Outcome of assisted reproductive technology in men with treated and untreated varicocele: Systematic review and meta-analysis

Asian Journal of Andrology

Volumn 18, Issue 2, 2016, Pages 254-258

  Esteves, Sandro C ^a   Roque, Matheus ^b   Agarwal, Ashok ^c  

^a Androfert   (Brazil)

^b ORIGEN   (Brazil)

^c Center for Reproductive Medicine   (United States)

Author keywords

assisted reproductive techniques; meta analysis; pregnancy outcome; systematic review; varicocele; varicocelectomy

Indexed keywords

BIRTH RATE; CONCEPTION; DNA FRAGMENTATION; HUMAN; INFERTILITY THERAPY; INTRACYTOPLASMIC SPERM INJECTION; MALE INFERTILITY; META ANALYSIS; OXIDATIVE STRESS; PREGNANCY OUTCOME; PREGNANCY RATE; RETROSPECTIVE STUDY; REVIEW; SEMEN ANALYSIS; SYSTEMATIC REVIEW; TREATMENT OUTCOME; VARICOCELE; VARICOCELECTOMY; COMPLICATION; FEMALE; INFERTILITY, MALE; MALE; PREGNANCY;

FEMALE; HUMANS; INFERTILITY, MALE; MALE; PREGNANCY; REPRODUCTIVE TECHNIQUES, ASSISTED; SEMEN ANALYSIS; TREATMENT OUTCOME; VARICOCELE;

EID: 84957873860     PISSN: 1008682X     EISSN: 17457262     Source Type: Journal    
DOI: 10.4103/1008-682X.163269     Document Type: Review

References (45)

