Evaluation of teratogenic effects of crocin and safranal, active ingredients of saffron, in mice

Toxicology and Industrial Health

Volumn 32, Issue 2, 2016, Pages 285-291

  Moallem, Seyed Adel ^a,b   Afshar, Mohammad ^b,c   Etemad, Leila ^d   Razavi, Bibi Marjan ^d,e   Hosseinzadeh, Hossein ^a  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c BIRJAND UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e SABZEVAR UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

crocin; Crocus sativus; mice; Saffron; safranal; teratogenicity

Indexed keywords

CAROTENOID; CROCIN; CYCLOHEXENE DERIVATIVE; SAFRANAL; TERATOGENIC AGENT; TERPENE; CROCUS SATIVUS EXTRACT; FOOD ADDITIVE; UNCLASSIFIED DRUG;

ANIMAL; BAGG ALBINO MOUSE; BODY WEIGHT; CHEMISTRY; CROCUS; DRUG EFFECTS; FEMALE; FETUS; MOUSE; ORGANOGENESIS; PATHOLOGY; PREGNANCY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALVARIA; CONTROLLED STUDY; CROCUS SATIVUS; EMBRYO DEVELOPMENT; FETUS DISEASE; FETUS WEIGHT; GROWTH RETARDATION; MANDIBLE; MAXIMUM TOLERATED DOSE; NONHUMAN; SKELETON MALFORMATION; TERATOGENICITY;

ANIMALS; BODY WEIGHT; CAROTENOIDS; CROCUS; CYCLOHEXENES; FEMALE; FETUS; MICE; MICE, INBRED BALB C; ORGANOGENESIS; PREGNANCY; TERATOGENS; TERPENES;

EID: 84956752363     PISSN: 07482337     EISSN: 14770393     Source Type: Journal    
DOI: 10.1177/0748233713500818     Document Type: Article

References (20)

1. Abdullaev FI, Espinosa-Aguirre JJ (2004) Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials. Cancer Detection and Prevention 28(6): 426–432.
2. Assimopoulou AN, Sinakos Z, Papageorgiou VP (2005) Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents. Phytotherapy Research 19(11): 997–1000.
3. Basheeruddin Asdaq SM, Inamdar MN (2010) Potential of Crocus sativus (saffron) and itsconstituent, crocin, as hypolipidemic and antioxidant in rats. Applied Biochemistry and Biotechnology 162: 358–372.
4. Dehghani Z, Dehghani S (2009) Effect of saffron on the increasing of abortion. In: International Symposium on Saffron: A Herbal Medicine of 3rd Millennium, May 13–14, Mashhad, Iran.
5. Golalipour MJ, Gharravi AM, Ghafari S, Afshar M, Khori V (2008) Effects of Crocus sativus on the fetal development of NMRI mice. Saudi Medical Journal 29(2): 309–310.
6. Gout BC, Bourges C, Paineau-Dubreuil S (2010) Satiereal, a Crocus sativus L. extract, reduces snacking and increases satiety in a randomized placebo-controlled study of mildly overweight, healthy women. Nutrition Research 30(5): 305–313.
7. Hosseinzadeh H, Karimi G, Niapoor M (2004) Antidepressant effect of Crocus sativus L. Stigma extracts and their constituents, crocin and safranal, in mice. Acta Horticulturae 650: 435–445.
8. Hosseinzadeh H, Nassiri-Asl M (2013) Avicenna's (IbnSina) the canon of medicine and saffron (Crocus sativus): a review. Phytotherapy Research 27: 475–483.
9. Hosseinzadeh H, Sadeghnia HR (2005). Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus. Journal of Pharmacy and Pharmaceutical Sciences 8(3): 394–399.
10. Hosseinzadeh H, Sadeghnia HR (2007) Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: involvement of GABAergic and opioids systems. Phytomedicine 14(4): 256–262.
11. Hosseinzadeh H, Talebzadeh F (2005) Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice. Fitoterapia 76(7–8): 722–724.
12. Inouye M (1976) Differential staining of cartilage and bone in fetal mouse skeletal by alcian blue and alizarin red s. Congenital Anomalies 16(3): 171–173.
13. Kimmel CA, Trammell C (1981) A rapid procedure for routine double staining of cartilage and bone in fetal and adult animals. Stain Technology 56(5): 271–273.
14. Martin G, Goh E, Neff AW (2002) Evaluation of the developmental toxicity of crocetin on Xenopus. Food and Chemical Toxicology 40(7): 959–964.
15. Moghaddasi MS (2010) Saffron chemicals and medicine usage. Journal of Medicinal Plants Research 4(6): 427–430.
16. Soeda S, Ochiai T, Shimeno H, Saito H, Abe K, Tanaka H et al. (2007) Pharmacological activities of crocin in saffron. Journal of Natural Medicines 61(2): 102–111.
17. Tafazoli M, Kermani T, Saadatjoo A (2004) Effects of saffron on abortion and its side effects on mice Balb/c. Ofogh-e-Danesh 10(3): 53–56.
18. Tian Y, Ishikawa H, Yamaguchi T, Yamauchi T, Yokoyama K (2005) Teratogenicity and developmental toxicity of chlorpyrifos. Maternal exposure during organogenesis in mice. Reproductive Toxicology 20(2): 267–270.
19. Zheng YQ, Liu JX, Wang JN, Xu L (2007) Effects of crocin on reperfusion-induced oxidative/nitrative injury to cerebral microvessels after global cerebral ischemia. Brain Research 1138: 86–94.
20. Zougagh MA, Rois A, Valcarcel M (2006) Determination of total safranal by in situ acid hydrolysis in supercritical fluid media: application to the quality control of commercial saffron. Analytica Chimica Acta 578(2): 117–121.