A dose–response study of vitamin D3 supplementation in healthy Chinese: a 5-arm randomized, placebo-controlled trial

European Journal of Nutrition

Volumn 55, Issue 1, 2016, Pages 383-392

  Yao, Pang ^a   Lu, Ling ^a   Hu, Yao ^a   Liu, Gang ^a   Chen, Xiafei ^b   Sun, Liang ^a   Ye, Xingwang ^a   Zheng, He ^a   Chen, Yan ^a   Hu, Frank B ^c   Li, Huaixing ^a   Lin, Xu ^a,d  

^a UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^b FUDAN UNIVERSITY   (China)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d FUDAN UNIVERSITY   (China)

Author keywords

Dose response; Safety; Serum 25 hydroxyvitamin D; Vitamin D3 supplementation

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; CALCIUM; COLECALCIFEROL; CREATININE; GAMMA GLUTAMYLTRANSFERASE; PARATHYROID HORMONE; PLACEBO; CALCIUM INTAKE;

ADULT; ARTICLE; CHINESE; COMMON COLD; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG SAFETY; FEMALE; HUMAN; HUMAN EXPERIMENT; KIDNEY FUNCTION TEST; LIVER FUNCTION TEST; MALE; NEPHROLITHIASIS; NORMAL HUMAN; PARATHYROID HORMONE BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; STOMACH DISCOMFORT; VITAMIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION; ADMINISTRATION AND DOSAGE; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD; BODY MASS; CALCIUM INTAKE; DIETARY SUPPLEMENT; DRUG EFFECTS; KIDNEY; LIVER; METABOLISM; MIDDLE AGED; SOCIOECONOMICS; WAIST CIRCUMFERENCE; YOUNG ADULT;

ADULT; ALANINE TRANSAMINASE; ASIAN CONTINENTAL ANCESTRY GROUP; ASPARTATE AMINOTRANSFERASES; BIOMARKERS; BODY MASS INDEX; CALCIUM, DIETARY; CHOLECALCIFEROL; CREATININE; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; HUMANS; KIDNEY; LIVER; MALE; MIDDLE AGED; PARATHYROID HORMONE; SOCIOECONOMIC FACTORS; VITAMIN D DEFICIENCY; WAIST CIRCUMFERENCE; YOUNG ADULT;

EID: 84957437293     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-015-0859-4     Document Type: Article

References (44)

