Indoor microbial communities: Influence on asthma severity in atopic and nonatopic children

Journal of Allergy and Clinical Immunology

Volumn 138, Issue 1, 2016, Pages 76-83.e1

  Dannemiller, Karen C ^a   Gent, Janneane F ^b   Leaderer, Brian P ^b   Peccia, Jordan ^a  

^a Yale University   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

Allergy; asthma severity; atopy; bacteria; children; DNA sequencing; fungi; indoor environment; microbial communities; nonallergic asthma

Indexed keywords

ANTIASTHMATIC AGENT; DNA; HOUSE DUST ALLERGEN; IMMUNOGLOBULIN E; ALLERGEN;

ALLERGIC ASTHMA; ARTICLE; ATOPY; BACTERIUM; CHEMOTAXONOMY; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DNA SEQUENCE; ENVIRONMENTAL EXPOSURE; FEMALE; FILOBASIDIELLA; FUNGAL COMMUNITY; FUNGAL STRAIN; FUNGUS; HOUSE DUST; HOUSEHOLD; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; KONDOA; LOGISTIC REGRESSION ANALYSIS; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; MICROBIAL COMMUNITY; MICROORGANISM; MODERATE PERSISTENT ASTHMA; MULTICENTER STUDY; NEXT GENERATION SEQUENCING; PATIENT SELECTION; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SCHOOL CHILD; SERUM; SEVERE PERSISTENT ASTHMA; SPECIES COMPOSITION; VOLUTELLA; WHEEZING; YEAST; ADOLESCENT; ADVERSE EFFECTS; ASTHMA; HYPERSENSITIVITY; IMMUNOLOGY; INDOOR AIR POLLUTION; METAGENOME; METAGENOMICS; MICROBIOLOGY; MICROFLORA; ODDS RATIO; PROCEDURES; RISK FACTOR; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

ADOLESCENT; AIR MICROBIOLOGY; AIR POLLUTION, INDOOR; ALLERGENS; ASTHMA; CHILD; FEMALE; HUMANS; HYPERSENSITIVITY; IMMUNOGLOBULIN E; MALE; METAGENOME; METAGENOMICS; MICROBIOTA; ODDS RATIO; RISK FACTORS; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 84957056431     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.11.027     Document Type: Article

References (43)

