Decoding ventromedial hypothalamic neural activity during male mouse aggression

Journal of Neuroscience

Volumn 34, Issue 17, 2014, Pages 5971-5984

  Falkner, Annegret L ^a   Dollar, Piotr ^b   Perona, Pietro ^b   Anderson, David J ^b   Lin, Dayu ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Aggression; Hypothalamus; Motivation; Physiology

Indexed keywords

ADULT; AGGRESSION; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CELL ACTIVITY; CONTROLLED STUDY; CORRELATION COEFFICIENT; GENDER; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; LINEAR REGRESSION ANALYSIS; MALE; MOUSE; NERVE CELL; NONHUMAN; OPTOGENETICS; PHYSIOLOGY; PRIORITY JOURNAL; SIGNAL NOISE RATIO; SOCIAL BEHAVIOR; SOCIAL INTERACTION; STIMULATION; URINE; VELOCITY; WILCOXON SIGNED RANKS TEST;

AGGRESSION; HYPOTHALAMUS; MOTIVATION; PHYSIOLOGY;

ACTION POTENTIALS; AGGRESSION; ANIMALS; BEHAVIOR, ANIMAL; MALE; MICE; NEURONS; VENTROMEDIAL HYPOTHALAMIC NUCLEUS;

EID: 84899489355     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5109-13.2014     Document Type: Article

References (36)

