Altered intestinal microbiota as a major driving force in alcoholic steatohepatitis

Gut

Volumn 65, Issue 5, 2016, Pages 728-729

  Tilg, Herbert ^a   Mathurin, Philippe ^b  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b LILLE UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL LIVER CIRRHOSIS; ALCOHOLIC FATTY LIVER; BACTEROIDETES; CAUSAL ATTRIBUTION; CLOSTRIDIUM; CLOSTRIDIUM LEPTUM; DISEASE ASSOCIATION; DISEASE SEVERITY; ENTEROBACTERIACEAE; FAECALIBACTERIUM PRAUSNITZII; HUMAN; INTESTINE FLORA; INTESTINE MUCOSA PERMEABILITY; LACTOBACILLUS RHAMNOSUS; MORTALITY; NONHUMAN; NOTE; PEPTOCLOSTRIDIUM DIFFICILE; PRIORITY JOURNAL; PROTEOBACTERIA; STREPTOCOCCUS; FATTY LIVER; INTESTINE; MICROFLORA; NONALCOHOLIC FATTY LIVER;

FATTY LIVER; FATTY LIVER, ALCOHOLIC; GASTROINTESTINAL MICROBIOME; HUMANS; INTESTINES; MICROBIOTA; NON-ALCOHOLIC FATTY LIVER DISEASE;

EID: 84956662151     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2015-311014     Document Type: Note

References (18)

1. Mathurin P, Bataller R. Trends in the management and burden of alcoholic liver disease. J Hepatol 2015;62(1 Suppl):S38-46.
2. Macnaughtan J, Jalan R. Clinical and Pathophysiological Consequences of Alterations in the Microbiome in Cirrhosis. Am J Gastroenterol 2015;110:1399-410.
3. Tilg H, Diehl AM. Cytokines in alcoholic and nonalcoholic steatohepatitis. N Engl J Med 2000;343:1467-76.
4. Adachi Y, Moore LE, Bradford BU, et al. Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology 1995;108:218-24.
5. Uesugi T, Froh M, Arteel GE, et al. Toll-like receptor 4 is involved in the mechanism of early alcoholinduced liver injury in mice. Hepatology 2001;34:101-8.
6. Wang Y, Kirpich I, Liu Y, et al. Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-inducible factor, promotes intestinal integrity and ameliorates alcohol-induced liver injury. Am J Pathol 2011;179:2866-75.
7. Mutlu EA, Gillevet PM, Rangwala H, et al. Colonic microbiome is altered in alcoholism. Am J Physiol Gastrointest Liver Physiol 2012;302:G966-78.
8. Leclercq S, Matamoros S, Cani PD, et al. Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity. Proc Natl Acad Sci USA 2014;111:E4485-93.
9. Llopis M, Cassard AM, Wrzosek L, et al. Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease. Gut 2016;65:830-9.
10. Sokol H, Pigneur B, Watterlot L, et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci USA 2008;105:16731-6.
11. Bertola A, Mathews S, Ki SH, et al. Mouse model of chronic and binge ethanol feeding (the NIAAA model). Nat Protoc 2013;8:627-37.
12. Chen P, Miyamoto Y, Mazagova M, et al. Microbiota Protects Mice Against Acute Alcohol-Induced Liver Injury. Alcohol Clin Exp Res 2015.
13. Smith MI, Yatsunenko T, Manary MJ, et al. Gut microbiomes of Malawian twin pairs discordant for kwashiorkor. Science 2013;339:548-54.
14. Koren O, Goodrich JK, Cullender TC, et al. Host remodeling of the gut microbiome and metabolic changes during pregnancy. Cell 2012;150:470-80.
15. Dao MC, Everard A, Aron-Wisnewsky J, et al. Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology. Gut 2016;65:426-36.
16. van Nood E, Vrieze A, Nieuwdorp M, et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med 2013;368:407-15.
17. Cammarota G, Ianiro G, Magalini S, et al. Decrease in Surgery for Clostridium difficile Infection After Starting a Program to Transplant Fecal Microbiota. Ann Intern Med 2015;163:487-8.
18. Youngster I, Russell GH, Pindar C, et al. Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection. JAMA 2014;312:1772-8.