Mother-to-child transmission of HTLV-1 epidemiological aspects, mechanisms and determinants of mother-to-child transmission

Viruses

Volumn 8, Issue 2, 2016, Pages

  Percher, Florent ^a,b,c   Jeannin, Patricia ^a,b   Martin Latil, Sandra ^d   Gessain, Antoine ^a,b   Afonso, Philippe V ^a,b   Vidy Roche, Aurore ^a,b,c   Ceccaldi, Pierre Emmanuel ^a,b,c  

^a INSTITUT PASTEUR   (France)

^b CNRS   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d FRENCH AGENCY FOR FOOD   (France)

Author keywords

Breastfeeding; HTLV 1; Human; Intestinal barrier; Retrovirus

Indexed keywords

CD45 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTOFERRIN;

ANTIBODY TITER; BREAST FEEDING; CHROMOSOME 6Q; CONFOCAL MICROSCOPY; GENETIC PREDISPOSITION; HEREDITY; HUMAN; HUMAN T CELL LEUKEMIA VIRUS INFECTION; HUMAN T-LYMPHOTROPIC VIRUS 1; IN SITU HYBRIDIZATION; LACTATION; LONG TERMINAL REPEAT; MOTHER CHILD RELATION; NONHUMAN; PASSIVE IMMUNIZATION; POLYMERASE CHAIN REACTION; REVIEW; SOCIAL DETERMINANTS OF HEALTH; TRANSCYTOSIS; VIRUS LOAD; VIRUS TRANSMISSION; ADULT; FEMALE; GENETICS; HTLV-I INFECTIONS; INFANT; MALE; PHYSIOLOGY; TRANSMISSION; VERTICAL TRANSMISSION; VIROLOGY;

ADULT; FEMALE; HTLV-I INFECTIONS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; INFANT; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MALE;

EID: 84957606227     PISSN: None     EISSN: 19994915     Source Type: Journal    
DOI: 10.3390/v8020040     Document Type: Review

References (72)

