High yield 1,3-propanediol production by rational engineering of the 3-hydroxypropionaldehyde bottleneck in Citrobacter werkmanii

Microbial Cell Factories

Volumn 15, Issue 1, 2016, Pages

  Maervoet, Veerle E T ^a   De Maeseneire, Sofie L ^a   Avci, Fatma G ^a,b   Beauprez, Joeri ^a   Soetaert, Wim K ^a   De Mey, Marjan ^a  

^a GHENT UNIVERSITY   (Belgium)

^b EGE UNIVERSITY   (Turkey)

Author keywords

1,3 propanediol; Citrobacter werkmanii DSM17579; Ethanol dehydrogenase; Glycerol; Lactate dehydrogenase; Multiple knock out mutant; NADH; Rational engineering

Indexed keywords

1,3 PROPANEDIOL; 3 HYDROXYPROPIONALDEHYDE; ACETYL COENZYME A; AEROBIC RESPIRATION CONTROL PROTEIN A; ALCOHOL DEHYDROGENASE; GLYCEROL DEHYDROGENASE; LACTATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PROPIONALDEHYDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG; 1,3-PROPANEDIOL; 3-HYDROXYPROPIONALDEHYDE; ALDEHYDE REDUCTASE; GLUCOSE; GLYCERALDEHYDE; GLYCEROL; GLYCEROL KINASE; PROPANE; PROPANEDIOL DERIVATIVE;

ADHE GENE; ANAEROBIC CAPACITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BIOREACTOR; CARBON SOURCE; CELL METABOLISM; CITRIC ACID CYCLE; CITROBACTER; CITROBACTER WERKMANII; ENZYME ACTIVITY; KLEBSIELLA; LDHA GENE; METABOLIC ENGINEERING; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN MODIFICATION; AMINO ACID SEQUENCE; ANALOGS AND DERIVATIVES; BATCH CELL CULTURE; CHEMISTRY; DRUG EFFECTS; ENZYME SPECIFICITY; ENZYMOLOGY; FERMENTATION; GENE INACTIVATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; METABOLOME; MICROBIOLOGY; MOLECULAR GENETICS; MUTATION; PH; PROCEDURES; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; BATCH CELL CULTURE TECHNIQUES; BIOREACTORS; CITROBACTER; FERMENTATION; GENE KNOCKOUT TECHNIQUES; GLUCOSE; GLYCERALDEHYDE; GLYCEROL; GLYCEROL KINASE; HYDROGEN-ION CONCENTRATION; METABOLIC ENGINEERING; METABOLOME; MOLECULAR SEQUENCE DATA; MUTATION; NAD; PROPANE; PROPYLENE GLYCOLS; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; SUGAR ALCOHOL DEHYDROGENASES;

EID: 84956829584     PISSN: None     EISSN: 14752859     Source Type: Journal    
DOI: 10.1186/s12934-016-0421-y     Document Type: Article

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