Association of 25-hydroxyvitamin D with areal and volumetric measures of bone mineral density and parathyroid hormone: impact of vitamin D-binding protein and its assays

Osteoporosis International

Volumn 27, Issue 2, 2016, Pages 617-626

  Jemielita, T O ^a   Leonard, M B ^b   Baker, J ^a,c   Sayed, S ^d   Zemel, B S ^a   Shults, J ^a   Herskovitz, R ^d   Denburg, M R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Bone mineral density; Parathyroid hormone; Vitamin D; Vitamin D binding protein

Indexed keywords

25 HYDROXYVITAMIN D; ALBUMIN; MONOCLONAL ANTIBODY; PARATHYROID HORMONE; POLYCLONAL ANTIBODY; VITAMIN D BINDING PROTEIN; 25-HYDROXYVITAMIN D; BIOLOGICAL MARKER; CALCIUM INTAKE; VITAMIN D;

ADULT; AFRICAN AMERICAN; AGED; ARTICLE; BIOAVAILABILITY; BONE DENSITY; COMPUTER ASSISTED TOMOGRAPHY; DUAL ENERGY X RAY ABSORPTIOMETRY; ENZYME LINKED IMMUNOSORBENT ASSAY; EUROPEAN AMERICAN; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PARATHYROID HORMONE BLOOD LEVEL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RACE DIFFERENCE; ADMINISTRATION AND DOSAGE; ANALOGS AND DERIVATIVES; ANTHROPOMETRY; BLOOD; CALCIUM INTAKE; CAUCASIAN; CLINICAL TRIAL; COMPARATIVE STUDY; EPIDEMIOLOGY; ETHNOLOGY; MIDDLE AGED; MULTICENTER STUDY; PHYSIOLOGY; PROCEDURES; STATISTICS AND NUMERICAL DATA; UNITED STATES; VERY ELDERLY; VITAMIN D DEFICIENCY; YOUNG ADULT;

ADULT; AFRICAN AMERICANS; AGED; AGED, 80 AND OVER; ANTHROPOMETRY; BIOLOGICAL AVAILABILITY; BIOMARKERS; BONE DENSITY; CALCIUM, DIETARY; ENZYME-LINKED IMMUNOSORBENT ASSAY; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; MALE; MIDDLE AGED; PARATHYROID HORMONE; UNITED STATES; VITAMIN D; VITAMIN D DEFICIENCY; VITAMIN D-BINDING PROTEIN; YOUNG ADULT;

EID: 84957430651     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-015-3296-6     Document Type: Article

References (53)