1. Gessain, A.; Cassar, O. Epidemiological aspects and world distribution of HTLV-1 Infection. Front. Microbiol. 2012, 3, 1-23. [CrossRef] [PubMed].
2. Richardson, J.H.; Edwards, A.J.; Cruickshank, J.K.; Rudge, P.; Dalgleish, A.G. In vivo cellular tropism of human T-cell leukemia virus type 1. J. Virol. 1990, 64, 5682-5687. [PubMed].
3. Nagai, M.; Brennan, M.B.; Sakai, J.A.; Mora, C.A.; Jacobson, S. CD8+ T cells are an in vivo reservoir for human T-cell lymphotropic virus type I. Blood 2001, 98, 1858-1861. [CrossRef] [PubMed].
4. Koyanagi, Y.; Yoshida, T.; Suzuki, M.; Uma, A.; Ananthasubramaniam, L.; Ramajayam, S.; Yamamoto, N. Dual infection of HIV-1 and HTLV-I in south India: A study on a patient with AIDS-related complex. Microbiol. Immunol. 1993, 37, 983-986. [CrossRef] [PubMed].
5. Afonso, P.V.; Ozden, S.; Cumont, M.C.; Seilhean, D.; Cartier, L.; Rezaie, P.; Mason, S.; Lambert, S.; Huerre, M.; Gessain, A. et al. Alteration of blood-brain barrier integrity by retroviral infection. PLoS Pathog. 2008, 4, e1000205. [CrossRef] [PubMed].
6. Carneiro-Proietti, A.B.; Amaranto-Damasio, M.S.; Leal-Horiguchi, C.F.; Bastos, R.H.; Seabra-Freitas, G.; Borowiak, D.R.; Ribeiro, M.A.; Proietti, F.A.; Ferreira, A.S.; Martins, M.L. Mother-to-Child transmission of human T-Cell lymphotropic viruses-1/2: What we know, and what are the gaps in understanding and preventing this route of infection. J. Pediatr. Infect. Dis. Soc. 2014, 3 (Suppl. 1), S24-S29. [CrossRef] [PubMed].
7. Murphy, E.L.; Hanchard, B.; Figueroa, J.P.; Gibbs, W.N.; Lofters, W.S.; Campbell, M.; Goedert, J.J.; Blattner, W.A. Modelling the risk of adult T-cell leukemia/lymphoma in persons infected with human T-lymphotropic virus type I. Int. J. Cancer 1989, 43, 250-253. [CrossRef] [PubMed].
8. Ando, Y.; Nakano, S.; Saito, K.; Shimamoto, I.; Ichijo, M.; Toyama, T.; Hinuma, Y. Transmission of adult T-cell leukemia retrovirus (HTLV-I) from mother to child: Comparison of bottle- with breast-fed babies. Jpn. J. Cancer Res. 1987, 78, 322-324. [PubMed].
9. Hino, S.; Sugiyama, H.; Doi, H.; Ishimaru, T.; Yamabe, T.; Tsuji, Y.; Miyamoto, T. Breaking the cycle of HTLV-I transmission via carrier mothers’ milk. Lancet 1987, 2, 158-159. [CrossRef].
10. Hino, S.; Katamine, S.; Miyata, H.; Tsuji, Y.; Yamabe, T.; Miyamoto, T. Primary prevention of HTLV-I in Japan. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 1996, 13 (Suppl. 1), S199-S203. [CrossRef] [PubMed].
11. Wiktor, S.Z.; Pate, E.J.; Rosenberg, P.S.; Barnett, M.; Palmer, P.; Medeiros, D.; Maloney, E.M.; Blattner, W. A. Mother-to-child transmission of human T-cell lymphotropic virus type I associated with prolonged breast-feeding. J. Hum. Virol. 1997, 1, 37-44. [PubMed].
12. Takahashi, K.; Takezaki, T.; Oki, T.; Kawakami, K.; Yashiki, S.; Fujiyoshi, T.; Usuku, K.; Mueller, N.; Osame, M.; Miyata, K. et al. Inhibitory effect of maternal antibody on mother-to-child transmission of human T-lymphotropic virus type I. The Mother-to-Child Transmission Study Group. Int. J. Cancer 1991, 49, 673-677. [CrossRef] [PubMed].
13. Hino, S. Establishment of the milk-borne transmission as a key factor for the peculiar endemicity of human T-lymphotropic virus type 1 (HTLV-1): The ATL Prevention Program Nagasaki. Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 2011, 87, 152-166. [CrossRef] [PubMed].
14. Hino, S.; Katamine, S.; Miyata, H.; Tsuji, Y.; Yamabe, T.; Miyamoto, T. Primary prevention of HTLV-1 in Japan. Leukemia 1997, 11 (Suppl. 3), 57-59. [CrossRef] [PubMed].
