Targeting HOTAIR induces mitochondria related apoptosis and inhibits tumor growth in head and neck squamous cell carcinoma in vitro and in vivo

Current Molecular Medicine

Volumn 15, Issue 10, 2015, Pages 952-960

  Kong, L ^a   Zhou, X ^a   Wu, Y ^a   Wang, Y ^a   Chen, L ^a   Li, P ^a   Liu, S ^a   Sun, S ^a   Ren, Y ^a   Mei, M ^a   Wang, X ^a   Zhang, L ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

HNSCC; HOTAIR; MICU1; Mitochondrial apoptosis; Tumor growth

Indexed keywords

BETA GALACTOSIDASE; CASPASE 3; COMPLEMENTARY RNA; HOMEOBOX TRANSCRIPT ANTISENSE RNA; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG; BAX PROTEIN, HUMAN; BCL2 PROTEIN, HUMAN; CALCIUM BINDING PROTEIN; CARRIER PROTEIN; CASP3 PROTEIN, HUMAN; CATION TRANSPORT PROTEIN; HOTAIR LONG UNTRANSLATED RNA, HUMAN; LONG UNTRANSLATED RNA; MICU1 PROTEIN, HUMAN; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CFU COUNTING; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE SILENCING; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MICROSCOPY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; TUMOR GROWTH; TUMOR VOLUME; TUNEL ASSAY; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CARCINOMA, SQUAMOUS CELL; CELL CYCLE; CELL PROLIFERATION; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; HEAD AND NECK NEOPLASMS; INTRALESIONAL DRUG ADMINISTRATION; METABOLISM; NUDE MOUSE; PATHOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CALCIUM-BINDING PROTEINS; CARCINOMA, SQUAMOUS CELL; CASPASE 3; CATION TRANSPORT PROTEINS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAD AND NECK NEOPLASMS; HUMANS; INJECTIONS, INTRALESIONAL; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, NUDE; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, LONG NONCODING; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84956886793     PISSN: 15665240     EISSN: 18755666     Source Type: Journal    
DOI: 10.2174/1566524016666151123112716     Document Type: Article

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