Increased baseline C-Reactive protein concentrations are associated with increased risk of infections: Results from 2 large danish population cohorts

Clinical Chemistry

Volumn 62, Issue 2, 2016, Pages 335-342

  Zacho, Jeppe ^a   Benfield, Thomas ^b   Tybjærg Hansen, Anne ^a,c,d,e   Nordestgaard, Børge G ^a,d,e  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^b HVIDOVRE HOSPITAL   (Denmark)

^c University of Copenhagen   (Denmark)

^d BISPEBJERG HOSPITAL   (Denmark)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN; ORAL ANTIDIABETIC AGENT;

ADULT; AGED; ARTICLE; BACTERIAL INFECTION; BLOOD CHEMISTRY; COHORT ANALYSIS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DENMARK; DIABETES MELLITUS; FEMALE; GENOTYPE; GRAM NEGATIVE INFECTION; GRAM POSITIVE INFECTION; HAZARD RATIO; HEPATITIS; HOSPITAL DISCHARGE; HUMAN; INTERNATIONAL CLASSIFICATION OF DISEASES; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; MENINGITIS; MIDDLE AGED; MULTICENTER STUDY; MYCOSIS; PARASITOSIS; PNEUMONIA; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RISK FACTOR; SEPSIS; URINARY TRACT INFECTION; VIRUS INFECTION; BACTERIAL INFECTIONS; BLOOD; GENETIC POLYMORPHISM; GENETICS; GRAM-NEGATIVE BACTERIAL INFECTIONS; VIRUS DISEASES;

ADULT; AGED; BACTERIAL INFECTIONS; C-REACTIVE PROTEIN; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DENMARK; FEMALE; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROSPECTIVE STUDIES; RISK FACTORS; SEPSIS; VIRUS DISEASES;

EID: 84957051236     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2015.249680     Document Type: Article

References (32)

