Azole resistance in Aspergillus fumigatus clinical isolates from an italian culture collection

Antimicrobial Agents and Chemotherapy

Volumn 60, Issue 1, 2016, Pages 682-685

  Lazzarini, Cristina ^a   Esposto, Maria Carmela ^a   Prigitano, Anna ^a   Cogliati, Massimo ^a   De Lorenzis, Gabriella ^b   Tortorano, Anna Maria ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA TUBULIN; HISTIDINE; LEUCINE; PYRROLE; ANTIFUNGAL AGENT; CYTOCHROME P-450 CYP51A, ASPERGILLUS; CYTOCHROME P450; FUNGAL PROTEIN; ITRACONAZOLE; MICROSATELLITE DNA; POSACONAZOLE; TRIAZOLE DERIVATIVE; VORICONAZOLE;

ANTIFUNGAL RESISTANCE; ARTICLE; ASPERGILLUS FUMIGATUS; AZOLE RESISTANCE; CELL CULTURE; CHRONIC DISEASE; CYP51A GENE; FUNGAL GENETICS; FUNGUS ISOLATION; FUNGUS MUTATION; GENE; GENE MUTATION; GENETIC CODE; GENOTYPE; HUMAN; INVASIVE ASPERGILLOSIS; NONHUMAN; POINT MUTATION; PREVALENCE; PRIORITY JOURNAL; TANDEM REPEAT; AMINO ACID SUBSTITUTION; ASPERGILLOSIS; BACTERIUM IDENTIFICATION; DRUG EFFECTS; ENZYMOLOGY; EPIDEMIOLOGICAL MONITORING; GENE EXPRESSION; GENETICS; ISOLATION AND PURIFICATION; ITALY; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MUTATION; PROMOTER REGION;

AMINO ACID SUBSTITUTION; ANTIFUNGAL AGENTS; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; BACTERIAL TYPING TECHNIQUES; CYTOCHROME P-450 ENZYME SYSTEM; DRUG RESISTANCE, FUNGAL; EPIDEMIOLOGICAL MONITORING; FUNGAL PROTEINS; GENE EXPRESSION; GENOTYPE; HUMANS; ITALY; ITRACONAZOLE; MICROBIAL SENSITIVITY TESTS; MICROSATELLITE REPEATS; MUTATION; PROMOTER REGIONS, GENETIC; TRIAZOLES; VORICONAZOLE;

EID: 84957928011     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.02234-15     Document Type: Article

References (13)

1. Verweij PE, Chowdhary A, Melchers WJG, Meis JF. 2015. Azole resistance in Aspergillus fumigatus: can we retain the clinical use of mold-active antifungal azoles. Clin Infect Dis http://dx.doi.org/10.1093/cid/civ885.
2. van der Linden JWM, Arendrup MC, Warris A, Lagrou K, Pelloux H, Hauser PM, Chryssanthou E, Mellado E, Kidd SE, Tortorano AM, Dannaoui E, Gaustad P, Baddley JW, Uekötter A, Lass-Flörl C, Klimko N, Moore CB, Denning DW, Pasqualotto AC, Kibbler C, Arikan-Akdagli S, Andes D, Meletiadis J, Naumiuk L, Nucci M, Melchers WJG, Verweij PE. 2015. Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus. Emerg Infect Dis 21:1041-1044. http://dx.doi.org/10.3201/eid2106.140717.
3. Denning DW, Bowyer P. 2013. Voriconazole resistance in Aspergillus fumigatus: should we be concerned? Clin Infect Dis 57:521-523. http://dx.doi.org/10.1093/cid/cit321.
4. Mellado E, Garcia-Effron G, Alcázar-Fuoli L, Melchers WJ, Verweij PE, Cuenca-Estrella M, Rodríguez-Tudela JL. 2007. A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations. Antimicrob Agents Chemother 51:1897-1904. http://dx.doi.org/10.1128/AAC.01092-06.
5. Verweij PE, Te Dorsthorst DT, Rijs AJ, De Vries-Hospers HG, Meis JF. 2002. Nationwide survey of in vitro activities of itraconazole and voriconazole against clinical Aspergillus fumigatus isolates cultured between 1945 and 1998. J Clin Microbiol 40:2648-2650. http://dx.doi.org/10.1128/JCM.40.7.2648-2650.2002.
6. Snelders E, Camps SM, Karawajczyk A, Schaftenaar G, Kema GH, van der Lee HA, Klaassen CH, Melchers WJ, Verweij PE. 2012. Triazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatus. PLoS One 7:e31801. http://dx.doi.org/10.1371/journal.pone.0031801.
7. Verweij PE, Snelders E, Kema GH, Mellado E, Melchers WJ. 2009. Azole resistance in A. fumigatus: a side effect of environmental fungicide use? Lancet Infect Dis 9:789-795. http://dx.doi.org/10.1016/S1473-3099(09)70265-8.
8. Rodriguez-Tudela JL, Donnelly JP, Arendrup MC, Arikan S, Barchiesi F, Bille J, Chryssanthou E, Cuenca-Estrella M, Dannaoui E, Denning DW, Fegeler W, Gaustad P, Lass-Flörl C, Moore C, Richardson M, Schmalreck A, Velegraki A, Verweij P. 2008. EUCAST technical note on the method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for conidia-forming moulds. Clin Microbiol Infect 14:982-984. http://dx.doi.org/10.1111/j.1469-0691.2008.02086.x.
9. Arendrup MC, Cuenca-Estrella M, Lass-Florl C, Hope WW, European Committee on Antimicrobial Susceptibility Testing Subcommittee on Antifungal Susceptibility Testing. 2012. EUCAST technical note on Aspergillus and amphotericin B, itraconazole, and posaconazole. Clin Microbiol Infect 18:E248-E250. http://dx.doi.org/10.1111/j.1469-0691.2012.03890.x.
10. Hope WW, Cuenca-Estrella M, Lass-Florl C, Arendrup MC. 2013. EUCAST technical note on voriconazole and Aspergillus spp. Clin Microbiol Infect 19:E278-E280. http://dx.doi.org/10.1111/1469-0691.12148.
11. Prigitano A, Venier V, Cogliati M, De Lorenzis G, Esposto MC, Tortorano AM. 2014. Azole-resistant Aspergillus fumigatus in the environment of northern Italy, May 2011 to June 2012. Euro Surveill 19(12):pii=20747. http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20747.
12. de Valk HA, Meis JF, Curfs IM, Muehlethaler K, Mouton JW, Klaassen CH. 2005. Use of a novel panel of nine short tandem repeats for exact and high-resolution fingerprinting of Aspergillus fumigatus isolates. J Clin Microbiol 43:4112-4120. http://dx.doi.org/10.1128/JCM.43.8.4112-4120.2005.
13. Vermeulen E, Lagrou K, Verweij PE. 2013. Azole resistance in Aspergillus fumigatus: a growing public health concern. Curr Opin Infect Dis 26:493-500. http://dx.doi.org/10.1097/QCO.0000000000000005.