1. 1 Douwes, J., Gibson, P., Pekkanen, J., Pearce, N., Non-eosinophilic asthma: importance and possible mechanisms. Thorax 57 (2002), 643–648.
2. 2 Pearce, N., Pekkanen, J., Beasley, R., How much asthma is really attributable to atopy?. Thorax 54 (1999), 268–272.
3. 3 Kim, H.Y., DeKruyff, R.H., Umetsu, D.T., The many paths to asthma: phenotype shaped by innate and adaptive immunity. Nat Immunol 11 (2010), 577–584.
4. 4 Amin, K., Ludviksdottir, D., Janson, C., Nettelbladt, O., Bjornsson, E., Roomans, G.M., et al. Inflammation and structural changes in the airways of patients with atopic and nonatopic asthma. Am J Respir Crit Care Med 162 (2000), 2295–2301.
5. 5 Umetsu, D.T., McIntire, J.J., Akbari, O., Macaubas, C., DeKruyff, R.H., Asthma: an epidemic of dysregulated immunity. Nat Immunol 3 (2002), 715–720.
6. 6 Levine, S.J., Wenzel, S.E., Narrative review: the role of Th2 immune pathway modulation in the treatment of severe asthma and its phenotypes. Ann Intern Med 152 (2010), 232–237.
7. 7 Michel, O., Kips, J., Duchateau, J., Vertongen, F., Robert, L., Collet, H., et al. Severity of asthma is related to endotoxin in house dust. Am J Respir Crit Care Med 154 (1996), 1641–1646.
8. 8 Zambelli-Weiner, A., Stockton, M., Ehrlich, E., Whitmer, M., Lewis, D., Olenchock, S., et al. House dust endotoxin exposure mitigates asthma severity in a tropical environment. J Allergy Clin Immunol, 113(suppl), 2004, S304.
9. 9 Goldman, D.L., Vicencio, A.G., The chitin connection. mBio, 3, 2012 e00056-12.
10. 10 Blatter, J., Forno, E., Brehm, J., Acosta-Pérez, E., Alvarez, M., Colón-Semidey, A., et al. Fungal exposure, atopy, and asthma exacerbations in Puerto Rican children. Ann Am Thorac Soc 11 (2014), 925–932.
11. 11 Douwes, J., Zuidhof, A., Doekes, G., van der Zee, S., Wouters, I., Boezen, M.H., et al. (1 → 3)- β -d-glucan and endotoxin in house dust and peak flow variability in children. Am J Respir Crit Care Med 162 (2000), 1348–1354.
12. 12 Mendell, M.J., Mirer, A.G., Cheung, K., Tong, M., Douwes, J., Respiratory and allergic health effects of dampness, mold, and dampness-related agents: a review of the epidemiologic evidence. Environ Health Perspect 119 (2011), 748–756.
13. 13 Murray, C.S., Poletti, G., Kebadze, T., Morris, J., Woodcock, A., Johnston, S.L., et al. Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children. Thorax 61 (2006), 376–382.
14. 14 Gent, J.F., Kezik, J.M., Hill, M.E., Tsai, E., Li, D.W., Leaderer, B.P., Household mold and dust allergens: exposure, sensitization and childhood asthma morbidity. Environ Res 118 (2012), 86–93.
15. 15 Belanger, K., Holford, T.R., Gent, J.F., Hill, M.E., Kezik, J.M., Leaderer, B.P., Household levels of nitrogen dioxide and pediatric asthma severity. Epidemiology 24 (2013), 320–330.
16. 16 US Department of Health and Human Services. Global Initiative for Asthma, Global Strategy for Asthma Management and Prevention. 2002. Available at: http://www.ginasthma.org/Guidelines/guidelines-2002-original%3a-workshop-report%2c-global-strategy-for-asthma-management-and-prevention.html. Accessed January 1, 2011.
17. 17 Mayo Clinic. Immunoglobulin E (IgE) serum. 2006. Available at: http://mayomedicallaboratories.com/test-catalog/pring.pht?unit_code=8159. Accessed April 5, 2011.
18. 18 Yamamoto, N., Bibby, K., Qian, J., Hospodsky, D., Rismani-Yazdi, H., Nazaroff, W.W., et al. Particle-size distributions and seasonal diversity of allergenic and pathogenic fungi in outdoor air. ISME J 6 (2012), 1801–1811.
19. 19 Adams, R.I., Bhangar, S., Pasut, W., Arens, E.A., Taylor, J.W., Lindow, S.E., et al. Chamber bioaerosol study: outdoor air and human occupants as sources of indoor airborne microbes. PLoS One, 10, 2015, e0128022.
20. 20 National Oceanic and Atmospheric Administration, National Centers for Environmental Information. 1981-2010 U.S. Climate Normals. Hartford Bradley International Airport, CT, US. Available at: http://www.ncdc.noaa.gov/cdo-web/datatools/normals. Accessed June 30, 2015.
21. 21 Belanger, K., Gent, J.F., Triche, E.W., Bracken, M.B., Leaderer, B.P., Association of indoor nitrogen dioxide exposure with respiratory symptoms in children with asthma. Am J Respir Crit Care Med 173 (2006), 297–303.
