Exposure of pregnant women to persistent organic pollutants and cord sex hormone levels

Human Reproduction

Volumn 31, Issue 1, 2016, Pages 190-198

  Warembourg, C ^a,b   Debost Legrand, A ^a,c   Bonvallot, N ^a,d   Massart, C ^e   Garlantezec R ^a,d   Monfort, C ^a,b   Gaudreau, E ^f   Chevrier, C ^a,b   Cordier, S ^a,b  

^a UNIVERSITÉ DE RENNES 1   (France)

^b UNIVERSITÉ DE RENNES 1   (France)

^c UNIVERSITY HOSPITAL OF CLERMONT FERRAND   (France)

^d EHESP SCHOOL OF PUBLIC HEALTH   (France)

^e INSTITUT NATIONAL DE SANTÉ PUBLIQUE DU QUÉBEC   (Canada)

^f RENNES UNIVERSITY HOSPITAL   (France)

Author keywords

Cohort studies; Endocrine disruptors; Hormones; Newborns; Organochlorine compounds; Polychlorinated biphenyls; Steroids

Indexed keywords

2,2',4,4',5,5' HEXACHLOROBIPHENYL; AROMATASE; BETA HEXACHLOROCYCLOHEXANE; DECABROMODIPHENYL ETHER; DIELDRIN; ENDOSULFAN; ESTRADIOL; HEPTACHLOR EPOXIDE; HEXACHLOROBENZENE; LINDANE; MUELLERIAN INHIBITING FACTOR; POLYCHLORINATED BIPHENYL; SEX HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; BIPHENYL DERIVATIVE; CHLORINATED HYDROCARBON; ENDOCRINE DISRUPTOR;

ADULT; ARTICLE; BIRTH WEIGHT; BODY MASS; COHORT ANALYSIS; EDUCATIONAL STATUS; ESTRADIOL BLOOD LEVEL; FEMALE; GESTATIONAL AGE; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HUMAN; MAJOR CLINICAL STUDY; MALE; NEWBORN; OBESITY; PARITY; PERSISTENT ORGANIC POLLUTANT; PREGNANCY OUTCOME; PREGNANT WOMAN; PRENATAL EXPOSURE; PROSPECTIVE STUDY; SENSITIVITY ANALYSIS; TESTOSTERONE BLOOD LEVEL; TOBACCO USE; UMBILICAL CORD BLOOD; ADVERSE EFFECTS; BLOOD; ENVIRONMENTAL EXPOSURE; FETUS BLOOD; FOLLOW UP; METABOLISM; PREGNANCY; SEX DIFFERENCE;

ADULT; BIPHENYL COMPOUNDS; ENDOCRINE DISRUPTORS; ENVIRONMENTAL EXPOSURE; FEMALE; FETAL BLOOD; FOLLOW-UP STUDIES; GONADAL STEROID HORMONES; HUMANS; HYDROCARBONS, CHLORINATED; INFANT, NEWBORN; MALE; PREGNANCY; SEX FACTORS;

EID: 84957579376     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/dev260     Document Type: Article

References (40)

