Active site-directed plasmin inhibitors: Extension on the P2 residue

Bioorganic and Medicinal Chemistry

Volumn 24, Issue 4, 2016, Pages 545-553

  Hidaka, Koushi ^a   Gohda, Keigo ^b   Teno, Naoki ^c   Wanaka, Keiko ^d   Tsuda, Yuko ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b Kansai   (Japan)

^c HIROSHIMA INTERNATIONAL UNIVERSITY   (Japan)

^d Kobe Research Projects on Thrombosis and Haemostasis   (Japan)

Author keywords

Active site directed inhibitor; Plasmin inhibitor; Selectivity; Urokinase

Indexed keywords

N (4 AMINOMETHYLCYCLOHEXANECARBONYL) LEVO TYR[O (QUINOLIN 2 YL)METHYL] NH OCTYL; PLASMIN; PLASMIN INHIBITOR; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG; UROKINASE; ANTIFIBRINOLYTIC AGENT; TYROSINE;

ARTICLE; CHEMICAL STRUCTURE; COMPLEX FORMATION; ENANTIOSELECTIVITY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HYDROPHOBICITY; MOLECULAR DOCKING; MOLECULAR INTERACTION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTIFIBRINOLYTIC AGENTS; CATALYTIC DOMAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBRINOLYSIN; HUMANS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 84956738192     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.12.009     Document Type: Article

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