15. Ribeiro, M.A.; Martins, M.L.; Teixeira, C.; Ladeira, R.; Oliveira Mde, F.; Januario, J.N.; Proietti, F.A.; Carneiro-Proietti, A.B. Blocking vertical transmission of human T cell lymphotropic virus type 1 and 2 through breastfeeding interruption. Pediatr. Infect. Dis. J. 2012, 31, 1139-1143. [CrossRef] [PubMed].
16. Hino, S.; Yamaguchi, K.; Katamine, S.; Sugiyama, H.; Amagasaki, T.; Kinoshita, K.; Yoshida, Y.; Doi, H.; Tsuji, Y.; Miyamoto, T. Mother-to-child transmission of human T-cell leukemia virus type-I. Jpn. J. Cancer Res. 1985, 76, 474-480. [PubMed].
17. Komuro, A.; Hayami, M.; Fujii, H.; Miyahara, S.; Hirayama, M. Vertical transmission of adult T-cell leukaemia virus. Lancet 1983, 1, 240. [CrossRef].
18. Satow, Y.; Hashido, M.; Ishikawa, K.; Honda, H.; Mizuno, M.; Kawana, T.; Hayami, M. Detection of HTLV-I antigen in peripheral and cord blood lymphocytes from carrier mothers. Lancet 1991, 338, 915-916. [PubMed].
19. Chakraborty, J.; Clark, S.; Okonta, H.; Duggan, J. A small animal model for mother-to-fetus transmission of ts1, a murine retrovirus. Viral Immunol. 2003, 16, 191-201. [CrossRef] [PubMed].
20. Duggan, J.; Okonta, H.; Chakraborty, J. Transmission of Moloney murine leukemia virus (ts-1) by breast milk. J. Gen. Virol. 2006, 87 Pt 9, 2679-2684. [CrossRef] [PubMed].
21. Bittner, J.J. Relation of nursing to the extra-chromosomal theory of breast cancer in mice. Am. J. Cancer 1939, 35, 90-97. [PubMed].
22. Le Jan, C.; Bellaton, C.; Greenland, T.; Mornex, J.F. Mammary transmission of caprine arthritis encephalitis virus: A 3D model for in vitro study. Reprod. Nutr. Dev. 2005, 45, 513-523. [CrossRef] [PubMed].
23. Kinoshita, K.; Hino, S.; Amagaski, T.; Ikeda, S.; Yamada, Y.; Suzuyama, J.; Momita, S.; Toriya, K.; Kamihira, S.; Ichimaru, M. Demonstration of adult T-cell leukemia virus antigen in milk from three sero-positive mothers. Gann 1984, 75, 103-105. [PubMed].
24. Matsubara, F.; Haraguchi, K.; Harada, K.; Koizumi, A. Screening for antibodies to human T-cell leukemia virus type I in Japanese breast milk. Biol. Pharm. Bull. 2012, 35, 773-776. [CrossRef] [PubMed].
25. Li, H.C.; Biggar, R.J.; Miley, W.J.; Maloney, E.M.; Cranston, B.; Hanchard, B.; Hisada, M. Provirus load in breast milk and risk of mother-to-child transmission of human T lymphotropic virus type I. J. Infect. Dis. 2004, 190, 1275-1278. [CrossRef] [PubMed].
26. Yamanouchi, K.; Kinoshita, K.; Moriuchi, R.; Katamine, S.; Amagasaki, T.; Ikeda, S.; Ichimaru, M.; Miyamoto, T.; Hino, S. Oral transmission of human T-cell leukemia virus type-I into a common marmoset (Callithrix jacchus) as an experimental model for milk-borne transmission. Jpn. J. Cancer Res. 1985, 76, 481-487. [PubMed].
27. Kinoshita, K.; Yamanouchi, K.; Ikeda, S.; Momita, S.; Amagasaki, T.; Soda, H.; Ichimaru, M.; Moriuchi, R.; Katamine, S.; Miyamoto, T. et al. Oral infection of a common marmoset with human T-cell leukemia virus type-I (HTLV-I) by inoculating fresh human milk of HTLV-I carrier mothers. Jpn. J. Cancer Res. 1985, 76, 1147-1153. [PubMed].
28. Uemura, Y.; Kotani, S.; Yoshimoto, S.; Fujishita, M.; Yano, S.; Ohtsuki, Y.; Miyoshi, I. Oral transmission of human T-cell leukemia virus type I in the rabbit. Jpn. J. Cancer Res. 1986, 77, 970-973. [PubMed].
