The sequential integration of pharmacotherapy and psychotherapy in the treatment of major depressive disorder: A meta-analysis of the sequential model and a critical review of the literature

American Journal of Psychiatry

Volumn 173, Issue 2, 2016, Pages 128-137

  Guidi, Jenny ^a   Tomba, Elena ^a   Fava, Giovanni A ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT;

ARTICLE; CLINICAL EFFECTIVENESS; COGNITIVE THERAPY; HUMAN; MAINTENANCE THERAPY; MAJOR DEPRESSION; META ANALYSIS; PRIORITY JOURNAL; PSYCHOTHERAPY; RANDOMIZED CONTROLLED TRIAL (TOPIC); RECURRENT DISEASE; RELAPSE; REMISSION; RISK REDUCTION; DEPRESSIVE DISORDER, MAJOR; MULTIMODALITY CANCER THERAPY; PROCEDURES; SECONDARY PREVENTION;

ANTIDEPRESSIVE AGENTS; COGNITIVE THERAPY; COMBINED MODALITY THERAPY; DEPRESSIVE DISORDER, MAJOR; HUMANS; PSYCHOTHERAPY; RECURRENCE; SECONDARY PREVENTION;

EID: 84957706069     PISSN: 0002953X     EISSN: 15357228     Source Type: Journal    
DOI: 10.1176/appi.ajp.2015.15040476     Document Type: Article

References (81)