1. Esteves SC, Miyaoka R, Agarwal A. An update on the clinical assessment of the infertile male. [Corrected]. Clinics (Sao Paulo) 2011; 66: 691-700.
2. Shiraishi K, Matsuyama H, Takihara H. Pathophysiology of varicocele in male infertility in the era of assisted reproductive technology. Int J Urol. 2012; 19: 538-50.
3. Masson P, Brannigan RE. The varicocele. Urol Clin North Am. 2014; 41: 129-44.
4. Agarwal A, Hamada A, Esteves SC. Insight into oxidative stress in varicocele-Associated male infertility: part 1. Nat Rev Urol. 2012; 9: 678-90.
5. Practice Committee of the American Society for Reproductive Medicine; Society for Male Reproduction, and Urology. Report on varicocele, and infertility: a committee opinion. Fertil Steril. 2014; 102: 1556-60.
6. Marmar JL, Agarwal A, Prabaskan S, Agarwal R, Short RA, et al. Reassessing the value of varicocelectomy as a treatment for male subfertility with a new meta-Analysis. Fertil Steril. 2007; 88: 639-48.
7. Kroese AC, de Lange NM, Collins J, Evers JL. Surgery or embolization for varicoceles in subfertile men. Cochrane Database Syst Rev. 2012; 10: CD000479.
8. Agarwal A, Prabakaran S, Allamaneni SS. Relationship between oxidative stress, varicocele, and infertility: a meta-Analysis. Reprod Biomed Online. 2006; 12: 630-3.
9. Blumer CG, Restelli AE, Giudice PT, Soler TB, Fraietta R, et al. Effect of varicocele on sperm function, and semen oxidative stress. BJU Int. 2012; 109: 259-65.
10. Wright C, Milne S, Leeson H. Sperm DNA damage caused by oxidative stress: modifiable clinical, lifestyle, and nutritional factors in male infertility. Reprod Biomed Online. 2012; 28: 684-703.
11. Esteves SC, Gosalvez J, Lopez-Fernandez C, Nunez-Calonge R, Caballero P, et al. Diagnostic accuracy of sperm DNA degradation index (DDSi) as a potential noninvasive biomarker to identify men with varicocele-Associated infertility. Int Urol Nephrol. 2015; 47: 1471-7.
12. Avendano C, Franchi A, Duran H, Oehninger S. DNA fragmentation of normal spermatozoa negatively impacts embryo quality, and intracytoplasmic sperm injection outcome. Fertil Steril. 2010; 94: 549-57.
13. Robinson L, Gallos ID, Conner SJ, Rajkhowa M, Miller D, et al. The effect of sperm DNA fragmentation on miscarriage rates: a systematic review, and meta-Analysis. Hum Reprod. 2012; 27: 2908-17.
14. Zini A, Blumenfeld A, Libman J, Willis J. Beneficial effect of microsurgical subinguinal varicocelectomy on human sperm DNA integrity. Hum Reprod. 2005; 20: 1018-21.
15. Agarwal A, Deepinder F, Cocuzza M, Agarwal R, Short RA, et al. Efficacy of varicocelectomy in improving semen parameters: new meta-Analytical approach. Urology. 2007; 70: 532-8.
16. McIntyre M, Hsieh TC, Lipshultz L. Varicocele repair in the era of modern assisted reproductive techniques. Curr Opin Urol. 2012; 22: 517-20.
17. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews, and meta-Analyses: the PRISMA statement. BMJ. 2009; 339: 332-9.
18. Miyaoka R, Esteves SC. A critical appraisal on the role of varicocele in male infertility. Adv Urol. 2012; 2012: 597495.
19. Zegers-Hochschild F, Adamson GD, de Mouzon J, Ishihara O, Mansour R, et al. International Committee for Monitoring Assisted Reproductive Technology (ICMART), and the World Health Organization (WHO) revised glossary of ART terminology, 2009. Fertil Steril. 2009; 92: 1520-4.
20. Higgins JP, Green S. Cochrane Handbook for Systematic Reviews of Interventions. Ver. 5.1.0. London: The Cochrane Colaboration; 2011.
21. Higgins JP, Thompson SG, Spiegelhalter DJ. A re-evaluation of random-effects meta-Analysis. J R Stat Soc Ser A Stat Soc. 2009; 172: 137-59.
22. Cocuzza M, Cocuzza MA, Bragais FM, Agarwal A. The role of varicocele repair in the new era of assisted reproductive technology. Clinics. 2008; 63: 395-404.
23. Zini A, Boman J, Baazeem A, Jarvi K, Libman J. Natural history of varicocele management in the era of intracytoplasmic sperm injection. Fertil Steril 2008a; 90: 2251-6.
24. Esteves SC, Oliveira FV, Bertolla RP. Clinical outcome of intracytoplasmic sperm injection in infertile men with treated, and untreated clinical varicocele. J Urol. 2010; 184: 1442-6.
25. Pasqualotto FF, Braga DP, Figueira RC, Setti AS, Iaconelli A Jr, et al. Varicocelectomy does not impact pregnancy outcomes following intracytoplasmic sperm injection procedures. J Androl. 2012; 33: 239-43.