1. Bischoff-Ferrari HA, Dietrich T, Orav EJ, Dawson-Hughes B (2004) Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults. Am J Med 116(9):634–639. doi:10.1016/j.amjmed.2003.12.029
2. Bischoff-Ferrari HA, Kiel DP, Dawson-Hughes B, Orav JE, Li R, Spiegelman D, Dietrich T, Willett WC (2009) Dietary calcium and serum 25-hydroxyvitamin D status in relation to BMD among U.S. adults. J Bone Miner Res 24(5):935–942. doi:10.1359/jbmr.081242
3. Valimaki VV, Alfthan H, Lehmuskallio E, Loyttyniemi E, Sahi T, Stenman UH, Suominen H, Valimaki MJ (2004) Vitamin D status as a determinant of peak bone mass in young Finnish men. J Clin Endocrinol Metab 89(1):76–80
4. Cauley JA, Lacroix AZ, Wu L, Horwitz M, Danielson ME, Bauer DC, Lee JS, Jackson RD, Robbins JA, Wu C, Stanczyk FZ, LeBoff MS, Wactawski-Wende J, Sarto G, Ockene J, Cummings SR (2008) Serum 25-hydroxyvitamin D concentrations and risk for hip fractures. Ann Intern Med 149(4):242–250
5. Gerdhem P, Ringsberg KA, Obrant KJ, Akesson K (2005) Association between 25-hydroxy vitamin D levels, physical activity, muscle strength and fractures in the prospective population-based OPRA Study of Elderly Women. Osteoporos Int 16(11):1425–1431. doi:10.1007/s00198-005-1860-1
6. Bischoff-Ferrari HA, Willett WC, Orav EJ, Lips P, Meunier PJ, Lyons RA, Flicker L, Wark J, Jackson RD, Cauley JA, Meyer HE, Pfeifer M, Sanders KM, Stahelin HB, Theiler R, Dawson-Hughes B (2012) A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med 367(1):40–49. doi:10.1056/NEJMoa1109617
7. Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B (2005) Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 293(18):2257–2264. doi:10.1001/jama.293.18.2257
8. Bischoff-Ferrari HA, Willett WC, Wong JB, Stuck AE, Staehelin HB, Orav EJ, Thoma A, Kiel DP, Henschkowski J (2009) Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med 169(6):551–561. doi:10.1001/archinternmed.2008.600
9. Dawson-Hughes B, Harris SS, Krall EA, Dallal GE (1997) Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 337(10):670–676. doi:10.1056/NEJM199709043371003
10. Prentice RL, Pettinger MB, Jackson RD, Wactawski-Wende J, Lacroix AZ, Anderson GL, Chlebowski RT, Manson JE, Van Horn L, Vitolins MZ, Datta M, LeBlanc ES, Cauley JA, Rossouw JE (2013) Health risks and benefits from calcium and vitamin D supplementation: Women’s Health Initiative clinical trial and cohort study. Osteoporos Int 24(2):567–580. doi:10.1007/s00198-012-2224-2
11. Group D (2010) Patient level pooled analysis of 68 500 patients from seven major vitamin D fracture trials in US and Europe. BMJ 340:b5463. doi:10.1136/bmj.b5463
12. Jackson RD, LaCroix AZ, Gass M, Wallace RB, Robbins J, Lewis CE, Bassford T, Beresford SA, Black HR, Blanchette P, Bonds DE, Brunner RL, Brzyski RG, Caan B, Cauley JA, Chlebowski RT, Cummings SR, Granek I, Hays J, Heiss G, Hendrix SL, Howard BV, Hsia J, Hubbell FA, Johnson KC, Judd H, Kotchen JM, Kuller LH, Langer RD, Lasser NL, Limacher MC, Ludlam S, Manson JE, Margolis KL, McGowan J, Ockene JK, O’Sullivan MJ, Phillips L, Prentice RL, Sarto GE, Stefanick ML, Van Horn L, Wactawski-Wende J, Whitlock E, Anderson GL, Assaf AR, Barad D, Women’s Health Initiative I (2006) Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 354(7):669–683. doi:10.1056/NEJMoa055218
13. Kremer R, Campbell PP, Reinhardt T, Gilsanz V (2009) Vitamin D status and its relationship to body fat, final height, and peak bone mass in young women. J Clin Endocrinol Metab 94(1):67–73. doi:10.1210/jc.2008-1575
14. Sherman SS, Tobin JD, Hollis BW, Gundberg CM, Roy TA, Plato CC (1992) Biochemical parameters associated with low bone density in healthy men and women. J Bone Miner Res 7(10):1123–1130. doi:10.1002/jbmr.5650071003
15. Aloia JF, Talwar SA, Pollack S, Yeh J (2005) A randomized controlled trial of vitamin D3 supplementation in African American women. Arch Intern Med 165(14):1618–1623. doi:10.1001/archinte.165.14.1618
16. Grant AM, Avenell A, Campbell MK, McDonald AM, MacLennan GS, McPherson GC, Anderson FH, Cooper C, Francis RM, Donaldson C, Gillespie WJ, Robinson CM, Torgerson DJ, Wallace WA, Group RT (2005) Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 365(9471):1621–1628. doi:10.1016/S0140-6736(05)63013-9
