Smart Cancer Cell Targeting Imaging and Drug Delivery System by Systematically Engineering Periodic Mesoporous Organosilica Nanoparticles

ACS Applied Materials and Interfaces

Volumn 8, Issue 5, 2016, Pages 2985-2993

  Lu, Nan ^a,c   Tian, Ying ^a   Tian, Wei ^a   Huang, Peng ^c,d   Liu, Ying ^a   Tang, Yuxia ^a   Wang, Chunyan ^a   Wang, Shouju ^a   Su, Yunyan ^a   Zhang, Yunlei ^a   Pan, Jing ^a   Teng, Zhaogang ^a,b   Lu, Guangming ^a,b  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

^c NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

^d Shenzhen University School of Medicine   (China)

Author keywords

cancer cell targeting; drug delivery; HER2 positive cancer; near infrared fluorescence imaging; periodic mesoporous organosilica

Indexed keywords

BIOCOMPATIBILITY; CELLS; CHEMOTHERAPY; CYTOLOGY; DIAGNOSIS; DISEASES; DRUG DELIVERY; FLUORESCENCE; INFRARED DEVICES; MEDICAL APPLICATIONS; MESOPOROUS MATERIALS; NANOPARTICLES; SILICA; TUMORS;

BIOMEDICAL APPLICATIONS; CANCER CELL TARGETING; CONFOCAL LASER SCANNING MICROSCOPY; HER2 POSITIVE CANCER; INTRACELLULAR DISTRIBUTION; NEAR-INFRARED FLUORESCENCE; NEAR-INFRARED FLUORESCENCE IMAGING; PERIODIC MESOPOROUS ORGANOSILICAS;

CELL ENGINEERING;

ANTINEOPLASTIC AGENT; DOXORUBICIN; NANOPARTICLE; ORGANOSILICON DERIVATIVE; SULFIDE;

CELL SURVIVAL; CELL TRACKING; CHEMISTRY; CONFOCAL MICROSCOPY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; HUMAN; MOLECULAR IMAGING; NEOPLASMS; PATHOLOGY; POROSITY; PROCEDURES; THERANOSTIC NANOMEDICINE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CELL TRACKING; DOXORUBICIN; DRUG DELIVERY SYSTEMS; HUMANS; MICROSCOPY, CONFOCAL; MOLECULAR IMAGING; NANOPARTICLES; NEOPLASMS; ORGANOSILICON COMPOUNDS; POROSITY; SULFIDES; THERANOSTIC NANOMEDICINE;

EID: 84957989602     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/acsami.5b09585     Document Type: Article

References (44)

