Therapeutic alliance in antidepressant treatment: Cause or effect of symptomatic levels?

Psychotherapy and Psychosomatics

Volumn 84, Issue 3, 2015, Pages 177-182

  Zilcha Mano, Sigal ^a   Roose, Steven P ^c   Barber, Jacques P ^b   Rutherford, Bret R ^c  

^a UNIVERSITY OF HAIFA   (Israel)

^b ADELPHI UNIVERSITY   (United States)

^c NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

Alliance; Antidepressant treatment; Depression; Placebo effect; Psychopharmacology; Therapy process

Indexed keywords

ANTIDEPRESSANT AGENT; CITALOPRAM; ESCITALOPRAM; PLACEBO;

ADULT; AGED; ARTICLE; CALIFORNIA PSYCHOTHERAPY ALLIANCE SCALE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DEPENDENT VARIABLE; DISEASE CONTROL; DRUG EFFICACY; EXPLORATORY RESEARCH; FEMALE; HAMILTON DEPRESSION RATING SCALE; HUMAN; LIFE EXPECTANCY; LONGITUDINAL STUDY; MAJOR DEPRESSION; MALE; MENTAL PATIENT; PHYSICIAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; PSYCHOLOGICAL RATING SCALE; PSYCHOPHARMACOLOGY; PSYCHOPHARMACOTHERAPY; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; SINGLE BLIND PROCEDURE; SYMPTOM; TREATMENT DURATION; TREATMENT OUTCOME; ADOLESCENT; DEPRESSIVE DISORDER, MAJOR; HUMAN RELATION; MIDDLE AGED; PSYCHOLOGY;

ADOLESCENT; ADULT; AGED; ANTIDEPRESSIVE AGENTS; DEPRESSIVE DISORDER, MAJOR; FEMALE; HUMANS; MALE; MIDDLE AGED; PROFESSIONAL-PATIENT RELATIONS; PSYCHOPHARMACOLOGY; TREATMENT OUTCOME;

EID: 84926163845     PISSN: 00333190     EISSN: 14230348     Source Type: Journal    
DOI: 10.1159/000379756     Document Type: Article

References (40)

