SN2-palmitate reduces fatty acid excretion in Chinese formula-fed infants

Journal of Pediatric Gastroenterology and Nutrition

Volumn 62, Issue 2, 2016, Pages 341-347

  Bar Yoseph, Fabiana ^a   Lifshitz, Yael ^a   Cohen, Tzafra ^a   Malard, Patrice ^b   Xu, Chungdi ^c  

^a Enzymotec Ltd   (Israel)

^b Biostime   (China)

^c SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

Author keywords

Beta palmitate; infant formula; palmitic acid; prebiotics; SN2 palmitate

Indexed keywords

FATTY ACID; PALMITIC ACID; SN2 PALMITATE; UNCLASSIFIED DRUG; PALMITIC ACID DERIVATIVE; TRIACYLGLYCEROL;

ADULT; ARTICLE; ARTIFICIAL MILK; BREAST MILK; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRY WEIGHT; FAT CONTENT; FECES; FECES ANALYSIS; FEMALE; HUMAN; INFANT; MALE; MULTICENTER STUDY; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; BREAST FEEDING; CHEMISTRY; CHINA; CLINICAL TRIAL; DIET; DIGESTION; DRUG EFFECTS; ESTERIFICATION; INTESTINE ABSORPTION; METABOLISM; NEWBORN; PREGNANCY;

ADULT; BREAST FEEDING; CHINA; DIET; DIGESTION; ESTERIFICATION; FATTY ACIDS; FECES; FEMALE; HUMANS; INFANT FORMULA; INFANT, NEWBORN; INTESTINAL ABSORPTION; MALE; MILK, HUMAN; PALMITATES; PALMITIC ACID; PREGNANCY; TRIGLYCERIDES;

EID: 84957057080     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/MPG.0000000000000971     Document Type: Article

References (34)