26. Gokce MI, Gulpinar O, Suer E, Mermerkaya M, Aydos K, et al. Effect of performing varicocelectomy before intracytoplasmic sperm injection on clinical outcomes in non-Azoospermic males. Int Urol Nephrol. 2013; 45: 367-72.
27. Duran EH, Morshedi M, Taylor S, Oehninger S. Sperm DNA quality predicts intrauterine insemination outcome: a prospective cohort study. Hum Reprod. 2002; 17: 3122-8.
28. Benchaib M, Braun V, Lornage J, Hadj S, Salle B, et al. Sperm DNA fragmentation decreases the pregnancy rate in an assisted reproductive technique. Hum Reprod. 2003; 18: 1023-8.
29. Henkel R, Hajimohammad M, Stalf T, Hoogendijk C, Mehnert C, et al. Influence of deoxyribonucleic acid damage on fertilization, and pregnancy. Fertil Steril. 2004; 81: 965-72.
30. Virro MR, Larson-Cook KL, Evenson DP. Sperm chromatin structure assay (SCSA) parameters are related to fertilization, blastocyst development, and ongoing pregnancy in in vitro fertilization, and intracytoplasmic sperm injection cycles. Fertil Steril. 2004; 81: 1289-95.
31. Muriel L, Garrido N, Fernandez JL, Remohi J, Pellicer A, et al. Value of the sperm deoxyribonucleic acid fragmentation level, as measured by the sperm chromatin dispersion test, in the outcome of in vitro fertilization, and intracytoplasmic sperm injection. Fertil Steril. 2006; 85: 371-83.
32. Bungum M, Humaidan P, Axmon A, Spano M, Bungum L, et al. Sperm DNA integrity assessment in prediction of assisted reproduction technology outcome. Hum Reprod. 2007; 22: 174-9.
33. Caglar GS, Koster F, Schopper B, Asimakopoulos B, Nehls B, et al. Semen DNA fragmentation index, evaluated with both TUNEL, and Comet assay, and the ICI outcome. In Vivo. 2007; 21: 1075-80.
34. Lin M, Lee RK, Li S, Lu C, Sun F, et al. Sperm chromatin structure assay parameters are not related to fertilization rates, embryo quality, and pregnancy rates in in vitro fertilization, and intracytoplasmic sperm injection, but might be related to spontaneous abortion rates. Fertil Steril. 2008; 90: 352-9.
35. Nicopoullos JD, Gilling-Smith C, Almeida PA, Homa S, Norman-Taylor JQ, et al. Sperm DNA fragmentation in subfertile men: the effect on the outcome of intracytoplasmic sperm injection, and correlation with sperm variables. BJU Int. 2008; 101: 1553-60.
36. Zhao J, Zhang Q, Wang Y, Li Y. Whether sperm deoxyribonucleic acid fragmentation has an effect on pregnancy, and miscarriage after in vitro fertilization/intracytoplasmic sperm injection: a systematic review, and meta-Analysis. Fertil Steril. 2014; 102: 998-1005.
37. Lewis SE. Should sperm DNA fragmentation testing be included in the male infertility work-up?. Reprod Biomed Online. 2015; 31: 134-7.
38. Smit M, Romijn JC, Wildhagen MF, Veldhoven JL, Weber RF, et al. Decreased sperm DNA fragmentation after surgical varicocelectomy is associated with increased pregnancy rate. J Urol. 2010; 183: 270-4.
39. Wang YJ, Zhang RQ, Lin YJ, Zhang RG, Zhang WL. Relationship between varicocele, and sperm DNA damage, and the effect of varicocele repair: a meta-Analysis. Reprod Biomed Online. 2012; 25: 307-14.
40. Zini A, Boman JM, Belzile E, Ciampi A. Sperm DNA damage is associated with an increase risk of pregnancy loss after IVF, and ICSI: systematic review, and meta-Analysis. Hum Reprod. 2008; 23: 2663-8.
41. Tesarik J, Greco E, Mendoza C. Late, but not early, paternal effect on human embryo development is related to sperm DNA fragmentation. Hum Reprod. 2004; 19: 611-5.
42. Simon L, Murphy K, Shamsi MB, Liu L, Emery B, et al. Paternal influence of sperm DNA integrity on early embryonic development. Hum Reprod. 2014; 29: 2402-12.
43. Evenson D, Wixon R. Meta-Analysis of sperm DNA fragmentation using the sperm chromatin structure assay. Reprod Biomed Online. 2006; 12: 466-72.
44. Meseguer M, Martinez-Conejero JA, O'Connor JE, Pellicer A, Remohi J, et al. The significance of sperm DNA oxidation in embryo development, and reproductive outcome in an oocyte donation program: a new model to study a male infertility prognostic factor. Fertil Steril. 2008; 89: 1191-9.
45. Penson DF, Paltiel AD, Krumholz HM, Palter S. The cost-effectiveness of treatment for varicocele related infertility. J Urol. 2002; 168: 2490-4.