1. Hatcher RL, Barends AW: How a return to theory could help alliance research. Psychotherapy 2006; 43: 292-299.
2. Bordin E: The generalizability of the psychoanalytic concept of the working alliance. Psychotherapy 1979; 16: 252-260.
3. Horvath AO, Del Re AC, Fluckiger C, Symonds D: Alliance in individual psychotherapy. Psychotherapy 2011; 48: 9-16.
4. DeRubeis RJ, Feeley M: Determinants of change in cognitive therapy for depression. Cognit Ther Res 1990; 14: 469-482.
5. Barber JP: Toward a working through of some core conflicts in psychotherapy research. Psychother Res 2009; 19: 1-12.
6. DeRubeis RJ, Brotman MA, Gibbons CJ: A conceptual and methodological analysis of the nonspecifics argument. J Clin Psychol 2005; 12: 174-183.
7. Barber JP, Luborsky L, Crits-Christoph P, Thase ME, Weiss R, Frank A, Onken LS, Gallop R: Therapeutic alliance as a predictor of outcome in treatment of cocaine dependence. Psychother Res 1999; 9: 54-73.
8. Barber JP, Connolly MB, Crits-Christoph P, Gladis L, Siqueland L: Alliance predicts patients' outcome beyond in-treatment change in symptoms. J Consult Clin Psychol 2000; 68: 1027-1032.
9. Zilcha-Mano S, Dinger U, McCarthy K, Barber J: Does alliance predict symptomatic change, or is it the other way around? J Consult Clin Psychol 2014; 82: 931-935.
10. Crits-Christoph P, Gibbons MBC, Mukherjee D: Psychotherapy process-outcome research; in Lambert MJ (ed.): Bergin and Garfield's Handbook of Psychotherapy and Behavior Vhange, ed 6. Hoboken, Wiley, 2013, pp 298-340.
11. Uhlenhuth EH, Rickels K, Fisher S, Park LC, Lipman RS, Mock J: Drug, doctor's verbal attitude and clinic setting in the symptomatic response to pharmacotherapy. Psychopharmacologia 1966; 9: 392-418.
12. Bech P: Karl Rickels: a tribute on his 90th birthday. Psychother Psychosom 2014; 83: 131-135.
13. Krupnick JL, Sotsky SM, Simmens S, Moyer J, Elkin I, Watkins J, Pilkonis PA: The role of the therapeutic alliance in psychotherapy and pharmacotherapy outcome: findings in the National Institute of Mental Health Treatment of Depression Collaborative Research Program. J Consult Clin Psychol 1996; 64: 532-539.
14. Wolfaardt UB, Reddon JR, Joyce AS: Assessing the efficacy of antidepressants: the transactional paradigm. Med. Hypotheses 2005; 64: 1229-1236.
15. Ekeland T: The healing context and efficacy in psychotherapy: psychotherapy and placebo phenomenon. Int J Psychother 1997; 2: 77-87.
16. Marshall M, Gray A, Lockwood A, Green R: Case management for people with severe mental disorders. Cochrane Database Syst Rev 2000; 2:CD0000050.
17. Dilallo JJ, Weiss G: Motivational interviewing and adolescent psychopharmacology. J Am Acad Child Adolesc Psychiatry 2009; 48: 108-113.
18. Strunk DR, Stewart MO, Hollon SD, DeRubeis RJ, Fawcett J, Amsterdam JD, Shelton RC: Can pharmacotherapists be too supportive? A process study of active medication and placebo in the treatment of depression. Psychol Med 2010; 40: 1379-1387.
19. Posternak MA, Zimmerman M: Therapeutic effect of follow-up assessments on antidepressant and placebo response rates in antidepressant efficacy trials: meta-analysis. J Ment Sci 2007; 190: 287-292.
20. Rutherford B, Sneed J, Devanand D, Eisenstadt R, Roose S: Antidepressant study design affects patient expectancy: a pilot study. Psychol Med 2010; 40: 781-788.
21. Rutherford BR, Marcus SM, Wang P, Sneed JR, Pelton G, Devanand D, Duan N, Roose SP: A randomized, prospective pilot study of patient expectancy and antidepressant outcome. Psychol Med 2013; 43: 975-982.
22. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR, ed 4. Washington, American Psychiatric Association, 2000.
23. Hamilton M: A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23: 56-62.
24. Guy W: Clinical Global Impressions. New Clinical Drug Evaluation Unit (ECDEU) Assessment Manual for Psychopharmacology. Rockville, National Institute of Mental Health, 1976, pp 218-222.
25. Gaston L, Marmar CR: The California Psychotherapy Alliance Scales; in Horvath AO, Greenberg LS (ed): The Working Alliance: Theory, Research, and Practice. Oxford, Wiley, 1994, pp 85-108.
26. First MB, Spitzer RL, Gibbon M, Williams JBW: Structured Clinical Interview for DSMIV Axis I Disorders, Clinician Version (SCIDCV). Washington, American Psychiatric Press, 1996.
27. Fawcett J, Epstein P, Fiester SJ, Elkin I, Autry JH: Clinical management - imipramine/placebo administration manual: NIMH Treatment of Depression Collaborative Research Program. Psychopharmacol Bull 1987; 23: 309-324.
28. Littell RC, Milliken GA, Stroup WW, Wolfinger RD, Schabenberger O: SAS for Mixed Models, ed 2. Cary, SAS Institute, 2006.
29. Collins LM, Sayer AG: New Methods for the Analysis of Change. Washington, American Psychological Association, 2001.
30. Zilcha-Mano S, Dinger U, McCarthy KS, Barrett MS, Barber JP: Changes in well-being and quality of life in a randomized trial comparing dynamic psychotherapy and pharmacotherapy for major depressive disorder. J Affect Disord 2014; 152: 538-542.
31. Curran PJ, Bauer DJ: The disaggregation of within-person and between-person effects in longitudinal models of change. Annu Rev Psychol 2011; 62: 583-619.
32. Raudenbush SW, Bryk AS: Hierarchical Linear Models, ed 2. Thousand Oaks, Sage, 2002.
33. Harrington A: The Placebo Effect. Cambridge, Harvard University Press, 1999.
34. Frank JD: Persuasion and Healing. Baltimore, Johns Hopkins University Press, 1961.
35. Rutherford BR, Roose SP: A model of placebo response in antidepressant clinical trials. Am J Psychiatry 2013; 170: 723-733.
36. Zilcha-Mano S, Barber J: Instability of depression severity at intake as a moderator of outcome in treatment for major depressive disorder. Psychother Psychosom 2014; 83: 382-383.
37. Papakostas GI, Fava M: Does the probability of receiving placebo influence clinical trial outcome? A meta-regression of double-blind, randomized clinical trials in MDD. Eur Neuropsychopharmacol 2009; 19: 34-40.
38. Fava GA, Guidi J, Rafanelli C, Sonino N: The clinical inadequacy of evidence-based medicine and the need for a conceptual framework based on clinical judgment. Psychother Psychosom 2015; 84: 1-3.
39. Kenny D, Harackiewicz J: Cross-lagged panel correlation: practice and promise. J Appl Psychol 1979; 64: 372-379.
40. Di Blasi Z, Kleijnen J: Context effects: powerful therapies or methodological bias? Eval Health Prof 2003; 26: 166-179.