17. Sanders KM, Stuart AL, Williamson EJ, Simpson JA, Kotowicz MA, Young D, Nicholson GC (2010) Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA 303(18):1815–1822. doi:10.1001/jama.2010.594
18. Gutierrez OM, Farwell WR, Kermah D, Taylor EN (2011) Racial differences in the relationship between vitamin D, bone mineral density, and parathyroid hormone in the National Health and Nutrition Examination Survey. Osteoporos Int 22(6):1745–1753. doi:10.1007/s00198-010-1383-2
19. Hannan MT, Litman HJ, Araujo AB, McLennan CE, McLean RR, McKinlay JB, Chen TC, Holick MF (2008) Serum 25-hydroxyvitamin D and bone mineral density in a racially and ethnically diverse group of men. J Clin Endocrinol Metab 93(1):40–46. doi:10.1210/jc.2007-1217
20. Barrett-Connor E, Siris ES, Wehren LE, Miller PD, Abbott TA, Berger ML, Santora AC, Sherwood LM (2005) Osteoporosis and fracture risk in women of different ethnic groups. J Bone Miner Res 20(2):185–194. doi:10.1359/JBMR.041007
21. Cauley JA, Lui LY, Ensrud KE, Zmuda JM, Stone KL, Hochberg MC, Cummings SR (2005) Bone mineral density and the risk of incident nonspinal fractures in black and white women. JAMA 293(17):2102–2108. doi:10.1001/jama.293.17.2102
22. Fang J, Freeman R, Jeganathan R, Alderman MH (2004) Variations in hip fracture hospitalization rates among different race/ethnicity groups in New York City. Ethn Dis 14(2):280–284
23. Finkelstein JS, Lee ML, Sowers M, Ettinger B, Neer RM, Kelsey JL, Cauley JA, Huang MH, Greendale GA (2002) Ethnic variation in bone density in premenopausal and early perimenopausal women: effects of anthropometric and lifestyle factors. J Clin Endocrinol Metab 87(7):3057–3067
24. Greendale GA, Sowers M, Han W, Huang MH, Finkelstein JS, Crandall CJ, Lee JS, Karlamangla AS (2012) Bone mineral density loss in relation to the final menstrual period in a multiethnic cohort: results from the Study of Women’s Health Across the Nation (SWAN). J Bone Miner Res 27(1):111–118. doi:10.1002/jbmr.534
25. Harris SS, Soteriades E, Coolidge JA, Mudgal S, Dawson-Hughes B (2000) Vitamin D insufficiency and hyperparathyroidism in a low income, multiracial, elderly population. J Clin Endocrinol Metab 85(11):4125–4130
26. Nesby-O’Dell S, Scanlon KS, Cogswell ME, Gillespie C, Hollis BW, Looker AC, Allen C, Doughertly C, Gunter EW, Bowman BA (2002) Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: third National Health and Nutrition Examination Survey, 1988–1994. Am J Clin Nutr 76(1):187–192
27. Bhan I, Powe CE, Berg AH, Ankers E, Wenger JB, Karumanchi SA, Thadhani RI (2012) Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patients. Kidney Int 82(1):84–89. doi:10.1038/ki.2012.19
28. Bikle DD, Gee E, Halloran B, Kowalski MA, Ryzen E, Haddad JG (1986) Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein. J Clin Endocrinol Metab 63(4):954–959
29. Bikle DD, Siiteri PK, Ryzen E, Haddad JG (1985) Serum protein binding of 1,25-dihydroxyvitamin D: a reevaluation by direct measurement of free metabolite levels. J Clin Endocrinol Metab 61(5):969–975
30. Powe CE, Ricciardi C, Berg AH, Erdenesanaa D, Collerone G, Ankers E, Wenger J, Karumanchi SA, Thadhani R, Bhan I (2011) Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship. J Bone Miner Res 26(7):1609–1616. doi:10.1002/jbmr.387
31. White P, Cooke N (2000) The multifunctional properties and characteristics of vitamin D-binding protein. Trends Endocrinol Metab 11(8):320–327
32. Arnaud J, Constans J (1993) Affinity differences for vitamin D metabolites associated with the genetic isoforms of the human serum carrier protein (DBP). Hum Genet 92(2):183–188
33. Constans J, Hazout S, Garruto RM, Gajdusek DC, Spees EK (1985) Population distribution of the human vitamin D binding protein: anthropological considerations. Am J Phys Anthropol 68(1):107–122. doi:10.1002/ajpa.1330680110
34. Powe CE, Evans MK, Wenger J, Zonderman AB, Berg AH, Nalls M, Tamez H, Zhang D, Bhan I, Karumanchi SA, Powe NR, Thadhani R (2013) Vitamin D-binding protein and vitamin D status of black Americans and white Americans. N Engl J Med 369(21):1991–2000. doi:10.1056/NEJMoa1306357