1. Araki A, Mitsui T, Miyashita C, Nakajima T, Naito H, Ito S, Sasaki S, Cho K, Ikeno T, Nonomura K et al. Association between maternal exposure to di(2-ethylhexyl) phthalate and reproductive hormone levels in fetal blood: The Hokkaido study on environment and children's health. PLoS One 2014;9: E109039.
2. Arbuckle TE, Hauser R, Swan SH, Mao CS, Longnecker MP, Main KM, Whyatt RM, Mendola P, Legrand M, Rovet J et al. Meeting report: Measuring endocrine-sensitive endpoints within the first years of life. Environ Health Perspect 2008;116: 948-951.
3. Barker DJ, Gluckman PD, Godfrey KM, Harding JE, Owens JA, Robinson JS. Fetal nutrition and cardiovascular disease in adult life. Lancet 1993; 341: 938-941.
4. Bender R, Lange S. Adjusting for multiple testing-when and how? J Clin Epidemiol 2001;54: 343-349.
5. Borlak J, Dangers M, Thum T. Aroclor 1254 modulates gene expression of nuclear transcription factors: Implications for albumin gene transcription and protein synthesis in rat hepatocyte cultures. Toxicol Appl Pharmacol 2002;181: 79-88.
6. Cao Y, Winneke G, Wilhelm M, Wittsiepe J, Lemm F, Fu?rst P, Ranft U, Imo? hl M, Kraft M, Oesch-Bartlomowicz B et al. Environmental exposure to dioxins and polychlorinated biphenyls reduce levels of gonadal hormones in newborns: Results from the Duisburg cohort study. Int J Hyg Environ Health 2008;211: 30-39.
7. Chevrier C, Warembourg C, Gaudreau E, Monfort C, Le Blanc A, Guldner L, Cordier S. Organochlorine pesticides, polychlorinated biphenyls, seafood consumption, and time-to-pregnancy. Epidemiology 2013; 24: 251-260.
8. Fisher JS. Environmental anti-androgens and male reproductive health: Focus on phthalates and testicular dysgenesis syndrome. Reproduction 2004; 127: 305-315.
9. Goeman JJ, Solari A. Multiple testing for exploratory research. Stat Sci 2011; 26: 584-597. Institute of Mathematical Statistics.
10. Govarts E, Nieuwenhuijsen M, Schoeters G, Ballester F, Bloemen K, de Boer M, Chevrier C, Eggesbo M, Guxens M, Kra?mer U et al. Birth weight and prenatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE): A meta-analysis within 12 European Birth Cohorts. Environ Health Perspect 2012;120: 162-170.
11. Grandjean P, Bellinger D, Bergman A, Cordier S, Davey-Smith G, Eskenazi B, Gee D, Gray K, Hanson M, van den Hazel P et al. The faroes statement: Human health effects of developmental exposure to chemicals in our environment. Basic Clin Pharmacol Toxicol 2008;102: 73-75.
12. Grandjean P, Gronlund C, Kjar IM, Jensen TK, Sorensen N, Andersson A-M, Juul A, Skakkebak NE, Budtz-Jorgensen E, Weihe P. Reproductive hormone profile and pubertal development in 14-year-old boys prenatally exposed to polychlorinated biphenyls. Reprod Toxicol 2012; 34: 498-503. Elsevier Inc.
13. Hammond GL. Diverse roles for sex hormone-binding globulin in reproduction. Biol Reprod 2011;85: 431-441.
14. He Y, Murphy MB, Yu RMK, Lam MHW, Hecker M, Giesy JP, Wu RSS, Lam PKS. Effects of 20 PBDE metabolites on steroidogenesis in the H295R cell line. Toxicol Lett 2008;176: 230-238.
15. Hickey M, Hart R, Keelan JA. The relationship between umbilical cord estrogens and perinatal characteristics. Cancer Epidemiol Biomarkers Prev 2014;23: 946-952.
16. Hill M, Pas?kova' A, Kanc?eva R, Veli'kova' M, Kuba'tova' J, Kancheva L, Adamcova' K, Mikes?ova' M, Z? iz?kaZ, Koucky'Metal. Steroidprofiling inpregnancy: Afocuson the human fetus. J Steroid Biochem Mol Biol 2014;139: 201-222.
17. Hollier LP, Keelan JA, Hickey M, Maybery MT, Whitehouse AJO. Measurement of androgen and estrogen concentrations in cord blood: Accuracy, biological interpretation, and applications to understanding human behavioral development. Front Endocrinol (Lausanne) 2014;5: 64.
18. Jansen HT, Cooke PS, Porcelli J, Liu T-C, Hansen LG. Estrogenic and antiestrogenic actions of PCBs in the female rat: In vitro and in vivo studies. Reprod Toxicol 1993;7: 237-248.
19. Josso N, Lamarre I, Picard JY, Berta P, Davies N, Morichon N, Peschanski M, Jeny R. Anti-mu?llerian hormone in early human development. Early Hum Dev 1993;33: 91-99.
