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Volumn 47, Issue 7, 2015, Pages 622-628

Cancer stem cell markers in prostate cancer: An immunohistochemical study of ALDH1, SOX2 and EZH2

Author keywords

Adenocarcinoma; ALDH1; androgen receptor; cancer stem cell theory; cancer stem cells; EZH2; immunohistochemistry; prognostic markers; prostate cancer; SOX2

Indexed keywords

ALDEHYDE DEHYDROGENASE ISOENZYME 1; EZH2 PROTEIN, HUMAN; ISOENZYME; POLYCOMB REPRESSIVE COMPLEX 2; RETINAL DEHYDROGENASE; SOX2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR SOX; TUMOR MARKER;

EID: 84957647695     PISSN: 00313025     EISSN: 14653931     Source Type: Journal    
DOI: 10.1097/PAT.0000000000000325     Document Type: Article
Times cited : (44)

References (48)
  • 1
    • 0037079003 scopus 로고    scopus 로고
    • Rules for making human tumor cells
    • Hahn WC, Weinberg RA. Rules for making human tumor cells. N Engl J Med 2002; 347: 1593-603.
    • (2002) N Engl J Med , vol.347 , pp. 1593-1603
    • Hahn, W.C.1    Weinberg, R.A.2
  • 3
    • 0032870826 scopus 로고    scopus 로고
    • Stem cell features of benign and malignant prostate epithelial cells
    • De Marzo AM, Nelson WG, Meeker AK, Coffey DS. Stem cell features of benign and malignant prostate epithelial cells. J Urol 1998; 160: 2381-92.
    • (1998) J Urol , vol.160 , pp. 2381-2392
    • De Marzo, A.M.1    Nelson, W.G.2    Meeker, A.K.3    Coffey, D.S.4
  • 4
    • 78650035864 scopus 로고    scopus 로고
    • Cancer stem cells: Problems for therapy?
    • Alison MR, Lim SM, Nicholson LJ. Cancer stem cells: problems for therapy? J Pathol 2011; 223: 147-61.
    • (2011) J Pathol , vol.223 , pp. 147-161
    • Alison, M.R.1    Lim, S.M.2    Nicholson, L.J.3
  • 5
    • 84871484351 scopus 로고    scopus 로고
    • Thoughts about cancer stem cells in solid tumors
    • La Porta CA. Thoughts about cancer stem cells in solid tumors. World J Stem Cells 2012; 4: 17-20.
    • (2012) World J Stem Cells , vol.4 , pp. 17-20
    • La Porta, C.A.1
  • 7
    • 0027058140 scopus 로고
    • Retinal oxidation activity and biological role of human cytosolic aldehyde dehydrogenase
    • Yoshida A, Hsu LC, Dave V. Retinal oxidation activity and biological role of human cytosolic aldehyde dehydrogenase. Enzyme 1992; 46: 239-44.
    • (1992) Enzyme , vol.46 , pp. 239-244
    • Yoshida, A.1    Hsu, L.C.2    Dave, V.3
  • 8
    • 33751300540 scopus 로고    scopus 로고
    • RNAi-mediated knockdown of aldehyde dehydrogenase class-1A1 and class-3A1 is specific and reveals that each contributes equally to the resistance against 4-hydroperoxycyclophosphamide
    • Moreb JS, Mohuczy D, Ostmark B, Zucali JR. RNAi-mediated knockdown of aldehyde dehydrogenase class-1A1 and class-3A1 is specific and reveals that each contributes equally to the resistance against 4-hydroperoxycyclophosphamide. Cancer Chemother Pharmacol 2007; 59: 127-36.
    • (2007) Cancer Chemother Pharmacol , vol.59 , pp. 127-136
    • Moreb, J.S.1    Mohuczy, D.2    Ostmark, B.3    Zucali, J.R.4
  • 9
    • 10444269018 scopus 로고    scopus 로고
    • Phenotypic characterization of murine primitive hematopoietic progenitor cells isolated on basis of aldehyde dehydrogenase activity
    • Armstrong L, Stojkovic M, Dimmick I, et al. Phenotypic characterization of murine primitive hematopoietic progenitor cells isolated on basis of aldehyde dehydrogenase activity. Stem Cells 2004; 22: 1142-51.