29. Kato, H.; Koya, Y.; Ohashi, T.; Hanabuchi, S.; Takemura, F.; Fujii, M.; Tsujimoto, H.; Hasegawa, A.; Kannagi, M. Oral administration of human T-cell leukemia virus type 1 induces immune unresponsiveness with persistent infection in adult rats. J. Virol. 1998, 72, 7289-7293. [PubMed].
30. Okochi, K.; Sato, H.; Hinuma, Y. A retrospective study on transmission of adult T cell leukemia virus by blood transfusion: Seroconversion in recipients. Vox Sang. 1984, 46, 245-253. [CrossRef] [PubMed].
31. Yamamoto, N.; Okada, M.; Koyanagi, Y.; Kannagi, M.; Hinuma, Y. Transformation of human leukocytes by cocultivation with an adult T cell leukemia virus producer cell line. Science 1982, 217, 737-739. [CrossRef] [PubMed].
32. Popovic, M.; Sarin, P.S.; Robert-Gurroff, M.; Kalyanaraman, V.S.; Mann, D.; Minowada, J.; Gallo, R.C. Isolation and transmission of human retrovirus (human T-cell leukemia virus). Science 1983, 219, 856-859. [CrossRef] [PubMed].
33. Jones, K.S.; Petrow-Sadowski, C.; Huang, Y.K.; Bertolette, D.C.; Ruscetti, F.W. Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4+ T cells. Nat. Med. 2008, 14, 429-436. [CrossRef] [PubMed].
34. Jarvinen, K.M.; Geller, L.; Bencharitiwong, R.; Sampson, H.A. Presence of functional, autoreactive human milk-specific IgE in infants with cow’s milk allergy. Clin. Exp. Allergy 2012, 42, 238-247. [CrossRef] [PubMed].
35. Ogra, S.S.; Weintraub, D.I.; Ogra, P.L. Immunologic aspects of human colostrum and milk: Interaction with the intestinal immunity of the neonate. Adv. Exp. Med. Biol. 1978, 107, 95-107. [PubMed].
36. Proietti, F.A.; Carneiro-Proietti, A.B.; Catalan-Soares, B.C.; Murphy, E.L. Global epidemiology of HTLV-I infection and associated diseases. Oncogene 2005, 24, 6058-6068. [CrossRef] [PubMed].
37. Kinoshita, K.; Amagasaki, T.; Hino, S.; Doi, H.; Yamanouchi, K.; Ban, N.; Momita, S.; Ikeda, S.; Kamihira, S.; Ichimaru, M. et al. Milk-borne transmission of HTLV-I from carrier mothers to their children. Jpn. J. Cancer Res. 1987, 78, 674-680. [PubMed].
38. Southern, S.O.; Southern, P.J. Persistent HTLV-I infection of breast luminal epithelial cells: A role in HTLV transmission? Virology 1998, 241, 200-214. [CrossRef] [PubMed].
39. Satomi, M.; Shimizu, M.; Shinya, E.; Watari, E.; Owaki, A.; Hidaka, C.; Ichikawa, M.; Takeshita, T.; Takahashi, H. Transmission of macrophage-tropic HIV-1 by breast-milk macrophages via DC-SIGN. J. Infect. Dis. 2005, 191, 174-181. [CrossRef] [PubMed].
40. LeVasseur, R.J.; Southern, S.O.; Southern, P.J. Mammary epithelial cells support and transfer productive human T-cell lymphotropic virus infections. J. Hum. Virol. 1998, 1, 214-223. [PubMed].
41. Takeuchi, H.; Takahashi, M.; Norose, Y.; Takeshita, T.; Fukunaga, Y.; Takahashi, H. Transformation of breast milk macrophages by HTLV-I: Implications for HTLV-I transmission via breastfeeding. Biomed. Res. 2010, 31, 53-61. [CrossRef] [PubMed].
42. Loureiro, P.; Southern, S.O.; Southern, P.J.; Pombo-de-Oliveira, M.S. Clinicopathological studies of a patient with adult T-cell leukemia and pseudogynecomasty. Am. J. Hematol. 2000, 65, 256-259. [CrossRef].
43. Buehring, G.C.; Kramme, P.M.; Schultz, R.D. Evidence for bovine leukemia virus in mammary epithelial cells of infected cows. Lab. Invest. 1994, 71, 359-365. [PubMed].
44. Schulz, O.; Pabst, O. Antigen sampling in the small intestine. Trends Immunol. 2013, 34, 155-161. [CrossRef] [PubMed].
45. Takenouchi, N.; Matsuoka, E.; Moritoyo, T.; Nagai, M.; Katsuta, K.; Hasui, K.; Ueno, K.; Eizuru, Y.; Usuku, K.; Osame, M. et al. Molecular pathologic analysis of the tonsil in HTLV-I-infected individuals. J. Acquir. Immune Defic. Syndr. 1999, 22, 200-207. [CrossRef] [PubMed].