1. Fava GA, Kellner R: Prodromal symptoms in affective disorders. Am J Psychiatry 1991; 148:823-830
2. Fava GA, GranDi S, Zielezny M, et al: Cognitive behavioral treatment of residual symptoms in primary major depressive disorder. Am J Psychiatry 1994; 151:1295-1299
3. Fava GA: Sequential treatment: a new way of integrating pharmacotherapy and psychotherapy. Psychother Psychosom 1999; 68:227-229
4. Fava GA,GranDi S, ZieleznyM,et al:Four-year outcomefor cognitive behavioral treatment of residual symptoms in major depression. Am J Psychiatry 1996; 153:945-947
5. Kupfer DJ: Maintenance treatment in recurrent depression: current and future directions: the first William Sargant Lecture. Br J Psychiatry 1992; 161:309-316
6. Carvalho AF, Berk M, Hyphantis TN, et al: The integrative management of treatment-resistant depression: a comprehensive review and perspectives. Psychother Psychosom 2014; 83:70-88
7. Fava GA, Tomba E: New modalities of assessment and treatment planning in depression: the sequential approach. CNS Drugs 2010; 24:453-465
8. GuiDi J, Fava GA, Fava M, et al: Efficacy of the sequential integration of psychotherapy and pharmacotherapy in major depressive disorder: a preliminary meta-analysis. Psychol Med 2011; 41:321-331
9. Pampallona S, Bollini P, TibaldiG, et al: Combinedpharmacotherapy and psychological treatment for depression: a systematic review. Arch Gen Psychiatry 2004; 61:714-719
10. Vittengl JR, Clark LA, Dunn TW, et al: Reducing relapse and recurrence in unipolar depression: a comparative meta-analysis of cognitive-behavioral therapy's effects. J Consult Clin Psychol 2007; 75:475-488
11. de Maat S, Dekker J, Schoevers R, et al: Short psychodynamic supportivepsychotherapy, antidepressants, andtheir combinationin the treatment of major depression: a mega-analysis based on three randomized clinical trials. Depress Anxiety 2008; 25:565-574
12. Imel ZE, Malterer MB, McKay KM, et al: A meta-analysis of psychotherapy and medication in unipolar depression and dysthymia. J Affect Disord 2008; 110:197-206
13. Beshai S, Dobson KS, Bockting CLH, et al: Relapse and recurrence prevention in depression: current research and future prospects. Clin Psychol Rev 2011; 31:1349-1360
14. Moher D, Liberati A, Tetzlaff J, et al: Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 2009; 62:1006-1012
15. Brakemeier EL, Merkl A, Wilbertz G, et al: Cognitive-behavioral therapy as continuation treatment to sustain response after electroconvulsive therapy in depression: a randomized controlled trial. Biol Psychiatry 2014; 76:194-202
16. Miller L, Weissman M: Interpersonal psychotherapy delivered over the telephone to recurrent depressives: a pilot study. Depress Anxiety 2002; 16:114-117
17. Holländare F, Johnsson S, Randestad M, et al: Randomized trial of Internet-based relapse prevention for partially remitted depression. Acta Psychiatr Scand 2011; 124:285-294
18. Jane-wit D, Horwitz RI, Concato J: Variation in results from randomized, controlled trials: stochastic or systematic? J Clin Epidemiol 2010; 63:56-63
19. Cochran WG: The combination of estimates from different experiments. Biometrics 1954; 10:101-129
20. Higgins JPT, Thompson SG: Quantifying heterogeneity in a metaanalysis. Stat Med 2002; 21:1539-1558
21. Begg C: Publication bias, in The Handbook of Research Synthesis. Edited by Cooper H, Hedges LV. New York, Russell Sage Foundation, 1994, pp 399-409
22. Egger M, Davey Smith G, Schneider M, et al: Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315:629-634
23. Fava GA, Rafanelli C, GranDi S, et al: Six-year outcome for cognitive behavioral treatment of residual symptoms in major depression. Am J Psychiatry 1998; 155:1443-1445
24. Fava GA, Ruini C, Rafanelli C, et al: Six-year outcome of cognitive behavior therapy for prevention of recurrent depression. Am J Psychiatry 2004; 161:1872-1876
25. Teasdale JD, Segal ZV, Williams JMG, et al: Prevention of relapse/ recurrence in major depression by mindfulness-based cognitive therapy. J Consult Clin Psychol 2000; 68:615-623
26. PerlisRH,NierenbergAA, Alpert JE, et al: Effects of adding cognitive therapy to fluoxetine dose increase on risk of relapse and residual depressive symptoms in continuation treatment of major depressive disorder. J Clin Psychopharmacol 2002; 22:474-480
27. Ma SH, Teasdale JD: Mindfulness-based cognitive therapy for depression: replication and exploration of differential relapse prevention effects. J Consult Clin Psychol 2004; 72:31-40
28. Paykel ES, Scott J, Cornwall PL, et al: Duration of relapse prevention after cognitive therapy in residual depression: follow-up of controlled trial. Psychol Med 2005; 35:59-68
29. Bockting CLH, Spinhoven P, Koeter MWJ, et al: Prediction of recurrence in recurrent depression and the influence of consecutive episodes on vulnerability for depression: a 2-year prospective study. J Clin Psychiatry 2006; 67:747-755