    • (2004) Stem Cells , vol.22 , pp. 1142-1151
    • Armstrong, L.1    Stojkovic, M.2    Dimmick, I.3
  • 10
    • 34250732230 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase activity in leukemic blasts defines a subgroup of acute myeloid leukemia with adverse prognosis and superior NOD/SCID engrafting potential
    • Cheung AM, Wan TS, Leung JC, et al. Aldehyde dehydrogenase activity in leukemic blasts defines a subgroup of acute myeloid leukemia with adverse prognosis and superior NOD/SCID engrafting potential. Leukemia 2007; 21: 1423-30.
    • (2007) Leukemia , vol.21 , pp. 1423-1430
    • Cheung, A.M.1    Wan, T.S.2    Leung, J.C.3
  • 11
    • 84863690032 scopus 로고    scopus 로고
    • Prognostic impact of the cancer stem cell related markers ALDH1 and EZH2 in triple negative and basal-like breast cancers
    • De Brot M, Rocha RM, Soares FA, Gobbi H. Prognostic impact of the cancer stem cell related markers ALDH1 and EZH2 in triple negative and basal-like breast cancers. Pathology 2012; 44: 303-12.
    • (2012) Pathology , vol.44 , pp. 303-312
    • De Brot, M.1    Rocha, R.M.2    Soares, F.A.3    Gobbi, H.4
  • 12
    • 0027480124 scopus 로고
    • Biological role of human cytosolic aldehyde dehydrogenase 1: Hormonal response, retinal oxidation and implication in testicular feminization
    • Yoshida A, Hsu LC, Yanagawa Y. Biological role of human cytosolic aldehyde dehydrogenase 1: hormonal response, retinal oxidation and implication in testicular feminization. Adv Exp Med Biol 1993; 328: 37-44.
    • (1993) Adv Exp Med Biol , vol.328 , pp. 37-44
    • Yoshida, A.1    Hsu, L.C.2    Yanagawa, Y.3
  • 13
    • 75949101677 scopus 로고    scopus 로고
    • ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome
    • Li T, Su Y, Mei Y, et al. ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome. Lab Invest 2010; 90: 234-44.
    • (2010) Lab Invest , vol.90 , pp. 234-244
    • Li, T.1    Su, Y.2    Mei, Y.3
  • 14
    • 84862151498 scopus 로고    scopus 로고
    • Gene expression profiles of prostate cancer stem cells isolated by aldehyde dehydrogenase activity assay
    • Nishida S, Hirohashi Y, Torigoe T, et al. Gene expression profiles of prostate cancer stem cells isolated by aldehyde dehydrogenase activity assay. J Urol 2012; 188: 294-9.
    • (2012) J Urol , vol.188 , pp. 294-299
    • Nishida, S.1    Hirohashi, Y.2    Torigoe, T.3
  • 15
    • 77953789724 scopus 로고    scopus 로고
    • High aldehyde dehydrogenase activity identifies tumor-initiating and metastasis-initiating cells in human prostate cancer
    • van den Hoogen C, van der Horst G, Cheung H, et al. High aldehyde dehydrogenase activity identifies tumor-initiating and metastasis-initiating cells in human prostate cancer. Cancer Res 2010; 70: 5163-73.
    • (2010) Cancer Res , vol.70 , pp. 5163-5173
    • Van Den Hoogen, C.1    Van Der Horst, G.2    Cheung, H.3
  • 16
    • 0030588658 scopus 로고    scopus 로고
    • Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22. 2
    • Chen H, Rossier C, Antonarakis SE. Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22. 2. Genomics 1996; 38: 30-7.
    • (1996) Genomics , vol.38 , pp. 30-37
    • Chen, H.1    Rossier, C.2    Antonarakis, S.E.3
  • 17
    • 79957563769 scopus 로고    scopus 로고
    • The roles of EZH2 in cell lineage commitment
    • Chou RH, Yu YL, Hung MC. The roles of EZH2 in cell lineage commitment. Am J Transl Res 2011; 3: 243-50.