46. Kazanji, M. HTLV type 1 infection in squirrel monkeys (Saimiri sciureus): A promising animal model for HTLV type 1 human infection. AIDS Res. Hum. Retrovir. 2000, 16, 1741-1746. [CrossRef] [PubMed].
47. Haynes, R.A., 2nd; Ware, E.; Premanandan, C.; Zimmerman, B.; Yu, L.; Phipps, A.J.; Lairmore, M.D. Cyclosporine-induced immune suppression alters establishment of HTLV-1 infection in a rabbit model. Blood 2010, 115, 815-823. [CrossRef] [PubMed].
48. Zacharopoulos, V.R.; Perotti, M.E.; Phillips, D.M. Lymphocyte-facilitated infection of epithelia by human T-cell lymphotropic virus type I. J. Virol. 1992, 66, 4601-4605. [PubMed].
49. Martin-Latil, S.; Gnadig, N.F.; Mallet, A.; Desdouits, M.; Guivel-Benhassine, F.; Jeannin, P.; Prevost, M.C.; Schwartz, O.; Gessain, A.; Ozden, S. et al. Transcytosis of HTLV-1 across a tight human epithelial barrier and infection of subepithelial dendritic cells. Blood 2012, 120, 572-580. [CrossRef] [PubMed].
50. Afonso, P.V.; Ozden, S.; Prevost, M.C.; Schmitt, C.; Seilhean, D.; Weksler, B.; Couraud, P.O.; Gessain, A.; Romero, I.A.; Ceccaldi, P.E. Human blood-brain barrier disruption by retroviral-infected lymphocytes: Role of myosin light chain kinase in endothelial tight-junction disorganization. J. Immunol. 2007, 179, 2576-2583. [CrossRef] [PubMed].
51. Hocini, H.; Bomsel, M. Infectious human immunodeficiency virus can rapidly penetrate a tight human epithelial barrier by transcytosis in a process impaired by mucosal immunoglobulins. J. Infect. Dis. 1999, 179 (Suppl. 3), S448-S453. [CrossRef] [PubMed].
52. Plancoulaine, S.; Buigues, R.P.; Murphy, E.L.; van Beveren, M.; Pouliquen, J.F.; Joubert, M.; Remy, F.; Tuppin, P.; Tortevoye, P.; de The, G. et al. Demographic and familial characteristics of HTLV-1 infection among an isolated, highly endemic population of African origin in French Guiana. Int. J. Cancer 1998, 76, 331-336. [CrossRef].
53. Plancoulaine, S.; Gessain, A.; Joubert, M.; Tortevoye, P.; Jeanne, I.; Talarmin, A.; de The, G.; Abel, L. Detection of a major gene predisposing to human T lymphotropic virus type I infection in children among an endemic population of African origin. J. Infect. Dis. 2000, 182, 405-412. [CrossRef] [PubMed].
54. Jeffery, K.J.; Usuku, K.; Hall, S.E.; Matsumoto, W.; Taylor, G.P.; Procter, J.; Bunce, M.; Ogg, G.S.; Welsh, K.I.; Weber, J.N. et al. HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy. Proc. Natl. Acad. Sci. USA 1999, 96, 3848-3853. [CrossRef] [PubMed].
55. Plancoulaine, S.; Gessain, A.; Tortevoye, P.; Boland-Auge, A.; Vasilescu, A.; Matsuda, F.; Abel, L. A major susceptibility locus for HTLV-1 infection in childhood maps to chromosome 6q27. Hum. Mol. Genet. 2006, 15, 3306-3312. [CrossRef] [PubMed].
56. Sawada, T.; Iwahara, Y.; Ishii, K.; Taguchi, H.; Hoshino, H.; Miyoshi, I. Immunoglobulin prophylaxis against milkborne transmission of human T cell leukemia virus type I in rabbits. J. Infect. Dis. 1991, 164, 1193-1196. [CrossRef] [PubMed].
57. Ureta-Vidal, A.; Angelin-Duclos, C.; Tortevoye, P.; Murphy, E.; Lepere, J.F.; Buigues, R.P.; Jolly, N.; Joubert, M.; Carles, G.; Pouliquen, J.F. et al. Mother-to-child transmission of human T-cell-leukemia/lymphoma virus type I: Implication of high antiviral antibody titer and high proviral load in carrier mothers. Int. J. Cancer 1999, 82, 832-836. [CrossRef].
