Increased surgical site infection rates following clindamycin use in head and neck free tissue transfer

Otolaryngology - Head and Neck Surgery (United States)

Volumn 154, Issue 2, 2016, Pages 272-278

  Pool, Christopher ^a   Kass, Jason ^a   Spivack, John ^a   Nahumi, Nadav ^a   Khan, Mohemmed ^a   Babus, Lenard ^a   Teng, Marita S ^a   Genden, Eric M ^a   Miles, Brett A ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

antibiotic prophylaxis; free tissue transfer; head and neck cancer; surgical site infection

Indexed keywords

CEFAZOLIN; CEFUROXIME; CLINDAMYCIN; GENTAMICIN; METRONIDAZOLE; SULTAMICILLIN; ANTIINFECTIVE AGENT;

ADULT; AGE; AGED; ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC THERAPY; ARTICLE; BODY MASS; COMORBIDITY; DRUG TREATMENT FAILURE; ENTEROCOCCUS FAECALIS; FEMALE; FREE TISSUE GRAFT; HAEMOPHILUS INFLUENZAE; HEAD AND NECK SURGERY; HUMAN; KLEBSIELLA; MAJOR CLINICAL STUDY; MALE; MICROVASCULAR SURGERY; ORAL SURGERY; PENICILLIN ALLERGY; PHARYNX RECONSTRUCTION; PRACTICE GUIDELINE; PREOPERATIVE RADIOTHERAPY; RETROSPECTIVE STUDY; SMOKING; STAPHYLOCOCCUS AUREUS; SURGICAL INFECTION; ADVERSE EFFECTS; FOLLOW UP; HEAD AND NECK NEOPLASMS; INCIDENCE; MIDDLE AGED; NECK DISSECTION; PLASTIC SURGERY; PROCEDURES; RISK FACTOR; SURGICAL WOUND INFECTION; UNITED STATES;

ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; CLINDAMYCIN; FEMALE; FOLLOW-UP STUDIES; FREE TISSUE FLAPS; HEAD AND NECK NEOPLASMS; HUMANS; INCIDENCE; MALE; MIDDLE AGED; NECK DISSECTION; RECONSTRUCTIVE SURGICAL PROCEDURES; RETROSPECTIVE STUDIES; RISK FACTORS; SURGICAL WOUND INFECTION; UNITED STATES;

EID: 84957574268     PISSN: 01945998     EISSN: 10976817     Source Type: Journal    
DOI: 10.1177/0194599815617129     Document Type: Article

References (31)