1. Du Clos TW, Mold C. C-reactive protein: An activator of innate immunity and a modulator of adaptive immunity. Immunol Res 2004;30:261-77.
2. Hirschfield GM, Pepys MB. C-reactive protein and cardiovascular disease: new insights from an old molecule. QJM 2003;96:793- 807.
3. Mold C, Gewurz H, Du Clos TW. Regulation of complement activation by C-reactive protein. Immunopharmacology 1999;42:23-30.
4. Zacho J, Tybjærg-Hansen A, Jensen JS, Grande P, Sillesen H, Nordestgaard BG. Genetically elevated C-reactive protein and ischemic heart and cerebrovascular disease. N Engl J Med 2008;359:1897-908.
5. Szalai AJ, Briles DE, Volanakis JE. HumanC-reactive protein is protective against fatal Streptococcus pneumoniae infection in transgenic mice. J Immunol 1995; 155:2557- 63.
6. Nadel S, Newport MJ, Booy R, Levin M. Variation in the tumor necrosis factor-alpha gene promoter region may be associated with death from meningococcal disease. J Infect Dis 1996;174:878 - 80.
7. Mira JP, Cariou A, Grall F, Delclaux C, Losser MR, Heshmati F, et al. Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality: A multicenter study. JAMA 1999;282:561- 8.
8. Fang XM, Schroder S, Hoeft A, Stuber F. Comparison of two polymorphisms of the interleukin-1 gene family: interleukin-1 receptor antagonist polymorphism contributes to susceptibility to severe sepsis. Crit Care Med 1999;27:1330 - 4.
9. D'Aiuto F, Casas JP, Shah T, Humphries SE, Hingorani AD, Tonetti MS. C-reactive protein (+1444C>T) polymorphism influences CRP response following a moderate inflammatory stimulus. Atherosclerosis 2005;179: 413-7.
10. Brull DJ, Serrano N, Zito F, Jones L, Montgomery HE, Rumley A, et al. Human CRP gene polymorphism influences CRP levels: implications for the prediction and pathogenesis of coronary heart disease. Arterioscler Thromb Vasc Biol 2003;23:2063-9.
11. Marsik C, Sunder-Plassmann R, Jilma B, Kovar FM, Mannhalter C, Wagner O, et al. The C-reactive protein (+)1444C/T alteration modulates the inflammation and coagulation response in human endotoxemia. Clin Chem 2006;52:1952-7.
12. Molkanen T, Rostila A, Ruotsalainen E, Alanne M, Perola M, Jarvinen A. Genetic polymorphism of the C-reactive protein (CRP) gene and a deep infection focus determine maximal serum CRP level in Staphylococcus aureus bacteremia. Eur J Clin Microbiol Infect Dis 2010;29:1131-7.
13. Mukamal KJ, Pai JK, O'Meara ES, Tracy RP, Psaty BM, Kuller LH, et al. CRP gene variation and risk of community-acquired pneumonia. Respirology 2010; 15:160 - 4.
14. Eklund C, Huttunen R, Syrjanen J, Laine J, Vuento R, Hurme M. Polymorphism of the C-reactive protein gene is associated with mortality in bacteraemia. Scand J Infect Dis 2006;38:1069 -73.
15. Roy S, Hill AV, Knox K, Griffiths D, Crook D. Research pointers: Association of common genetic variant with susceptibility to invasive pneumococcal disease. BMJ 2002;324:1369.
16. Giha HA, Nasr A, Ekstrom M, Israelsson E, Arambepola G, Arnot D, et al. Association of a single nucleotide polymorphism in the C-reactive protein gene (-286) with susceptibility to Plasmodium falciparum malaria. Mol Med 2010;16:27-33.
17. Kuikka LK, Salminen S, Ouwehand A, Gueimonde M, Strandberg TE, Finne-Soveri UH, et al. Inflammation markers and malnutrition as risk factors for infections and impaired health-related quality of life among older nursing home residents. J AmMed Dir Assoc 2009;10: 348 -53.
18. Pfitzner T, Krocker D, Perka C, Matziolis G. C-reactive protein. An independent risk factor for the development of infection after primary arthroplasty [in German]. Orthopade 2008;37:1116 -20.
19. Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA 2007;298:299 -308.
20. Schnohr P, Jensen JS, Scharling H, Nordestgaard BG. Coronary heart disease risk factors ranked by importance for the individual and community. A 21 year follow-up of 12 000 men and women from the Copenhagen City Heart Study. Eur Heart J 2002;23:620 - 6.
21. Frikke-Schmidt R, Nordestgaard BG, Stene MC, Sethi AA, Remaley AT, Schnohr P, et al. Association of loss-offunction mutations in the ABCA1 gene with highdensity lipoprotein cholesterol levels and risk of ischemic heart disease. JAMA 2008;299:2524 -32.
22. Lynge E, Sandegaard JL, Rebolj M. The Danish National Patient Register. Scand J Public Health 2011;39:30 -3.
23. Benfield T, Jensen JS, Nordestgaard BG. Influence of diabetes and hyperglycaemia on infectious disease hospitalisation and outcome. Diabetologia 2007;50: 549 -54.
24. Miller DT, Zee RY, Suk DJ, Kozlowski P, Chasman DI, Lazarus R, et al. Association of common CRP gene variants with CRP levels and cardiovascular events. Ann Hum Genet 2005;69:623-38.
25. Bojesen SE, Tybjaerg-Hansen A, Nordestgaard BG. Integrin beta3 Leu33Pro homozygosity and risk of cancer. J Natl Cancer Inst 2003;95:1150 -7.
26. Klein JP, Moeschberg ML. Refinements of the semiparametric proportional hazards model. In: Survival analysis. Techniques for censored and truncated data. 2nd Ed. New York: Springer-Verlag;2003:295-325.
27. Rajs G, Finzi-Yeheskel Z, Rajs A, Mayer M. C-reactive protein concentrations in cerebral spinal fluid in grampositive and gram-negative bacterial meningitis. Clin Chem 2002;48:591-2.
28. Jessen KM, Lindboe SB, Petersen AL, Eugen-Olsen J, Benfield T. Common TNF-alpha, IL-1 beta, PAI-1, UPA, CD14 and TLR4 polymorphisms are not associated with disease severity or outcome from Gram negative sepsis. BMC Infect Dis 2007;7:108.
29. Agrawal A, Suresh MV, Singh SK, Ferguson DA Jr. The protective function of human C-reactive protein in mouse models of Streptococcus pneumoniae infection. Endocr Metab Immune Disord Drug Targets 2008;8: 231-7.
30. Allin KH, Bojesen SE, Nordestgaard BG. Baseline C-reactive protein is associated with incident cancer and survival in patients with cancer. J Clin Oncol 2009; 27:2217-24.
31. Nordestgaard BG. Does elevated C-reactive protein cause human atherothrombosis? Novel insights from genetics, intervention trials, and elsewhere. Curr Opin Lipidol 2009;20:393- 401.
32. Dahl M, Vestbo J, Zacho J, Lange P, Tybjaerg-Hansen A, Nordestgaard BG. Creactive protein and chronic obstructive pulmonary disease: A Mendelian randomisation approach. Thorax 2011;66:197-204.