22. 22 Belanger, K., Beckett, W., Triche, E., Bracken, M.B., Holford, T., Ren, P., et al. Symptoms of wheeze and persistent cough in the first year of life: associations with indoor allergens, air contaminants, and maternal history of asthma. Am J Epidemiol 158 (2003), 195–202.
23. 23 Leaderer, B.P., Belanger, K., Triche, E., Holford, T., Gold, D.R., Kim, Y., et al. Dust mite, cockroach, cat, and dog allergen concentrations in homes of asthmatic children in the northeastern United States: impact of socioeconomic factors and population density. Environ Health Perspect 110 (2002), 419–425.
24. 24 Dannemiller, K.C., Gent, J.F., Leaderer, B.P., Peccia, J., Influence of housing characteristics on bacterial and fungal communities in homes of asthmatic children. Indoor Air, 2015, 10.1111/ina.12205 [Epub ahead of print].
25. 25 Manter, D., Vivanco, J., Use of the ITS primers, ITS1F and ITS4, to characterize fungal abundance and diversity in mixed-template samples by qPCR and length heterogeneity analysis. J Microbiol Methods 71 (2007), 7–14.
26. 26 Larena, I., Salazar, O., Gonzalez, V., Julian, M.C., Rubio, V., Design of a primer for ribosomal DNA internal transcribed spacer with enhanced specificity for ascomycetes. J Biotechnol 75 (1999), 187–194.
27. 27 Caporaso, J.G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F.D., Costello, E.K., et al. QIIME allows analysis of high-throughput community sequencing data. Nat Methods 7 (2010), 335–336.
28. 28 Dannemiller, K.C., Reeves, D., Bibby, K., Yamamoto, N., Peccia, J., Fungal high-throughput taxonomic identification tool for use with next-generation sequencing (FHiTINGS). J Basic Microb 54 (2013), 315–321.
29. 29 Gauch, H.G., Whittaker, R.H., Wentworth, T.R., A comparative study of reciprocal averaging and other ordination techniques. J Ecol 65 (1977), 157–174.
30. 30 Horn, H.S., Measurement of “overlap” in comparative ecological studies. Am Nat 100 (1966), 419–424.
31. 31 Caporaso, J.G., Lauber, C.L., Walters, W.A., Berg-Lyons, D., Lozupone, C.A., Turnbaugh, P.J., et al. Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample. Proc Natl Acad Sci U S A 108:suppl 1 (2011), 4516–4522.
32. 32 Lozupone, C., Knight, R., UniFrac: a new phylogenetic method for comparing microbial communities. Appl Environ Microb 71 (2005), 8228–8235.
33. 33 Dannemiller, K.C., Lang-Yona, N., Yamamoto, N., Rudich, Y., Peccia, J., Combining real-time PCR and next-generation DNA sequencing to provide quantitative comparisons of fungal aerosol populations. Atmos Environ 84 (2014), 113–121.
34. 34 Storey, J.D., Tibshirani, R., Statistical significance for genomewide studies. Proc Natl Acad Sci U S A 100 (2003), 9440–9445.
35. 35 Trent, M.S., Stead, C.M., Tran, A.X., Hankins, J.V., Invited review: diversity of endotoxin and its impact on pathogenesis. J Endotoxin Res 12 (2006), 205–223.
36. 36 Simon-Nobbe, B., Denk, U., Pöll, V., Rid, R., Breitenbach, M., The spectrum of fungal allergy. Int Arch Allergy Immunol 145 (2008), 58–86.
37. 37 Findley, K., Oh, J., Yang, J., Conlan, S., Deming, C., Meyer, J.A., et al. Topographic diversity of fungal and bacterial communities in human skin. Nature 498 (2013), 367–370.
38. 38 Cui, L., Morris, A., Ghedin, E., The human mycobiome in health and disease. Genome Med, 5, 2013, 63.
39. 39 Liu, A.H., Endotoxin exposure in allergy and asthma: Reconciling a paradox. J Allergy Clin Immunol 109 (2002), 379–392.
40. 40 Lynch, S.V., Wood, R.A., Boushey, H., Bacharier, L.B., Bloomberg, G.R., Kattan, M., et al. Effects of early-life exposure to allergens and bacteria on recurrent wheeze and atopy in urban children. J Allergy Clin Immunol 134 (2014), 593–601.e12.
41. 41 Fujimura, K.E., Demoor, T., Rauch, M., Faruqi, A.A., Jang, S., Johnson, C.C., et al. House dust exposure mediates gut microbiome Lactobacillus enrichment and airway immune defense against allergens and virus infection. Proc Natl Acad Sci U S A 111 (2014), 805–810.
42. 42 Dannemiller, K., Mendell, M.J., Macher, J.M., Kumagai, K., Bradman, A., Holland, N., et al. Next-generation DNA sequencing reveals that low fungal diversity in house dust is associated with childhood asthma development. Indoor Air 24 (2014), 236–247.
43. 43 Kozyrskyj, A.L., Mustard, C.A., Simons, F.R., Socioeconomic status, drug insurance benefits, and new prescriptions for inhaled corticosteroids in schoolchildren with asthma. Arch Pediat Adol Med 155 (2001), 1219–1224.