1. Hanasono MM, Corbitt CA, Yu P, Skoracki RJ,. Success of sequential free flaps in head and neck reconstruction. J Plast Reconstr Aesthet Surg. 2014; 67: 1186-1193.
2. Novakovic D, Patel RS, Goldstein DP, Gullane PJ,. Salvage of failed free flaps used in head and neck reconstruction. Head Neck Oncol. 2009; 1: 33.
3. Urken ML, Weinberg H, Buchbinder D, et al. Microvascular free flaps in head and neck reconstruction: report of 200 cases and review of complications. Arch Otolaryngol Head Neck Surg. 1994; 120: 633-640.
4. Becker GD,. Identification and management of the patient at high risk for wound infection. Head Neck Surg. 1986; 8: 205-210.
5. Dor P, Klastersky J,. Prophylactic antibiotics in oral, pharyngeal and laryngeal surgery for cancer: (a double-blind study). Laryngoscope. 1973; 83: 1992-1998.
6. Ketcham AS, Bloch JH, Crawford DT, Lieberman JE, Smith RR,. The role of prophylactic antibiotic therapy in control of staphylococcal infections following cancer surgery. Surg Gynecol Obstet. 1962; 114: 345-352.
7. Becker GD, Parell GJ,. Cefazolin prophylaxis in head and neck cancer surgery. Ann Otol Rhinol Laryngol. 1979; 88: 183-186.
8. Durand ML, Yarlagadda BB, Rich DL, et al. The time course and microbiology of surgical site infections after head and neck free flap surgery. Laryngoscope. 2014; 125: 1084-1089.
9. Karakida K, Aoki T, Ota Y, et al. Analysis of risk factors for surgical-site infections in 276 oral cancer surgeries with microvascular free-flap reconstructions at a single university hospital. J Infect Chemother. 2010; 16: 334-339.
10. Yang CH, Chew KY, Solomkin JS, Lin PY, Chiang YC, Kuo YR,. Surgical site infections among high-risk patients in clean-contaminated head and neck reconstructive surgery: concordance with preoperative oral flora. Ann Plast Surg. 2013; 71 (suppl 1): S55-S60.
11. Benatar MJ, Dassonville O, Chamorey E, et al. Impact of preoperative radiotherapy on head and neck free flap reconstruction: a report on 429 cases. J Plast Reconstr Aesthet Surg. 2013; 66: 478-482.
12. Shuman AG, Shuman EK, Hauff SJ, et al. Preoperative topical antimicrobial decolonization in head and neck surgery. Laryngoscope. 2012; 122: 2454-2460.
13. Aas JA, Paster BJ, Stokes LN, Olsen I, Dewhirst FE,. Defining the normal bacterial flora of the oral cavity. J Clin Microbiol. 2005; 43: 5721-5732.
14. Bratzler DW, Dellinger EP, Olsen KM, et al. Clinical practice guidelines for antimicrobial prophylaxis in surgery. Surg Infect (Larchmt). 2013; 14: 73-156.
15. Langerman A, Ham SA, Pisano J, Pariser J, Hohmann SF, Meltzer DO,. Laryngectomy complications are associated with perioperative antibiotic choice. Otolaryngol Head Neck Surg. 2015; 153: 60-68.
16. Mitchell RM, Mendez E, Schmitt NC, Bhrany AD, Futran ND,. Antibiotic prophylaxis in patients undergoing head and neck free flap reconstruction. [published online 23, 2015 ]. JAMA Otolaryngol Head Neck Surg.
17. Yarlagadda BB, Deschler DG, Rich DL, et al. Head and neck free flap surgical site infections in the era of the Surgical Care Improvement Project. [published online 12, 2015 ]. Head Neck.
18. Centers for Disease Control and Prevention. Surgical site infection event. http://www.cdc.gov/nhsn/PDFs/pscManual/9pscSSIcurrent.pdf. Published 1, 2015. Accessed March 5, 2015.
19. Ata A, Valerian BT, Lee EC, Bestle SL, Elmendorf SL, Stain SC,. The effect of diabetes mellitus on surgical site infections after colorectal and noncolorectal general surgical operations. Am Surg. 2010; 76: 697-702.
20. Waisbren E, Rosen H, Bader AM, Lipsitz SR, Rogers SO Jr, Eriksson E,. Percent body fat and prediction of surgical site infection. J Am Coll Surg. 2010; 210: 381-389.
21. Sonalika WG, Amsavardani Tayaar S, Bhat KG, Patil BR, Muddapur MV,. Oral microbial carriage in oral squamous cell carcinoma patients at the time of diagnosis and during radiotherapy: a comparative study. Oral Oncol. 2012; 48: 881-886.
22. Callender DL,. Antibiotic prophylaxis in head and neck oncologic surgery: the role of gram-negative coverage. Int J Antimicrob Agents. 1999; 12 (suppl 1): S21-S25.
23. Johnson JT, Kachman K, Wagner RL, Myers EN,. Comparison of ampicillin/sulbactam versus clindamycin in the prevention of infection in patients undergoing head and neck surgery. Head Neck. 1997; 19: 367-371.
24. Weber RS, Raad I, Frankenthaler R, et al. Ampicillin-sulbactam vs clindamycin in head and neck oncologic surgery: the need for gram-negative coverage. Arch Otolaryngol Head Neck Surg. 1992; 118: 1159-1163.
25. Solensky R,. Hypersensitivity reactions to beta-lactam antibiotics. Clin Rev Allergy Immunol. 2003; 24: 201-220.
26. Bhattacharya S,. The facts about penicillin allergy: a review. J Adv Pharm Technol Res. 2010; 1: 11-17.
27. Idsoe O, Guthe T, Willcox RR, de Weck AL,. Nature and extent of penicillin side-reactions, with particular reference to fatalities from anaphylactic shock. Bull World Health Organ. 1968; 38: 159-188.
28. Pichichero ME,. A review of evidence supporting the American Academy of Pediatrics recommendation for prescribing cephalosporin antibiotics for penicillin-allergic patients. Pediatrics. 2005; 115: 1048-1057.
29. Anne S, Reisman RE,. Risk of administering cephalosporin antibiotics to patients with histories of penicillin allergy. Ann Allergy Asthma Immunol. 1995; 74: 167-170.
30. Pichichero ME,. Use of selected cephalosporins in penicillin-allergic patients: a paradigm shift. Diagn Microbiol Infect Dis. 2007; 57 (3): 13S-18S.
31. Smith JW, Johnson JE, Cluff LE,. Studies on the epidemiology of adverse drug reactions: II. An evaluation of penicillin allergy. N Engl J Med. 1966; 274: 998-1002.