20. Keelan JA, Mattes E, Tan H, Dinan A, Newnham JP, Whitehouse AJO, Jacoby P, Hickey M. Androgen concentrations in umbilical cord blood and their association with maternal, fetal and obstetric factors. PLoS One 2012;7: E42827.
21. Kupfer D. Effects of pesticides and related compounds on steroid metabolism and function. CRC Crit Rev Toxicol 1975;4: 83-124.
22. Letcher RJ, van Holsteijn I, Drenth HJ, Norstrom RJ, Bergman A, Safe S, Pieters R, van den Berg M. Cytotoxicity and aromatase (CYP19) activity modulation by organochlorines in human placental JEG-3 and JAR choriocarcinoma cells. Toxicol Appl Pharmacol 1999;160: 10-20.
23. Lilienthal H, Hack A, Roth-Ha?rer A, Grande SW, Talsness CE. Effects of developmental exposure to 2, 2 , 4, 4 , 5-pentabromodiphenyl ether (PBDE-99) on sex steroids, sexual development, and sexually dimorphic behavior in rats. Environ Health Perspect 2006;114: 194-201.
24. Lin L-C, Wang S-L, Chang Y-C, Huang P-C, Cheng J-T, Su P-H, Liao P-C. Associations between maternal phthalate exposure and cord sex hormones in human infants. Chemosphere 2011;83: 1192-1199.
25. MaR, Sassoon DA. PCBs exert an estrogenic effect through repression of the Wnt7a signaling pathway in the female reproductive tract. Environ Health Perspect 2006;114: 898-904.
26. Main KM, Mortensen GK, Kaleva MM, Boisen KA, Damgaard IN, Chellakooty M, Schmidt IM, Suomi A-M, Virtanen HE, Petersen DVH et al. Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age. Environ Health Perspect 2006;114: 270-276.
27. McGlynn KA, GuoX, Graubard BI, BrockJW, KlebanoffMA, LongneckerMP. Maternal pregnancy levels of polychlorinated biphenyls and risk of hypospadias and cryptorchidism in male offspring. Environ Health Perspect 2009;117: 1472-1476.
28. Meeker JD, Hauser R. Exposure to polychlorinated biphenyls (PCBs) and male reproduction. Syst Biol Reprod Med 2010;56: 122-131.
29. Patterson DG, Isaacs SG, Alexander LR, Turner WE, Hampton L, Bernert JT, Needham LL. Determination of specific polychlorinated dibenzo-p-dioxins and dibenzofurans in blood and adipose tissue by isotope dilutionhigh- resolution mass spectrometry. IARC Sci Publ 1991;299-342.
30. Rosner W. The functions of corticosteroid-binding globulin and sex hormone-binding globulin: Recent advances. Endocr Rev 1990;11: 80-91.
31. Rothman KJ. No adjustments are needed for multiple comparisons. Epidemiology 1990;1: 43-46.
32. SotoAM, Chung KL, Sonnenschein C. The pesticides endosulfan, toxaphene, and dieldrin have estrogenic effects on human estrogen-sensitive cells. Environ Health Perspect 1994;102: 380-383.
33. Stoker TE, Cooper RL, Lambright CS, Wilson VS, Furr J, Gray LE. In vivo and in vitro anti-androgenic effects of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture. Toxicol Appl Pharmacol 2005;207: 78-88.
34. Thompson AL, Lampl M. Prenatal and postnatal energetic conditions and sex steroids levels across the first year of life.Am J Hum Biol 2013;25: 643-654.
35. Toppari J, Juul A. Trends in puberty timing in humans and environmental modifiers. Mol Cell Endocrinol 2010;324: 39-44.
36. Troisi R, Potischman N, Roberts J, Siiteri P, Daftary A, Sims C, Hoover RN. Associations of maternal and umbilical cord hormone concentrations with maternal, gestational and neonatal factors (United States). Cancer Causes Control 2003;14: 347-355.
37. WHO, UNEP. State of the science of endocrine disrupting chemicals.World Health Organization, 2012.
38. Wojtowicz AK, Milewicz T, Gregoraszczuk EL. DDTand its metabolite DDE alter steroid hormone secretion in human term placental explants by regulation of aromatase activity. Toxicol Lett 2007;173: 24-30.
39. Wolff MS, Camann D, Gammon M, Stellman SD. Proposed PCB congener groupings for epidemiological studies. Environ Health Perspect 1997; 105: 13-14.
40. Woodhouse AJ, Cooke GM. Suppression of aromatase activity in vitro by PCBs 28 and 105 and Aroclor 1221. Toxicol Lett 2004;152: 91-100.