1. Holick MF (2007) Vitamin D deficiency. N Engl J Med 357:266–281. doi:10.1056/NEJMc072359
2. Lu L, Yu Z, Pan A, Hu FB, Franco OH, Li H, Li X, Yang X, Chen Y, Lin X (2009) Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals. Diabetes Care 32:1278–1283. doi:10.2337/dc09-0209
3. Choi HS, Oh HJ, Choi H, Choi WH, Kim JG, Kim KM, Kim KJ, Rhee Y, Lim S-K (2011) Vitamin D insufficiency in Korea-a greater threat to younger generation: the Korea National Health and Nutrition Examination Survey (KNHANES) 2008. J Clin Endocrinol Metab 96:643–651. doi:10.1210/jc.2010-2133
4. Thomas MK, Lloyd-Jones DM, Thadhani RI, Shaw AC, Deraska DJ, Kitch BT, Vamvakas EC, Dick IM, Prince RL, Finkelstein JS (1998) Hypovitaminosis D in medical inpatients. N Engl J Med 338:777–783. doi:10.1056/NEJM199803193381201
5. Holick MF (2006) High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc 81:353–373. doi:10.4065/81.3.353
6. Chapuy MC, Preziosi P, Maamer M, Arnaud S, Galan P, Hercberg S, Meunier PJ (1997) Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos Int 7:439–443. doi:10.1007/s001980050030
7. Bakhtiyarova S, Lesnyak O, Kyznesova N, Blankenstein MA, Lips P (2006) Vitamin D status among patients with hip fracture and elderly control subjects in Yekaterinburg, Russia. Osteoporos Int 17:441–446. doi:10.1007/s00198-005-0006-9
8. Lips P (2006) Vitamin D physiology. Prog Biophys Mol Bio 92:4–8. doi:10.1016/j.pbiomolbio.2006.02.016
9. Scragg R, Sowers M, Bell C (2004) Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the third national health and nutrition examination survey. Diabetes Care 27:2813–2818. doi:10.2337/diacare.27.12.2813
10. Mosayebi G, Ghazavi A, Ghasami K, Jand Y, Kokhaei P (2011) Therapeutic effect of vitamin D3 in multiple sclerosis patients. Immunol Investig 40:627–639. doi:10.3109/08820139.2011.573041
11. Gagnon C, Lu ZX, Magliano DJ, Dunstan DW, Shaw JE, Zimmet PZ, Sikaris K, Ebeling PR, Daly RM (2012) Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years: results from a national, population-based prospective study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab). J Clin Endocrinol Metab 97:1953–1961. doi:10.1210/jc.2011-3187
12. Forouhi NG, Luan Ja, Cooper A, Boucher BJ, Wareham NJ (2008) Baseline serum 25-hydroxy vitamin D is predictive of future glycemic status and insulin resistance: the medical research council ely prospective study 1990–2000. Diabetes 57:2619–2625. doi:10.2337/db08-0593
13. Forman JP, Scott JB, Ng K, Drake BF, Suarez EG, Hayden DL, Bennett GG, Chandler PD, Hollis BW, Emmons KM, Giovannucci EL, Fuchs CS, Chan AT (2013) Effect of vitamin D supplementation on blood pressure in blacks. Hypertension 61:779–785. doi:10.1161/HYPERTENSIONAHA.111.00659
14. Chiu KC, Chu A, Go VLW, Saad MF (2004) Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr 79:820–825
15. Chacko SA, Song Y, Manson JE, Van Horn L, Eaton C, Martin LW, McTiernan A, Curb JD, Wylie-Rosett J, Phillips LS, Plodkowski RA, Liu S (2011) Serum 25-hydroxyvitamin D concentrations in relation to cardiometabolic risk factors and metabolic syndrome in postmenopausal women. Am J Clin Nutr 94:209–217. doi:10.3945/ajcn.110.010272
16. Choi HS, Kim K-A, Lim C-Y, Rhee SY, Hwang Y-C, Kim KM, Kim KJ, Rhee Y, Lim S-K (2011) Low serum vitamin D is associated with high risk of diabetes in Korean adults. J Nutr 141:1524–1528. doi:10.3945/jn.111.139121
17. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Mayne ST, Rosen CJ, Shapses SA (2011) The 2011 report on dietary reference Intakes for calcium and vitamin D from the institute of medicine: what clinicians need to know. J Clin Endocrinol Metab 96:53–58. doi:10.1210/jc.2010-2704
18. Wang TJ, Zhang F, Richards JB et al (2010) Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 376:180–188. doi:10.1016/S0140-6736(10)60588-0
19. Zittermann A, Ernst J, Gummert J, Borgermann J (2014) Vitamin D supplementation, body weight and human serum 25-hydroxyvitamin D response: a systematic review. Eur J Nutr 53:367–374. doi:10.1007/s00394-013-0634-3
20. Raimundo F, Lang M, Scopel L, Marcondes N, Araújo M, Faulhaber G, Furlanetto T (2014) Effect of fat on serum 25-hydroxyvitamin D levels after a single oral dose of vitamin D in young healthy adults: a double-blind randomized placebo-controlled study. Eur J Nutr. doi:10.1007/s00394-014-0718-8