30. Kuyken W, Byford S, Taylor RS, et al: Mindfulness-based cognitive therapy to prevent relapse in recurrent depression. J Consult Clin Psychol 2008; 76:966-978
31. Bondolfi G, Jermann F, der Linden MV, et al: Depression relapse prophylaxis with mindfulness-based cognitive therapy: replication and extension in the Swiss health care system. J Affect Disord 2010; 122:224-231
32. Godfrin KA, van Heeringen C: The effects of mindfulness-based cognitive therapy on recurrence of depressive episodes, mental health and quality of life: a randomized controlled study. Behav Res Ther 2010; 48:738-746
33. Segal ZV, Bieling P, Young T, et al: Antidepressant monotherapy vs sequential pharmacotherapy and mindfulness-based cognitive therapy, or placebo, for relapse prophylaxis in recurrent depression. Arch Gen Psychiatry 2010; 67:1256-1264
34. Stangier U, Hilling C, Heidenreich T, et al: Maintenance cognitivebehavioral therapy and manualized psychoeducation in the treatmentof recurrent depression: a multicenter prospective randomized controlled trial. Am J Psychiatry 2013; 170:624-632
35. Williams JMG, Crane C, Barnhofer T, et al: Mindfulness-based cognitive therapy for preventing relapse in recurrent depression: a randomized dismantling trial. J Consult Clin Psychol 2014; 82:275-286
36. American Psychiatric Association Work Group on Major Depressive Disorder: Practice guideline for the treatment of patients with major depressive disorder, 3rd ed. Washington, DC, American Psychiatric Association Publishing, 2010
37. Raue PJ, Schulberg HC, Heo M, et al: Patients' depression treatment preferences and initiation, adherence, and outcome: a randomized primary care study. Psychiatr Serv 2009; 60:337-343
38. Kocsis JH, Leon AC, Markowitz JC, et al: Patient preference as a moderator of outcome for chronic forms of major depressive disorder treated with nefazodone, cognitive behavioral analysis system of psychotherapy, or their combination. J Clin Psychiatry 2009; 70:354-361
39. Mergl R, Henkel V, Allgaier AK, et al: Are treatment preferences relevant in response to serotonergic antidepressants and cognitive behavioral therapy in depressed primary patients? Psychother Psychosom 2010; 79:131-135
40. Tomba E, Fava GA: Treatment selection in depression: the role of clinical judgment. Psychiatr Clin North Am 2012; 35:87-98
41. Fournier JC, DeRubeis RJ, Hollon SD, et al: Antidepressant drug effects and depression severity: a patient-level meta-analysis. JAMA 2010; 303:47-53
42. El-Mallakh RS, Briscoe B: Studies of long-term use of antidepressants: how should the data from them be interpreted? CNS Drugs 2012; 26:97-109
43. Paykel ES, Hollyman JA, Freeling P, et al: Predictors of therapeutic benefit from amitriptyline in mild depression: a general practice placebo-controlled trial. J Affect Disord 1988; 14:83-95
44. NICE Clinical Guidelines: Depression in adults: the treatment and management of depression in adults. www. nice. org. uk/CG90
45. Moret C, Isaac M, Briley M: Problems associated with long-term treatment with selective serotonin reuptake inhibitors. J Psychopharmacol 2009; 23:967-974
46. Nieuwstraten C, Labiris NR, Holbrook A: Systematic overview of drug interactions with antidepressant medications. Can J Psychiatry 2006; 51:300-316
47. Fava GA, Gatti A, Belaise C, et al: Withdrawal symptoms after selective serotonin reuptake inhibitor discontinuation: a systematic review. Psychother Psychosom 2015; 84:72-81
48. Chouinard G, Chouinard VA: New classification of selective serotonin reuptake inhibitor withdrawal. Psychother Psychosom 2015; 84:63-71
49. Cuijpers P, Dekker J, Hollon SD, et al: Adding psychotherapy to pharmacotherapy in the treatment of depressive disorders in adults: a meta-analysis. J Clin Psychiatry 2009; 70:1219-1229
50. Cuijpers P, van Straten A, Hollon SD, et al: The contribution of active medication to combined treatments of psychotherapy and pharmacotherapy for adult depression: a meta-analysis. Acta Psychiatr Scand 2010; 121:415-423
51. Biesheuvel-LeliefeldKE,KokGD,BocktingCL, et al: Effectivenessof psychological interventions in preventing recurrence of depressive disorder: meta-analysis and meta-regression. J Affect Disord 2015; 174:400-410
52. Forand NR, DeRubeis RJ, Amsterdam JD: Combining medication and psychotherapy in the treatment of major mental disorders, in Bergin and Garfield's Handbook of Psychotherapy and Behavior Change, 6th ed. Edited by Lambert MJ. Hoboken, NJ, Wiley, 2013, pp 735-774
53. Hollon SD, DeRubeis RJ, Fawcett J, et al: Effect of cognitive therapy with antidepressant medications vs antidepressants alone on the rate of recovery inmajor depressive disorder: a randomized clinical trial. JAMA Psychiatry 2014; 71:1157-1164
54. Thase ME: Large-scale study suggests specific indicators for combined cognitive therapy and pharmacotherapy in major depressive disorder. JAMA Psychiatry 2014; 71:1101-1102
