Inhibition of T-Cell-Mediated and infection-Induced periodontal bone resorption by TACE blockade

Interface Oral Health Science 2011

Volumn , Issue , 2012, Pages 173-175

  Kanzaki, Hiroyuki ^a   Han, Xiaozhe ^a   Asami, Yukiko ^a   Suzuki, Maiko ^a   Kawai, Toshihisa ^a   Taubman, Martin ^a  

^a FORSYTH INSTITUTE   (United States)

Author keywords

Osteoclastogenesis; Periodontitis; sRANKL; TACE; TNF

Indexed keywords

EID: 84957035560     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-4-431-54070-0_45     Document Type: Chapter

References (9)

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2. Kawai T, Matsuyama T, Hosokawa Y et al (2006) B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal disease. Am J Pathol 169:987-998
3. Yasuda H, Shima N, Nakagawa N et al (1999) A novel molecular mechanism modulating osteo-clast differentiation and function. Bone 25:109-113
4. Shibutani T, Murahashi Y, Tsukada E et al (1997) Experimentally induced periodontitis in bea- gle dogs causes rapid increases in osteoclastic resorption of alveolar bone. J Periodontol 68:385-391
5. Lum L, Wong BR, Josien R et al (1999) Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival. J Biol Chem 274:13613-13618
6. Kanzaki H, Xiaozhe H, Kawai T et al (2010) TACE, a therapeutic target in periodontal disease. J Dent Res 89(Spec Iss B):1144
7. Kobayashi K, Takahashi N, Jimi E et al (2000) Tumor necrosis factor alpha stimulates osteo- clast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. J Exp Med 191:275-286
8. Rossomando EF, Kennedy JE, Hadjimichael J (1990) Tumour necrosis factor alpha in gingival crevicular fluid as a possible indicator of periodontal disease in humans. Arch Oral Biol 35(6): 431-434
9. Fuller K, Murphy C, Kirstein B et al (2002) TNFalpha potently activates osteoclasts, through a direct action independent of and strongly synergistic with RANKL. Endocrinology 143(3): 1108-1118