhou X, Zhao L, Hui F, Wang H, et al. Roflumilast for the treatment of COPD in an Asian population: a randomized, double-blind, parallel-group study. Chest. 2014;145:44-52.
-
(2014)
Chest
, vol.145
, pp. 44-52
-
-
Zheng, J.1
Yang, J.2
Zhou, X.3
Zhao, L.4
Hui, F.5
Wang, H.6
-
25
-
-
84924250308
-
Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial
-
Martinez FJ, Calverley PM, Goehring UM, Brose M, Fabbri LM, Rabe KF. Effect of roflumilast on exacerbations in patients with severe chronic obstructive pulmonary disease uncontrolled by combination therapy (REACT): a multicentre randomised controlled trial. Lancet. 2015;385:857-66.
-
(2015)
Lancet
, vol.385
, pp. 857-866
-
-
Martinez, F.J.1
Calverley, P.M.2
Goehring, U.M.3
Brose, M.4
Fabbri, L.M.5
Rabe, K.F.6
-
26
-
-
84873661428
-
Efficacy and safety of roflumilast in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis
-
Oba Y, Lone NA. Efficacy and safety of roflumilast in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. Ther Adv Respir Dis. 2013;7:13-24.
-
(2013)
Ther Adv Respir Dis
, vol.7
, pp. 13-24
-
-
Oba, Y.1
Lone, N.A.2
-
27
-
-
84899792562
-
Phosphodiesterase 4 inhibitors for chronic obstructive pulmonary disease
-
Chong J, Leung B, Poole P. Phosphodiesterase 4 inhibitors for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2013;11, CD002309.
-
(2013)
Cochrane Database Syst Rev
, vol.11
-
-
Chong, J.1
Leung, B.2
Poole, P.3
-
28
-
-
42949152368
-
Bronchodilator responsiveness in patients with COPD
-
Tashkin DP, Celli B, Decramer M, Liu D, Burkhart D, Cassino C, et al. Bronchodilator responsiveness in patients with COPD. Eur Respir J. 2008;31(4):742-50.
-
(2008)
Eur Respir J
, vol.31
, Issue.4
, pp. 742-750
-
-
Tashkin, D.P.1
Celli, B.2
Decramer, M.3
Liu, D.4
Burkhart, D.5
Cassino, C.6
-
29
-
-
20144372614
-
The MCID of the transition dyspnea index is a total score of one unit
-
Mahler DA, Witek Jr TJ. The MCID of the transition dyspnea index is a total score of one unit. COPD. 2005;2:99-103.
-
(2005)
COPD
, vol.2
, pp. 99-103
-
-
Mahler, D.A.1
Witek, T.J.2
-
30
-
-
77954800883
-
Once-daily bronchodilators for chronic obstructive pulmonary disease: indacaterol versus tiotropium
-
Donohue JF, Fogarty C, Lötvall J, Mahler DA, Worth H, Yorgancioglu A, et al. Once-daily bronchodilators for chronic obstructive pulmonary disease: indacaterol versus tiotropium. Am J Respir Crit Care Med. 2010;182:155-62.
-
(2010)
Am J Respir Crit Care Med
, vol.182
, pp. 155-162
-
-
Donohue, J.F.1
Fogarty, C.2
Lötvall, J.3
Mahler, D.A.4
Worth, H.5
Yorgancioglu, A.6
-
31
-
-
84867119092
-
Efficacy and safety of twice-daily aclidinium bromide in COPD patients: the ATTAIN study
-
Jones PW, Singh D, Bateman ED, Agusti A, Lamarca R, de Miquel G, et al. Efficacy and safety of twice-daily aclidinium bromide in COPD patients: the ATTAIN study. Eur Respir J. 2012;40:830-6.
-
(2012)
Eur Respir J
, vol.40
, pp. 830-836
-
-
Jones, P.W.1
Singh, D.2
Bateman, E.D.3
Agusti, A.4
Lamarca, R.5
Miquel, G.6
-
32
-
-
84877676197
-
Efficacy and safety of once-daily QVA149 compared with twice-daily salmeterol-fluticasone in patients with chronic obstructive pulmonary disease (ILLUMINATE): a randomised, double-blind, parallel group study
-
Vogelmeier CF, Bateman ED, Pallante J, Alagappan VK, D'Andrea P, Chen H, et al. Efficacy and safety of once-daily QVA149 compared with twice-daily salmeterol-fluticasone in patients with chronic obstructive pulmonary disease (ILLUMINATE): a randomised, double-blind, parallel group study. Lancet Respir Med. 2013;1:51-60.
-
(2013)
Lancet Respir Med
, vol.1
, pp. 51-60
-
-
Vogelmeier, C.F.1
Bateman, E.D.2
Pallante, J.3
Alagappan, V.K.4
D'Andrea, P.5
Chen, H.6
-
33
-
-
27144525197
-
Patterns of comorbidities in newly diagnosed COPD and asthma in primary care
-
Soriano JB, Visick GT, Muellerova H, Payvandi N, Hansell AL. Patterns of comorbidities in newly diagnosed COPD and asthma in primary care. Chest. 2005;128:2099-107.
-
(2005)
Chest
, vol.128
, pp. 2099-2107
-
-
Soriano, J.B.1
Visick, G.T.2
Muellerova, H.3
Payvandi, N.4
Hansell, A.L.5
|