1. Agostoni C, Braegger C, Decsi T, et al. Breast-feeding: a commentary by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 2009;49:112-25.
2. Giovannini M, Riva E, Agostoni C. Fatty acids in pediatric nutrition. Pediatr Clin North Am 1995;42:861-77.
3. Breckenridge WC, Marai L, Kuksis A. Triglyceride structure of human milk fat. Can J Biochem 1969;47:761-9.
4. Mu H, Hoy CE. The digestion of dietary triacylglycerols. Prog Lipid Res 2004;43:105-33.
5. Hamosh M, Scow RO. Lingual lipase and its role in the digestion of dietary lipid. J Clin Invest 1973;52:88-95.
6. Abrahamse E, Minekus M, van Aken GA, et al. Development of the digestive system-experimental challenges and approaches of infant lipid digestion. Food Dig 2012;3:63-77.
7. Manson WG, Weaver LT. Fat digestion in the neonate. Arch Dis Child Fetal Neonatal Ed 1997;76:F206-11.
8. Mattson FH, Volpenhein RA. The digestion and absorption of triglycerides. J Biol Chem 1964;239:2772-7.
9. Innis SM. Dietary triacylglycerol structure and its role in infant nutrition. Adv Nutr 2011;2:275-83.
10. Innis SM, Dyer R, Nelson CM. Evidence that palmitic acid is absorbed as sn-2 monoacylglycerol from human milk by breast-fed infants. Lipids 1994;29:541-5.
11. Nelson CM, Innis SM. Plasma lipoprotein fatty acids are altered by the positional distribution of fatty acids in infant formula triacylglycerols and human milk. Am J Clin Nutr 1999;70:62-9.
12. Mattson FH, Volpenhein RA. The specific distribution of fatty acids in the glycerides of vegetable fats. J Biol Chem 1961;236: 1891-4.
13. Small DM. The effects of glyceride structure on absorption and metabolism. Annu Rev Nutr 1991;11:413-34.
14. Quinlan PT, Lockton S, Irwin J, et al. The relationship between stool hardness and stool composition in breast-and formula-fed infants. J Pediatr Gastroenterol Nutr 1995;20:81-90.
15. Carnielli VP, Luijendijk IH, Van Goudoever JB, et al. Structural position and amount of palmitic acid in infant formulas: effects on fat, fatty acid, and mineral balance. J Pediatr Gastroenterol Nutr 1996;23:553-60.
16. Kennedy K, Fewtrell MS, Morley R, et al. Double-blind, randomized trial of a synthetic triacylglycerol in formula-fed term infants: effects on stool biochemistry, stool characteristics, and bone mineralization. Am J Clin Nutr 1999;70:920-7.
17. Lopez-Lopez A, Castellote-Bargallo AI, Campoy-Folgoso C, et al. The influence of dietary palmitic acid triacylglyceride position on the fatty acid, calcium and magnesium contents of at term newborn faeces. Early Hum Dev 2001;65 (suppl):S83-94.
18. Carnielli VP, Luijendijk IH, van Goudoever JB, et al. Feeding premature newborn infants palmitic acid in amounts and stereoisomeric position similar to that of human milk: effects on fat and mineral balance. Am J Clin Nutr 1995;61:1037-42.
19. Lucas A, Quinlan P, Abrams S, et al. Randomised controlled trial of a synthetic triglyceride milk formula for preterm infants. Arch Dis Child Fetal Neonatal Ed 1997;77:F178-84.
20. Bar-Yoseph F, Lifshitz Y, Cohen T. Review of sn-2 palmitate oil implications for infant health. Prostaglandins Leukot Essent Fatty Acids 2013;89:139-43.
21. Litmanovitz I, Davidson K, Eliakim A, et al. High beta-palmitate formula and bone strength in term infants: a randomized, double-blind, controlled trial. Calcif Tissue Int 2013;92:35-41.
22. Yaron S, Shachar D, Abramas L, et al. Effect of high beta-palmitate content in infant formula on the intestinal microbiota of term infants. J Pediatr Gastroenterol Nutr 2013;56:376-81.
23. Litmanovitz I, Bar-Yoseph F, Lifshitz Y, et al. Reduced crying in term infants fed high beta-palmitate formula: a double-blind randomized clinical trial. BMC Pediatr 2014;14:152.
24. Mugambi MN, Musekiwa A, Lombard M, et al. Synbiotics, probiotics or prebiotics in infant formula for full term infants: a systematic review. Nutr J 2012;11:81.
25. Macfarlane GT, Steed H, Macfarlane S. Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebiotics. J Appl Microbiol 2008;104:305-44.
26. Dixon WJ, Massey FJ. Introduction to Statistical Analysis. 4th ed. New York: McGraw-Hill; 1983:281-4.
27. O'Brien PC. Procedures for comparing samples with multiple endpoints. Biometrics 1984;40:1079-87.
28. Calder PC, Etschmann SK, de Jong EC, et al. Early nutrition and immunity: progress and perspectives. Br J Nutr 2006;96:774-90.
29. Fanaro S, Boehm G, Garssen J, et al. Galacto-oligosaccharides and longchain fructo-oligosaccharides as prebiotics in infant formulas: a review. Acta Paediatr Suppl 2005;94:22-6.
30. Vandenplas Y. Oligosaccharides in infant formula. Br J Nutr 2002; 87(Suppl 2):S293-6.
31. Overduin J, Schoterman MH, Calame W, et al. Dietary galacto-oligosaccharides and calcium: effects on energy intake, fat-pad weight and satiety-related, gastrointestinal hormones in rats. Br J Nutr 2013; 109:1338-48.
32. van den Heuvel EG, Schaafsma G, Muys T, et al. Nondigestible oligosaccharides do not interfere with calcium and nonheme-iron absorption in young, healthy men. Am J Clin Nutr 1998;67:445-51.
33. Roman C, Carriere F, Villeneuve P, et al. Quantitative and qualitative study of gastric lipolysis in premature infants: do MCTenriched infant formulas improve fat digestion? Pediatr Res 2007;61: 83-8.
34. Johnson K, Ross L, Miller R, et al. Pancreatic lipase-related protein 2 digests fats in human milk and formula in concert with gastric lipase and carboxyl ester lipase. Pediatr Res 2013;74:127-32.