21. Gallagher JC, Sai A, Templin T 2nd, Smith L (2012) Dose response to vitamin D supplementation in postmenopausal women: a randomized trial. Ann Intern Med 156:425–437. doi:10.7326/0003-4819-156-6-201203200-00005
22. Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, Benjamin EJ, D’Agostino RB, Wolf M, Vasan RS (2008) Vitamin D deficiency and risk of cardiovascular disease. Circulation 117:503–511. doi:10.1161/CIRCULATIONAHA.107.706127
23. Kendrick J, Targher G, Smits G, Chonchol M (2009) 25-hydroxyvitamin D deficiency is independently associated with cardiovascular disease in the third national health and nutrition examination survey. Atherosclerosis 205:255–260. doi:10.1016/j.atherosclerosis.2008.10.033
24. Ng K, Scott JB, Drake BF, Chan AT, Hollis BW, Chandler PD, Bennett GG, Giovannucci EL, Gonzalez-Suarez E, Meyerhardt JA, Emmons KM, Fuchs CS (2014) Dose response to vitamin D supplementation in African Americans: results of a 4-arm, randomized, placebo-controlled trial. Am J Clin Nutr 99:587–598. doi:10.3945/ajcn.113.067777
25. Blum M, Dolnikowski G, Seyoum E, Harris S, Booth S, Peterson J, Saltzman E, Dawson-Hughes B (2008) Vitamin D3 in fat tissue. Endocrine 33:90–94. doi:10.1007/s12020-008-9051-4
26. Ye X, Yu Z, Li H, Franco OH, Liu Y, Lin X (2007) Distributions of C-reactive protein and its association with metabolic syndrome in middle-aged and older Chinese people. J Am Coll Cardiol 49:1798–1805. doi:10.1016/j.jacc.2007.01.065
27. Lai JKC, Lucas RM, Banks E, Ponsonby AL, Ausimmune Investigator G (2012) Variability in vitamin D assays impairs clinical assessment of vitamin D status. Intern Med J 42:43–50. doi:10.1111/j.1445-5994.2011.02471.x
28. Hathcock JN, Shao A, Vieth R, Heaney R (2007) Risk assessment for vitamin D. Am J Clin Nutr 85:6–18
29. Barrett-Connor E, Siris ES, Wehren LE, Miller PD, Abbott TA, Berger ML, Santora AC, Sherwood LM (2005) Osteoporosis and fracture risk in women of different ethnic groups. J Bone Miner Res 20:185–194. doi:10.1359/JBMR.041007
30. Gutierrez OM, Farwell WR, Kermah D, Taylor EN (2011) Racial differences in the relationship between vitamin D, bone mineral density, and parathyroid hormone in the national health and nutrition examination survey. Osteoporos Int 22:1745–1753. doi:10.1007/s00198-010-1383-2
31. Jarrett F, Michelle Ducasa G, David BB, Berwick M (2014) The effect of oral supplementation of vitamin D3 on serum levels of vitamin D: a review. Epidemiology 4:148. doi:10.4172/2161-1165.1000148
32. Smith SM, Gardner KK, Locke J, Zwart SR (2009) Vitamin D supplementation during Antarctic winter. Am J Clin Nutr 89:1092–1098. doi:10.3945/ajcn.2008.27189
33. Talwar SA, Aloia JF, Pollack S, Yeh JK (2007) Dose response to vitamin D supplementation among postmenopausal African American women. Am J Clin Nutr 86:1657–1662
34. Mitchell D, Henao M, Finkelstein J, Burnett-Bowie S-A (2012) Prevalence and predictors of vitamin D deficiency in healthy adults. Endocr Pract 18:914–923. doi:10.4158/EP12072.OR
35. Sasaki S (2008) Dietary reference intakes (DRIs) in Japan. Asia Pac J Clin Nutr 17:420–444
36. Paik HY (2008) Dietary reference intakes for Koreans (KDRIs). Asia Pac J Clin Nutr 17:416–419
37. Chinese Nutrition Society (2014) Dietary Reference intakes (DRIs) in Chinese (2013). Science Press (CN)
38. Awumey EMK, Mitra DA, Hollis BW, Kumar R, Bell NH (1998) Vitamin D metabolism is altered in Asian Indians in the Southern United States: a clinical research center study. J Clin Endocrinol Metab 83:169–173. doi:10.1210/jc.2007-2308
39. Holick MF, Biancuzzo RM, Chen TC, Klein EK, Young A, Bibuld D, Reitz R, Salameh W, Ameri A, Tannenbaum AD (2008) Vitamin D2 is as effective as vitamin D3 in maintaining circulating concentrations of 25-hydroxyvitamin D. J Clin Endocrinol Metab 93:677–681. doi:10.1210/jc.2007-2308
40. Gallagher JC, Peacock M, Yalamanchili V, Smith LM (2013) Effects of vitamin D supplementation in older African American women. J Clin Endocrinol Metab 98:1137–1146. doi:10.1210/jc.2012-3106
41. Gallagher JC, Jindal PS, Smith LM (2014) Vitamin D supplementation in young white and african american women. J Bone Miner Res 29:173–181. doi:10.1002/jbmr.2010
42. Ross AC, Taylor CL, Yaktine AL, Valle. HBD (2011) Dietary reference intakes for calcium and vitamin D. National Academies Press (US)
43. Holick MF (2004) Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 80:1678S–1688S
44. Lips P (2001) Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 22:477–501