55. Keller MB, McCullough JP, Klein DN, et al: A comparison of nefazodone, the cognitive behavioral-analysis system of psychotherapy, and their combination for the treatment of chronic depression. N Engl J Med 2000; 342:1462-1470
56. Wiersma JE, Van Schaik DJ, Hoogendorn AW, et al: The effectiveness of the cognitive behavioral analysis system of psychotherapy for chronic depression: a randomized controlled trial. Psychother Psychosom 2014; 83:263-269
57. Cuijpers P, Geraedts AS, van Oppen P, et al: Interpersonal psychotherapy for depression: a meta-analysis. Am J Psychiatry 2011; 168:581-592
58. Sterne JAC, Egger M, Smith GD: Investigating and dealing with publication and other biases, in Systematic Reviews in Health Care: Meta-Analysis in Context, 2nd ed. Edited by Egger M, Smith GD, Altman DG. London, BMJ Books, 2001, pp 189-208
59. Zilcha-Mano S, Roose SP, Barber JP, et al: Therapeutic alliance in antidepressant treatment: cause or effect of symptomatic levels? Psychother Psychosom 2015; 84:177-182
60. Bech P: Measurement of psychological distress and well-being. Psychother Psychosom 1990; 54:77-89
61. Segal ZV, Pearson JL, Thase ME: Challenges in preventing relapse in major depression: report of a National Institute of Mental Health Workshop on state of the science of relapse prevention in major depression. J Affect Disord 2003; 77:97-108
62. Reus VI, Weingartner H, Post RM: Clinical implications of statedependent learning. Am J Psychiatry 1979; 136:927-931
63. Scott J, Teasdale JD, Paykel ES, et al: Effects of cognitive therapy on psychological symptoms and social functioning in residual depression. Br J Psychiatry 2000; 177:440-446
64. Petersen T, Harley R, Papakostas GI, et al: Continuation cognitivebehavioural therapy maintains attributional style improvement in depressed patients responding acutely to fluoxetine. Psychol Med 2004; 34:555-561
65. Paykel ES, Ramana R, Cooper Z, et al: Residual symptoms after partial remission: an important outcome in depression. PsycholMed 1995; 25:1171-1180
66. Judd LL, Paulus MP, Zeller P: The role of residual subthreshold depressive symptoms in early episode relapse in unipolar major depressive disorder. Arch Gen Psychiatry 1999; 56:764-765
67. Cosci F, Fava GA: Staging of mental disorders: systematic review. Psychother Psychosom 2013; 82:20-34
68. Fava GA, Tomba E: Treatment of comorbid anxiety disorders and depression, in The Wiley Handbook of Anxiety Disorders. Edited by Emmelkamp PMG, Ehring T. Chichester, Wiley, 2014, pp 1165-1182
69. Goldapple K, Segal Z, Garson C, et al: Modulation of cortical-limbic pathwaysin majordepression: treatment-specific effects of cognitive behavior therapy. Arch Gen Psychiatry 2004; 61:34-41
70. Karlsson H, Hirvonen J, Salminen J, et al: Increased serotonin receptor 1A binding in major depressive disorder after psychotherapy, but not after SSRI pharmacotherapy, is related to improved social functioning capacity. Psychother Psychosom 2013; 82:260-261
71. Abdallah CG, NiciuMJ, Fenton LR, et al: Decreased occipital cortical glutamate levels in response to successful cognitive-behavioral therapy and pharmacotherapy for major depressive disorder. Psychother Psychosom 2014; 83:298-307
72. Roffman JL, Witte JM, Tanner AS, et al: Neural predictors of successful brief psychodynamic psychotherapy for persistent depression. Psychother Psychosom 2014; 83:364-370
73. SegalZV,WilliamsJMG,Teasdale JD: Mindfulness-Based Cognitive Therapy for Depression. New York, Guilford Press, 2002
74. Fava GA, Tomba E: Increasing psychological well-being and resilience by psychotherapeutic methods. J Pers 2009; 77: 1903-1934
75. Fava GA: Rational use of antidepressant drugs. Psychother Psychosom 2014; 83:197-204
76. Kaymaz N, van Os J, Loonen AJ, et al: Evidence that patients with single versus recurrent depressive episodes are differentially sensitive to treatment discontinuation: a meta-analysis of placebo-controlled randomized trials. J Clin Psychiatry 2008; 69:1423-1436
77. Judd LL, Paulus MJ, Schettler PJ, et al: Does incomplete recovery from first lifetime major depressive episode herald a chronic course of illness? Am J Psychiatry 2000; 157:1501-1504
78. Belaise C, Gatti A, Chouinard VA, et al: Persistent postwithdrawal disorders induced by paroxetine, a selective serotonin reuptake inhibitor, and treated with specific cognitive behavioral therapy. Psychother Psychosom 2014; 83:247-248
79. Fava GA, Ruini C, Rafanelli C, et al: Cognitive behavior approach to loss of clinical effect during long-term antidepressant treatment: a pilot study. Am J Psychiatry 2002; 159:2094-2095
80. Fabbri S, Fava GA, Rafanelli C, et al: Family intervention approach to loss of clinical effect during long-term antidepressant treatment: a pilot study. J Clin Psychiatry 2007; 68:1348-1351
81. Phillips ML, Chase HW, Sheline YI, et al: Identifying predictors, moderators, and mediators of antidepressant response in major depressive disorder: neuroimaging approaches. Am J Psychiatry 2015; 172:124-138