1. Archer J (1968) The effect of strange male odor on aggressive behavior in male mice. J Mammal 49:572-575. CrossRef Medline
2. Bard P (1928) A diencephalic mechanism for the expression of rage with special reference to the sympathetic nervous system. Am J Physiol 84: 490-515.
3. Bean NJ (1982) Modulation of agonistic behavior by the dual olfactory system in male mice. Physiol Behav 29:433-437. CrossRef Medline
4. Bruce HM (1965) Effect of castration on the reproductive pheromones of male mice. J Reprod Fertil 10:141-143. CrossRef Medline
5. Canteras NS, Simerly RB, SwansonLW (1992) Connections of the posterior nucleus of the amygdala. J Comp Neurol 324:143-179. CrossRef Medline
6. Canteras NS, Simerly RB, Swanson LW (1994) Organization of projections from the ventromedial nucleus of the hypothalamus: a Phaseolus vulgaris-leucoagglutinin study in the rat. J Comp Neurol 348:41-79. CrossRef Medline
7. Canteras NS, Simerly RB, Swanson LW (1995) Organization of projections from the medial nucleus of the amygdala: a PHAL study in the rat. J Comp Neurol 360:213-245. CrossRef Medline
8. Dollar P, Welinder P, Perona P (2010) Cascaded pose regression. Paper presented at the 23rd IEEE Conference on Computer Vision and Pattern Recognition. San Francisco, June 13-18, 2010.
9. Ettrup KS, Sørensen JC, Rodell A, Alstrup AK, Bjarkam CR (2012) Hypothalamic deep brain stimulation influences autonomic and limbic circuitry involved in the regulation of aggression and cardiocerebrovascular control in the Gottingen minipig. Stereotact Funct Neurosurg 90:281-291. CrossRef Medline
10. Fish EW, De Bold JF, Miczek KA (2002) Aggressive behavior as a reinforcer in mice: activation by allopregnanolone. Psychopharmacology 163:459-466. CrossRef Medline
11. 3H]oxytocin-binding sites in the Wistar rat brain studied by autoradiography. Neuroscience 20:599-614. CrossRef Medline
12. Hedrich HJ, Bullock GR (2004) The laboratory mouse. Amsterdam: Elsevier Academic.
13. Huang XF, Han M, Storlien LH (2004) Differential expression of 5-HT2A and 5-HT2c receptor mRNAs in mice prone, or resistant, to chronic high-fat diet-induced obesity. Mol Brain Res 127:39-47. CrossRef Medline
14. Kruk MR, Van der Poel AM, Meelis W, Hermans J, Mostert PG, Mos J, Lohman AHM (1983) Discriminant-analysis of the localization of aggression-inducing electrode placements in the hypothalamus of male rats. Brain Res 260:61-79. CrossRef Medline
15. Kruk MR, Halász J, Meelis W, Haller J (2004) Fast positive feedback between the adrenocortical stress response and a brain mechanism involved in aggressive behavior. Behav Neurosci 118:1062-1070. CrossRef Medline
16. Levey AI (1993) Immunological localization of M1-M5 muscarinic acetylcholine receptors in peripheral tissues and brain. Life Sci 52:441-448. CrossRef Medline
17. Leypold BG, Yu CR, Leinders-Zufall T, Kim MM, Zufall F, Axel R (2002) Altered sexual and social behaviors in trp2 mutant mice. Proc Natl Acad Sci U S A 99:6376-6381. CrossRef Medline
18. Lin D, Boyle MP, Dollar P, Lee H, Lein ES, Perona P, Anderson DJ (2011) Functional identification of an aggression locus in the mouse hypothalamus. Nature 470:221-226. CrossRef Medline
19. Lipp HP, Hunsperger RW (1978) Threat, attack and flight elicited by electrical stimulation of the ventromedial hypothalamus of the marmoset monkey Callithrix jacchus. Brain Behav Evol 15:260-293. CrossRef Medline
20. Luo M, Fee MS, Katz LC (2003) Encoding pheromonal signals in the accessory olfactory bulb of behaving mice. Science 299:1196-1201. CrossRef Medline
21. Mandiyan VS, Coats JK, Shah NM (2005) Deficits in sexual and aggressive behaviors in Cnga2 mutant mice. Nat Neurosci 8:1660-1662. CrossRef Medline
22. May ME, Kennedy CH (2009) Aggression as positive reinforcement in mice under various ratio-and time-based reinforcement schedules. J Exp Anal Behav 91:185-196. CrossRef Medline
23. Millhouse OE (1973) The organization of the ventromedial hypothalamic nucleus. Brain Res 55:71-87. CrossRef Medline
24. Mugford RA (1973) Intermale fighting affected by home-cage odors of male and female mice. J Comp Physiol Psychol 84:289-295. CrossRef Medline
25. Nishizuka M, Pfaff DW (1989) Intrinsic synapses in the ventromedial nucleus of the hypothalamus: an ultrastructural study. J Comp Neurol 286: 260-268. CrossRef Medline
26. Novotny M, Harvey S, Jemiolo B, Alberts J (1985) Synthetic pheromones that promote inter-male aggression in mice. Proc Natl Acad Sci U S A 82:2059-2061. CrossRef Medline
27. Putkonen PT (1966) Attack elicited by forebrain and hypothalamic stimulation in the chicken. Experientia 22:405-407. CrossRef Medline
28. Roberts WW, Kiess HO (1964) Motivational properties of hypothalamic aggression in cats. J Comp Physiol Psych 58:187-193.
29. Siegel A, Pott CB (1988) Neural substrates of aggression and flight in the cat. Prog Neurobiol 31:261-283. CrossRef Medline
30. Siegel A, Roeling TAP, Gregg TR, Kruk MR (1999) Neuropharmacology of brain-stimulation-evoked aggression. Neurosci Biobehav Res 23:359-389. CrossRef Medline
31. Stowers L, Holy TE, Meister M, Dulac C, Koentges G (2002) Loss of sex discrimination and male-male aggression in mice deficient for TRP2. Science 295:1493-1500. CrossRef Medline
32. Tibshirani R (1996) Regression shrinkage and selection via the Lasso. J R Stat Soc B Met 58:267-288.
33. Tinbergen N (1951) The study of instinct. Oxford, UK: Clarendon.
34. Wang Z, Balet Sindreu C, Li V, Nudelman A, Chan GCK, Storm DR (2006) Pheromone detection in male mice depends on signaling through the type 3 adenylyl cyclase in the main olfactory epithelium. J Neurosci 26:7375-7379. CrossRef Medline
35. Wysocki CJ, Wellington JL, Beauchamp GK (1980) Access of urinary nonvolatiles to the mammalian vomeronasal organ. Science 207:781-783. CrossRef Medline
36. Zhang L, Ma W, Barker JL, Rubinow DR (1999) Sex differences in expression of serotonin receptors (subtypes 1A and 2A) in rat brain: a possible role of testosterone. Neuroscience 94:251-259. CrossRef Medline