1. Torre, L. A.; Bray, F.; Siegel, R. L.; Ferlay, J.; Lortet-Tieulent, J.; Jemal, A. Global Cancer Statistics, 2012 Ca-Cancer J. Clin. 2015, 65, 87-108 10.3322/caac.21262
2. Liang, X. L.; Li, Y. Y.; Li, X. D.; Jing, L. J.; Deng, Z. J.; Yue, X. L.; Li, C. H.; Dai, Z. F. PEGylated Polypyrrole Nanoparticles Conjugating Gadolinium Chelates for Dual-Modal MRI/Photoacoustic Imaging Guided Photothermal Therapy of Cancer Adv. Funct. Mater. 2015, 25, 1451-1462 10.1002/adfm.201402338
3. Zhang, L. E.; Zeng, L. Y.; Pan, Y. W.; Luo, S.; Ren, W. Z.; Gong, A.; Ma, X. H.; Liang, H. Z.; Lu, G. M.; Wu, A. G. Inorganic Photosensitizer Coupled Gd-Based Upconversion Luminescent Nanocomposites for In Vivo Magnetic Resonance Imaging and Near-Infrared-Responsive Photodynamic Therapy in Cancers Biomaterials 2015, 44, 82-90 10.1016/j.biomaterials.2014.12.040
4. 3 Composite Theranostic Nanosystem for Multi-Modality Tumor Imaging and Therapy Adv. Mater. 2015, 27, 2775-2782 10.1002/adma.201500870
5. 1 Imaging Anal. Chem. 2015, 87, 8941-8948 10.1021/acs.analchem.5b02095
6. Wu, J. B.; Shi, C. H.; Chu, G. C.-Y.; Xu, Q. J.; Zhang, Y.; Li, Q. L.; Yu, J. S.; Zhau, H. E.; Chung, L. W. K. Near-Infrared Fluorescence Heptamethine Carbocyanine Dyes Mediate Imaging and Targeted Drug Delivery for Human Brain Tumor Biomaterials 2015, 67, 1-10 10.1016/j.biomaterials.2015.07.028
7. Yang, L. J.; Zhou, Z. J.; Liu, H. Y.; Wu, C. Q.; Zhang, H.; Huang, G. M.; Ai, H.; Gao, J. H. Europium-Engineered Iron Oxide Nanocubes with High T-1 and T-2 Contrast Abilities for MRI in Living Subjects Nanoscale 2015, 7, 6843-6850 10.1039/C5NR00774G
8. Dong, W. J.; Li, Y. S.; Niu, D. C.; Ma, Z.; Liu, X. H.; Gu, J. L.; Zhao, W. R.; Zheng, Y. Y.; Shi, J. L. A Simple Route to Prepare Monodisperse Au NP-Decorated, Dye-Doped, Superparamagnetic Nanocomposites for Optical, MR, and CT Trimodal Imaging Small 2013, 9, 2500-2508 10.1002/smll.201202649
9. Zhou, M.; Li, J. J.; Liang, S.; Sood, A. K.; Liang, D.; Li, C. CuS Nanodots with Ultrahigh Efficient Renal Clearance for Positron Emission Tomography Imaging and Image-Guided Photothermal Therapy ACS Nano 2015, 9, 7085-7096 10.1021/acsnano.5b02635
10. 4 Nanocapsules for MRI/US Imaging and Photothermal Therapy with Near-Infrared Irradiation ACS Appl. Mater. Interfaces 2015, 7, 14231-14242 10.1021/acsami.5b01873
11. Zha, Z. B.; Deng, Z. J.; Li, Y. Y.; Li, C. H.; Wang, J. R.; Wang, S. M.; Qu, E. Z.; Dai, Z. F. Biocompatible Polypyrrole Nanoparticles as a Novel Organic Photoacoustic Contrast Agent for Deep Tissue Imaging Nanoscale 2013, 5, 4462-4467 10.1039/c3nr00627a
12. Parambadath, S.; Rana, V. K.; Zhao, D. Y.; Ha, C.-S. N,N′-Diureylenepiperazine-Bridged Periodic Mesoporous Organosilica for Controlled Drug Delivery Microporous Mesoporous Mater. 2011, 141, 94-101 10.1016/j.micromeso.2010.10.051
13. 2 Nanocomposites for Magnetic Resonance Imaging and Potential Photodynamic Therapy Nanoscale 2013, 5, 2107-2113 10.1039/c3nr33978e
14. Zha, Z. B.; Yue, X. L.; Ren, Q. S.; Dai, Z. F. Uniform Polypyrrole Nanoparticles with High Photothermal Conversion Efficiency for Photothermal Ablation of Cancer Cells Adv. Mater. 2013, 25, 777-782 10.1002/adma.201202211
15. Ma, X. H.; Gong, A.; Xiang, L. C.; Chen, T. X.; Gao, Y. X.; Liang, X. J.; Shen, Z. Y.; Wu, A. G. Biocompatible Composite Nanoparticles with Large Longitudinal Relaxivity for Targeted Imaging and Early Diagnosis of Cancer J. Mater. Chem. B 2013, 1, 3419-3428 10.1039/c3tb20648c
16. Yu, M. X.; Zheng, J. Clearance Pathways and Tumor Targeting of Imaging Nanoparticles ACS Nano 2015, 9, 6655-6674 10.1021/acsnano.5b01320
