Vitamin D3 treatment of vitamin D–insufficient asthmatic patients does not alter immune cell function

Journal of Allergy and Clinical Immunology

Volumn 138, Issue 1, 2016, Pages 286-289.e9

  Reid, Brandy ^a   Girodet, Pierre Olivier ^b,c   Boomer, Jonathan S ^a   Abdel Gadir, Azza ^d   Zheng, Kathy ^b   Wechsler, Michael E ^e   Bacharier, Leonard B ^a   Kunselman, Susan J ^f   King, Tonya S ^f   Israel, Elliot ^b   Castro, Mario ^a   Cernadas, Manuela ^b   Green, Jonathan M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c UNIVERSITÉ DE BORDEAUX   (France)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e DEPARTMENT OF MEDICINE   (United States)

^f PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D 3 1ALPHA HYDROXYLASE; COLECALCIFEROL; CORTICOSTEROID; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 12P40; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR; IFNG PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; ASTHMA; CD4+ T LYMPHOCYTE; CYTOKINE RELEASE; HUMAN; IMMUNOCOMPETENT CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; VITAMIN D DEFICIENCY; COMPLICATION; CONTROLLED STUDY; DENDRITIC CELL; DRUG EFFECT; GENE EXPRESSION; GENETICS; IMMUNOLOGY; METABOLISM; MONOCYTE; RANDOMIZED CONTROLLED TRIAL;

ADRENAL CORTEX HORMONES; ASTHMA; CD4-POSITIVE T-LYMPHOCYTES; CHOLECALCIFEROL; DENDRITIC CELLS; GENE EXPRESSION; HUMANS; INTERFERON-GAMMA; INTERLEUKINS; MONOCYTES; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA; VITAMIN D DEFICIENCY;

EID: 84957921696     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.11.030     Document Type: Article

References (9)

1. 1 Paul, G., Brehm, J.M., Alcorn, J.F., Holguin, F., Aujla, S.J., Celedon, J.C., Vitamin D and asthma. Am J Respir Crit Care Med 185 (2012), 124–132.
2. 2 Xystrakis, E., Kusumakar, S., Boswell, S., Peek, E., Urry, Z., Richards, D.F., et al. Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients. J Clin Invest 116 (2006), 146–155.
3. 3 Gupta, A., Dimeloe, S., Richards, D.F., Chambers, E.S., Black, C., Urry, Z., et al. Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma. Thorax 69 (2014), 508–515.
4. 4 Jeffery, L.E., Burke, F., Mura, M., Zheng, Y., Qureshi, O.S., Hewison, M., et al. 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J Immunol 183 (2009), 5458–5467.
5. 5 Castro, M., King, T.S., Kunselman, S.J., Cabana, M.D., Denlinger, L., Holguin, F., et al. Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA 311 (2014), 2083–2091.
6. 6 Ginhoux, F., Jung, S., Monocytes and macrophages: developmental pathways and tissue homeostasis. Nat Rev Immunol 14 (2014), 392–404.
7. 7 Landsman, L., Bar-On, L., Zernecke, A., Kim, K.W., Krauthgamer, R., Shagdarsuren, E., et al. CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival. Blood 113 (2009), 963–972.
8. 8 Powe, C.E., Evans, M.K., Wenger, J., Zonderman, A.B., Berg, A.H., Nalls, M., et al. Vitamin D-binding protein and vitamin D status of black Americans and white Americans. N Engl J Med 369 (2013), 1991–2000.
9. 9 Adams, J.S., Ren, S., Liu, P.T., Chun, R.F., Lagishetty, V., Gombart, A.F., et al. Vitamin d-directed rheostatic regulation of monocyte antibacterial responses. J Immunol 182 (2009), 4289–4295.