Effective Modulation of Male Aggression through Lateral Septum to Medial Hypothalamus Projection

Current Biology

Volumn 26, Issue 5, 2016, Pages 593-604

  Wong, Li Chin ^a   Wang, Li ^a   D'Amour, James A ^a   Yumita, Tomohiro ^a   Chen, Genghe ^a   Yamaguchi, Takashi ^a   Chang, Brian C ^a   Bernstein, Hannah ^a,b   You, Xuedi ^a   Feng, James E ^a   Froemke, Robert C ^a,c   Lin, Dayu ^a,c  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^c NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRESSION; ANIMAL; C57BL MOUSE; MALE; MEDIOBASAL HYPOTHALAMUS; MOUSE; OPTOGENETICS; PHYSIOLOGY; SEPTUM NUCLEUS; SEXUAL BEHAVIOR;

AGGRESSION; ANIMALS; HYPOTHALAMUS, MIDDLE; MALE; MICE; MICE, INBRED C57BL; OPTOGENETICS; SEPTAL NUCLEI; SEXUAL BEHAVIOR, ANIMAL;

EID: 84956634118     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2015.12.065     Document Type: Article

References (46)

1. P. Bard A diencephalic mechanism for the expression of rage with special reference to the sympathetic nervous system Am. J. Physiol. 84 1928 490 515
2. E.A. Spiegel, H.R. Miller, and M.J. Oppenheimer Forebrain and rage reactions J. Neurophysiol. 3 1940 538 548
3. J.L. Goodson, A.K. Evans, and K.K. Soma Neural responses to aggressive challenge correlate with behavior in nonbreeding sparrows Neuroreport 16 2005 1719 1723
4. W. Zeman, and F.A. King Tumors of the septum pellucidum and adjacent structures with abnormal affective behavior: an anterior midline structure syndrome J. Nerv. Ment. Dis. 127 1958 490 502
5. D.J. Albert, and G.L. Chew The septal forebrain and the inhibitory modulation of attack and defense in the rat. A review Behav. Neural Biol. 30 1980 357 388
6. B.M. Slotnick, M.F. McMullen, and S. Fleischer Changes in emotionality following destruction of the septal area in albino mice Brain Behav. Evol. 8 1973 241 252
7. M. Potegal, A. Blau, and M. Glusman Effects of anteroventral septal lesions on intraspecific aggression in male hamsters Physiol. Behav. 26 1981 407 412
8. M.M. McDonald, C.M. Markham, A. Norvelle, H.E. Albers, and K.L. Huhman GABAA receptor activation in the lateral septum reduces the expression of conditioned defeat and increases aggression in Syrian hamsters Brain Res. 1439 2012 27 33
9. G. Lee, and S.C. Gammie GABA(A) receptor signaling in the lateral septum regulates maternal aggression in mice Behav. Neurosci. 123 2009 1169 1177
10. J.M. Ramirez, C. Salas, and M. Portavella Offense and defense after lateral septal lesions in Columba livia Int. J. Neurosci. 41 1988 241 250
11. J.L. Goodson, R. Eibach, J. Sakata, and E. Adkins-Regan Effect of septal lesions on male song and aggression in the colonial zebra finch (Taeniopygia guttata) and the territorial field sparrow (Spizella pusilla) Behav. Brain Res. 98 1999 167 180
12. A. Siegel, and D. Skog Effects of electrical stimulation of the septum upon attack behavior elicited from the hypothalamus in the cat Brain Res. 23 1970 371 380
13. M. Potegal, A. Blau, and M. Glusman Inhibition of intraspecific aggression in male hamsters by septal stimulation Physiol. Psychol. 9 1981 213 218
14. P.Y. Risold, and L.W. Swanson Connections of the rat lateral septal complex Brain Res. Brain Res. Rev. 24 1997 115 195
15. H.W. Blume, Q.J. Pittman, S. Lafontaine, and L.P. Renaud Lateral septum-medial hypothalamic connections: an electrophysiological study in the rat Neuroscience 7 1982 2783 2792
16. J.H. Lammers, M.R. Kruk, W. Meelis, and A.M. van der Poel Hypothalamic substrates for brain stimulation-induced attack, teeth-chattering and social grooming in the rat Brain Res. 449 1988 311 327
17. H.P. Lipp, and R.W. Hunsperger Threat, attack and flight elicited by electrical stimulation of the ventromedial hypothalamus of the marmoset monkey Callithrix jacchus Brain Behav. Evol. 15 1978 260 293
18. A. Siegel, and C.B. Pott Neural substrates of aggression and flight in the cat Prog. Neurobiol. 31 1988 261 283
19. A. Siegel, T.A.P. Roeling, T.R. Gregg, and M.R. Kruk Neuropharmacology of brain-stimulation-evoked aggression Neurosci. Biobehav. Rev. 23 1999 359 389
20. D. Lin, M.P. Boyle, P. Dollar, H. Lee, E.S. Lein, P. Perona, and D.J. Anderson Functional identification of an aggression locus in the mouse hypothalamus Nature 470 2011 221 226
21. C.F. Yang, M.C. Chiang, D.C. Gray, M. Prabhakaran, M. Alvarado, S.A. Juntti, E.K. Unger, J.A. Wells, and N.M. Shah Sexually dimorphic neurons in the ventromedial hypothalamus govern mating in both sexes and aggression in males Cell 153 2013 896 909