17. Xie, J.; Lee, S.; Chen, X. Y. Nanoparticle-Based Theranostic Agents Adv. Drug Delivery Rev. 2010, 62, 1064-1079 10.1016/j.addr.2010.07.009
18. Choi, K. Y.; Liu, G.; Lee, S.; Chen, X. Y. Theranostic Nanoplatforms for Simultaneous Cancer Imaging and Therapy: Current Approaches and Future Perspectives Nanoscale 2012, 4, 330-342 10.1039/C1NR11277E
19. Sun, Y.; Zheng, Y. Y.; Li, P.; Wang, D.; Niu, C. C.; Gong, Y. P.; Huang, R. Z.; Wang, Z. B.; Wang, Z. G.; Ran, H. T. Evaluation of Superparamagnetic Iron Oxide-Polymer Composite Microcapsules for Magnetic Resonance-Guided High-Intensity Focused Ultrasound Cancer Surgery BMC Cancer 2014, 14, 800-810 10.1186/1471-2407-14-800
20. Kunjachan, S.; Ehling, J.; Storm, G.; Kiessling, F.; Lammers, T. Noninvasive Imaging of Nanomedicines and Nanotheranostics: Principles Chem. Rev. 2015, 115, 10907 10.1021/cr500314d
21. Zhao, Z. H.; Wang, X. M.; Zhang, Z. J.; Zhang, H.; Liu, H. Y.; Zhu, X. L.; Li, H.; Chi, X. Q.; Yin, Z. Y.; Gao, J. H. Real-Time Monitoring of Arsenic Trioxide Release and Delivery by Activatable T-1 Imaging ACS Nano 2015, 9, 2749-2759 10.1021/nn506640h
22. Lee, J. E.; Lee, N.; Kim, T.; Kim, J.; Hyeon, T. Multifunctional Mesoporous Silica Nanocomposite Nanoparticles for Theranostic Applications Acc. Chem. Res. 2011, 44, 893-902 10.1021/ar2000259
23. Xia, Y. N.; Li, W. Y.; Cobley, C. M.; Chen, J. Y.; Xia, X. H.; Zhang, Q.; Yang, M. X.; Cho, E. C.; Brown, P. K. Gold Nanocages: From Synthesis to Theranostic Applications Acc. Chem. Res. 2011, 44, 914-924 10.1021/ar200061q
24. Liao, M. Y.; Lai, P. S.; Yu, H. P.; Lin, H. P.; Huang, C. C. Innovative Ligand-Assisted Synthesis of NIR-Activated Iron Oxide for Cancer Theranostics Chem. Commun. 2012, 48, 5319-5321 10.1039/c2cc31448g
25. Liu, F. Y.; He, X. X.; Chen, H. D.; Zhang, J. P.; Zhang, H. M.; Wang, Z. X. Gram-Scale Synthesis of Coordination Polymer Nanodots with Renal Clearance Properties for Cancer Theranostic Applications Nat. Commun. 2015, 6, 8003-8011 10.1038/ncomms9003
26. Teng, Z. G.; Wang, S. J.; Su, X. D.; Chen, G. T.; Liu, Y.; Luo, Z. M.; Luo, W.; Tang, Y. X.; Ju, H. X.; Zhao, D. Y.; Lu, G. M. Facile Synthesis of Yolk-Shell Structured Inorganic-Organic Hybrid Spheres with Ordered Radial Mesochannels Adv. Mater. 2014, 26, 3741-3747 10.1002/adma.201400136
27. Asefa, T.; MacLachlan, M. J.; Coombs, N.; Ozin, G. A. Periodic Mesoporous Organosilicas with Organic Groups Inside the Channel Walls Nature 1999, 402, 867-871 10.1038/47229
28. Chen, Y.; Xu, P. F.; Chen, H. R.; Li, Y. S.; Bu, W. B.; Shu, Z.; Li, Y. P.; Zhang, J. M.; Zhang, L. X.; Pan, L. M.; Cui, X. Z.; Hua, Z. L.; Wang, J.; Zhang, L. L.; Shi, J. L. Colloidal HPMO Nanoparticles: Silica-Etching Chemistry Tailoring, Topological Transformation, and Nano-Biomedical Applications Adv. Mater. 2013, 25, 3100-3105 10.1002/adma.201204685
29. Teng, Z. G.; Su, X. D.; Zheng, Y. Y.; Zhang, J. J.; Liu, Y.; Wang, S. J.; Wu, J.; Chen, G. T.; Wang, J. D.; Zhao, D. Y.; Lu, G. M. A Facile Multi-Interface Transformation Approach to Monodisperse Multiple-Shelled Periodic Mesoporous Organosilica Hollow Spheres J. Am. Chem. Soc. 2015, 137, 7935-7944 10.1021/jacs.5b05369
30. Croissant, J.; Cattoën, X.; Man, M. W. C.; Gallud, A.; Raehm, L.; Trens, P.; Maynadier, M.; Durand, J.-O. Biodegradable Ethylene-Bis(Propyl)Disulfide-Based Periodic Mesoporous Organosilica Nanorods and Nanospheres for Efficient In-Vitro Drug Delivery Adv. Mater. 2014, 26, 6174-6180 10.1002/adma.201401931