    • (2011) Am J Transl Res , vol.3 , pp. 243-250
    • Chou, R.H.1    Yu, Y.L.2    Hung, M.C.3
  • 18
    • 84877065166 scopus 로고    scopus 로고
    • EZH2, an epigenetic driver of prostate cancer
    • Yang YA, Yu J. EZH2, an epigenetic driver of prostate cancer. Protein Cell 2013; 4: 331-41.
    • (2013) Protein Cell , vol.4 , pp. 331-341
    • Yang, Y.A.1    Yu, J.2
  • 19
  • 20
    • 33644822360 scopus 로고    scopus 로고
    • EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast
    • Bachmann IM, Halvorsen OJ, Collett K, et al. EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. J Clin Oncol 2006; 24: 268-73.
    • (2006) J Clin Oncol , vol.24 , pp. 268-273
    • Bachmann, I.M.1    Halvorsen, O.J.2    Collett, K.3
  • 22
    • 25144525014 scopus 로고    scopus 로고
    • Core transcriptional regulatory circuitry in human embryonic stem cells
    • Boyer LA, Lee TI, Cole MF, et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 2005; 122: 947-56.
    • (2005) Cell , vol.122 , pp. 947-956
    • Boyer, L.A.1    Lee, T.I.2    Cole, M.F.3
  • 23
    • 84884739559 scopus 로고    scopus 로고
    • SOX2 plays a critical role in EGFR-mediated self-renewal of human prostate cancer stem-like cells
    • Rybak AP, Tang D. SOX2 plays a critical role in EGFR-mediated self-renewal of human prostate cancer stem-like cells. Cell Signal 2013; 25: 2734-42.
    • (2013) Cell Signal , vol.25 , pp. 2734-2742
    • Rybak, A.P.1    Tang, D.2
  • 24
    • 80051654241 scopus 로고    scopus 로고
    • SOX2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cell
    • Jia X, Li X, Xu Y, et al. SOX2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cell. J Mol Cell Biol 2011; 3: 230-8.
    • (2011) J Mol Cell Biol , vol.3 , pp. 230-238
    • Jia, X.1    Li, X.2    Xu, Y.3
  • 27
    • 84871922236 scopus 로고    scopus 로고
    • Prostate cancer: Time for active surveillance of intermediate-risk disease?
    • Ahmed HU. Prostate cancer: Time for active surveillance of intermediate-risk disease? Nat Rev Urol 2013; 10: 6-8.
    • (2013) Nat Rev Urol , vol.10 , pp. 6-8
    • Ahmed, H.U.1
  • 28
    • 84868563896 scopus 로고    scopus 로고
    • Active surveillance for prostate cancer: A systematic review of the literature
    • Dall'Era MA, Albertsen PC, Bangma C, et al. Active surveillance for prostate cancer: a systematic review of the literature. Eur Urol 2012; 62: 976-83.
    • (2012) Eur Urol , vol.62 , pp. 976-983
    • Dall'Era, M.A.1    Albertsen, P.C.2    Bangma, C.3
  • 29
    • 69749118207 scopus 로고    scopus 로고
    • Tertiary Gleason patterns and biochemical recurrence after prostatectomy: Proposal for a modified Gleason scoring system
    • Trock BJ, Guo CC, Gonzalgo ML, Magheli A, Loeb S, Epstein JI. Tertiary Gleason patterns and biochemical recurrence after prostatectomy: proposal for a modified Gleason scoring system. J Urol 2009; 182: 1364-70.
    • (2009) J Urol , vol.182 , pp. 1364-1370
    • Trock, B.J.1    Guo, C.C.2    Gonzalgo, M.L.3    Magheli, A.4    Loeb, S.5    Epstein, J.I.6
  • 30
    • 0027267407 scopus 로고
    • Influence of capsular penetration on progression following radical prostatectomy: A study of 196 cases with long-term followup
    • Epstein JI, Carmichael MJ, Pizov G, Walsh PC. Influence of capsular penetration on progression following radical prostatectomy: a study of 196 cases with long-term followup. J Urol 1993; 150: 135-41.