58. Sawada, T.; Tohmatsu, J.; Obara, T.; Koide, A.; Kamihira, S.; Ichimaru, M.; Kashiwagi, S.; Kajiyama, W.; Matsumura, N.; Kinoshita, K. et al. High risk of mother-to-child transmission of HTLV-I in p40tax antibody-positive mothers. Jpn. J. Cancer Res. 1989, 80, 506-508. [CrossRef] [PubMed].
59. Hirata, M.; Hayashi, J.; Noguchi, A.; Nakashima, K.; Kajiyama, W.; Kashiwagi, S.; Sawada, T. The effects of breastfeeding and presence of antibody to p40tax protein of human T cell lymphotropic virus type-I on mother to child transmission. Int. J. Epidemiol. 1992, 21, 989-994. [CrossRef] [PubMed].
60. Hisada, M.; Maloney, E.M.; Sawada, T.; Miley, W.J.; Palmer, P.; Hanchard, B.; Goedert, J.J.; Manns, A. Virus markers associated with vertical transmission of human T lymphotropic virus type 1 in Jamaica. Clin. Infect. Dis. 2002, 34, 1551-1557. [CrossRef] [PubMed].
61. Moriuchi, M.; Moriuchi, H. A milk protein lactoferrin enhances human T cell leukemia virus type I and suppresses HIV-1 infection. J. Immunol. 2001, 166, 4231-4236. [CrossRef] [PubMed].
62. Moriuchi, M.; Moriuchi, H. Induction of lactoferrin gene expression in myeloid or mammary gland cells by human T-cell leukemia virus type 1 (HTLV-1) tax: Implications for milk-borne transmission of HTLV-1. J. Virol. 2006, 80, 7118-7126. [CrossRef] [PubMed].
63. Banerjee, P.; Tripp, A.; Lairmore, M.D.; Crawford, L.; Sieburg, M.; Ramos, J.C.; Harrington, W., Jr.; Beilke, M.A.; Feuer, G. Adult T-cell leukemia/lymphoma development in HTLV-1-infected humanized SCID mice. Blood 2010, 115, 2640-2648. [CrossRef] [PubMed].
64. Villaudy, J.; Wencker, M.; Gadot, N.; Gillet, N.A.; Scoazec, J.Y.; Gazzolo, L.; Manz, M.G.; Bangham, C.R.; Dodon, M.D. HTLV-1 propels thymic human T cell development in “human immune system” Rag2cmice. PLoS Pathog. 2011, 7, e1002231. [CrossRef] [PubMed].
65. Dodon, M.D.; Villaudy, J.; Gazzolo, L.; Haines, R.; Lairmore, M. What we are learning on HTLV-1 pathogenesis from animal models. Front. Microbiol. 2012, 3, 320. [CrossRef] [PubMed].
66. Ouzilou, L.; Caliot, E.; Pelletier, I.; Prevost, M.C.; Pringault, E.; Colbere-Garapin, F. Poliovirus transcytosis through M-like cells. J. Gen. Virol. 2002, 83 Pt 9, 2177-2182. [CrossRef] [PubMed].
67. Renz, H.; Brandtzaeg, P.; Hornef, M. The impact of perinatal immune development on mucosal homeostasis and chronic inflammation. Nat. Rev. Immunol. 2012, 12, 9-23. [CrossRef] [PubMed].
68. Van de Pavert, S.A.; Mebius, R.E. New insights into the development of lymphoid tissues. Nat. Rev. Immunol. 2010, 10, 664-674. [CrossRef] [PubMed].
69. Maranduba, C.M.; De Castro, S.B.; de Souza, G.T.; Rossato, C.; da Guia, F.C.; Valente, M.A.; Rettore, J.V.; Maranduba, C.P.; de Souza, C.M.; do Carmo, A.M. et al. Intestinal microbiota as modulators of the immune system and neuroimmune system: Impact on the host health and homeostasis. J. Immunol. Res. 2015, 2015. [CrossRef] [PubMed].
70. Shu, Z.; Ma, J.; Tuerhong, D.; Yang, C.; Upur, H. How intestinal bacteria can promote HIV replication. AIDS Rev. 2013, 15, 32-37. [PubMed].
71. Kane, M.; Case, L.K.; Kopaskie, K.; Kozlova, A.; MacDearmid, C.; Chervonsky, A.V.; Golovkina, T.V. Successful transmission of a retrovirus depends on the commensal microbiota. Science 2011, 334, 245-249. [CrossRef] [PubMed].
72. Fernandez, L.; Langa, S.; Martin, V.; Jimenez, E.; Martin, R.; Rodriguez, J.M. The microbiota of human milk in healthy women. Cell Mol. Biol. 2013, 59, 31-42. [PubMed].