31. Teng, Z. G.; Su, X. D.; Lee, B. H.; Huang, C. G.; Liu, Y.; Wang, S. J.; Wu, J.; Xu, P.; Sun, J.; Shen, D. K.; Li, W.; Lu, G. M. Yolk-Shell Structured Mesoporous Nanoparticles with Thioether-Bridged Organosilica Frameworks Chem. Mater. 2014, 26, 5980-5987 10.1021/cm502777e
32. Besson, E.; Mehdi, A.; Reyé, C.; Corriu, R. J. P. Soft Route for Monodisperse Gold Nanoparticles Confined within SH-Functionalized Walls of Mesoporous Silica J. Mater. Chem. 2009, 19, 4746-4752 10.1039/b902568e
33. Kim, J. H.; Fang, B. Z.; Song, M. Y.; Yu, J. S. Topological Transformation of Thioether-Bridged Organosilicas into Nanostructured Functional Materials Chem. Mater. 2012, 24, 2256-2264 10.1021/cm203520a
34. 121-Conjugated Mesoporous Silica Nanoparticle: A Tumor Targeted Drug Delivery System ACS Appl. Mater. Interfaces 2014, 6, 21677-21685 10.1021/am506849p
35. Hue, J. J.; Lee, H. J.; Jon, S.; Nam, S. Y.; Yun, Y. W.; Kim, J. S.; Lee, B. J. Distribution and Accumulation of Cy5.5-Labeled Thermally Cross-Linked Superparamagnetic Iron Oxide Nanoparticles in the Tissues of ICR Mice J. Vet. Sci. 2013, 14, 473-479 10.4142/jvs.2013.14.4.473
36. Yang, M.; Cheng, K.; Qi, S.; Liu, H.; Jiang, Y.; Jiang, H.; Li, J.; Chen, K.; Zhang, H.; Cheng, Z. Affibody Modified and Radiolabeled Gold-Iron Oxide Hetero-Nanostructures for Tumor PET, Optical and MR Imaging Biomaterials 2013, 34, 2796-2806 10.1016/j.biomaterials.2013.01.014
37. Habicht, G.; Haupt, C.; Friedrich, R. P.; Hortschansky, P.; Sachse, C.; Meinhardt, J.; Wieligmann, K.; Gellermann, G. P.; Brodhun, M.; Gotz, J.; Halbhuber, K. J.; Rocken, C.; Horn, U.; Fandrich, M. Directed Selection of a Conformational Antibody Domain that Prevents Mature Amyloid Fibril Formation by Stabilizing Abeta Protofibrils Proc. Natl. Acad. Sci. U. S. A. 2007, 104, 19232-19237 10.1073/pnas.0703793104
38. Lin, J. Y.; Li, Y.; Li, Y. X.; Wu, H. J.; Yu, F.; Zhou, S. F.; Xie, L. Y.; Luo, F. H.; Lin, C. J.; Hou, Z. Q. Drug/Dye-Loaded, Multifunctional PEG-Chitosan-Iron Oxide Nanocomposites for Methotraxate Synergistically Self-Targeted Cancer Therapy and Dual Model Imaging ACS Appl. Mater. Interfaces 2015, 7, 11908-11920 10.1021/acsami.5b01685
39. Slowing, I. I.; Vivero-Escoto, J. L.; Wu, C. W.; Lin, V. S. Y. Mesoporous Silica Nanoparticles as Controlled Release Drug Delivery and Gene Transfection Carriers Adv. Drug Delivery Rev. 2008, 60, 1278-1288 10.1016/j.addr.2008.03.012
40. 4 Nanocomposite with Mesoporous Silica Coating for Drug Delivery and Imaging-Guided Therapy of Cancer Biomaterials 2015, 60, 62-71 10.1016/j.biomaterials.2015.04.053
41. Tang, Y. X.; Teng, Z. G.; Liu, Y.; Tian, Y.; Sun, J.; Wang, S. J.; Wang, C. Y.; Wang, J. D.; Lu, G. M. Cytochrome C Capped Mesoporous Silica Nanocarriers for pH-Sensitive and Sustained Drug Release J. Mater. Chem. B 2014, 2, 4356-4362 10.1039/c4tb00497c
42. Chen, Y.; Meng, Q. S.; Wu, M. Y.; Wang, S. G.; Xu, P. F.; Chen, H. R.; Li, Y. P.; Zhang, L. X.; Wang, L. Z.; Shi, J. L. Hollow Mesoporous Organosilica Nanoparticles: A Generic Intelligent Framework-Hybridization Approach for Biomedicine J. Am. Chem. Soc. 2014, 136, 16326-16334 10.1021/ja508721y
43. Bauhuber, S.; Hozsa, C.; Breunig, M.; Göpferich, A. Delivery of Nucleic Acids via Disulfide-Based Carrier Systems Adv. Mater. 2009, 21, 3286-3306 10.1002/adma.200802453
44. Lee, M. H.; Yang, Z.; Lim, C. W.; Lee, Y. H.; Dongbang, S.; Kang, C.; Kim, J. S. Disulfide-Cleavage-Triggered Chemosensors and Their Biological Applications Chem. Rev. 2013, 113, 5071-5109 10.1021/cr300358b