Morin, a bioflavonoid suppresses monosodium urate crystal-induced inflammatory immune response in RAW 264.7 macrophages through the inhibition of inflammatory mediators, intracellular ROS levels and NF-κB activation

PLoS ONE

Volumn 10, Issue 12, 2015, Pages

  Dhanasekar, Chitra ^a   Kalaiselvan, Sowmiya ^a   Rasool, Mahaboobkhan ^a  

^a VIT UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; ACETYLGLUCOSAMINIDASE; ACID PHOSPHATASE; BETA GALACTOSIDASE; CATHEPSIN D; COLCHICINE; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; MORIN; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; ANTIGOUT AGENT; ANTIINFLAMMATORY AGENT; AUTACOID; CCL2 PROTEIN, MOUSE; FLAVONOID; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; IL1B PROTEIN, MOUSE; MACROGOL DERIVATIVE; NITRIC OXIDE; NOS2 PROTEIN, MOUSE; PTGS2 PROTEIN, MOUSE; RELA PROTEIN, MOUSE; TUMOR NECROSIS FACTOR; URIC ACID; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE; VASCULOTROPIN A;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLOOXYGENASE 2 GENE; DRUG MECHANISM; DRUG STRUCTURE; FLOW CYTOMETRY; GENE; GENE EXPRESSION; HYPOXANTHINE PHOSPHO RIBOSYL TRANSFERSE GENE; IMMUNE RESPONSE; IN VITRO STUDY; INDUCIBLE NITRIC OXIDE SYNTHASE GENE; INTERLEUKIN 1BETA GENE; INTERLEUKIN 6 GENE; LIPID PEROXIDATION; MONOCYTE CHEMOTACTIC PROTEIN 1 GENE; NONHUMAN; PROTEIN EXPRESSION; TRANSCRIPTION FACTOR RELA GENE; TUMOR NECROSIS FACTOR ALPHA GENE; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; ARTHRITIS, GOUTY; BIOSYNTHESIS; CELL LINE; DRUG EFFECTS; IMMUNOLOGY; INFLAMMATION; MACROPHAGE; METABOLISM; MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, GOUTY; CELL LINE; CHEMOKINE CCL2; COLCHICINE; CYCLOOXYGENASE 2; FLAVONOIDS; GOUT SUPPRESSANTS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; INTERLEUKIN-6; MACROPHAGES; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; POLYETHYLENE GLYCOLS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA; URIC ACID; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84957574127     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0145093     Document Type: Article

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