35. Bikle DD, Gee E (1989) Free, and not total, 1,25-dihydroxyvitamin D regulates 25-hydroxyvitamin D metabolism by keratinocytes. Endocrinology 124(2):649–654
36. Chun RF, Lauridsen AL, Suon L, Zella LA, Pike JW, Modlin RL, Martineau AR, Wilkinson RJ, Adams J, Hewison M (2010) Vitamin D-binding protein directs monocyte responses to 25-hydroxy- and 1,25-dihydroxyvitamin D. J Clin Endocrinol Metab 95(7):3368–3376. doi:10.1210/jc.2010-0195
37. Bouillon R, Jones K, Schoenmakers I (2014) Vitamin D-binding protein and vitamin D in blacks and whites. N Engl J Med 370(9):879. doi:10.1056/NEJMc1315850#SA3
38. Carter GD, Phinney KW (2014) Assessing vitamin D status: time for a rethink? Clin Chem 60(6):809–811. doi:10.1373/clinchem.2013.219386
39. Hollis BW, Bikle DD (2014) Vitamin D-binding protein and vitamin D in blacks and whites. N Engl J Med 370(9):879–880. doi:10.1056/NEJMc1315850#SA4
40. Baker JF, Davis M, Alexander R, Zemel BS, Mostoufi-Moab S, Shults J, Sulik M, Schiferl DJ, Leonard MB (2013) Associations between body composition and bone density and structure in men and women across the adult age spectrum. Bone 53(1):34–41. doi:10.1016/j.bone.2012.11.035
41. Leonard MB, Elmi A, Mostoufi-Moab S, Shults J, Burnham JM, Thayu M, Kibe L, Wetzsteon RJ, Zemel BS (2010) Effects of sex, race, and puberty on cortical bone and the functional muscle bone unit in children, adolescents, and young adults. J Clin Endocrinol Metabol 95(4):1681–1689. doi:10.1210/jc.2009-1913
42. Subar AF, Thompson FE, Kipnis V, Midthune D, Hurwitz P, McNutt S, McIntosh A, Rosenfeld S (2001) Comparative validation of the Block, Willett, and National Cancer Institute food frequency questionnaires: the Eating at America’s Table Study. Am J Epidemiol 154(12):1089–1099
43. Hollis BW (1997) Quantitation of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D by radioimmunoassay using radioiodinated tracers. Methods Enzymol 282:174–186
44. Clive DR, Sudhaker D, Giacherio D, Gupta M, Schreiber MJ, Sackrison JL, MacFarlane GD (2002) Analytical and clinical validation of a radioimmunoassay for the measurement of 1,25 dihydroxy vitamin D. Clin Biochem 35(7):517–521
45. Gao P, Scheibel S, D’Amour P, John MR, Rao SD, Schmidt-Gayk H, Cantor TL (2001) Development of a novel immunoradiometric assay exclusively for biologically active whole parathyroid hormone 1–84: implications for improvement of accurate assessment of parathyroid function. J Bone Miner Res 16(4):605–614. doi:10.1359/jbmr.2001.16.4.605
46. Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium (2011) Dietary reference intakes for calcium and vitamin D. In: Ross AC, Taylor CL, Yaktine AL, Del Valle HB (eds) National Academies Press, Washington DC
47. Cosman F, Nieves J, Dempster D, Lindsay R (2007) Vitamin D economy in blacks. J Bone Miner Res 22(Suppl 2):V34–V38. doi:10.1359/jbmr.07s220
48. Denburg MR, Kalkwarf HJ, de Boer IH, Hewison M, Shults J, Zemel BS, Stokes D, Foerster D, Laskin B, Ramirez A, Leonard MB (2013) Vitamin D bioavailability and catabolism in pediatric chronic kidney disease. Pediatr Nephrol 28(9):1843–1853. doi:10.1007/s00467-013-2493-9
49. Bouillon R, van Baelen H, de Moor P (1977) The measurement of the vitamin D-binding protein in human serum. J Clin Endocrinol Metab 45(2):225–231. doi:10.1210/jcem-45-2-225
50. M’Buyamba-Kabangu JR, Fagard R, Lijnen P, Bouillon R, Lissens W, Amery A (1987) Calcium, vitamin D-endocrine system, and parathyroid hormone in black and white males. Calcif Tissue Int 41(2):70–74
51. Winters SJ, Chennubhatla R, Wang C, Miller JJ (2009) Influence of obesity on vitamin D-binding protein and 25-hydroxy vitamin D levels in African American and white women. Metabolism 58(4):438–442. doi:10.1016/j.metabol.2008.10.017
52. Christiansen M, Jorgensen CS, Laursen I, Hirschberg D, Hojrup P, Houen G (2007) Protein chemical characterization of Gc globulin (vitamin D-binding protein) isoforms; Gc-1f, Gc-1s and Gc-2. Biochim Biophys Acta 1774(4):481–492. doi:10.1016/j.bbapap.2007.01.005
53. Powe CE, Karumanchi SA, Thadhani R (2014) Vitamin D-binding protein and vitamin D in blacks and whites. N Engl J Med 370(9):880–881. doi:10.1056/NEJMc1315850