    • (1993) J Urol , vol.150 , pp. 135-141
    • Epstein, J.I.1    Carmichael, M.J.2    Pizov, G.3    Walsh, P.C.4
  • 32
    • 0031879963 scopus 로고    scopus 로고
    • Clinical and pathological significance of the level and extent of capsular invasion in clinical stage T1-2 prostate cancer
    • Wheeler TM, Dillioglugil O, Kattan MW, et al. Clinical and pathological significance of the level and extent of capsular invasion in clinical stage T1-2 prostate cancer. Hum Pathol 1998; 29: 856-62.
    • (1998) Hum Pathol , vol.29 , pp. 856-862
    • Wheeler, T.M.1    Dillioglugil, O.2    Kattan, M.W.3
  • 33
    • 85030374053 scopus 로고    scopus 로고
    • ALDH1A1 as a marker of stem cells in prostate cancer: Correlation with Gleason scores and tumor stage and relevance for patient outcome
    • Bremer B, Tacha D. ALDH1A1 as a marker of stem cells in prostate cancer: correlation with Gleason scores and tumor stage and relevance for patient outcome. Arch Pathol Lab Med 2011; 135: 1102-230; (Abstr 761).
    • (2011) Arch Pathol Lab Med , vol.135 , pp. 1102-1230
    • Bremer, B.1    Tacha, D.2
  • 34
    • 84886407605 scopus 로고    scopus 로고
    • Characterization and clinical relevance of ALDHbright populations in prostate cancer
    • Le Magnen C, Bubendorf L, Rentsch CA, et al. Characterization and clinical relevance of ALDHbright populations in prostate cancer. Clin Cancer Res 2013; 19: 5361-71.
    • (2013) Clin Cancer Res , vol.19 , pp. 5361-5371
    • Le Magnen, C.1    Bubendorf, L.2    Rentsch, C.A.3
  • 35
    • 0035170731 scopus 로고    scopus 로고
    • Reactive stroma in prostate cancer progression
    • Tuxhorn JA, Ayala GE, Rowley DR. Reactive stroma in prostate cancer progression. J Urol 2001; 166: 2472-83.
    • (2001) J Urol , vol.166 , pp. 2472-2483
    • Tuxhorn, J.A.1    Ayala, G.E.2    Rowley, D.R.3
  • 36
    • 10344234761 scopus 로고    scopus 로고
    • Molecular insights into prostate cancer progression: The missing link of tumor microenvironment
    • Chung LW, Baseman A, Assikis V, Zhau HE. Molecular insights into prostate cancer progression: the missing link of tumor microenvironment. J Urol 2005; 173: 10-20.
    • (2005) J Urol , vol.173 , pp. 10-20
    • Chung, L.W.1    Baseman, A.2    Assikis, V.3    Zhau, H.E.4
  • 37
    • 85030376700 scopus 로고    scopus 로고
    • Genes upregulated in prostate cancer reactive stroma promote prostate cancer progression in vivo
    • Dakhova O, Rowley D, Ittmann M. Genes upregulated in prostate cancer reactive stroma promote prostate cancer progression in vivo. Clin Cancer Res 2013; 22: 22.
    • (2013) Clin Cancer Res , vol.22 , pp. 22
    • Dakhova, O.1    Rowley, D.2    Ittmann, M.3
  • 38
    • 77953847706 scopus 로고    scopus 로고
    • The value of EZH2, p27(kip1), BMI-1 and MIB-1 on biopsy specimens with low-risk prostate cancer in selecting men with significant prostate cancer at prostatectomy
    • Wolters T, Vissers KJ, Bangma CH, Schroder FH, van Leenders GJ. The value of EZH2, p27(kip1), BMI-1 and MIB-1 on biopsy specimens with low-risk prostate cancer in selecting men with significant prostate cancer at prostatectomy. BJU Int 2010; 106: 280-6.
    • (2010) BJU Int , vol.106 , pp. 280-286
    • Wolters, T.1    Vissers, K.J.2    Bangma, C.H.3    Schroder, F.H.4    Van Leenders, G.J.5
  • 40
    • 18644382388 scopus 로고    scopus 로고
    • The polycomb group protein EZH2 is involved in progression of prostate cancer
    • Varambally S, Dhanasekaran SM, Zhou M, et al. The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 2002; 419: 624-9.