22. H. Lee, D.W. Kim, R. Remedios, T.E. Anthony, A. Chang, L. Madisen, H. Zeng, and D.J. Anderson Scalable control of mounting and attack by Esr1+ neurons in the ventromedial hypothalamus Nature 509 2014 627 632
23. A.L. Falkner, P. Dollar, P. Perona, D.J. Anderson, and D. Lin Decoding ventromedial hypothalamic neural activity during male mouse aggression J. Neurosci. 34 2014 5971 5984
24. O.E. Millhouse The organization of the ventromedial hypothalamic nucleus Brain Res. 55 1973 71 87
25. O.E. Millhouse Certain ventromedial hypothalamic afferents Brain Res. 55 1973 89 105
26. T.P. Sheehan, R.A. Chambers, and D.S. Russell Regulation of affect by the lateral septum: implications for neuropsychiatry Brain Res. Brain Res. Rev. 46 2004 71 117
27. T.E. Anthony, N. Dee, A. Bernard, W. Lerchner, N. Heintz, and D.J. Anderson Control of stress-induced persistent anxiety by an extra-amygdala septohypothalamic circuit Cell 156 2014 522 536
28. T. Kita, H. Nishijo, S. Eifuku, K. Terasawa, and T. Ono Place and contingency differential responses of monkey septal neurons during conditional place-object discrimination J. Neurosci. 15 1995 1683 1703
29. L. Vong, C. Ye, Z. Yang, B. Choi, S. Chua Jr., and B.B. Lowell Leptin action on GABAergic neurons prevents obesity and reduces inhibitory tone to POMC neurons Neuron 71 2011 142 154
30. C. Zhao, B. Eisinger, and S.C. Gammie Characterization of GABAergic neurons in the mouse lateral septum: a double fluorescence in situ hybridization and immunohistochemical study using tyramide signal amplification PLoS ONE 8 2013 e73750
31. J.H. Jennings, D.R. Sparta, A.M. Stamatakis, R.L. Ung, K.E. Pleil, T.L. Kash, and G.D. Stuber Distinct extended amygdala circuits for divergent motivational states Nature 496 2013 224 228
32. Q. Tong, C. Ye, R.J. McCrimmon, H. Dhillon, B. Choi, M.D. Kramer, J. Yu, Z. Yang, L.M. Christiansen, C.E. Lee, and et al. Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia Cell Metab. 5 2007 383 393
33. J.V. Brady, and W.J. Nauta Subcortical mechanisms in emotional behavior: affective changes following septal forebrain lesions in the albino rat J. Comp. Physiol. Psychol. 46 1953 339 346
34. J.P. Herman, and W.E. Cullinan Neurocircuitry of stress: central control of the hypothalamo-pituitary-adrenocortical axis Trends Neurosci. 20 1997 78 84
35. F.J. Sodetz, and B.N. Bunnell Septal ablation and the social behavior of the golden hamster Physiol. Behav. 5 1970 79 88
36. R. Numan The Behavioral Neuroscience of the Septal Region 2000 Springer
37. I. Mesic, Y.F. Guzman, A.L. Guedea, V. Jovasevic, K.A. Corcoran, K. Leaderbrand, K. Nishimori, A. Contractor, and J. Radulovic Double Dissociation of the Roles of Metabotropic Glutamate Receptor 5 and Oxytocin Receptor in Discrete Social Behaviors Neuropsychopharmacology 40 2015 2337 2346
38. J.N. Ferguson, L.J. Young, and T.R. Insel The neuroendocrine basis of social recognition Front. Neuroendocrinol. 23 2002 200 224
39. J.D. Hahn, and L.W. Swanson Connections of the juxtaventromedial region of the lateral hypothalamic area in the male rat Front. Syst. Neurosci. 9 2015 66
40. N.S. Canteras, R.B. Simerly, and L.W. Swanson Organization of projections from the ventromedial nucleus of the hypothalamus: a Phaseolus vulgaris-leucoagglutinin study in the rat J. Comp. Neurol. 348 1994 41 79
41. M.R. Kruk, A.M. Van der Poel, W. Meelis, J. Hermans, P.G. Mostert, J. Mos, and A.H.M. Lohman Discriminant analysis of the localization of aggression-inducing electrode placements in the hypothalamus of male rats Brain Res. 260 1983 61 79
42. R.B. Robinson, and S.A. Siegelbaum Hyperpolarization-activated cation currents: from molecules to physiological function Annu. Rev. Physiol. 65 2003 453 480
43. J. Qiu, M.A. Bosch, K. Jamali, C. Xue, M.J. Kelly, and O.K. Rønnekleiv Estrogen upregulates T-type calcium channels in the hypothalamus and pituitary J. Neurosci. 26 2006 11072 11082
44. L. Roux, and G. Buzsáki Tasks for inhibitory interneurons in intact brain circuits Neuropharmacology 88 2015 10 23
45. P. Dollar, P. Welinder, and P. Perona Cascaded pose regression Proceedings of the 2010 IEEE Conference on Computer Vision and Pattern Recognition 2010 2010 1078 1085
46. X.P. Burgos-Artizzu, P. Dollár, D. Lin, D.J. Anderson, and P. Perona Social behavior recognition in continuous videos Proceedings of the 2012 IEEE Conference on Computer Vision and Pattern Recognition 2012 2012 1322 1329