Is BOK required for apoptosis induced by endoplasmic reticulum stress?

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 5, 2016, Pages E492-E493

  Fernandez Marrero, Yuniel ^a   Ke, Francine ^b,c   Echeverry, Nohemy ^a,d   Bouillet, Philippe ^b,c   Bachmann, Daniel ^a   Strasser, Andreas ^b,c   Kaufmann, Thomas ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

B CELL LYMPHOMA 2 OVARIAN KILLER PROTEIN; BIM PROTEIN; PROTEIN; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PUMA PROTEIN; THAPSIGARGIN; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; APOPTOSIS; ENDOPLASMIC RETICULUM MEMBRANE; ENDOPLASMIC RETICULUM STRESS; EXON; FIBROBLAST; GENE TARGETING; GENETIC BACKGROUND; GENOTYPE; HUMAN; IN VIVO STUDY; LETTER; LIVER INJURY; MAST CELL; MOUSE EMBRYONIC FIBROBLAST; MOUSE STRAIN; MYELOID PROGENITOR CELL; NEUTROPHIL; NONHUMAN; PRIMARY CELL; PRIORITY JOURNAL; PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; TRANSIENT TRANSFECTION; ANIMAL; ENDOPLASMIC RETICULUM; METABOLISM; OXIDATIVE STRESS; PHYSIOLOGY;

ANIMALS; APOPTOSIS; ENDOPLASMIC RETICULUM; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 84956650519     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1516347113     Document Type: Letter

References (5)

1. Ke F, et al. (2012) BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice. Cell Death Differ 19(6):915-925
2. Echeverry N, et al. (2013) Intracellular localization of the BCL-2 family member BOK and functional implications. Cell Death Differ 20(6):785-799
3. Schulman JJ, Wright FA, Kaufmann T, Wojcikiewicz RJ (2013) The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage. J Biol Chem 288(35):25340-25349
4. Carpio MA, et al. (2015) BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress. Proc Natl Acad Sci USA 112(23):7201-7206
5. Vanden Berghe T, et al. (2015) Passenger mutations confound interpretation of all genetically modified congenic mice. Immunity 43(1):200-209