    • (2002) Nature , vol.419 , pp. 624-629
    • Varambally, S.1    Dhanasekaran, S.M.2    Zhou, M.3
  • 41
    • 0037846472 scopus 로고    scopus 로고
    • Multiplex biomarker approach for determining risk of prostate-specific antigen-defined recurrence of prostate cancer
    • Rhodes DR, Sanda MG, Otte AP, Chinnaiyan AM, Rubin MA. Multiplex biomarker approach for determining risk of prostate-specific antigen-defined recurrence of prostate cancer. J Natl Cancer Inst 2003; 95: 661-8.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 661-668
    • Rhodes, D.R.1    Sanda, M.G.2    Otte, A.P.3    Chinnaiyan, A.M.4    Rubin, M.A.5
  • 42
    • 77950874502 scopus 로고    scopus 로고
    • Comprehensive evaluation of the role of EZH2 in the growth, invasion, and aggression of a panel of prostate cancer cell lines
    • Karanikolas BD, Figueiredo ML, Wu L. Comprehensive evaluation of the role of EZH2 in the growth, invasion, and aggression of a panel of prostate cancer cell lines. Prostate 2010; 70: 675-88.
    • (2010) Prostate , vol.70 , pp. 675-688
    • Karanikolas, B.D.1    Figueiredo, M.L.2    Wu, L.3
  • 43
    • 33646596977 scopus 로고    scopus 로고
    • The gene for polycomb group protein enhancer of zeste homolog 2 (EZH2) is amplified in late-stage prostate cancer
    • Saramaki OR, Tammela TL, Martikainen PM, Vessella RL, Visakorpi T. The gene for polycomb group protein enhancer of zeste homolog 2 (EZH2) is amplified in late-stage prostate cancer. Genes Chromosomes Cancer 2006; 45: 639-45.
    • (2006) Genes Chromosomes Cancer , vol.45 , pp. 639-645
    • Saramaki, O.R.1    Tammela, T.L.2    Martikainen, P.M.3    Vessella, R.L.4    Visakorpi, T.5
  • 44
    • 84890462644 scopus 로고    scopus 로고
    • Triptolide inhibits histone methyltransferase EZH2 and modulates the expression of its target genes in prostate cancer cells
    • Tamgue O, Chai CS, Hao L, et al. Triptolide inhibits histone methyltransferase EZH2 and modulates the expression of its target genes in prostate cancer cells. Asian Pac J Cancer Prev 2013; 14: 5663-9.
    • (2013) Asian Pac J Cancer Prev , vol.14 , pp. 5663-5669
    • Tamgue, O.1    Chai, C.S.2    Hao, L.3
  • 46
    • 42549118037 scopus 로고    scopus 로고
    • Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer
    • Hoffmann MJ, Engers R, Florl AR, Otte AP, Muller M, Schulz WA. Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer. Cancer Biol Ther 2007; 6: 1403-12.
    • (2007) Cancer Biol Ther , vol.6 , pp. 1403-1412
    • Hoffmann, M.J.1    Engers, R.2    Florl, A.R.3    Otte, A.P.4    Muller, M.5    Schulz, W.A.6
  • 47
    • 84872241633 scopus 로고    scopus 로고
    • Sox2 is an androgen receptor-repressed gene that promotes castration-resistant prostate cancer
    • Kregel S, Kiriluk KJ, Rosen AM, et al. Sox2 is an androgen receptor-repressed gene that promotes castration-resistant prostate cancer. PLoS One 2013; 8: 11.
    • (2013) PLoS One , vol.8 , pp. 11
    • Kregel, S.1    Kiriluk, K.J.2    Rosen, A.M.3
  • 48
    • 84879782687 scopus 로고    scopus 로고
    • SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/beta-catenin signal network
    • Li X, Xu Y, Chen Y, et al. SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/beta-catenin signal network. Cancer Lett 2013; 336: 379-89.
    • (2013) Cancer Lett , vol.336 , pp. 379-389
    • Li, X.1    Xu, Y.2    Chen, Y.3


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